Quinazolinone Derivatives as Orally Available Ghrelin Receptor Antagonists for the Treatment of Diabetes and Obesity
Rudolph, Joachim, Esler, William P, O'Connor, Stephen, Coish, Philip D. G, Wickens, Philip L, Brands, Michael, Bierer, Donald E, Bloomquist, Brian T, Bondar, Georgiy, Chen, Libing, Chuang, Chih-Yuan, Claus, Thomas H, Fathi, Zahra, Fu, Wenlang, Khire, Uday R, Kristie, James A, Liu, Xiao-Gao, Lowe, Derek B, McClure, Andrea C, Michels, Martin, Ortiz, Astrid A, Ramsden, Philip D, Schoenleber, Robert W, Shelekhin, Tatiana E, Vakalopoulos, Alexandros, Tang, Weifeng, Wang, Lei, Yi, Lin, Gardell, Stephen J, Livingston, James N, Sweet, Laurel J, Bullock, William H
Published in Journal of medicinal chemistry (18.10.2007)
Published in Journal of medicinal chemistry (18.10.2007)
Get full text
Journal Article
Development of Orally Efficacious Allosteric Inhibitors of TNFα via Fragment-Based Drug Design
Dietrich, Justin D, Longenecker, Kenton L, Wilson, Noel S, Goess, Christian, Panchal, Sanjay C, Swann, Steven L, Petros, Andrew M, Hobson, Adrian D, Ihle, David, Song, Danying, Richardson, Paul, Comess, Kenneth M, Cox, Philip B, Dombrowski, Amanda, Sarris, Kathy, Donnelly-Roberts, Diana L, Duignan, David B, Gomtsyan, Arthur, Jung, Paul, Krueger, A Chris, Mathieu, Suzanne, McClure, Andrea, Stoll, Vincent S, Wetter, Jill, Mankovich, John A, Hajduk, Philip J, Vasudevan, Anil, Stoffel, Robert H, Sun, Chaohong
Published in Journal of medicinal chemistry (14.01.2021)
Published in Journal of medicinal chemistry (14.01.2021)
Get full text
Journal Article
Discovery of morpholine-based aryl sulfonamides as Na(v)1.7 inhibitors
Wu, Yong-Jin, Guernon, Jason, McClure, Andrea, Venables, Brian, Rajamani, Ramkumar, Robbins, Kevin J., Knox, Ronald J., Matchett, Michele, Pieschl, Rick L., Herrington, James, Bristow, Linda J., Meanwell, Nicholas A., Olson, Richard, Thompson, Lorin A., Dzierba, Carolyn
Published in Bioorganic & medicinal chemistry letters (01.03.2018)
Published in Bioorganic & medicinal chemistry letters (01.03.2018)
Get full text
Journal Article
Discovery of non-zwitterionic aryl sulfonamides as Na(v)1.7 inhibitors with efficacy in preclinical behavioral models and translational measures of nociceptive neuron activation
Wu, Yong-Jin, Guernon, Jason, McClure, Andrea, Luo, Guanglin, Rajamani, Ramkumar, Ng, Alicia, Easton, Amy, Newton, Amy, Bourin, Clotilde, Parker, Dawn, Mosure, Kathleen, Barnaby, Omar, Soars, Matthew G., Knox, Ronald J., Matchett, Michele, Pieschl, Rick, Herrington, James, Chen, Ping, Sivarao, D. V., Bristow, Linda J., Meanwell, Nicholas A., Bronson, Joanne, Olson, Richard, Thompson, Lorin A., Dzierba, Carolyn
Published in Bioorganic & medicinal chemistry (15.10.2017)
Published in Bioorganic & medicinal chemistry (15.10.2017)
Get full text
Journal Article
Covalent immobilization of single-stranded DNA onto optical fibers using various linkers
Henke, Lisa, Piunno, Paul A.E., McClure, Andrea C., Krull, Ulrich J.
