Discovery and Development of Simeprevir (TMC435), a HCV NS3/4A Protease Inhibitor
Rosenquist, Åsa, Samuelsson, Bertil, Johansson, Per-Ola, Cummings, Maxwell D., Lenz, Oliver, Raboisson, Pierre, Simmen, Kenny, Vendeville, Sandrine, de Kock, Herman, Nilsson, Magnus, Horvath, Andras, Kalmeijer, Ronald, de la Rosa, Guy, Beumont-Mauviel, Maria
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
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Journal Article
Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance
Hare, Stephen, Vos, Ann M., Clayton, Reginald F., Thuring, Jan W., Cummings, Maxwell D., Cherepanov, Peter, Coffin, John M.
Published in Proceedings of the National Academy of Sciences - PNAS (16.11.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (16.11.2010)
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Journal Article
In Vitro Resistance Profile of the Hepatitis C Virus NS3/4A Protease Inhibitor TMC435
LENZ, Oliver, VERBINNEN, Thierry, VERMEIREN, Katrien, IVENS, Tania, RABOISSON, Pierre, EDLUND, Michael, STORM, Susan, VRANG, Lotta, DE KOCK, Herman, FANNING, Gregory C, SIMMEN, Kenneth A, LIN, Tse-I, VIJGEN, Leen, CUMMINGS, Maxwell D, LINDBERG, Jimmy, MARTIN BERKE, Jan, DEHERTOGH, Pascale, FRANSEN, Els, SCHOLLIERS, Annick
Published in Antimicrobial Agents and Chemotherapy (01.05.2010)
Published in Antimicrobial Agents and Chemotherapy (01.05.2010)
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Journal Article
Induced-Fit Binding of the Macrocyclic Noncovalent Inhibitor TMC435 to its HCV NS3/NS4A Protease Target
Cummings, Maxwell D, Lindberg, Jimmy, Lin, Tse -I, de Kock, Herman, Lenz, Oliver, Lilja, Elisabet, Felländer, Sara, Baraznenok, Vera, Nyström, Susanne, Nilsson, Magnus, Vrang, Lotta, Edlund, Michael, Rosenquist, Åsa, Samuelsson, Bertil, Raboisson, Pierre, Simmen, Kenneth
Published in Angewandte Chemie (International ed.) (22.02.2010)
Published in Angewandte Chemie (International ed.) (22.02.2010)
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Journal Article
Conformational Sampling of Macrocyclic Drugs in Different Environments: Can We Find the Relevant Conformations?
Poongavanam, Vasanthanathan, Danelius, Emma, Peintner, Stefan, Alcaraz, Lilian, Caron, Giulia, Cummings, Maxwell D, Wlodek, Stanislaw, Erdelyi, Mate, Hawkins, Paul C. D, Ermondi, Giuseppe, Kihlberg, Jan
Published in ACS omega (30.09.2018)
Published in ACS omega (30.09.2018)
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Journal Article
Structure-Based Site of Metabolism Prediction for Cytochrome P450 2D6
Moors, Samuel L. C, Vos, Ann M, Cummings, Maxwell D, Van Vlijmen, Herman, Ceulemans, Arnout
Published in Journal of medicinal chemistry (08.09.2011)
Published in Journal of medicinal chemistry (08.09.2011)
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Journal Article
Binding of a potent small-molecule inhibitor of six-helix bundle formation requires interactions with both heptad-repeats of the RSV fusion protein
Roymans, Dirk, De Bondt, Hendrik L, Arnoult, Eric, Geluykens, Peggy, Gevers, Tom, Van Ginderen, Marcia, Verheyen, Nick, Kim, Hidong, Willebrords, Rudy, Bonfanti, Jean-François, Bruinzeel, Wouter, Cummings, Maxwell D, van Vlijmen, Herman, Andries, Koen
Published in Proceedings of the National Academy of Sciences - PNAS (05.01.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (05.01.2010)
