Discovery of GSK3527497: A Candidate for the Inhibition of Transient Receptor Potential Vanilloid‑4 (TRPV4)
Brooks, Carl A, Barton, Linda S, Behm, David J, Brnardic, Edward J, Costell, Melissa H, Holt, Dennis A, Jolivette, Larry J, Matthews, Jay M, McAtee, John J, McCleland, Brent W, Patterson, Jaclyn R, Pero, Joseph E, Rivero, Ralph A, Roethke, Theresa J, Sanchez, Robert M, Shenje, Raynold, Terrell, Lamont R, Lawhorn, Brian G
Published in Journal of medicinal chemistry (24.10.2019)
Published in Journal of medicinal chemistry (24.10.2019)
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Journal Article
Design and Optimization of Sulfone Pyrrolidine Sulfonamide Antagonists of Transient Receptor Potential Vanilloid‑4 with in Vivo Activity in a Pulmonary Edema Model
Pero, Joseph E, Matthews, Jay M, Behm, David J, Brnardic, Edward J, Brooks, Carl, Budzik, Brian W, Costell, Melissa H, Donatelli, Carla A, Eisennagel, Stephen H, Erhard, Karl, Fischer, Michael C, Holt, Dennis A, Jolivette, Larry J, Li, Huijie, Li, Peng, McAtee, John J, McCleland, Brent W, Pendrak, Israil, Posobiec, Lorraine M, Rivera, Katrina L.K, Rivero, Ralph A, Roethke, Theresa J, Sender, Matthew R, Shu, Arthur, Terrell, Lamont R, Vaidya, Kalindi, Xu, Xiaoping, Lawhorn, Brian G
Published in Journal of medicinal chemistry (27.12.2018)
Published in Journal of medicinal chemistry (27.12.2018)
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Journal Article
Tetrahydroindazole derivatives as potent and peripherally selective cannabinoid-1 (CB1) receptor inverse agonists
Matthews, Jay M., McNally, James J., Connolly, Peter J., Xia, Mingde, Zhu, Bin, Black, Shawn, Chen, Cailin, Hou, Cuifen, Liang, Yin, Tang, Yuting, Macielag, Mark J.
Published in Bioorganic & medicinal chemistry letters (01.11.2016)
Published in Bioorganic & medicinal chemistry letters (01.11.2016)
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Journal Article
Tetrahydropyrazolo[4,3-c]pyridine derivatives as potent and peripherally selective cannabinoid-1 (CB1) receptor inverse agonists
Zhu, Bin, Matthews, Jay M., Xia, Mingde, Black, Shawn, Chen, Cailin, Hou, Cuifen, Liang, Yin, Tang, Yuting, Macielag, Mark J.
Published in Bioorganic & medicinal chemistry letters (15.11.2016)
Published in Bioorganic & medicinal chemistry letters (15.11.2016)
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Journal Article
The design and synthesis of novel, phosphonate-containing transient receptor potential melastatin 8 (TRPM8) antagonists
Matthews, Jay M., Qin, Ning, Colburn, Raymond W., Dax, Scott L., Hawkins, Mike, McNally, James J., Reany, Laura, Youngman, Mark A., Baker, Judith, Hutchinson, Tasha, Liu, Yi, Lubin, Mary Lou, Neeper, Michael, Brandt, Michael R., Stone, Dennis J., Flores, Christopher M.
Published in Bioorganic & medicinal chemistry letters (15.04.2012)
Published in Bioorganic & medicinal chemistry letters (15.04.2012)
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Journal Article
Arylglycine derivatives as potent transient receptor potential melastatin 8 (TRPM8) antagonists
Zhu, Bin, Xia, Mingde, Xu, Xiaoqing, Ludovici, Donald W., Tennakoon, Manomi, Youngman, Mark A., Matthews, Jay M., Dax, Scott L., Colburn, Raymond W., Qin, Ning, Hutchinson, Tasha L., Lubin, Mary Lou, Brandt, Michael R., Stone, Dennis J., Flores, Christopher M., Macielag, Mark J.
Published in Bioorganic & medicinal chemistry letters (01.04.2013)
Published in Bioorganic & medicinal chemistry letters (01.04.2013)
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Journal Article
Design and synthesis of indane-ureido-thioisobutyric acids: A novel class of PPARα agonists
Matthews, Jay M., Chen, Xiaoli, Cryan, Ellen, Hlasta, Dennis J., Rybczynski, Philip J., Strauss, Kim, Tang, Yuting, Xu, June Z., Yang, Maria, Zhou, Lubing, Demarest, Keith T.
