Towards an Understanding of the Mechanism of Pyrimethamine-Sulfadoxine Resistance in Plasmodium falciparum: Genotyping of Dihydrofolate Reductase and Dihydropteroate Synthase of Kenyan Parasites
NZILA, A. M, MBERU, E. K, SULO, J, DAYO, H, WINSTANLEY, P. A, SIBLEY, C. H, WATKINS, W. M
Published in Antimicrobial Agents and Chemotherapy (01.04.2000)
Published in Antimicrobial Agents and Chemotherapy (01.04.2000)
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Kenyan Plasmodium falciparum Field Isolates: Correlation between Pyrimethamine and Chlorcycloguanil Activity In Vitro and Point Mutations in the Dihydrofolate Reductase Domain
NZILA-MOUNDA, A, MBERU, E. K, SIBLEY, C. H, PLOWE, C. V, WINSTANLEY, P. A, WATKINS, W. M
Published in Antimicrobial Agents and Chemotherapy (01.01.1998)
Published in Antimicrobial Agents and Chemotherapy (01.01.1998)
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The antimalarial triazine WR99210 and the prodrug PS-15: folate reversal of in vitro activity against Plasmodium falciparum and a non-antifolate mode of action of the prodrug
Kinyanjui, SM, Mberu, EK, Winstanley, PA, Jacobus, DP, Watkins, WM
Published in The American journal of tropical medicine and hygiene (01.06.1999)
Published in The American journal of tropical medicine and hygiene (01.06.1999)
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The changing in vitro susceptibility pattern to pyrimethamine/sulfadoxine in Plasmodium falciparum field isolates from Kilifi, Kenya
Mberu, EK, Mosobo, MK, Nzila, AM, Kokwaro, GO, Sibley, CH, Watkins, WM
Published in The American journal of tropical medicine and hygiene (01.03.2000)
Published in The American journal of tropical medicine and hygiene (01.03.2000)
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Pyrimethamine–sulfadoxine resistance in Plasmodium falciparum: what next?
Sibley, Carol Hopkins, Hyde, John E, Sims, Paul F.G, Plowe, Christopher V, Kublin, James G, Mberu, Edward K, Cowman, Alan F, Winstanley, Peter A, Watkins, William M, Nzila, Alexis M
Published in Trends in Parasitology (01.12.2001)
Published in Trends in Parasitology (01.12.2001)
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Book Review
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Ferriprotoporphyrin catalysed decomposition of artemether: Analytical and pharmacological implications
Muhia, D.K., Thomas, C.G., Ward, S.A., Edwards, G., Mberu, E.K., Watkins, W.M.
Published in Biochemical pharmacology (30.08.1994)
Published in Biochemical pharmacology (30.08.1994)
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Japanese poor metabolizers of proguanil do not have an increased risk of malaria chemoprophylaxis breakthrough
Mberu, E.K., Wansor, T., Sato, H., Nishikawa, Y., Watkins, W.M.
Published in Transactions of the Royal Society of Tropical Medicine and Hygiene (01.11.1995)
Published in Transactions of the Royal Society of Tropical Medicine and Hygiene (01.11.1995)
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Conference Proceeding
Cutaneous hypersensitivity reactions to thiacetazone, HIV infection and thiacetazone concentrations in plasma
WATKINS, W. M., MUNGAI, M., MUHIA, D. K., MBERU, E. K., GATHUA, S., WINSTANLEY, P. A., GILKS's, C. F., NUNN, P.
Published in British journal of clinical pharmacology (01.02.1996)
Published in British journal of clinical pharmacology (01.02.1996)
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Towards optimal regimens of parenteral quinine for young African children with cerebral malaria: unbound quinine concentrations following a simple loading dose regimen
Winstanley, P.A., Mberu, E.K., Watkins, W.M., Murphy, S.A., Lowe, B., Marsh, K.
Published in Transactions of the Royal Society of Tropical Medicine and Hygiene (01.09.1994)
Published in Transactions of the Royal Society of Tropical Medicine and Hygiene (01.09.1994)
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A single dose of intramuscular sulfadoxine-pyrimethamine as an adjunct to quinine in the treatment of severe malaria: pharmacokinetics and efficacy
Newton, C.R.J.C., Winstanley, P.A., Watkins, W.M., Mwangi, I.N., Waruiru, C.M., Mberu, E.K., Warn, P.A., Nevill, C.G., Marsh, K.
Published in Transactions of the Royal Society of Tropical Medicine and Hygiene (01.03.1993)
Published in Transactions of the Royal Society of Tropical Medicine and Hygiene (01.03.1993)
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Halofantrine pharmacokinetics in Kenyan children with non‐severe and severe malaria
Watkins, WM, Winstanley, PA, Mberu, EK, Kokwaro, G, Murphy, SA, Newton, CJ, Mwangi, I, Forster, D, Marsh, K
Published in British journal of clinical pharmacology (01.03.1995)
Published in British journal of clinical pharmacology (01.03.1995)
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Variability in the metabolism of proguanil to the active metabolite cycloguanil in healthy Kenyan adults
Watkins, W.M., Mberu, E.K., Nevill, C.G., Ward, S.A., Breckenridge, A.M., Koech, D.K.
Published in Transactions of the Royal Society of Tropical Medicine and Hygiene (01.07.1990)
Published in Transactions of the Royal Society of Tropical Medicine and Hygiene (01.07.1990)
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The efficacy of antifolate antimalarial combinations in Africa: a predictive model based on pharmacodynamic and pharmacokinetic analyses
Watkins, W.M., Mberu, E.K., Winstanley, P.A., Plowe, C.V.
Published in Parasitology Today (01.12.1997)
Published in Parasitology Today (01.12.1997)
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Book Review
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The Effect of Quinine on the Electroretinograms of Children with Pediatric Cerebral Malaria
Lochhead, Jonathan, Movaffaghy, Armand, Falsini, Benedetto, Winstanley, Peter A, Mberu, Edward K, Riva, Charles E, Molyneux, Malcolm E, Taylor, Terrie E, Harding, Simon P
Published in The Journal of infectious diseases (15.04.2003)
Published in The Journal of infectious diseases (15.04.2003)
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Antimalarial activity in crude extracts of Malawian medicinal plants
Connelly, M P, Fabiano, E, Patel, I H, Kinyanjui, S M, Mberu, E K, Watkins, W M
Published in Annals of tropical medicine and parasitology (01.12.1996)
Published in Annals of tropical medicine and parasitology (01.12.1996)
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