Synthesis of Small 3‑Fluoro- and 3,3-Difluoropyrrolidines Using Azomethine Ylide Chemistry
McAlpine, Indrawan, Tran-Dubé, Michelle, Wang, Fen, Scales, Stephanie, Matthews, Jean, Collins, Michael R, Nair, Sajiv K, Nguyen, Mary, Bian, Jianwei, Alsina, Luis Martinez, Sun, Jianmin, Zhong, Jiaying, Warmus, Joseph S, O’Neill, Brian T
Published in Journal of organic chemistry (17.07.2015)
Published in Journal of organic chemistry (17.07.2015)
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N-(Pyridin-2-yl) arylsulfonamide inhibitors of 11β-hydroxysteroid dehydrogenase type 1: Discovery of PF-915275
Siu, Michael, Johnson, Theodore O., Wang, Yong, Nair, Sajiv K., Taylor, Wendy D., Cripps, Stephan J., Matthews, Jean J., Edwards, Martin P., Pauly, Thomas A., Ermolieff, Jacques, Castro, Arturo, Hosea, Natilie A., LaPaglia, Amy, Fanjul, Andrea N., Vogel, Jennifer E.
Published in Bioorganic & medicinal chemistry letters (01.07.2009)
Published in Bioorganic & medicinal chemistry letters (01.07.2009)
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N-(Pyridin-2-yl) arylsulfonamide inhibitors of 11β-hydroxysteroid dehydrogenase type 1: Strategies to eliminate reactive metabolites
Nair, Sajiv K., Matthews, Jean J., Cripps, Stephan J., Cheng, Hengmiao, Hoffman, Jacqui E., Smith, Christopher, Kupchinsky, Stanley, Siu, Michael, Taylor, Wendy D., Wang, Yong, Johnson, Theodore O., Dress, Klaus R., Edwards, Martin P., Zhou, Sue, Hosea, Natilie A., LaPaglia, Amy, Kang, Ping, Castro, Arturo, Ermolieff, Jacques, Fanjul, Andrea, Vogel, Jennifer E., Rejto, Paul, Dalvie, Deepak
Published in Bioorganic & medicinal chemistry letters (15.04.2013)
Published in Bioorganic & medicinal chemistry letters (15.04.2013)
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Managing clinical failure: a complex adaptive system perspective
Matthews, Jean I, Thomas, Paul T
Published in International journal of health care quality assurance (01.01.2007)
Published in International journal of health care quality assurance (01.01.2007)
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Design and Synthesis of Functionally Active 5‑Amino-6-Aryl Pyrrolopyrimidine Inhibitors of Hematopoietic Progenitor Kinase 1
Gallego, Rebecca A., Bernier, Louise, Chen, Hui, Cho-Schultz, Sujin, Chung, Loanne, Collins, Michael, Del Bel, Matthew, Elleraas, Jeff, Costa Jones, Cinthia, Cronin, Ciaran N., Edwards, Martin, Fang, Xu, Fisher, Timothy, He, Mingying, Hoffman, Jacqui, Huo, Ruiduan, Jalaie, Mehran, Johnson, Eric, Johnson, Ted W., Kania, Robert S., Kraus, Manfred, Lafontaine, Jennifer, Le, Phuong, Liu, Tongnan, Maestre, Michael, Matthews, Jean, McTigue, Michele, Miller, Nichol, Mu, Qiming, Qin, Xulong, Ren, Shijian, Richardson, Paul, Rohner, Allison, Sach, Neal, Shao, Li, Smith, Graham, Su, Ruirui, Sun, Bin, Timofeevski, Sergei, Tran, Phuong, Wang, Shuiwang, Wang, Wei, Zhou, Ru, Zhu, Jinjiang, Nair, Sajiv K.
Published in Journal of medicinal chemistry (13.04.2023)
Published in Journal of medicinal chemistry (13.04.2023)
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Discovery of N‑((3R,4R)‑4-Fluoro-1-(6-((3-methoxy-1-methyl‑1H‑pyrazol-4-yl)amino)-9-methyl‑9H‑purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Design: A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR Mutants with Selectivity over Wild-Type EGFR
Planken, Simon, Behenna, Douglas C, Nair, Sajiv K, Johnson, Theodore O, Nagata, Asako, Almaden, Chau, Bailey, Simon, Ballard, T. Eric, Bernier, Louise, Cheng, Hengmiao, Cho-Schultz, Sujin, Dalvie, Deepak, Deal, Judith G, Dinh, Dac M, Edwards, Martin P, Ferre, Rose Ann, Gajiwala, Ketan S, Hemkens, Michelle, Kania, Robert S, Kath, John C, Matthews, Jean, Murray, Brion W, Niessen, Sherry, Orr, Suvi T. M, Pairish, Mason, Sach, Neal W, Shen, Hong, Shi, Manli, Solowiej, James, Tran, Khanh, Tseng, Elaine, Vicini, Paolo, Wang, Yuli, Weinrich, Scott L, Zhou, Ru, Zientek, Michael, Liu, Longqing, Luo, Yiqin, Xin, Shuibo, Zhang, Chengyi, Lafontaine, Jennifer
Published in Journal of medicinal chemistry (13.04.2017)
Published in Journal of medicinal chemistry (13.04.2017)
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Discovery of 1‑{(3R,4R)‑3-[({5-Chloro-2-[(1-methyl‑1H‑pyrazol-4-yl)amino]‑7H‑pyrrolo[2,3‑d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants
