Structure based design, synthesis and SAR of cyclic hydroxyethylamine (HEA) BACE-1 inhibitors
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Published in Bioorganic & medicinal chemistry letters (01.04.2011)
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Solubility-Driven Optimization of Phosphodiesterase‑4 Inhibitors Leading to a Clinical Candidate
Press, Neil J, Taylor, Roger J, Fullerton, Joseph D, Tranter, Pamela, McCarthy, Clive, Keller, Thomas H, Arnold, Nicola, Beer, David, Brown, Lyndon, Cheung, Robert, Christie, Julie, Denholm, Alastair, Haberthuer, Sandra, Hatto, Julia D. I, Keenan, Mark, Mercer, Mark K, Oakman, Helen, Sahri, Helene, Tuffnell, Andrew R, Tweed, Morris, Tyler, John W, Wagner, Trixie, Fozard, John R, Trifilieff, Alexandre
Published in Journal of medicinal chemistry (13.09.2012)
Published in Journal of medicinal chemistry (13.09.2012)
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TMEM16A Potentiation: A Novel Therapeutic Approach for the Treatment of Cystic Fibrosis
Danahay, Henry L, Lilley, Sarah, Fox, Roy, Charlton, Holly, Sabater, Juan, Button, Brian, McCarthy, Clive, Collingwood, Stephen P, Gosling, Martin
Published in American journal of respiratory and critical care medicine (15.04.2020)
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ETD001: A novel inhaled ENaC blocker with an extended duration of action in vivo
Danahay, Henry, McCarthy, Clive, Schofield, Thomas, Fox, Roy, Charlton, Holly, Lilley, Sarah, Sabater, Juan, Salathe, Matthias, Baumlin, Nathalie, Collingwood, Stephen P, Gosling, Martin
Published in Journal of cystic fibrosis (07.06.2024)
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WALKER EDWARD RICHARD, MOULTON BEN, MCCARTHY CLIVE, MCMAHON PEARL SIOBHAN
Year of Publication 07.06.2023
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Year of Publication 07.06.2023
Patent
Identification of NVP-CLR457 as an Orally Bioavailable Non-CNS-Penetrant pan-Class IA Phosphoinositol-3-Kinase Inhibitor
Fairhurst, Robin A., Furet, Pascal, Imbach-Weese, Patricia, Stauffer, Frédéric, Rueeger, Heinrich, McCarthy, Clive, Ripoche, Sebastien, Oswald, Susanne, Arnaud, Bertrand, Jary, Aline, Maira, Michel, Schnell, Christian, Guthy, Daniel A., Wartmann, Markus, Kiffe, Michael, Desrayaud, Sandrine, Blasco, Francesca, Widmer, Toni, Seiler, Frank, Gutmann, Sascha, Knapp, Mark, Caravatti, Giorgio
Published in Journal of medicinal chemistry (23.06.2022)
Published in Journal of medicinal chemistry (23.06.2022)
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Abstract 5014: Profile of ARX001822, a highly potent, selective and orally bioavailable A2a antagonist effective in preventing adenosinergic suppression of T cell activation
Finan, Peter M., Pettipher, Roy, White, Jonathan, Patel, Viral, Moulton, Ben, Porres, Soraya, Gherbi, Karolina, Rosethorne, Elizabeth M., Charlton, Steven J., McCarthy, Clive
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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A Drug Resistance Screen Using a Selective MET Inhibitor Reveals a Spectrum of Mutations That Partially Overlap with Activating Mutations Found in Cancer Patients
TIEDT, Ralph, DEGENKOLBE, Elisa, BLANK, Jutta, HAASEN, Dorothea, DRUECKES, Peter, WARTMANN, Markus, MCCARTHY, Clive, SELLERS, William R, HOFMANN, Francesco, FURET, Pascal, APPLETON, Brent A, WAGNER, Sabrina, SCHOEPFER, Joseph, BUCK, Emily, RUDDY, David A, MONAHAN, John E, JONES, Michael D
Published in Cancer research (Chicago, Ill.) (01.08.2011)
Published in Cancer research (Chicago, Ill.) (01.08.2011)
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Discovery and Optimization of 4-(8-(3-Fluorophenyl)-1,7-naphthyridin-6-yl)transcyclohexanecarboxylic Acid, an Improved PDE4 Inhibitor for the Treatment of Chronic Obstructive Pulmonary Disease (COPD)
