Homology models of the HIV-1 attachment inhibitor BMS-626529 bound to gp120 suggest a unique mechanism of action
Langley, David R., Roy Kimura, S., Sivaprakasam, Prasanna, Zhou, Nannan, Dicker, Ira, McAuliffe, Brian, Wang, Tao, Kadow, John F., Meanwell, Nicholas A., Krystal, Mark
Published in Proteins, structure, function, and bioinformatics (01.02.2015)
Published in Proteins, structure, function, and bioinformatics (01.02.2015)
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In Vitro Antiviral Characteristics of HIV-1 Attachment Inhibitor BMS-626529, the Active Component of the Prodrug BMS-663068
NOWICKA-SANS, Beata, GONG, Yi-Fei, LI ZHU, MAJUMDAR, Antara, STOCK, David, LATAILLADE, Max, HANNA, George J, MATISKELLA, John D, UEDA, Yasutsugu, TAO WANG, KADOW, John F, MEANWELL, Nicholas A, MCAULIFFE, Brian, KRYSTAL, Mark, DICKER, Ira, HO, Hsu-Tso, NANNAN ZHOU, EGGERS, Betsy, LIN, Pin-Fang, RAY, Neelanjana, WIND-ROTOLO, Megan
Published in Antimicrobial Agents and Chemotherapy (01.07.2012)
Published in Antimicrobial Agents and Chemotherapy (01.07.2012)
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Inhibitors of Human Immunodeficiency Virus Type 1 (HIV-1) Attachment. 5. An Evolution from Indole to Azaindoles Leading to the Discovery of 1-(4-Benzoylpiperazin-1-yl)-2-(4,7-dimethoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione (BMS-488043), a Drug Candidate That Demonstrates Antiviral Activity in HIV-1-Infected Subjects
Wang, Tao, Yin, Zhiwei, Zhang, Zhongxing, Bender, John A, Yang, Zhong, Johnson, Graham, Yang, Zheng, Zadjura, Lisa M, D’Arienzo, Celia J, DiGiugno Parker, Dawn, Gesenberg, Christophe, Yamanaka, Gregory A, Gong, Yi-Fei, Ho, Hsu-Tso, Fang, Hua, Zhou, Nannan, McAuliffe, Brian V, Eggers, Betsy J, Fan, Li, Nowicka-Sans, Beata, Dicker, Ira B, Gao, Qi, Colonno, Richard J, Lin, Pin-Fang, Meanwell, Nicholas A, Kadow, John F
Published in Journal of medicinal chemistry (10.12.2009)
Published in Journal of medicinal chemistry (10.12.2009)
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Journal Article
Biochemical and Genetic Characterizations of a Novel Human Immunodeficiency Virus Type 1 Inhibitor That Blocks gp120-CD4 Interactions
Guo, Qi, Ho, Hsu-Tso, Dicker, Ira, Fan, Li, Zhou, Nannan, Friborg, Jacques, Wang, Tao, McAuliffe, Brian V, Wang, Hwei-Gene Heidi, Rose, Ronald E, Fang, Hua, Scarnati, Helen T, Langley, David R, Meanwell, Nicholas A, Abraham, Ralph, Colonno, Richard J, Lin, Pin-Fang
Published in Journal of Virology (01.10.2003)
Published in Journal of Virology (01.10.2003)
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Journal Article
Envelope Conformational Changes Induced by Human Immunodeficiency Virus Type 1 Attachment Inhibitors Prevent CD4 Binding and Downstream Entry Events
HO, Hsu-Tso, LI FAN, GONG, Yi-Fei, TAO WANG, ZHIWEI YIN, UEDA, Yasutsugu, MATISKELLA, John, KADOW, John, CLAPHAM, Paul, ROBINSON, James, COLONNO, Richard, LIN, Pin-Fang, NOWICKA-SANS, Beata, MCAULIFFE, Brian, LI, Chang-Ben, YAMANAKA, Gregory, NANNAN ZHOU, HUA FANG, DICKER, Ira, DALTERIO, Richard
Published in Journal of Virology (01.04.2006)
Published in Journal of Virology (01.04.2006)
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Inhibition of Envelope-Mediated CD4+-T-Cell Depletion by Human Immunodeficiency Virus Attachment Inhibitors
ALEXANDER, Louis, ZHANG, Sharon, MCAULIFFE, Brian, CONNORS, David, NANNON ZHOU, TAO WANG, AGLER, Michele, KADOW, John, LIN, Pin-Fang
Published in Antimicrobial Agents and Chemotherapy (01.11.2009)
Published in Antimicrobial Agents and Chemotherapy (01.11.2009)
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Measurement of the on-road wind environment in channelled roadways