Cheng, Hengmiao, Nair, Sajiv K, Murray, Brion W, Almaden, Chau, Bailey, Simon, Baxi, Sangita, Behenna, Doug, Cho-Schultz, Sujin, Dalvie, Deepak, Dinh, Dac M, Edwards, Martin P, Feng, Jun Li, Ferre, Rose Ann, Gajiwala, Ketan S, Hemkens, Michelle D, Jackson-Fisher, Amy, Jalaie, Mehran, Johnson, Ted O, Kania, Robert S, Kephart, Susan, Lafontaine, Jennifer, Lunney, Beth, Liu, Kevin K.-C, Liu, Zhengyu, Matthews, Jean, Nagata, Asako, Niessen, Sherry, Ornelas, Martha A, Orr, Suvi T. M, Pairish, Mason, Planken, Simon, Ren, Shijian, Richter, Daniel, Ryan, Kevin, Sach, Neal, Shen, Hong, Smeal, Tod, Solowiej, Jim, Sutton, Scott, Tran, Khanh, Tseng, Elaine, Vernier, William, Walls, Marlena, Wang, Shuiwang, Weinrich, Scott L, Xin, Shuibo, Xu, Haiwei, Yin, Min-Jean, Zientek, Michael, Zhou, Ru, Kath, John C
Published in Journal of medicinal chemistry (10.03.2016)
Published in Journal of medicinal chemistry (10.03.2016)
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Discovery of N -((3 R ,4 R )-4-Fluoro-1-(6-((3-methoxy-1-methyl-1 H -pyrazol-4-yl)amino)-9-methyl-9 H -purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Design: A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR Mutants with Selectivity over Wild-Type EGFR
Planken, Simon, Behenna, Douglas C., Nair, Sajiv K., Johnson, Theodore O., Nagata, Asako, Almaden, Chau, Bailey, Simon, Ballard, T. Eric, Bernier, Louise, Cheng, Hengmiao, Cho-Schultz, Sujin, Dalvie, Deepak, Deal, Judith G., Dinh, Dac M., Edwards, Martin P., Ferre, Rose Ann, Gajiwala, Ketan S., Hemkens, Michelle, Kania, Robert S., Kath, John C., Matthews, Jean, Murray, Brion W., Niessen, Sherry, Orr, Suvi T. M., Pairish, Mason, Sach, Neal W., Shen, Hong, Shi, Manli, Solowiej, James, Tran, Khanh, Tseng, Elaine, Vicini, Paolo, Wang, Yuli, Weinrich, Scott L., Zhou, Ru, Zientek, Michael, Liu, Longqing, Luo, Yiqin, Xin, Shuibo, Zhang, Chengyi, Lafontaine, Jennifer
Published in Journal of medicinal chemistry (13.04.2017)
Published in Journal of medicinal chemistry (13.04.2017)
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The development and SAR of pyrrolidine carboxamide 11β-HSD1 inhibitors
Cheng, Hengmiao, Hoffman, Jacqui, Le, Phuong, Nair, Sajiv K., Cripps, Stephan, Matthews, Jean, Smith, Christopher, Yang, Michele, Kupchinsky, Stan, Dress, Klaus, Edwards, Martin, Cole, Bridget, Walters, Evan, Loh, Christine, Ermolieff, Jacques, Fanjul, Andrea, Bhat, Ganesh B., Herrera, Jocelyn, Pauly, Tom, Hosea, Natilie, Paderes, Genevieve, Rejto, Paul
Published in Bioorganic & medicinal chemistry letters (01.05.2010)
Published in Bioorganic & medicinal chemistry letters (01.05.2010)
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Journal Article
N-(Pyridin-2-yl) arylsulfonamide inhibitors of 11[beta]-hydroxysteroid dehydrogenase type 1: Strategies to eliminate reactive metabolites
Nair, Sajiv K, Matthews, Jean J, Cripps, Stephan J, Cheng, Hengmiao, Hoffman, Jacqui E, Smith, Christopher, Kupchinsky, Stanley, Siu, Michael, Taylor, Wendy D, Wang, Yong, Johnson, Theodore O, Dress, Klaus R, Edwards, Martin P, Zhou, Sue, Hosea, Natilie A, LaPaglia, Amy, Kang, Ping, Castro, Arturo, Ermolieff, Jacques, Fanjul, Andrea, Vogel, Jennifer E, Rejto, Paul, Dalvie, Deepak
Published in Bioorganic & medicinal chemistry letters (15.04.2013)
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Published in Bioorganic & medicinal chemistry letters (15.04.2013)
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Novel synthesis of CP-734432, an EP4 agonist, using Sharpless asymmetric dihydroxylation
Nair, Sajiv K., Matthews, Jean J., Cripps, Stephan J., Ma, Chunrong, Dovalsantos, Elena Z., Grubbs, Alan W., Sach, Neal W., Hoeve, Wolter ten, Koster, Han, Flahive, Erik J., Tanis, Steven P., Renner, Matt, Wiltenburg, Jim van
Published in Tetrahedron letters (17.03.2010)
Published in Tetrahedron letters (17.03.2010)
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The development and SAR of pyrrolidine carboxamide 11b-HSD1 inhibitors
Cheng, Hengmiao, Hoffman, Jacqui, Le, Phuong, Nair, Sajiv K, Cripps, Stephan, Matthews, Jean, Smith, Christopher, Yang, Michele, Kupchinsky, Stan, Dress, Klaus, Edwards, Martin, Cole, Bridget, Walters, Evan, Loh, Christine, Ermolieff, Jacques, Fanjul, Andrea, Bhat, Ganesh B, Herrera, Jocelyn, Pauly, Tom, Hosea, Natilie, Paderes, Genevieve, Rejto, Paul
Published in Bioorganic & medicinal chemistry letters (01.05.2010)
Published in Bioorganic & medicinal chemistry letters (01.05.2010)
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