Published in Analytica chimica acta (10.06.1997)
Published in Analytica chimica acta (10.06.1997)
Get full text
Journal Article
Discovery of morpholine-based aryl sulfonamides as Nav1.7 inhibitors
Wu, Yong-Jin, Guernon, Jason, McClure, Andrea, Venables, Brian, Rajamani, Ramkumar, Robbins, Kevin J., Knox, Ronald J., Matchett, Michele, Pieschl, Rick L., Herrington, James, Bristow, Linda J., Meanwell, Nicholas A., Olson, Richard, Thompson, Lorin A., Dzierba, Carolyn
Published in Bioorganic & medicinal chemistry letters (01.03.2018)
Published in Bioorganic & medicinal chemistry letters (01.03.2018)
Get full text
Journal Article
Discovery of non-zwitterionic aryl sulfonamides as Nav1.7 inhibitors with efficacy in preclinical behavioral models and translational measures of nociceptive neuron activation
Wu, Yong-Jin, Guernon, Jason, McClure, Andrea, Luo, Guanglin, Rajamani, Ramkumar, Ng, Alicia, Easton, Amy, Newton, Amy, Bourin, Clotilde, Parker, Dawn, Mosure, Kathleen, Barnaby, Omar, Soars, Matthew G., Knox, Ronald J., Matchett, Michele, Pieschl, Rick, Herrington, James, Chen, Ping, Sivarao, D.V., Bristow, Linda J., Meanwell, Nicholas A., Bronson, Joanne, Olson, Richard, Thompson, Lorin A., Dzierba, Carolyn
Published in Bioorganic & medicinal chemistry (15.10.2017)
Published in Bioorganic & medicinal chemistry (15.10.2017)
Get full text
Journal Article
Discovery of morpholine-based aryl sulfonamides as Na v 1.7 inhibitors
Wu, Yong-Jin, Guernon, Jason, McClure, Andrea, Venables, Brian, Rajamani, Ramkumar, Robbins, Kevin J, Knox, Ronald J, Matchett, Michele, Pieschl, Rick L, Herrington, James, Bristow, Linda J, Meanwell, Nicholas A, Olson, Richard, Thompson, Lorin A, Dzierba, Carolyn
Published in Bioorganic & medicinal chemistry letters (01.03.2018)
Published in Bioorganic & medicinal chemistry letters (01.03.2018)
Get full text
Journal Article
Structure activity relationship studies on chemically non-reactive glycine sulfonamide inhibitors of diacylglycerol lipase
Chupak, Louis S., Zheng, Xiaofan, Hu, Shuanghua, Huang, Yazhong, Ding, Min, Lewis, Martin A., Westphal, Ryan S., Blat, Yuval, McClure, Andrea, Gentles, Robert G.
Published in Bioorganic & medicinal chemistry (01.04.2016)
Published in Bioorganic & medicinal chemistry (01.04.2016)
Get full text
Journal Article
Targeting the BACE1 Active Site Flap Leads to a Potent Inhibitor That Elicits Robust Brain Aβ Reduction in Rodents
Wu, Yong-Jin, Guernon, Jason, Yang, Fukang, Snyder, Lawrence, Shi, Jianliang, Mcclure, Andrea, Rajamani, Ramkumar, Park, Hyunsoo, Ng, Alicia, Lewis, Hal, Chang, ChiehYing, Camac, Dan, Toyn, Jeremy H, Ahlijanian, Michael K, Albright, Charles F, Macor, John E, Thompson, Lorin A
Published in ACS medicinal chemistry letters (10.03.2016)
Published in ACS medicinal chemistry letters (10.03.2016)
Get full text
Journal Article
Discovery of non-zwitterionic aryl sulfonamides as Na v 1.7 inhibitors with efficacy in preclinical behavioral models and translational measures of nociceptive neuron activation
Wu, Yong-Jin, Guernon, Jason, McClure, Andrea, Luo, Guanglin, Rajamani, Ramkumar, Ng, Alicia, Easton, Amy, Newton, Amy, Bourin, Clotilde, Parker, Dawn, Mosure, Kathleen, Barnaby, Omar, Soars, Matthew G, Knox, Ronald J, Matchett, Michele, Pieschl, Rick, Herrington, James, Chen, Ping, Sivarao, D V, Bristow, Linda J, Meanwell, Nicholas A, Bronson, Joanne, Olson, Richard, Thompson, Lorin A, Dzierba, Carolyn