Published in Bioorganic & medicinal chemistry letters (15.12.2007)
Published in Bioorganic & medicinal chemistry letters (15.12.2007)
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Journal Article
Nrf2 활성화제로서 히드록시피리드옥사제핀
KOETTING MICHAEL CLINTON, MATTHEWS JAY M, LAWHORN BRIAN GRIFFIN, ELBAN MARK, GLOGOWSKI MICHAL PAWEL, PATTERSON JACLYN RENEE
Year of Publication 20.10.2021
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Year of Publication 20.10.2021
Patent
Synthesis, resolution, and absolute configuration of novel tricyclic benzodiazepines
Matthews, Jay M., Dyatkin, Alexey B., Evangelisto, Mary, Gauthier, Diane A., Hecker, Leonard R., Hoekstra, William J., Liu, Fuqiang, Poulter, Brenda L., Sorgi, Kirk L., Maryanoff, Bruce E.
Published in Tetrahedron: asymmetry (19.04.2004)
Published in Tetrahedron: asymmetry (19.04.2004)
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Journal Article
Synthesis and biological evaluation of novel indoloazepine derivatives as non-peptide vasopressin V2 receptor antagonists
Matthews, Jay M, Greco, Michael N, Hecker, Leonard R, Hoekstra, William J, Andrade-Gordon, Patricia, Garavilla, Lawrence de, Demarest, Keith T, Ericson, Eric, Gunnet, Joseph W, Hageman, William, Look, Richard, Moore, John B, Maryanoff, Bruce E
Published in Bioorganic & medicinal chemistry letters (24.02.2003)
Published in Bioorganic & medicinal chemistry letters (24.02.2003)
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Journal Article
Discovery of a dihydropyrimidine series of molecules that selectively mimic the biological actions of calcitonin
MATTHEWS, Jay M, LIOTTA, Fina, HAGEMAN, William, RIVERO, Ralph A, WESTOVER, Lori, YANG, Maria, JUN XU, DEMAREST, Keith
Published in Bioorganic & medicinal chemistry letters (08.03.2004)
Published in Bioorganic & medicinal chemistry letters (08.03.2004)
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Journal Article
Potent nonpeptide vasopressin receptor antagonists based on oxazino- and thiazinobenzodiazepine templates
Matthews, Jay M., Hoekstra, William J., Dyatkin, Alexey B., Hecker, Leonard R., Hlasta, Dennis J., Poulter, Brenda L., Andrade-Gordon, Patricia, de Garavilla, Lawrence, Demarest, Keith T., Ericson, Eric, Gunnet, Joseph W., Hageman, William, Look, Richard, Moore, John B., Reynolds, Charles H., Maryanoff, Bruce E.
Published in Bioorganic & medicinal chemistry letters (07.06.2004)
Published in Bioorganic & medicinal chemistry letters (07.06.2004)
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Journal Article
TRPV4 길항제
LI PENG, MATTHEWS JAY M, LAWHORN BRIAN GRIFFIN, BRNARDIC EDWARD J, TERRELL LAMONT ROSCOE, SENDER MATTHEW ROBERT, PERO JOSEPH E, MCATEE JOHN JEFFREY, BEHM DAVID J, BROOKS CARL A
Year of Publication 09.05.2019
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Year of Publication 09.05.2019
Patent
CHARACTERIZATION OF RWJ‐351647, A NOVEL NONPEPTIDE VASOPRESSIN V 2 RECEPTOR ANTAGONIST
Gunnet, Joseph W, Matthews, Jay M, Maryanoff, Bruce E, De Garavilla, Lawrence, Andrade‐Gordon, Patricia, Damiano, Bruce, Hageman, William, Look, Richard, Stahle, Paul, Streeter, Anthony J, Wines, Pamela G, Demarest, Keith T
Published in Clinical and experimental pharmacology & physiology (01.04.2006)
Published in Clinical and experimental pharmacology & physiology (01.04.2006)
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Journal Article
TRPV4 길항제
MATTHEWS JAY M, LAWHORN BRIAN GRIFFIN, SANCHEZ ROBERT, YE GUOSEN, TERRELL LAMONT ROSCOE, PATTERSON JACLYN R, PERO JOSEPH E, SENDER MATTHEW ROBERT, MCATEE JOHN JEFFREY, BARTON LINDA S, THOMAS JAMES V, BRNARDIC EDWARD J, BUDZIK BRIAN W, BEHM DAVID J, BROOKS CARL A
Year of Publication 08.05.2019
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Year of Publication 08.05.2019
Patent
Determination of the absolute configuration of a key tricyclic component of a novel vasopressin receptor antagonist by use of vibrational circular dichroism
Dyatkin, Alexey B., Freedman, Teresa B., Cao, Xiaolin, Dukor, Rina K., Maryanoff, Bruce E., Maryanoff, Cynthia A., Matthews, Jay M., Shah, Rekha D., Nafie, Laurence A.
Published in Chirality (New York, N.Y.) (2002)
Published in Chirality (New York, N.Y.) (2002)
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