McTavish, Sean, Ghorbanishohrat, Fa, McAuliffe, Brian
Published in Journal of wind engineering and industrial aerodynamics (01.09.2024)
Published in Journal of wind engineering and industrial aerodynamics (01.09.2024)
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GSK3640254 Is a Novel HIV-1 Maturation Inhibitor with an Optimized Virology Profile
Dicker, Ira, Jeffrey, Jerry L, Protack, Tricia, Lin, Zeyu, Cockett, Mark, Chen, Yan, Sit, Sing-Yuen, Gartland, Martin, Meanwell, Nicholas A, Regueiro-Ren, Alicia, Drexler, Dieter, Cantone, Joseph, McAuliffe, Brian, Krystal, Mark
Published in Antimicrobial agents and chemotherapy (18.01.2022)
Published in Antimicrobial agents and chemotherapy (18.01.2022)
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Application of Cassette Ultracentrifugation Using Non-labeled Compounds and Liquid Chromatography-Tandem Mass Spectrometry Analysis for High-Throughput Protein Binding Determination
Kieltyka, Kasia, McAuliffe, Brian, Cianci, Christopher, Drexler, Dieter M., Shou, Wilson, Zhang, Jun
Published in Journal of pharmaceutical sciences (01.03.2016)
Published in Journal of pharmaceutical sciences (01.03.2016)
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5,6,7,8-Tetrahydro-1,6-naphthyridine Derivatives as Potent HIV-1-Integrase-Allosteric-Site Inhibitors
Peese, Kevin M, Allard, Christopher W, Connolly, Timothy, Johnson, Barry L, Li, Chen, Patel, Manoj, Sorensen, Margaret E, Walker, Michael A, Meanwell, Nicholas A, McAuliffe, Brian, Minassian, Beatrice, Krystal, Mark, Parker, Dawn D, Lewis, Hal A, Kish, Kevin, Zhang, Ping, Nolte, Robert T, Simmermacher, Jean, Jenkins, Susan, Cianci, Christopher, Naidu, B. Narasimhulu
Published in Journal of medicinal chemistry (14.02.2019)
Published in Journal of medicinal chemistry (14.02.2019)
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Design, synthesis and SAR study of novel C2-pyrazolopyrimidine amides and amide isosteres as allosteric integrase inhibitors
Patel, Manoj, Cianci, Christopher, Allard, Christopher W., Parker, Dawn D., Simmermacher, Jean, Jenkins, Susan, Mcauliffe, Brian, Minassian, Beatrice, Discotto, Linda, Krystal, Mark, Meanwell, Nicholas A., Naidu, B. Narasimhulu
Published in Bioorganic & medicinal chemistry letters (01.11.2020)
Published in Bioorganic & medicinal chemistry letters (01.11.2020)
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Journal Article
Scaffold modifications to the 4-(4,4-dimethylpiperidinyl) 2,6-dimethylpyr-idinyl class of HIV-1 allosteric integrase inhibitors
Parcella, Kyle, Patel, Manoj, Tu, Yong, Eastman, Kyle, Peese, Kevin, Gillis, Eric, Belema, Makonen, Dicker, Ira B., McAuliffe, Brian, Ding, Bo, Falk, Paul, Simmermacher, Jean, Parker, Dawn D., Sivaprakasam, Prasanna, Khan, Javed A., Kish, Kevin, Lewis, Hal, Hanumegowda, Umesh, Jenkins, Susan, Kadow, John F., Krystal, Mark, Meanwell, Nicholas A., Naidu, B. Narasimhulu
Published in Bioorganic & medicinal chemistry (01.08.2022)
Published in Bioorganic & medicinal chemistry (01.08.2022)
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Journal Article
Design, Synthesis, and Preclinical Profiling of GSK3739936 (BMS-986180), an Allosteric Inhibitor of HIV‑1 Integrase with Broad-Spectrum Activity toward 124/125 Polymorphs
Naidu, B. Narasimhulu, Patel, Manoj, McAuliffe, Brian, Ding, Bo, Cianci, Christopher, Simmermacher, Jean, Jenkins, Susan, Parker, Dawn D, Sivaprakasam, Prasanna, Khan, Javed A, Kish, Kevin, Lewis, Hal, Hanumegowda, Umesh, Krystal, Mark, Meanwell, Nicholas A, Kadow, John F
Published in Journal of medicinal chemistry (24.03.2022)
Published in Journal of medicinal chemistry (24.03.2022)
