Development of an antibody fragment that stabilizes GPCR/G-protein complexes
Maeda, Shoji, Koehl, Antoine, Matile, Hugues, Hu, Hongli, Hilger, Daniel, Schertler, Gebhard F. X., Manglik, Aashish, Skiniotis, Georgios, Dawson, Roger J. P., Kobilka, Brian K.
Published in Nature communications (13.09.2018)
Published in Nature communications (13.09.2018)
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Journal Article
Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria
Charman, Susan A., Arbe-Barnes, Sarah, Bathurst, Ian C., Brun, Reto, Campbell, Michael, Charman, William N., Chiu, Francis C. K., Chollet, Jacques, Craft, J. Carl, Creek, Darren J., Dong, Yuxiang, Matile, Hugues, Maurer, Melanie, Morizzi, Julia, Nguyen, Tien, Papastogiannidis, Petros, Scheurer, Christian, Shackleford, David M., Sriraghavan, Kamaraj, Stingelin, Lukas, Tang, Yuanqing, Urwyler, Heinrich, Wang, Xiaofang, White, Karen L., Wittlin, Sergio, Zhou, Lin, Vennerstrom, Jonathan L., Wellems, Thomas E.
Published in Proceedings of the National Academy of Sciences - PNAS (15.03.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (15.03.2011)
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Journal Article
Structure of the malaria vaccine candidate antigen CyRPA and its complex with a parasite invasion inhibitory antibody
Favuzza, Paola, Guffart, Elena, Tamborrini, Marco, Scherer, Bianca, Dreyer, Anita M, Rufer, Arne C, Erny, Johannes, Hoernschemeyer, Joerg, Thoma, Ralf, Schmid, Georg, Gsell, Bernard, Lamelas, Araceli, Benz, Joerg, Joseph, Catherine, Matile, Hugues, Pluschke, Gerd, Rudolph, Markus G
Published in eLife (14.02.2017)
Published in eLife (14.02.2017)
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Journal Article
Modulating cholesteryl ester transfer protein activity maintains efficient pre-β-HDL formation and increases reverse cholesterol transport[S]
Niesor, Eric J., Magg, Christine, Ogawa, Naoto, Okamoto, Hiroshi, von der Mark, Elisabeth, Matile, Hugues, Schmid, Georg, Clerc, Roger G., Chaput, Evelyne, Blum-Kaelin, Denise, Huber, Walter, Thoma, Ralf, Pflieger, Philippe, Kakutani, Makoto, Takahashi, Daisuke, Dernick, Gregor, Maugeais, Cyrille
Published in Journal of lipid research (01.12.2010)
Published in Journal of lipid research (01.12.2010)
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Journal Article
Structure–Activity Relationship of the Antimalarial Ozonide Artefenomel (OZ439)
Dong, Yuxiang, Wang, Xiaofang, Kamaraj, Sriraghavan, Bulbule, Vivek J, Chiu, Francis C. K, Chollet, Jacques, Dhanasekaran, Manickam, Hein, Christopher D, Papastogiannidis, Petros, Morizzi, Julia, Shackleford, David M, Barker, Helena, Ryan, Eileen, Scheurer, Christian, Tang, Yuanqing, Zhao, Qingjie, Zhou, Lin, White, Karen L, Urwyler, Heinrich, Charman, William N, Matile, Hugues, Wittlin, Sergio, Charman, Susan A, Vennerstrom, Jonathan L
Published in Journal of medicinal chemistry (13.04.2017)
Published in Journal of medicinal chemistry (13.04.2017)
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Journal Article
Passive immunoprotection of Plasmodium falciparum-infected mice designates the CyRPA as candidate malaria vaccine antigen
Dreyer, Anita M, Matile, Hugues, Papastogiannidis, Petros, Kamber, Jolanda, Favuzza, Paola, Voss, Till S, Wittlin, Sergio, Pluschke, Gerd
Published in The Journal of immunology (1950) (15.06.2012)
Published in The Journal of immunology (1950) (15.06.2012)
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Journal Article
Incretin-like effects of small molecule trace amine-associated receptor 1 agonists
Raab, Susanne, Wang, Haiyan, Uhles, Sabine, Cole, Nadine, Alvarez-Sanchez, Ruben, Künnecke, Basil, Ullmer, Christoph, Matile, Hugues, Bedoucha, Marc, Norcross, Roger D, Ottaway-Parker, Nickki, Perez-Tilve, Diego, Conde Knape, Karin, Tschöp, Matthias H, Hoener, Marius C, Sewing, Sabine
Published in Molecular metabolism (Germany) (01.01.2016)
Published in Molecular metabolism (Germany) (01.01.2016)
