Discovery of N-{2-Methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}-N′-[2-(propane-2-sulfonyl)phenyl]-1,3,5-triazine-2,4-diamine (ASP3026), a Potent and Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor
Iikubo, Kazuhiko, Kondoh, Yutaka, Shimada, Itsuro, Matsuya, Takahiro, Mori, Kenichi, Ueno, Yoko, Okada, Minoru
Published in Chemical & pharmaceutical bulletin (2018)
Published in Chemical & pharmaceutical bulletin (2018)
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Journal Article
Abstract 2586: ASP8273 selectively inhibits mutant EGFR signal pathway and induces tumor shrinkage in EGFR mutated tumor models
Konagai, Satoshi, Sakagami, Hideki, Yamamoto, Hiroko, Tanaka, Hiroaki, Matsuya, Takahiro, Mimasu, Shinya, Tomimoto, Yusuke, Mori, Masamichi, Koshio, Hiroyuki, Hirano, Masaaki, Kuromitsu, Sadao, Takeuchi, Masahiro
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Abstract B188: Preclinical antitumor activity of ASP8273, a mutant-selective irreversible EGFR inhibitor in an AXL-overexpressing NSCLC model
Kaneko, Naoki, Tanaka, Hiroaki, Konagai, Satoshi, Yamamoto, Hiroko, Sakagami, Hideki, Eguchi, Tomohiro, Matsuya, Takahiro, Mori, Masamichi, Koshio, Hiroyuki, Terasaka, Tadashi, Hirano, Masaaki, Kuromitsu, Sadao, Takeuchi, Masahiro
Published in Molecular cancer therapeutics (01.12.2015)
Published in Molecular cancer therapeutics (01.12.2015)
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Journal Article
Neural Circuits Containing Pallidotegmental GABAergic Neurons are Involved in the Prepulse Inhibition of the Startle Reflex in Mice
Takahashi, Kenji, Nagai, Taku, Kamei, Hiroyuki, Maeda, Kenji, Matsuya, Takahiro, Arai, Sawako, Mizoguchi, Hiroyuki, Yoneda, Yukio, Nabeshima, Toshitaka, Takuma, Kazuhiro, Yamada, Kiyofumi
Published in Biological psychiatry (1969) (15.07.2007)
Published in Biological psychiatry (1969) (15.07.2007)
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Journal Article
Radiosynthesis, biodistribution and imaging of [11 C]YM155, a novel survivin suppressant, in a human prostate tumor-xenograft mouse model
Murakami, Yoshihiro, Matsuya, Takahiro, Kita, Aya, Yamanaka, Kentaro, Noda, Akihiro, Mitsuoka, Keisuke, Nakahara, Takahito, Miyoshi, Sosuke, Nishimura, Shintaro
Published in Nuclear medicine and biology (01.02.2013)
Published in Nuclear medicine and biology (01.02.2013)
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Synergistic Effects of Adenosine A2A Antagonist and L-DOPA on Rotational Behaviors in 6-Hydroxydopamine-Induced Hemi-Parkinsonian Mouse Model
Matsuya, Takahiro, Takuma, Kazuhiro, Sato, Kosuke, Asai, Makoto, Murakami, Yoshihiro, Miyoshi, Sosuke, Noda, Akihiro, Nagai, Taku, Mizoguchi, Hiroyuki, Nishimura, Shintaro, Yamada, Kiyofumi
Published in Journal of Pharmacological Sciences (2007)
Published in Journal of Pharmacological Sciences (2007)
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Involvement of hippocampal extracellular signal-regulated kinase 1/2 in spatial working memory in rats
Nagai, Taku, Kamei, Hiroyuki, Dohniwa, Misato, Takayanagi, Masanori, Suzuki, Masakazu, Matsuya, Takahiro, Nabeshima, Toshitaka, Takuma, Kazuhiro, Yamada, Kiyofumi
Published in Neuroreport (18.09.2006)
Published in Neuroreport (18.09.2006)
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Brain Adenosine A2A Receptor Occupancy by a Novel A1/A2A Receptor Antagonist, ASP5854, in Rhesus Monkeys: Relationship to Anticataleptic Effect
Mihara, Takuma, Noda, Akihiro, Arai, Hiroshi, Mihara, Kayoko, Iwashita, Akinori, Murakami, Yoshihiro, Matsuya, Takahiro, Miyoshi, Sosuke, Nishimura, Shintaro, Matsuoka, Nobuya
Published in The Journal of nuclear medicine (1978) (01.07.2008)
Published in The Journal of nuclear medicine (1978) (01.07.2008)
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Quantitation of cardiac sympathetic innervation in rabbits using 11C-hydroxyephedrine PET: relation to 123I-MIBG uptake
Nomura, Yusuke, Matsunari, Ichiro, Takamatsu, Hiroyuki, Murakami, Yoshihiro, Matsuya, Takahiro, Taki, Junichi, Nakajima, Kenichi, Nekolla, Stephan G, Chen, Wei-Ping, Kajinami, Kouji
Published in European journal of nuclear medicine and molecular imaging (01.08.2006)
Published in European journal of nuclear medicine and molecular imaging (01.08.2006)
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Journal Article
Mutant-Selective Irreversible EGFR Inhibitor, Naquotinib, Inhibits Tumor Growth in NSCLC Models with EGFR-Activating Mutations, T790M Mutation, and AXL Overexpression
