A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy
Ronan, Baptiste, Flamand, Odile, Vescovi, Lionel, Dureuil, Christine, Durand, Laurence, Fassy, Florence, Bachelot, Marie-France, Lamberton, Annabelle, Mathieu, Magali, Bertrand, Thomas, Marquette, Jean-Pierre, El-Ahmad, Youssef, Filoche-Romme, Bruno, Schio, Laurent, Garcia-Echeverria, Carlos, Goulaouic, Hélène, Pasquier, Benoit
Published in Nature chemical biology (01.12.2014)
Published in Nature chemical biology (01.12.2014)
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Journal Article
Selective Inhibition of Mutant Isocitrate Dehydrogenase 1 (IDH1) via Disruption of a Metal Binding Network by an Allosteric Small Molecule
Deng, Gejing, Shen, Junqing, Yin, Ming, McManus, Jessica, Mathieu, Magali, Gee, Patricia, He, Timothy, Shi, Chaomei, Bedel, Olivier, McLean, Larry R., Le-Strat, Frank, Zhang, Ying, Marquette, Jean-Pierre, Gao, Qiang, Zhang, Bailin, Rak, Alexey, Hoffmann, Dietmar, Rooney, Eamonn, Vassort, Aurelie, Englaro, Walter, Li, Yi, Patel, Vinod, Adrian, Francisco, Gross, Stefan, Wiederschain, Dmitri, Cheng, Hong, Licht, Stuart
Published in The Journal of biological chemistry (09.01.2015)
Published in The Journal of biological chemistry (09.01.2015)
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Journal Article
Automated harvesting and processing of protein crystals through laser photoablation
Zander, Ulrich, Hoffmann, Guillaume, Cornaciu, Irina, Marquette, Jean-Pierre, Papp, Gergely, Landret, Christophe, Seroul, Gaël, Sinoir, Jérémy, Röwer, Martin, Felisaz, Frank, Rodriguez-Puente, Sonia, Mariaule, Vincent, Murphy, Peter, Mathieu, Magali, Cipriani, Florent, Márquez, José Antonio
Published in Acta crystallographica. Section D, Structural biology (01.04.2016)
Published in Acta crystallographica. Section D, Structural biology (01.04.2016)
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Journal Article
Discovery of (2S)‑8-[(3R)‑3-Methylmorpholin-4-yl]-1-(3-methyl-2-oxobutyl)-2-(trifluoromethyl)-3,4-dihydro‑2H‑pyrimido[1,2‑a]pyrimidin-6-one: A Novel Potent and Selective Inhibitor of Vps34 for the Treatment of Solid Tumors
Pasquier, Benoit, El-Ahmad, Youssef, Filoche-Rommé, Bruno, Dureuil, Christine, Fassy, Florence, Abecassis, Pierre-Yves, Mathieu, Magali, Bertrand, Thomas, Benard, Tsiala, Barrière, Cédric, El Batti, Samira, Letallec, Jean-Philippe, Sonnefraud, Véronique, Brollo, Maurice, Delbarre, Laurence, Loyau, Véronique, Pilorge, Fabienne, Bertin, Luc, Richepin, Patrick, Arigon, Jérôme, Labrosse, Jean-Robert, Clément, Jacques, Durand, Florence, Combet, Romain, Perraut, Pierre, Leroy, Vincent, Gay, Frédéric, Lefrançois, Dominique, Bretin, François, Marquette, Jean-Pierre, Michot, Nadine, Caron, Anne, Castell, Christelle, Schio, Laurent, McCort, Gary, Goulaouic, Hélène, Garcia-Echeverria, Carlos, Ronan, Baptiste
Published in Journal of medicinal chemistry (08.01.2015)
Published in Journal of medicinal chemistry (08.01.2015)
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Journal Article
Differential Water Thermodynamics Determine PI3K-Beta/Delta Selectivity for Solvent-Exposed Ligand Modifications
Robinson, Daniel, Bertrand, Thomas, Carry, Jean-Christophe, Halley, Frank, Karlsson, Andreas, Mathieu, Magali, Minoux, Hervé, Perrin, Marc-Antoine, Robert, Benoit, Schio, Laurent, Sherman, Woody
Published in Journal of chemical information and modeling (23.05.2016)
Published in Journal of chemical information and modeling (23.05.2016)
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Journal Article
An end-to-end automated platform process for high-throughput engineering of next-generation multi-specific antibody therapeutics
Furtmann, Norbert, Schneider, Marion, Spindler, Nadja, Steinmann, Bjoern, Li, Ziyu, Focken, Ingo, Meyer, Joachim, Dimova, Dilyana, Kroll, Katja, Leuschner, Wulf Dirk, Debeaumont, Audrey, Mathieu, Magali, Lange, Christian, Dittrich, Werner, Kruip, Jochen, Schmidt, Thorsten, Birkenfeld, Joerg
Published in mAbs (01.01.2021)
Published in mAbs (01.01.2021)
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Journal Article
Crystal Structure of the RNA-Dependent RNA Polymerase of Hepatitis C Virus
Bressanelli, Stéphane, Tomei, Licia, Roussel, Alain, Incitti, Ilario, Vitale, Rosa Letizia, Mathieu, Magali, De Francesco, Raffaele, Rey, Félix A.
