Phenyl‐Glutarimides: Alternative Cereblon Binders for the Design of PROTACs
Min, Jaeki, Mayasundari, Anand, Keramatnia, Fatemeh, Jonchere, Barbara, Yang, Seung Wook, Jarusiewicz, Jamie, Actis, Marisa, Das, Sourav, Young, Brandon, Slavish, Jake, Yang, Lei, Li, Yong, Fu, Xiang, Garrett, Shalandus H., Yun, Mi‐Kyung, Li, Zhenmei, Nithianantham, Stanley, Chai, Sergio, Chen, Taosheng, Shelat, Anang, Lee, Richard E., Nishiguchi, Gisele, White, Stephen W., Roussel, Martine F., Potts, Patrick Ryan, Fischer, Marcus, Rankovic, Zoran
Published in Angewandte Chemie International Edition (13.12.2021)
Published in Angewandte Chemie International Edition (13.12.2021)
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Journal Article
Structural basis for substrate recognition and chemical inhibition of oncogenic MAGE ubiquitin ligases
Yang, Seung Wook, Huang, Xin, Lin, Wenwei, Min, Jaeki, Miller, Darcie J., Mayasundari, Anand, Rodrigues, Patrick, Griffith, Elizabeth C., Gee, Clifford T., Li, Lei, Li, Wei, Lee, Richard E., Rankovic, Zoran, Chen, Taosheng, Potts, Patrick Ryan
Published in Nature communications (01.10.2020)
Published in Nature communications (01.10.2020)
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Journal Article
Degradation of Janus kinases in CRLF2-rearranged acute lymphoblastic leukemia
Chang, Yunchao, Min, Jaeki, Jarusiewicz, Jamie A., Actis, Marisa, Yu-Chen Bradford, Shanshan, Mayasundari, Anand, Yang, Lei, Chepyala, Divyabharathi, Alcock, Lisa J., Roberts, Kathryn G., Nithianantham, Stanley, Maxwell, Dylan, Rowland, Lauren, Larsen, Randolph, Seth, Aman, Goto, Hiroaki, Imamura, Toshihiko, Akahane, Koshi, Hansen, Baranda S., Pruett-Miller, Shondra M., Paietta, Elisabeth M., Litzow, Mark R., Qu, Chunxu, Yang, Jun J., Fischer, Marcus, Rankovic, Zoran, Mullighan, Charles G.
Published in Blood (09.12.2021)
Published in Blood (09.12.2021)
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Journal Article
Organocatalytic, Diastereo- and Enantioselective Synthesis of Nonsymmetric cis-Stilbene Diamines: A Platform for the Preparation of Single-Enantiomer cis-Imidazolines for Protein–Protein Inhibition
Vara, Brandon A, Mayasundari, Anand, Tellis, John C, Danneman, Michael W, Arredondo, Vanessa, Davis, Tyler A, Min, Jaeki, Finch, Kristin, Guy, R. Kiplin, Johnston, Jeffrey N
Published in Journal of organic chemistry (01.08.2014)
Published in Journal of organic chemistry (01.08.2014)
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Journal Article
Monitoring Ligand-Induced Protein Ordering in Drug Discovery
Grace, Christy R., Ban, David, Min, Jaeki, Mayasundari, Anand, Min, Lie, Finch, Kristin E., Griffiths, Lyra, Bharatham, Nagakumar, Bashford, Donald, Kiplin Guy, R., Dyer, Michael A., Kriwacki, Richard W.
Published in Journal of molecular biology (27.03.2016)
Published in Journal of molecular biology (27.03.2016)
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Journal Article
PqsD Is Responsible for the Synthesis of 2,4-Dihydroxyquinoline, an Extracellular Metabolite Produced by Pseudomonas aeruginosa
Zhang, Yong-Mei, Frank, Matthew W., Zhu, Kun, Mayasundari, Anand, Rock, Charles O.