Tanaka, Hiroaki, Sakagami, Hideki, Kaneko, Naoki, Konagai, Satoshi, Yamamoto, Hiroko, Matsuya, Takahiro, Yuri, Masatoshi, Yamanaka, Yosuke, Mori, Masamichi, Takeuchi, Masahiro, Koshio, Hiroyuki, Hirano, Masaaki, Kuromitsu, Sadao
Published in Molecular cancer therapeutics (01.08.2019)
Published in Molecular cancer therapeutics (01.08.2019)
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Synthesis and structure–activity relationships of pyrazine-2-carboxamide derivatives as novel echinoderm microtubule-associated protein-like 4 (EML4)–anaplastic lymphoma kinase (ALK) inhibitors
Iikubo, Kazuhiko, Kurosawa, Kazuo, Matsuya, Takahiro, Kondoh, Yutaka, Kamikawa, Akio, Moritomo, Ayako, Iwai, Yoshinori, Tomiyama, Hiroshi, Shimada, Itsuro
Published in Bioorganic & medicinal chemistry (15.04.2019)
Published in Bioorganic & medicinal chemistry (15.04.2019)
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Naquotinib exerts antitumor activity in activated B-cell-like diffuse large B-cell lymphoma
Tanaka, Hiroaki, Kaneko, Naoki, Sakagami, Hideki, Matsuya, Takahiro, Hiramoto, Masashi, Yamanaka, Yosuke, Mori, Masamichi, Koshio, Hiroyuki, Hirano, Masaaki, Takeuchi, Masahiro
Published in Leukemia research (01.01.2020)
Published in Leukemia research (01.01.2020)
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Abstract 1728: ASP8273, a novel mutant-selective irreversible EGFR inhibitor, inhibits growth of non-small cell lung cancer (NSCLC) cells with EGFR activating and T790M resistance mutations
Sakagami, Hideki, Konagai, Satoshi, Yamamoto, Hiroko, Tanaka, Hiroaki, Matsuya, Takahiro, Mori, Masamichi, Koshio, Hiroyuki, Yuri, Masatoshi, Hirano, Masaaki, Kuromitsu, Sadao
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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Journal Article
Brain Adenosine A 2A Receptor Occupancy by a Novel A 1 /A 2A Receptor Antagonist, ASP5854, in Rhesus Monkeys: Relationship to Anticataleptic Effect
Mihara, Takuma, Noda, Akihiro, Arai, Hiroshi, Mihara, Kayoko, Iwashita, Akinori, Murakami, Yoshihiro, Matsuya, Takahiro, Miyoshi, Sosuke, Nishimura, Shintaro, Matsuoka, Nobuya
Published in Journal of Nuclear Medicine (01.07.2008)
Published in Journal of Nuclear Medicine (01.07.2008)
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Journal Article
Brain Adenosine A^sub 2A^ Receptor Occupancy by a Novel A^sub 1^/A^sub 2A^ Receptor Antagonist, ASP5854, in Rhesus Monkeys: Relationship to Anticataleptic Effect
Mihara, Takuma, Noda, Akihiro, Arai, Hiroshi, Mihara, Kayoko, Iwashita, Akinori, Murakami, Yoshihiro, Matsuya, Takahiro, Miyoshi, Sosuke, Nishimura, Shintaro, Matsuoka, Nobuya
Published in The Journal of nuclear medicine (1978) (01.07.2008)
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Published in The Journal of nuclear medicine (1978) (01.07.2008)
Journal Article
Synthesis and evaluation of [11C]FR194921 as a nonxanthine-type PET tracer for adenosine A1 receptors in the brain
Matsuya, Takahiro, Takamatsu, Hiroyuki, Murakami, Yoshihiro, Noda, Akihiro, Ichise, Rikiya, Awaga, Yuji, Nishimura, Shintaro
Published in Nuclear medicine and biology (01.11.2005)
Published in Nuclear medicine and biology (01.11.2005)
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Journal Article
PYRAZINE CARBOXAMIDE COMPOUND
TAKEMOTO YUKIHIRO, SHINDOU NOBUAKI, SAKAGAMI HIDEKI, MATSUYA TAKAHIRO, FUKUDOME HIROKI, HAMAGUCHI HISAO, KONDOH YUTAKA, KIKUCHI SHIGETOSHI, ONDA KENICHI, SHIMADA ITSURO, IIDA MAIKO
Year of Publication 26.09.2014
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Year of Publication 26.09.2014
Patent
Original Article: Neural Circuits Containing Pallidotegmental GABAergic Neurons are Involved in the Prepulse Inhibition of the Startle Reflex in Mice
Takahashi, Kenji, Nagai, Taku, Kamei, Hiroyuki, Maeda, Kenji, Matsuya, Takahiro, Arai, Sawako, Mizoguchi, Hiroyuki, Yoneda, Yukio, Nabeshima, Toshitaka, Takuma, Kazuhiro, Yamada, Kiyofumi
Published in Biological psychiatry (1969) (01.07.2007)
Published in Biological psychiatry (1969) (01.07.2007)
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DIAMINO HETEROCYCLIC CARBOXAMIDE COMPOUND
MATSUYA TAKAHIRO, TOMIYAMA HIROSHI, KONDOH YUTAKA, KUROSAWA KAZUO, IIKUBO KAZUHIKO, SHIMADA ITSURO, KAMIKAWA AKIO, IWAI YOSHINORI
Year of Publication 20.01.2012
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Year of Publication 20.01.2012
Patent
LABELED DERIVATIVE FOR IMAGE DIAGNOSIS OF TUMOR
MIYOSHI SOUSUKE, MITSUOKA KEISUKE, KURIU AYA, JITSUOKA MAKOTO, MATSUYA TAKAHIRO, MURAKAMI YOSHIHIRO, NODA AKIHIRO, YAMANAKA KENTARO, NAKAHARA TAKAHITO
Year of Publication 29.11.2012
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Year of Publication 29.11.2012
Patent