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Journal Article
Cryo-EM structure of the rhodopsin-Gαi-βγ complex reveals binding of the rhodopsin C-terminal tail to the gβ subunit
Tsai, Ching-Ju, Marino, Jacopo, Adaixo, Ricardo, Pamula, Filip, Muehle, Jonas, Maeda, Shoji, Flock, Tilman, Taylor, Nicholas Mi, Mohammed, Inayatulla, Matile, Hugues, Dawson, Roger Jp, Deupi, Xavier, Stahlberg, Henning, Schertler, Gebhard
Published in eLife (28.06.2019)
Published in eLife (28.06.2019)
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Journal Article
Analysis of adult neurogenesis: evidence for a prominent "non-neurogenic" DCX-protein pool in rodent brain
Kremer, Thomas, Jagasia, Ravi, Herrmann, Annika, Matile, Hugues, Borroni, Edilio, Francis, Fiona, Kuhn, Hans Georg, Czech, Christian
Published in PloS one (14.05.2013)
Published in PloS one (14.05.2013)
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Journal Article
Peroxide Bond-Dependent Antiplasmodial Specificity of Artemisinin and OZ277 (RBx11160)
KAISER, Marcel, WITTLIN, Sergio, NEHRBASS-STUEDLI, Angela, YUXIANG DONG, XIAOFANG WANG, HEMPHILL, Andrew, MATILE, Hugues, BRUN, Reto, VENNERSTROM, Jonathan L
Published in Antimicrobial Agents and Chemotherapy (01.08.2007)
Published in Antimicrobial Agents and Chemotherapy (01.08.2007)
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Journal Article
Multidimensional profiling of plasma lipoproteins by size exclusion chromatography followed by reverse-phase protein arrays
Dernick, Gregor, Obermüller, Stefan, Mangold, Cyrill, Magg, Christine, Matile, Hugues, Gutmann, Oliver, von der Mark, Elisabeth, Handschin, Corinne, Maugeais, Cyrille, Niesor, Eric J.
Published in Journal of lipid research (01.12.2011)
Published in Journal of lipid research (01.12.2011)
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Journal Article
An Assessment of Drug-Haematin Binding as a Mechanism for Inhibition of Haematin Polymerisation by Quinoline Antimalarials
Dorn, Arnulf, Vippagunta, Sudha Rani, Matile, Hugues, Jaquet, Catherine, Vennerstrom, Jonathan L, Ridley, Robert G
Published in Biochemical pharmacology (15.03.1998)
Published in Biochemical pharmacology (15.03.1998)
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Journal Article
A Common Mechanism for Blockade of Heme Polymerization by Antimalarial Quinolines
Sullivan, David J., Matile, Hugues, Ridley, Robert G., Goldberg, Daniel E.
Published in The Journal of biological chemistry (20.11.1998)
Published in The Journal of biological chemistry (20.11.1998)
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Journal Article
Structural Specificity of Chloroquine−Hematin Binding Related to Inhibition of Hematin Polymerization and Parasite Growth
Vippagunta, Sudha Rani, Dorn, Arnulf, Matile, Hugues, Bhattacharjee, Apurba K, Karle, Jean M, Ellis, William Y, Ridley, Robert G, Vennerstrom, Jonathan L
Published in Journal of medicinal chemistry (04.11.1999)
Published in Journal of medicinal chemistry (04.11.1999)
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Journal Article
Comparative Antimalarial Activities of Six Pairs of 1,2,4,5-Tetraoxanes (Peroxide Dimers) and 1,2,4,5,7,8-Hexaoxonanes (Peroxide Trimers)
YUXIANG DONG, CREEK, Darren, CHOLLET, Jacques, MATILE, Hugues, CHARMAN, Susan A, WITTLIN, Sergio, WOOD, James K, VENNERSTROM, Jonathan L
Published in Antimicrobial Agents and Chemotherapy (01.08.2007)
Published in Antimicrobial Agents and Chemotherapy (01.08.2007)
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Journal Article
Hematin Polymerization Assay as a High-Throughput Screen for Identification of New Antimalarial Pharmacophores
KUROSAWA, Yae, DORN, Arnulf, KITSUJI-SHIRANE, Michiko, SHIMADA, Hisao, SATOH, Tomoko, MATILE, Hugues, HOFHEINZ, Werner, MASCIADRI, Raffaello, KANSY, Manfred, RIDLEY, Robert G
Published in Antimicrobial Agents and Chemotherapy (01.10.2000)
Published in Antimicrobial Agents and Chemotherapy (01.10.2000)
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Journal Article