Published in The Journal of biological chemistry (24.10.2008)
Published in The Journal of biological chemistry (24.10.2008)
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Journal Article
Assignment of the Four Disulfides in the N-terminal Somatomedin B Domain of Native Vitronectin Isolated from Human Plasma
Horn, Nancy A, Hurst, Gregory B, Mayasundari, Anand, Whittemore, Neil A, Serpersu, Engin H, Peterson, Cynthia B
Published in The Journal of biological chemistry (20.08.2004)
Published in The Journal of biological chemistry (20.08.2004)
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Journal Article
The Solution Structure of the N-terminal Domain of Human Vitronectin
Mayasundari, Anand, Whittemore, Neil A., Serpersu, Engin H., Peterson, Cynthia B.
Published in The Journal of biological chemistry (01.07.2004)
Published in The Journal of biological chemistry (01.07.2004)
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Journal Article
Structural insights into targeted degradation of casein kinase 1-α
Young, Sarah, Nishiguchi, Gisele, Abdelhamed, Sherif, Caine, Elizabeth, Mascibroda, Lauren, Kooijman, Jeffrey, Miller, Darcie, McGowan, Kevin, Mayasundari, Anand, Shi, Zhe, Aggarwal, Anup, Fischer, Marcus, Klco, Jeffery, Rankovic, Zoran
Published in Biophysical journal (08.02.2024)
Published in Biophysical journal (08.02.2024)
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Journal Article
Slow Amyloid Nucleation via α-Helix-Rich Oligomeric Intermediates in Short Polyglutamine-Containing Huntingtin Fragments
Jayaraman, Murali, Kodali, Ravindra, Sahoo, Bankanidhi, Thakur, Ashwani K., Mayasundari, Anand, Mishra, Rakesh, Peterson, Cynthia B., Wetzel, Ronald
Published in Journal of molecular biology (03.02.2012)
Published in Journal of molecular biology (03.02.2012)
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Journal Article
Identification of Potent, Selective, and Orally Bioavailable Small-Molecule GSPT1/2 Degraders from a Focused Library of Cereblon Modulators
Nishiguchi, Gisele, Keramatnia, Fatemeh, Min, Jaeki, Chang, Yunchao, Jonchere, Barbara, Das, Sourav, Actis, Marisa, Price, Jeanine, Chepyala, Divyabharathi, Young, Brandon, McGowan, Kevin, Slavish, P. Jake, Mayasundari, Anand, Jarusiewicz, Jamie A, Yang, Lei, Li, Yong, Fu, Xiang, Garrett, Shalandus H, Papizan, James B, Kodali, Kiran, Peng, Junmin, Pruett Miller, Shondra M, Roussel, Martine F, Mullighan, Charles, Fischer, Marcus, Rankovic, Zoran
Published in Journal of medicinal chemistry (10.06.2021)
Published in Journal of medicinal chemistry (10.06.2021)
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Journal Article
Efficacy of Retinoids in IKZF1-Mutated BCR-ABL1 Acute Lymphoblastic Leukemia
Churchman, Michelle L., Low, Jonathan, Qu, Chunxu, Paietta, Elisabeth M., Kasper, Lawryn H., Chang, Yunchao, Payne-Turner, Debbie, Althoff, Mark J., Song, Guangchun, Chen, Shann-Ching, Ma, Jing, Rusch, Michael, McGoldrick, Dan, Edmonson, Michael, Gupta, Pankaj, Wang, Yong-Dong, Caufield, William, Freeman, Burgess, Li, Lie, Panetta, John C., Baker, Sharyn, Yang, Yung-Li, Roberts, Kathryn G., McCastlain, Kelly, Iacobucci, Ilaria, Peters, Jennifer L., Centonze, Victoria E., Notta, Faiyaz, Dobson, Stephanie M., Zandi, Sasan, Dick, John E., Janke, Laura, Peng, Junmin, Kodali, Kiran, Pagala, Vishwajeeth, Min, Jaeki, Mayasundari, Anand, Williams, Richard T., Willman, Cheryl L., Rowe, Jacob, Luger, Selina, Dickins, Ross A., Guy, R. Kiplin, Chen, Taosheng, Mullighan, Charles G.
Published in Cancer cell (14.09.2015)
Published in Cancer cell (14.09.2015)
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Journal Article
Organocatalytic, Diastereo- and Enantioselective Synthesis of Nonsymmetric cis-Stilbene Diamines: A Platform for the Preparation of Single-Enantiomer cis-lmidazolines for Protein-Protein Inhibition
Vara, Brandon A., Mayasundari, Anand, Tellis, John C., Danneman, Michael W., Arredondo, Vanessa, Davis, Tyler A., Min, Jaeki, Finch, Kristin, Guy, R. Kiplin, Johnston, Jeffrey N.