Published in Bioorganic & medicinal chemistry (15.10.2017)
Get full text
Published in Bioorganic & medicinal chemistry (15.10.2017)
Journal Article
PYRROLO[2,1-F] [1,2,4] TRIAZIN-4-YLAMINES IGF-1R KINASE INHIBITORS FOR THE TREATMENT OF CANCER AND OTHER HYPERPROLIFERATIVE DISEASES
DIXON, JULIE, LOWE, DEREK, ACHEBE, FURAHI, LEE, WENDY, SHELEKHIN, TATIANA, BURKE, JENNIFER, IWUAGWU, CHRISTIANA, GUNN, DAVID, WANG, GAN, YING, SHIHONG, PHILLIPS, BARTON, DUMAS, JACQUES, CANTIN, DAVID, O'CONNOR, STEPHEN J, EHRGOTT, FREDERICK, LOBELL, MARIO, PARCELLA, KYLE, MA, XIN, MCCLURE, ANDREA
Year of Publication 19.08.2014
Get full text
Year of Publication 19.08.2014
Patent
PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS
KLUENDER HAROLD C.E, BRANDS MICHAEL, MIRANDA KARL, JONES BENJAMIN D, DIXON JULIE A, MCCLURE ANDREA, BIERER DONALD, BRENNAN CATHERINE, FU WENLANG, FAN JIANMEI, MAGNUSON STEVEN, PHILLIPS BARTON, CHANDLER BRENT
Year of Publication 29.08.2013
Get full text
Year of Publication 29.08.2013
Patent
Pyrrolo[2,1-f][1,2,4]triazin-4-ylamines IGF-1R kinase inhibitors for the treatment of cancer and other hyperproliferative diseases
DIXON JULIE, LOWE DEREK, O'CONNOR STEPHEN, SHELEKHIN TATIANA, LOBELL MARIO, CANTIN DAVID, PARCELLA KYLE, MA XIN, DUMAS JACQUES, MCCLURE ANDREA, GUNN DAVID, LEE WENDY, BURKE JENNIFER, IWUAGWU CHRISTIANA, EHRGOTT FREDERICK, WANG GAN, PHILLIPS BARTON, YING SHIHONG, ACHEBE FURAHI
Year of Publication 30.04.2013
Get full text
Year of Publication 30.04.2013
Patent
PYRROLO[2,1-F] [1,2,4]-TRIAZIN-4-YLAMINES AS IGF-1R KINASE INHIBITORS FOR THE TREATMENT OF CANCER AND OTHER HYPERPROLIFERATIVE DISEASES
DIXON, JULIE, LOWE, DEREK, ACHEBE, FURAHI, LEE, WENDY, SHELEKHIN, TATIANA, BURKE, JENNIFER, IWUAGWU, CHRISTIANA, GUNN, DAVID, WANG, GAN, YING, SHIHONG, PHILLIPS, BARTON, DUMAS, JACQUES, CANTIN, DAVID, O'CONNOR, STEPHEN J, EHRGOTT, FREDERICK, LOBELL, MARIO, PARCELLA, KYLE, MA, XIN, MCCLURE, ANDREA
Year of Publication 26.12.2012
Get full text
Year of Publication 26.12.2012
Patent
Pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis
BRANDS MICHAEL, MIRANDA KARL, JONES BENJAMIN D, DIXON JULIE A, MCCLURE ANDREA, BIERER DONALD, KLUENDER HAROLD C. E, BRENNAN CATHERINE, FU WENLANG, FAN JIANMEI, MAGNUSON STEVEN, PHILLIPS BARTON, CHANDLER BRENT
Year of Publication 25.12.2012
Get full text
Year of Publication 25.12.2012
Patent
Pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis
Dixon, Julie A, Brennan, Catherine, Miranda, Karl, Chandler, Brent, Phillips, Barton, Fan, Jianmei, Brands, Michael, McClure, Andrea, Jones, Benjamin D, Fu, Wenlang, Bierer, Donald, Magnuson, Steven, Kluender, Harold C. E
Year of Publication 25.12.2012
Get full text
Year of Publication 25.12.2012
Patent
PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS
FU, WENLANG, BRENNAN, CATHERINE, KLUENDER, HAROLD C. E, FAN, JIANMEI, CHANDLER, BRENT, PHILLIPS, BARTON, BRANDS, MICHAEL, MIRANDA, KARL, DIXON, JULIE A, MAGNUSON, STEVEN, BIERER, DONALD, JONES, BENJAMIN, MCCLURE, ANDREA
Year of Publication 20.12.2011
Get full text
Year of Publication 20.12.2011
Patent