LDHA-mediated ROS generation in chondrocytes is a potential therapeutic target for osteoarthritis
Arra, Manoj, Swarnkar, Gaurav, Ke, Ke, Otero, Jesse E., Ying, Jun, Duan, Xin, Maruyama, Takashi, Rai, Muhammad Farooq, O’Keefe, Regis J., Mbalaviele, Gabriel, Shen, Jie, Abu-Amer, Yousef
Published in Nature communications (09.07.2020)
Published in Nature communications (09.07.2020)
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Journal Article
Inflammatory osteolysis: a conspiracy against bone
Mbalaviele, Gabriel, Novack, Deborah V, Schett, Georg, Teitelbaum, Steven L
Published in The Journal of clinical investigation (01.06.2017)
Published in The Journal of clinical investigation (01.06.2017)
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Journal Article
Chemotherapy activates inflammasomes to cause inflammation-associated bone loss
Wang, Chun, Kaur, Khushpreet, Xu, Canxin, Abu-Amer, Yousef, Mbalaviele, Gabriel
Published in eLife (11.04.2024)
Published in eLife (11.04.2024)
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Journal Article
Gasdermin D mediates the pathogenesis of neonatal-onset multisystem inflammatory disease in mice
Xiao, Jianqiu, Wang, Chun, Yao, Juo-Chin, Alippe, Yael, Xu, Canxin, Kress, Dustin, Civitelli, Roberto, Abu-Amer, Yousef, Kanneganti, Thirumala-Devi, Link, Daniel C, Mbalaviele, Gabriel
Published in PLoS biology (02.11.2018)
Published in PLoS biology (02.11.2018)
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Journal Article
IκB-ζ signaling promotes chondrocyte inflammatory phenotype, senescence, and erosive joint pathology
Arra, Manoj, Swarnkar, Gaurav, Alippe, Yael, Mbalaviele, Gabriel, Abu-Amer, Yousef
Published in Bone Research (11.02.2022)
Published in Bone Research (11.02.2022)
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Journal Article
Inflammatory osteolysis is regulated by site-specific ISGylation of the scaffold protein NEMO
Adapala, Naga Suresh, Swarnkar, Gaurav, Arra, Manoj, Shen, Jie, Mbalaviele, Gabriel, Ke, Ke, Abu-Amer, Yousef
Published in eLife (23.03.2020)
Published in eLife (23.03.2020)
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Journal Article
Selective inhibition of the p38α MAPK-MK2 axis inhibits inflammatory cues including inflammasome priming signals
Wang, Chun, Hockerman, Susan, Jacobsen, E Jon, Alippe, Yael, Selness, Shaun R, Hope, Heidi R, Hirsch, Jeffrey L, Mnich, Stephen J, Saabye, Matthew J, Hood, William F, Bonar, Sheri L, Abu-Amer, Yousef, Haimovich, Ariela, Hoffman, Hal M, Monahan, Joseph B, Mbalaviele, Gabriel
Published in The Journal of experimental medicine (07.05.2018)
Published in The Journal of experimental medicine (07.05.2018)
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Journal Article
Bone matrix components activate the NLRP3 inflammasome and promote osteoclast differentiation
Alippe, Yael, Wang, Chun, Ricci, Biancamaria, Xiao, Jianqiu, Qu, Chao, Zou, Wei, Novack, Deborah V., Abu-Amer, Yousef, Civitelli, Roberto, Mbalaviele, Gabriel
Published in Scientific reports (26.07.2017)
Published in Scientific reports (26.07.2017)
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Journal Article
Radiation causes tissue damage by dysregulating inflammasome-gasdermin D signaling in both host and transplanted cells
Xiao, Jianqiu, Wang, Chun, Yao, Juo-Chin, Alippe, Yael, Yang, Tong, Kress, Dustin, Sun, Kai, Kostecki, Kourtney L, Monahan, Joseph B, Veis, Deborah J, Abu-Amer, Yousef, Link, Daniel C, Mbalaviele, Gabriel
Published in PLoS biology (06.08.2020)
Published in PLoS biology (06.08.2020)
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Journal Article
Fracture healing is delayed in the absence of gasdermin-interleukin-1 signaling
Sun, Kai, Wang, Chun, Xiao, Jianqiu, Brodt, Michael D, Yuan, Luorongxin, Yang, Tong, Alippe, Yael, Hu, Huimin, Hao, Dingjun, Abu-Amer, Yousef, Silva, Matthew J, Shen, Jie, Mbalaviele, Gabriel
Published in eLife (04.03.2022)
Published in eLife (04.03.2022)
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Journal Article
Gasdermin D deficiency attenuates arthritis induced by traumatic injury but not autoantibody-assembled immune complexes
Yang, Tong, Sun, Kai, Wang, Chun, Swarnkar, Gaurav, Quan, Songtao, Kress, Dustin, Xiao, Jianqiu, Alippe, Yael, Zheng, Hongjun, Brophy, Robert H, Hao, Dingjun, McAlinden, Audrey, Abu-Amer, Yousef, Shen, Jie, Mbalaviele, Gabriel
Published in Arthritis research & therapy (16.11.2021)
Published in Arthritis research & therapy (16.11.2021)
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Journal Article
Glutamine metabolism modulates chondrocyte inflammatory response
Arra, Manoj, Swarnkar, Gaurav, Adapala, Naga Suresh, Naqvi, Syeda Kanwal, Cai, Lei, Rai, Muhammad Farooq, Singamaneni, Srikanth, Mbalaviele, Gabriel, Brophy, Robert, Abu-Amer, Yousef
Published in eLife (02.08.2022)
Published in eLife (02.08.2022)
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Journal Article
N-cadherin and cadherin 11 modulate postnatal bone growth and osteoblast differentiation by distinct mechanisms
Di Benedetto, Adriana, Watkins, Marcus, Grimston, Susan, Salazar, Valerie, Donsante, Christine, Mbalaviele, Gabriel, Radice, Glenn L, Civitelli, Roberto
Published in Journal of cell science (01.08.2010)
Published in Journal of cell science (01.08.2010)
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Journal Article
Inhibition of the NLRP3 inflammasome prevents ovarian aging
Navarro-Pando, José M, Alcocer-Gómez, Elísabet, Castejón-Vega, Beatriz, Navarro-Villarán, Elena, Condés-Hervás, Mónica, Mundi-Roldan, María, Muntané, Jordi, Pérez-Pulido, Antonio J, Bullon, Pedro, Wang, Chun, Hoffman, Hal M, Sanz, Alberto, Mbalaviele, Gabriel, Ryffel, Bernhard, Cordero, Mario D
Published in Science advances (01.01.2021)
Published in Science advances (01.01.2021)
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Journal Article
Constitutive activation of IKK2/NF-κB impairs osteogenesis and skeletal development
Swarnkar, Gaurav, Zhang, Kaihua, Mbalaviele, Gabriel, Long, Fanxin, Abu-Amer, Yousef
Published in PloS one (11.03.2014)
Published in PloS one (11.03.2014)
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Journal Article
Inhibition of the NLRP3 inflammasome improves lifespan in animal murine model of Hutchinson–Gilford Progeria
González‐Dominguez, Alvaro, Montañez, Raúl, Castejón‐Vega, Beatriz, Nuñez‐Vasco, Jéssica, Lendines‐Cordero, Débora, Wang, Chun, Mbalaviele, Gabriel, Navarro‐Pando, José M, Alcocer‐Gómez, Elísabet, Cordero, Mario D
Published in EMBO molecular medicine (07.10.2021)
Published in EMBO molecular medicine (07.10.2021)
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Journal Article