Press, Neil J., Taylor, Roger J., Fullerton, Joseph D., Tranter, Pamela, McCarthy, Clive, Keller, Thomas H., Arnold, Nicola, Beer, David, Brown, Lyndon, Cheung, Robert, Christie, Julie, Denholm, Alastair, Haberthuer, Sandra, Hatto, Julia D. I., Keenan, Mark, Mercer, Mark K., Oakman, Helen, Sahri, Helene, Tuffnell, Andrew R., Tweed, Morris, Trifilieff, Alexandre
Published in Journal of medicinal chemistry (10.09.2015)
Published in Journal of medicinal chemistry (10.09.2015)
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Development of isoform selective PI3-kinase inhibitors as pharmacological tools for elucidating the PI3K pathway
Bruce, Ian, Akhlaq, Mohammed, Bloomfield, Graham C., Budd, Emma, Cox, Brian, Cuenoud, Bernard, Finan, Peter, Gedeck, Peter, Hatto, Julia, Hayler, Judy F., Head, Denise, Keller, Thomas, Kirman, Louise, Leblanc, Catherine, Grand, Darren Le, McCarthy, Clive, O’Connor, Desmond, Owen, Charles, Oza, Mrinalini S., Pilgrim, Gaynor, Press, Nicola E., Sviridenko, Lilya, Whitehead, Lewis
Published in Bioorganic & medicinal chemistry letters (01.09.2012)
Published in Bioorganic & medicinal chemistry letters (01.09.2012)
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Macrocyclic BACE-1 inhibitors acutely reduce Aβ in brain after po application
Lerchner, Andreas, Machauer, Rainer, Betschart, Claudia, Veenstra, Siem, Rueeger, Heinrich, McCarthy, Clive, Tintelnot-Blomley, Marina, Jaton, Anne-Lise, Rabe, Sabine, Desrayaud, Sandrine, Enz, Albert, Staufenbiel, Matthias, Paganetti, Paolo, Rondeau, Jean-Michel, Neumann, Ulf
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
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Optimisation of a 5-[3-phenyl-(2-cyclic-ether)-methyl-ether]-4-aminopyrrolopyrimidine series of IGF-1R inhibitors
Fairhurst, Robin A., Marsilje, Thomas H., Stutz, Stefan, Boos, Andreas, Niklaus, Michel, Chen, Bei, Jiang, Songchun, Lu, Wenshuo, Furet, Pascal, McCarthy, Clive, Stauffer, Frédéric, Guagnano, Vito, Vaupel, Andrea, Michellys, Pierre-Yves, Schnell, Christian, Jeay, Sébastien
Published in Bioorganic & medicinal chemistry letters (15.04.2016)
Published in Bioorganic & medicinal chemistry letters (15.04.2016)
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ENaC 억제제로서의 벤조디아졸륨 화합물
WENT NAOMI, SCHOFIELD THOMAS BEAUREGARD, MCCARTHY CLIVE, HAY DUNCAN ALEXANDER, HARGRAVE JONATHAN DAVID
Year of Publication 15.07.2019
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Year of Publication 15.07.2019
Patent
호흡기 질환을 치료하기 위한 화합물
INGRAM PETER, WALKER EDWARD, WENT NAOMI, MA ALBERT, SMITH MATTHEW, SCHOFIELD THOMAS BEAUREGARD, MCCARTHY CLIVE, KHOR SOMEINA, HAY DUNCAN ALEXANDER, COLLINGWOOD STEPHEN, HARGRAVE JONATHAN DAVID, STIMSON CHRISTOPHER
Year of Publication 22.04.2022
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Year of Publication 22.04.2022
Patent
Discovery and Optimization of 4‑(8-(3-Fluorophenyl)-1,7-naphthyridin-6-yl)transcyclohexanecarboxylic Acid, an Improved PDE4 Inhibitor for the Treatment of Chronic Obstructive Pulmonary Disease (COPD)
Press, Neil J., Taylor, Roger J., Fullerton, Joseph D., Tranter, Pamela, McCarthy, Clive, Keller, Thomas H., Arnold, Nicola, Beer, David, Brown, Lyndon, Cheung, Robert, Christie, Julie, Denholm, Alastair, Haberthuer, Sandra, Hatto, Julia D. I., Keenan, Mark, Mercer, Mark K., Oakman, Helen, Sahri, Helene, Tuffnell, Andrew R., Tweed, Morris, Trifilieff, Alexandre
Published in Journal of medicinal chemistry (10.09.2015)
Published in Journal of medicinal chemistry (10.09.2015)
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Discovery and SAR of potent, orally available 2,8-diaryl-quinoxalines as a new class of JAK2 inhibitors
Pissot-Soldermann, Carole, Gerspacher, Marc, Furet, Pascal, Gaul, Christoph, Holzer, Philipp, McCarthy, Clive, Radimerski, Thomas, Regnier, Catherine H., Baffert, Fabienne, Drueckes, Peter, Tavares, Gisele A., Vangrevelinghe, Eric, Blasco, Francesca, Ottaviani, Giorgio, Ossola, Flavio, Scesa, Julien, Reetz, Janitha
Published in Bioorganic & medicinal chemistry letters (15.04.2010)
Published in Bioorganic & medicinal chemistry letters (15.04.2010)
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