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Journal Article
Scaffold modifications to the 4-(4,4-dimethylpiperidinyl) 2,6-dimethylpyridinyl class of HIV-1 allosteric integrase inhibitors
Parcella, Kyle, Patel, Manoj, Tu, Yong, Eastman, Kyle, Peese, Kevin, Gillis, Eric, Belema, Makonen, Dicker, Ira B., McAuliffe, Brian, Ding, Bo, Falk, Paul, Simmermacher, Jean, Parker, Dawn D., Sivaprakasam, Prasanna, Khan, Javed A., Kish, Kevin, Lewis, Hal, Hanumegowda, Umesh, Jenkins, Susan, Kadow, John F., Krystal, Mark, Meanwell, Nicholas A., Naidu, B. Narasimhulu
Published in Bioorganic & medicinal chemistry (01.08.2022)
Published in Bioorganic & medicinal chemistry (01.08.2022)
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Structure-based amelioration of PXR transactivation in a novel series of macrocyclic allosteric inhibitors of HIV-1 integrase
Sivaprakasam, Prasanna, Wang, Zhongyu, Meanwell, Nicholas A., Khan, Javed A., Langley, David R., Johnson, Stephen R., Li, Guo, Pendri, Annapurna, Connolly, Timothy P., Gao, Mian, Camac, Daniel M., Klakouski, Cheryl, Zvyaga, Tatyana, Cianci, Christopher, McAuliffe, Brian, Ding, Bo, Discotto, Linda, Krystal, Mark R., Jenkins, Susan, Peese, Kevin M., Narasimhulu Naidu, B.
Published in Bioorganic & medicinal chemistry letters (15.11.2020)
Published in Bioorganic & medicinal chemistry letters (15.11.2020)
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Inhibition of influenza virus replication via small molecules that induce the formation of higher-order nucleoprotein oligomers
Gerritz, Samuel W, Cianci, Christopher, Kim, Sean, Pearce, Bradley C, Deminie, Carol, Discotto, Linda, McAuliffe, Brian, Minassian, Beatrice F, Shi, Shuhao, Zhu, Shirong, Zhai, Weixu, Pendri, Annapurna, Li, Guo, Poss, Michael A, Edavettal, Suzanne, McDonnell, Patricia A, Lewis, Hal A, Maskos, Klaus, Mörtl, Mario, Kiefersauer, Reiner, Steinbacher, Stefan, Baldwin, Eric T, Metzler, William, Bryson, James, Healy, Matthew D, Philip, Thomas, Zoeckler, Mary, Schartman, Richard, Sinz, Michael, Leyva-Grado, Victor H, Hoffmann, Hans-Heinrich, Langley, David R, Meanwell, Nicholas A, Krystal, Mark
Published in Proceedings of the National Academy of Sciences - PNAS (13.09.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (13.09.2011)
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Journal Article
Genotypic correlates of susceptibility to HIV-1 attachment inhibitor BMS-626529, the active agent of the prodrug BMS-663068
Zhou, Nannan, Nowicka-Sans, Beata, McAuliffe, Brian, Ray, Neelanjana, Eggers, Betsy, Fang, Hua, Fan, Li, Healy, Matthew, Langley, David R, Hwang, Carey, Lataillade, Max, Hanna, George J, Krystal, Mark
Published in Journal of antimicrobial chemotherapy (01.03.2014)
Published in Journal of antimicrobial chemotherapy (01.03.2014)
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Journal Article
Discovery and Preclinical Profiling of GSK3839919, a Potent HIV‑1 Allosteric Integrase Inhibitor
Parcella, Kyle, Wang, Tao, Eastman, Kyle, Zhang, Zhongxing, Yin, Zhiwei, Patel, Manoj, Tu, Yong, Zheng, Barbara Zhizhen, Walker, Michael A., Saulnier, Mark G., Frennesson, David, Bowsher, Michael, Gillis, Eric, Peese, Kevin, Belema, Makonen, Cianci, Christopher, Dicker, Ira B., McAuliffe, Brian, Ding, Bo, Falk, Paul, Simmermacher, Jean, Parker, Dawn D., Sivaprakasam, Prasanna, Kish, Kevin, Lewis, Hal, Hanumegowda, Umesh, Jenkins, Susan, Kadow, John F., Krystal, Mark, Meanwell, Nicholas A., Naidu, B. Narasimhulu
Published in ACS medicinal chemistry letters (09.06.2022)
Published in ACS medicinal chemistry letters (09.06.2022)
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