A Randomized, Placebo-Controlled, Respiratory Syncytial Virus Human Challenge Study of the Antiviral Efficacy, Safety, and Pharmacokinetics of RV521, an Inhibitor of the RSV-F Protein
DeVincenzo, John, Tait, Dereck, Efthimiou, John, Mori, Julie, Kim, Young-In, Thomas, Elaine, Wilson, Lynn, Harland, Rachel, Mathews, Neil, Cockerill, Stuart, Powell, Kenneth, Littler, Edward
Published in Antimicrobial agents and chemotherapy (27.01.2020)
Published in Antimicrobial agents and chemotherapy (27.01.2020)
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Journal Article
State of the Art in Respiratory Syncytial Virus Drug Discovery and Development
Cockerill, G. Stuart, Good, James A. D, Mathews, Neil
Published in Journal of medicinal chemistry (11.04.2019)
Published in Journal of medicinal chemistry (11.04.2019)
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Journal Article
Discovery of Sisunatovir (RV521), an Inhibitor of Respiratory Syncytial Virus Fusion
Cockerill, G. Stuart, Angell, Richard M, Bedernjak, Alexandre, Chuckowree, Irina, Fraser, Ian, Gascon-Simorte, Jose, Gilman, Morgan S. A, Good, James A. D, Harland, Rachel, Johnson, Sara M, Ludes-Meyers, John H, Littler, Edward, Lumley, James, Lunn, Graham, Mathews, Neil, McLellan, Jason S, Paradowski, Michael, Peeples, Mark E, Scott, Claire, Tait, Dereck, Taylor, Geraldine, Thom, Michelle, Thomas, Elaine, Villalonga Barber, Carol, Ward, Simon E, Watterson, Daniel, Williams, Gareth, Young, Paul, Powell, Kenneth
Published in Journal of medicinal chemistry (08.04.2021)
Published in Journal of medicinal chemistry (08.04.2021)
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Journal Article
Identification of 1,5-Naphthyridine Derivatives as a Novel Series of Potent and Selective TGF-β Type I Receptor Inhibitors
Gellibert, Françoise, Woolven, James, Fouchet, Marie-Hélène, Mathews, Neil, Goodland, Helen, Lovegrove, Victoria, Laroze, Alain, Nguyen, Van-Loc, Sautet, Stéphane, Wang, Ruolan, Janson, Cheryl, Smith, Ward, Krysa, Gaël, Boullay, Valérie, de Gouville, Anne-Charlotte, Huet, Stéphane, Hartley, David
Published in Journal of medicinal chemistry (26.08.2004)
Published in Journal of medicinal chemistry (26.08.2004)
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Discovery of 4-{4-[3-(Pyridin-2-yl)-1H-pyrazol-4-yl]pyridin-2-yl}-N-(tetrahydro-2H- pyran-4-yl)benzamide (GW788388): A Potent, Selective, and Orally Active Transforming Growth Factor-β Type I Receptor Inhibitor
Gellibert, Françoise, de Gouville, Anne-Charlotte, Woolven, James, Mathews, Neil, Nguyen, Van-Loc, Bertho-Ruault, Cécile, Patikis, Angela, Grygielko, Eugene T, Laping, Nicholas J, Huet, Stéphane
Published in Journal of medicinal chemistry (06.04.2006)
Published in Journal of medicinal chemistry (06.04.2006)
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Journal Article
PHARMACEUTICAL COMPOUNDS
LUMLEY JAMES, COCKERILL STUART, PILKINGTON CHRISTOPHER, MATHEWS NEIL, ANGELL RICHARD
Year of Publication 05.11.2014
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Year of Publication 05.11.2014
Patent
Identification and optimisation of a novel series of pyrimidine based cyclooxygenase-2 (COX-2) inhibitors. Utilisation of a biotransformation approach
Beswick, Paul J., Blackaby, Andrew P., Bountra, Chas, Brown, Terry, Browning, Kerry, Campbell, Ian B., Corfield, John, Gleave, Robert J., Guntrip, Steve B., Hall, Richard M., Hindley, Sean, Lambeth, Paul F., Lucas, Fiona, Mathews, Neil, Naylor, Alan, Player, Hazel, Price, Helen S., Sidebottom, Phillip J., Taylor, Nicholas L., Webb, Graham, Wiseman, Joanne
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
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Journal Article
Identification of [4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)-2-pyrimidinyl] amines and ethers as potent and selective cyclooxygenase-2 inhibitors
Swarbrick, Martin E., Beswick, Paul J., Gleave, Robert J., Green, Richard H., Bingham, Sharon, Bountra, Chas, Carter, Malcolm C., Chambers, Laura J., Chessell, Iain P., Clayton, Nick M., Collins, Sue D., Corfield, John A., Hartley, C. David, Kleanthous, Savvas, Lambeth, Paul F., Lucas, Fiona S., Mathews, Neil, Naylor, Alan, Page, Lee W., Payne, Jeremy J., Pegg, Neil A., Price, Helen S., Skidmore, John, Stevens, Alexander J., Stocker, Richard, Stratton, Sharon C., Stuart, Alastair J., Wiseman, Joanne O.