Published in Proceedings of the National Academy of Sciences - PNAS (09.11.1999)
Published in Proceedings of the National Academy of Sciences - PNAS (09.11.1999)
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Journal Article
The Crystal Structures of Four Peptide Deformylases Bound to the Antibiotic Actinonin Reveal Two Distinct Types: A Platform for the Structure-based Design of Antibacterial Agents
Guilloteau, Jean-Pierre, Mathieu, Magali, Giglione, Carmela, Blanc, Véronique, Dupuy, Alain, Chevrier, Miline, Gil, Patricia, Famechon, Alain, Meinnel, Thierry, Mikol, Vincent
Published in Journal of molecular biology (26.07.2002)
Published in Journal of molecular biology (26.07.2002)
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Journal Article
Escherichia coli FolC Structure Reveals an Unexpected Dihydrofolate Binding Site Providing an Attractive Target for Anti-microbial Therapy
Mathieu, Magali, Debousker, Guy, Vincent, Sophie, Viviani, Fabrice, Bamas-Jacques, Nathalie, Mikol, Vincent
Published in The Journal of biological chemistry (13.05.2005)
Published in The Journal of biological chemistry (13.05.2005)
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Journal Article
Complexation of Two Proteic Insect Inhibitors to the Active Site of Chymotrypsin Suggests Decoupled Roles for Binding and Selectivity
Roussel, Alain, Mathieu, Magali, Dobbs, Aaron, Luu, Bang, Cambillau, Christian, Kellenberger, Christine
Published in The Journal of biological chemistry (19.10.2001)
Published in The Journal of biological chemistry (19.10.2001)
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Journal Article
Structure of the Sec7 domain of the Arf exchange factor ARNO
Cherfils, Jacqueline, Ménétrey, Julie, Mathieu, Magali, Le Bras, Gérard, Robineau, Sylviane, Béraud-Dufour, Sophie, Antonny, Bruno, Chardin, Pierre
Published in Nature (London) (05.03.1998)
Published in Nature (London) (05.03.1998)
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Journal Article
N-terminal arm exchange is observed in the 2.15 Å crystal structure of oxidized nitrite reductase from Pseudomonas aeruginosa
Nurizzo, Didier, Silvestrini, Maria-Chiara, Mathieu, Magali, Cutruzzolà, Francesca, Bourgeois, Dominique, Fülöp, Vilmos, Hajdu, Janos, Brunori, Maurizio, Tegoni, Mariella, Cambillau, Christian
Published in Structure (London) (15.09.1997)
Published in Structure (London) (15.09.1997)
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Journal Article
1024 Non-tumour risk factors for cutaneous melanoma relapse
Autier, P, Aegerter, Mathieu Boniol, Magali Boniol, P, Saiag, P
Published in European journal of cancer (1990) (01.09.2015)
Published in European journal of cancer (1990) (01.09.2015)
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Journal Article
The 1.8 A crystal structure of the dimeric peroxisomal 3-ketoacyl-CoA thiolase of Saccharomyces cerevisiae: implications for substrate binding and reaction mechanism
Mathieu, M, Modis, Y, Zeelen, J P, Engel, C K, Abagyan, R A, Ahlberg, A, Rasmussen, B, Lamzin, V S, Kunau, W H, Wierenga, R K
Published in Journal of molecular biology (31.10.1997)
Published in Journal of molecular biology (31.10.1997)
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Journal Article
Alteration mapping on drill cores using a HySpex SWIR-320m hyperspectral camera: Application to the exploration of an unconformity-related uranium deposit (Saskatchewan, Canada)
Mathieu, Magali, Roy, Régis, Launeau, Patrick, Cathelineau, Michel, Quirt, David
Published in Journal of geochemical exploration (01.01.2017)
Published in Journal of geochemical exploration (01.01.2017)
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Journal Article