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Journal Article
TMC647055, a Potent Nonnucleoside Hepatitis C Virus NS5B Polymerase Inhibitor with Cross-Genotypic Coverage
DEVOGELAERE, Benoit, BERKE, Jan Martin, LENZ, Oliver, CUMMINGS, Maxwell D, CLAYTON, Reginald F, VENDEVILLE, Sandrine, RABOISSON, Pierre, SIMMEN, Kenneth A, FANNING, Gregory C, LIN, Tse-I, VIJGEN, Leen, DEHERTOGH, Pascale, FRANSEN, Els, CLEIREN, Erna, VAN DER HELM, Liesbet, NYANGUILE, Origène, TAHRI, Abdellah, AMSSOMS, Katie
Published in Antimicrobial Agents and Chemotherapy (01.09.2012)
Published in Antimicrobial Agents and Chemotherapy (01.09.2012)
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Journal Article
Structure-Based Design of a Benzodiazepine Scaffold Yields a Potent Allosteric Inhibitor of Hepatitis C NS5B RNA Polymerase
Vandyck, Koen, Cummings, Maxwell D, Nyanguile, Origène, Boutton, Carlo W, Vendeville, Sandrine, McGowan, David, Devogelaere, Benoit, Amssoms, Katie, Last, Stefaan, Rombauts, Klara, Tahri, Abdellah, Lory, Pedro, Hu, Lili, Beauchamp, Derek A, Simmen, Kenny, Raboisson, Pierre
Published in Journal of medicinal chemistry (23.07.2009)
Published in Journal of medicinal chemistry (23.07.2009)
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Journal Article
1,5-Benzodiazepines, a Novel Class of Hepatitis C Virus Polymerase Nonnucleoside Inhibitors
NYANGUILE, Origene, PAUWELS, Frederik, DEHERTOGH, Pascale, CUMMINGS, Maxwell D, BONFANTI, Jean-Francois, SIMMEN, Kenneth A, RABOISSON, Pierre, VAN DEN BROECK, Walter, BOUTTON, Carlo W, QUIRYNEN, Ludo, IVENS, Tania, VAN DER HELM, Liesbet, VANDERCRUYSSEN, Geneviève, MOSTMANS, Wendy, DELOUVROY, Frédéric
Published in Antimicrobial Agents and Chemotherapy (01.12.2008)
Published in Antimicrobial Agents and Chemotherapy (01.12.2008)
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Journal Article
1a/1b Subtype Profiling of Nonnucleoside Polymerase Inhibitors of Hepatitis C Virus
NYANGUILE, Origène, DEVOGELAERE, Benoit, VANDERCRUYSSEN, Geneviève, VERMEIREN, Katrien, MOSTMANS, Wendy, DEHERTOGH, Pascale, DELOUVROY, Frédéric, VENDEVILLE, Sandrine, VANDYCK, Koen, DOCKX, Koen, CLEIREN, Ema, RABOISSON, Pierre, VIJGEN, Leen, SIMMEN, Kenneth A, FANNING, Gregory C, VAN DEN BROECK, Walter, PAUWELS, Frederik, CUMMINGS, Maxwell D, DE BONDT, Hendrik L, VOS, Ann M, BERKE, Jan M, LENZ, Oliver
Published in Journal of Virology (01.03.2010)
Published in Journal of Virology (01.03.2010)
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Journal Article
Targeting Enteropeptidase with Reversible Covalent Inhibitors To Achieve Metabolic Benefits
Sun, Weimei, Zhang, Xuqing, Cummings, Maxwell D, Albarazanji, Kamal, Wu, Jiejun, Wang, Mina, Alexander, Richard, Zhu, Bin, Zhang, YueMei, Leonard, James, Lanter, James, Lenhard, James
Published in The Journal of pharmacology and experimental therapeutics (01.12.2020)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2020)
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Journal Article
Structure of the C-terminally truncated human ProMMP9, a gelatin-binding matrix metalloproteinase
Elkins, Patricia A., Ho, Yen Sen, Smith, Ward W., Janson, Cheryl A., D'Alessio, Karla J., McQueney, Michael S., Cummings, Maxwell D., Romanic, Anne M.