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
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Journal Article
Diphenylcarboxamides as Inhibitors of HCV Non-Structural Protein NS5a
Carter, Malcolm, Baxter, Bob, Bushnell, David, Cockerill, Stuart, Chapman, Jo, Fram, Sally, Goulding, Emma, Lockyer, Mike, Mathews, Neil, Najarro, Pilar, Rupassara, Dilupa, Salter, James, Thomas, Elaine, Wheelhouse, Chris, Borger, Jessica, Powell, Kenneth
Published in Antiviral research (01.04.2010)
Published in Antiviral research (01.04.2010)
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Journal Article
Identification of 2,3-diaryl-pyrazolo[1,5-b]pyridazines as potent and selective cyclooxygenase-2 inhibitors
BESWICK, Paul, BINGHAM, Sharon, GUNTRIP, Stephen, HASLAM, Claudine, LAMBETH, Paul, LUCAS, Fiona, MATHEWS, Neil, MURKIT, Graham, NAYLOR, Alan, PEGG, Neil, PICKUP, Elizabeth, PLAYER, Hazel, BOUNTRA, Chas, PRICE, Helen, STEVENS, Alexander, STRATTON, Sharon, WISEMAN, Joanne, BROWN, Terry, BROWNING, Kerry, CAMPBELL, Ian, CHESSELL, Lain, CLAYTON, Nick, COLLINS, Sue, CORFIELD, John
Published in Bioorganic & medicinal chemistry letters (01.11.2004)
Published in Bioorganic & medicinal chemistry letters (01.11.2004)
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Journal Article
Identification of [4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)-2-pyrimi-dinyl] amines and ethers as potent and selective cyclooxygenase-2 inhibitors
SWARBRICK, Martin E, BESWICK, Paul J, COLLINS, Sue D, CORFIELD, John A, HARTLEY, C. David, KLEANTHOUS, Sawas, LAMBETH, Paul F, LUCAS, Fiona S, MATHEWS, Neil, NAYLOR, Alan, PAGE, Lee W, PAYNE, Jeremy J, GLEAVE, Robert J, PEGG, Neil A, PRICE, Helen S, SKIDMORE, John, STEVENS, Alexander J, STOCKER, Richard, STRATTON, Sharon C, STUART, Alastair J, WISEMAN, Joanne O, GREEN, Richard H, BINGHAM, Sharon, BOUNTRA, Chas, CARTER, Malcolm C, CHAMBERS, Laura J, CHESSELL, Lain P, CLAYTON, Nick M
Published in Bioorganic & medicinal chemistry letters (2009)
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Published in Bioorganic & medicinal chemistry letters (2009)
Journal Article
Synthesis and serotonergic activity of substituted 2, N-benzylcarboxamido-5-(2-ethyl-1-dioxoimidazolidinyl)-N, N-dimethyltryptamine derivatives: novel antagonists for the vascular 5-HT(1B)-like receptor
Moloney, G P, Martin, G R, Mathews, N, Milne, A, Hobbs, H, Dodsworth, S, Sang, P Y, Knight, C, Williams, M, Maxwell, M, Glen, R C
Published in Journal of medicinal chemistry (15.07.1999)
Published in Journal of medicinal chemistry (15.07.1999)
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Journal Article
BENZIMIDAZOLES FOR THE TREATMENT AND PREVENTION OF RESPIRATORY SYNCYTIAL VIRUS INFECTION
MATHEWS, NEIL, LUMLEY, JAMES, PILKINGTON, CHRISTOPHER, ANGELL, RICHARD, COCKERILL, STUART
Year of Publication 16.06.2020
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Year of Publication 16.06.2020
Patent