Conformational switching of the 26S proteasome enables substrate degradation
Matyskiela, Mary E, Lander, Gabriel C, Martin, Andreas
Published in Nature structural & molecular biology (01.07.2013)
Published in Nature structural & molecular biology (01.07.2013)
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Journal Article
Complete subunit architecture of the proteasome regulatory particle
Lander, Gabriel C., Estrin, Eric, Matyskiela, Mary E., Bashore, Charlene, Nogales, Eva, Martin, Andreas
Published in Nature (London) (09.02.2012)
Published in Nature (London) (09.02.2012)
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Journal Article
A Cereblon Modulator (CC-220) with Improved Degradation of Ikaros and Aiolos
Matyskiela, Mary E, Zhang, Weihong, Man, Hon-Wah, Muller, George, Khambatta, Godrej, Baculi, Frans, Hickman, Matthew, LeBrun, Laurie, Pagarigan, Barbra, Carmel, Gilles, Lu, Chin-Chun, Lu, Gang, Riley, Mariko, Satoh, Yoshitaka, Schafer, Peter, Daniel, Thomas O, Carmichael, James, Cathers, Brian E, Chamberlain, Philip P
Published in Journal of medicinal chemistry (25.01.2018)
Published in Journal of medicinal chemistry (25.01.2018)
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Journal Article
A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase
Matyskiela, Mary E, Lu, Gang, Ito, Takumi, Pagarigan, Barbra, Lu, Chin-Chun, Miller, Karen, Fang, Wei, Wang, Nai-Yu, Nguyen, Derek, Houston, Jack, Carmel, Gilles, Tran, Tam, Riley, Mariko, Nosaka, Lyn'Al, Lander, Gabriel C, Gaidarova, Svetlana, Xu, Shuichan, Ruchelman, Alexander L, Handa, Hiroshi, Carmichael, James, Daniel, Thomas O, Cathers, Brian E, Lopez-Girona, Antonia, Chamberlain, Philip P
Published in Nature (London) (14.07.2016)
Published in Nature (London) (14.07.2016)
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Journal Article
Crystal structure of the SALL4–pomalidomide–cereblon–DDB1 complex
Matyskiela, Mary E., Clayton, Thomas, Zheng, Xinde, Mayne, Christopher, Tran, Eileen, Carpenter, Aaron, Pagarigan, Barbra, McDonald, Joseph, Rolfe, Mark, Hamann, Lawrence G., Lu, Gang, Chamberlain, Philip P.
Published in Nature structural & molecular biology (01.04.2020)
Published in Nature structural & molecular biology (01.04.2020)
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Journal Article
Molecular glue CELMoD compounds are regulators of cereblon conformation
Watson, Edmond R, Novick, Scott, Matyskiela, Mary E, Chamberlain, Philip P, H de la Peña, Andres, Zhu, Jinyi, Tran, Eileen, Griffin, Patrick R, Wertz, Ingrid E, Lander, Gabriel C
Published in Science (American Association for the Advancement of Science) (04.11.2022)
Published in Science (American Association for the Advancement of Science) (04.11.2022)
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Journal Article
Ubp6 deubiquitinase controls conformational dynamics and substrate degradation of the 26S proteasome
Bashore, Charlene, Dambacher, Corey M, Goodall, Ellen A, Matyskiela, Mary E, Lander, Gabriel C, Martin, Andreas
Published in Nature structural & molecular biology (01.09.2015)
Published in Nature structural & molecular biology (01.09.2015)
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Journal Article
SALL4 mediates teratogenicity as a thalidomide-dependent cereblon substrate
Matyskiela, Mary E., Couto, Suzana, Zheng, Xinde, Lu, Gang, Hui, Julia, Stamp, Katie, Drew, Clifton, Ren, Yan, Wang, Maria, Carpenter, Aaron, Lee, Chung-Wein, Clayton, Thomas, Fang, Wei, Lu, Chin-Chun, Riley, Mariko, Abdubek, Polat, Blease, Kate, Hartke, James, Kumar, Gondi, Vessey, Rupert, Rolfe, Mark, Hamann, Lawrence G., Chamberlain, Philip P.