Published in Acta crystallographica. Section D, Biological crystallography. (01.07.2002)
Published in Acta crystallographica. Section D, Biological crystallography. (01.07.2002)
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Journal Article
Virologic response and characterisation of HCV genotype 2–6 in patients receiving TMC435 monotherapy (study TMC435-C202)
Lenz, Oliver, Vijgen, Leen, Berke, Jan Martin, Cummings, Maxwell D, Fevery, Bart, Peeters, Monika, Smedt, Goedele De, Moreno, Christophe, Picchio, Gaston
Published in Journal of hepatology (01.03.2013)
Published in Journal of hepatology (01.03.2013)
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Journal Article
Oxysterols are agonist ligands of RORγt and drive Th17 cell differentiation
Soroosh, Pejman, Wu, Jiejun, Xue, Xiaohua, Song, Jiao, Sutton, Steven W., Sablad, Marciano, Yu, Jingxue, Nelen, Marina I., Liu, Xuejun, Castro, Glenda, Luna, Rosa, Crawford, Shelby, Banie, Homayon, Dandridge, Rose A., Deng, Xiaohu, Bittner, Anton, Kuei, Chester, Tootoonchi, Mandana, Rozenkrants, Natasha, Herman, Krystal, Gao, Jingjin, Yang, Xia V., Sachen, Kacey, Ngo, Karen, Fung-Leung, Wai-Ping, Nguyen, Steven, de Leon-Tabaldo, Aimee, Blevitt, Jonathan, Zhang, Yan, Cummings, Maxwell D., Rao, Tadimeti, Mani, Neelakandha S., Liu, Changlu, McKinnon, Murray, Milla, Marcos E., Fourie, Anne M., Sun, Siquan
Published in Proceedings of the National Academy of Sciences - PNAS (19.08.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (19.08.2014)
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Journal Article
Discovery and optimization of a series of small-molecule allosteric inhibitors of MALT1 protease
Lu, Tianbao, Connolly, Peter J., Philippar, Ulrike, Sun, Weimei, Cummings, Maxwell D., Barbay, Kent, Gys, Luc, Van Nuffel, Luc, Austin, Nigel, Bekkers, Mariette, Shen, Fang, Cai, Ann, Attar, Ricardo, Meerpoel, Lieven, Edwards, James
Published in Bioorganic & medicinal chemistry letters (01.12.2019)
Published in Bioorganic & medicinal chemistry letters (01.12.2019)
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Journal Article
Design and synthesis of a series of bioavailable fatty acid synthase (FASN) KR domain inhibitors for cancer therapy
Lu, Tianbao, Schubert, Carsten, Cummings, Maxwell D., Bignan, Gilles, Connolly, Peter J., Smans, Karine, Ludovici, Donald, Parker, Michael H., Meyer, Christophe, Rocaboy, Christian, Alexander, Richard, Grasberger, Bruce, De Breucker, Sabine, Esser, Norbert, Fraiponts, Erwin, Gilissen, Ron, Janssens, Boudewijn, Peeters, Danielle, Van Nuffel, Luc, Vermeulen, Peter, Bischoff, James, Meerpoel, Lieven
Published in Bioorganic & medicinal chemistry letters (01.07.2018)
Published in Bioorganic & medicinal chemistry letters (01.07.2018)
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Journal Article
Structure-based design, synthesis, and biological evaluation of novel 1,4-diazepines as HDM2 antagonists
Raboisson, Pierre, Marugán, Juan José, Schubert, Carsten, Koblish, Holly K., Lu, Tianbao, Zhao, Shuyuan, Player, Mark R., Maroney, Anna C., Reed, Rolanda L., Huebert, Norman D., Lattanze, Jennifer, Parks, Daniel J., Cummings, Maxwell D.
Published in Bioorganic & medicinal chemistry letters (01.04.2005)
Published in Bioorganic & medicinal chemistry letters (01.04.2005)
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Journal Article
Optimization and biological evaluation of thiazole-bis-amide inverse agonists of RORγt
Gege, Christian, Albers, Michael, Kinzel, Olaf, Kleymann, Gerald, Schlüter, Thomas, Steeneck, Christoph, Hoffmann, Thomas, Xue, Xiaohua, Cummings, Maxwell D., Spurlino, John, Milligan, Cynthia, Fourie, Anne M., Edwards, James P., Leonard, Kristi, Coe, Kevin, Scott, Brian, Pippel, Dan, Goldberg, Steven D.
Published in Bioorganic & medicinal chemistry letters (15.06.2020)
Published in Bioorganic & medicinal chemistry letters (15.06.2020)
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Journal Article