Published in Journal of organic chemistry (01.08.2014)
Published in Journal of organic chemistry (01.08.2014)
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Journal Article
NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells
Paugh, Steven W, Bonten, Erik J, Savic, Daniel, Ramsey, Laura B, Thierfelder, William E, Gurung, Prajwal, Malireddi, R K Subbarao, Actis, Marcelo, Mayasundari, Anand, Min, Jaeki, Coss, David R, Laudermilk, Lucas T, Panetta, John C, McCorkle, J Robert, Fan, Yiping, Crews, Kristine R, Stocco, Gabriele, Wilkinson, Mark R, Ferreira, Antonio M, Cheng, Cheng, Yang, Wenjian, Karol, Seth E, Fernandez, Christian A, Diouf, Barthelemy, Smith, Colton, Hicks, J Kevin, Zanut, Alessandra, Giordanengo, Audrey, Crona, Daniel, Bianchi, Joy J, Holmfeldt, Linda, Mullighan, Charles G, den Boer, Monique L, Pieters, Rob, Jeha, Sima, Dunwell, Thomas L, Latif, Farida, Bhojwani, Deepa, Carroll, William L, Pui, Ching-Hon, Myers, Richard M, Guy, R Kiplin, Kanneganti, Thirumala-Devi, Relling, Mary V, Evans, William E
Published in Nature genetics (01.06.2015)
Published in Nature genetics (01.06.2015)
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Journal Article
From PROTAC to inhibitor: Structure-guided discovery of potent and orally bioavailable BET inhibitors
Koravovic, Mladen, Mayasundari, Anand, Tasic, Gordana, Keramatnia, Fatemeh, Stachowski, Timothy R., Cui, Huarui, Chai, Sergio C., Jonchere, Barbara, Yang, Lei, Li, Yong, Fu, Xiang, Hiltenbrand, Ryan, Paul, Leena, Mishra, Vibhor, Klco, Jeffery M., Roussel, Martine F., Pomerantz, William CK, Fischer, Marcus, Rankovic, Zoran, Savic, Vladimir
Published in European journal of medicinal chemistry (05.05.2023)
Published in European journal of medicinal chemistry (05.05.2023)
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Journal Article
Phenyl Dihydrouracil: An Alternative Cereblon Binder for PROTAC Design
Jarusiewicz, Jamie A., Yoshimura, Satoshi, Mayasundari, Anand, Actis, Marisa, Aggarwal, Anup, McGowan, Kevin, Yang, Lei, Li, Yong, Fu, Xiang, Mishra, Vibhor, Heath, Richard, Narina, Shilpa, Pruett-Miller, Shondra M., Nishiguchi, Gisele, Yang, Jun J., Rankovic, Zoran
Published in ACS medicinal chemistry letters (09.02.2023)
Published in ACS medicinal chemistry letters (09.02.2023)
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Journal Article
TMOD-19. GERMLINE ELP1 DEFICIENCY SENSITIZES CEREBELLAR GRANULE NEURON PROGENITORS TO SHH MEDULLOBLASTOMA
Tanveer Ahmad, Shiekh, Garcia-Lopez, Jesus, Li, Yiran, Hadley, Jennifer, Paul, Leena, Gudenas, Brian, Batts, Melissa, Soliman, Taha, Pitre, Aaron, Kojic, Marija, Manz, Frederik, Zindy, Frederique, Jones, Alun, Mayasundari, Anand, Bianski, Brandon, Tinkle, Christopher, Shirinifard, Abbas, Janke, Laura Janke, Lu, Meifen, Onar-Thomas, Arzu, Pfister, Stefan, Gajjar, Amar, Baker, Suzanne, Roussel, Martine, Rankovic, Zoran, Robinson, Giles, Orr, Brent, Wainwright, Brandon, Kutscher, Lena, Waszak, Sebastian, Lin, Hong, Northcott, Paul
Published in Neuro-oncology (Charlottesville, Va.) (11.11.2024)
Published in Neuro-oncology (Charlottesville, Va.) (11.11.2024)
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