Published in Nature chemical biology (01.10.2018)
Published in Nature chemical biology (01.10.2018)
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Journal Article
CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cells
Surka, Christine, Jin, Liqing, Mbong, Nathan, Lu, Chin-Chun, Jang, In Sock, Rychak, Emily, Mendy, Derek, Clayton, Thomas, Tindall, Elizabeth, Hsu, Christy, Fontanillo, Celia, Tran, Eileen, Contreras, Adrian, Ng, Stanley W.K., Matyskiela, Mary, Wang, Kai, Chamberlain, Philip, Cathers, Brian, Carmichael, James, Hansen, Joshua, Wang, Jean C.Y., Minden, Mark D., Fan, Jinhong, Pierce, Daniel W., Pourdehnad, Michael, Rolfe, Mark, Lopez-Girona, Antonia, Dick, John E., Lu, Gang
Published in Blood (04.02.2021)
Published in Blood (04.02.2021)
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Journal Article
Evolution of Cereblon-Mediated Protein Degradation as a Therapeutic Modality
Chamberlain, Philip P, D’Agostino, Laura A, Ellis, J. Michael, Hansen, Joshua D, Matyskiela, Mary E, McDonald, Joseph J, Riggs, Jennifer R, Hamann, Lawrence G
Published in ACS medicinal chemistry letters (12.12.2019)
Published in ACS medicinal chemistry letters (12.12.2019)
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Journal Article
Cereblon Modulators Target ZBTB16 and Its Oncogenic Fusion Partners for Degradation via Distinct Structural Degrons
Matyskiela, Mary E, Zhu, Jinyi, Baughman, Joshua M, Clayton, Thomas, Slade, Michelle, Wong, Hon Kit, Danga, Kristina, Zheng, Xinde, Labow, Mark, LeBrun, Laurie, Lu, Gang, Chamberlain, Philip P, Thompson, Joel W
Published in ACS chemical biology (18.12.2020)
Published in ACS chemical biology (18.12.2020)
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Journal Article
UBE2G1 governs the destruction of cereblon neomorphic substrates
Lu, Gang, Weng, Stephanie, Matyskiela, Mary, Zheng, Xinde, Fang, Wei, Wood, Scott, Surka, Christine, Mizukoshi, Reina, Lu, Chin-Chun, Mendy, Derek, Jang, In Sock, Wang, Kai, Marella, Mathieu, Couto, Suzana, Cathers, Brian, Carmichael, James, Chamberlain, Philip, Rolfe, Mark
Published in eLife (20.09.2018)
Published in eLife (20.09.2018)
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Journal Article
Profiling CELMoD-Mediated Degradation of Cereblon Neosubstrates
Thompson, Joel W, Clayton, Thomas, Khambatta, Gody, Bateman, Leslie A, Carroll, Christopher W, Chamberlain, Philip P, Matyskiela, Mary E
Published in Methods in molecular biology (Clifton, N.J.) (2021)
Published in Methods in molecular biology (Clifton, N.J.) (2021)
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Journal Article
An architectural map of the anaphase-promoting complex
Thornton, Brian R, Ng, Tessie M, Matyskiela, Mary E, Carroll, Christopher W, Morgan, David O, Toczyski, David P
Published in Genes & development (15.02.2006)
Published in Genes & development (15.02.2006)
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Journal Article
Functionally Distinct Isoforms of Cik1 Are Differentially Regulated by APC/C-Mediated Proteolysis
Benanti, Jennifer A., Matyskiela, Mary E., Morgan, David O., Toczyski, David P.
Published in Molecular cell (13.03.2009)
Published in Molecular cell (13.03.2009)
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Journal Article
Targeted Gene Disruption of Methionine Aminopeptidase 2 Results in an Embryonic Gastrulation Defect and Endothelial Cell Growth Arrest
Yeh, Jing-Ruey J., Ju, Rong, Brdlik, Cathleen M., Zhang, Wenjun, Zhang, Yi, Matyskiela, Mary E., Shotwell, Joseph D., Crews, Craig M.
Published in Proceedings of the National Academy of Sciences - PNAS (05.07.2006)
Published in Proceedings of the National Academy of Sciences - PNAS (05.07.2006)
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Journal Article
Avadomide induces degradation of ZMYM2 fusion oncoproteins in hematologic malignancies
Renneville, Aline, Gasser, Jessica A, Grinshpun, Daniel E, Jean Beltran, Pierre M, Udeshi, Namrata D, Matyskiela, Mary E, Clayton, Thomas, McConkey, Marie, Viswanathan, Kaushik, Tepper, Alexander, Guirguis, Andrew A, Sellar, Rob S, Cotteret, Sophie, Marzac, Christophe, Saada, Véronique, De Botton, Stéphane, Kiladjian, Jean-Jacques, Cayuela, Jean-Michel, Rolfe, Mark, Chamberlain, Philip P, Carr, Steven A, Ebert, Benjamin L
Published in Blood cancer discovery (01.05.2021)
Published in Blood cancer discovery (01.05.2021)
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