Biology of the Major Facilitative Folate Transporters SLC19A1 and SLC46A1
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Book Chapter
Journal Article
Folate receptors and transporters: biological role and diagnostic/therapeutic targets in cancer and other diseases
Frigerio, Barbara, Bizzoni, Claudia, Jansen, Gerrit, Leamon, Christopher P, Peters, Godefridus J, Low, Philip S, Matherly, Larry H, Figini, Mariangela
Published in Journal of experimental & clinical cancer research (12.03.2019)
Published in Journal of experimental & clinical cancer research (12.03.2019)
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Journal Article
Human reduced folate carrier: translation of basic biology to cancer etiology and therapy
Matherly, Larry H, Hou, Zhanjun, Deng, Yijun
Published in Cancer and metastasis reviews (01.03.2007)
Published in Cancer and metastasis reviews (01.03.2007)
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Journal Article
Structure-Based Design of Transport-Specific Multitargeted One-Carbon Metabolism Inhibitors in Cytosol and Mitochondria
Nayeen, Md. Junayed, Katinas, Jade M., Magdum, Tejashree, Shah, Khushbu, Wong, Jennifer E., O’Connor, Carrie E., Fifer, Alexandra N., Wallace-Povirk, Adrianne, Hou, Zhanjun, Matherly, Larry H., Gangjee, Aleem
Published in Journal of medicinal chemistry (24.08.2023)
Published in Journal of medicinal chemistry (24.08.2023)
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Journal Article
Targeted therapy of pyrrolo[2,3-d]pyrimidine antifolates in a syngeneic mouse model of high grade serous ovarian cancer and the impact on the tumor microenvironment
Wallace-Povirk, Adrianne, Rubinsak, Lisa, Malysa, Agnes, Dzinic, Sijana H, Ravindra, Manasa, Schneider, Mathew, Glassbrook, James, O'Connor, Carrie, Hou, Zhanjun, Kim, Seongho, Back, Jessica, Polin, Lisa, Morris, Robert T, Gangjee, Aleem, Gibson, Heather, Matherly, Larry H
Published in Scientific reports (05.07.2022)
Published in Scientific reports (05.07.2022)
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Journal Article
Folate Transport and One-Carbon Metabolism in Targeted Therapies of Epithelial Ovarian Cancer
Wallace-Povirk, Adrianne, Hou, Zhanjun, Nayeen, Md Junayed, Gangjee, Aleem, Matherly, Larry H
Published in Cancers (31.12.2021)
Published in Cancers (31.12.2021)
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Journal Article
Structural determinants of human proton-coupled folate transporter oligomerization: role of GXXXG motifs and identification of oligomeric interfaces at transmembrane domains 3 and 6
Wilson, Mike R, Kugel, Sita, Huang, Jenny, Wilson, Lucas J, Wloszczynski, Patrick A, Ye, Jun, Matherly, Larry H, Hou, Zhanjun
Published in Biochemical journal (01.07.2015)
Published in Biochemical journal (01.07.2015)
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Journal Article
Therapeutic targeting of a novel 6-substituted pyrrolo [2,3-d]pyrimidine thienoyl antifolate to human solid tumors based on selective uptake by the proton-coupled folate transporter
Kugel Desmoulin, Sita, Wang, Lei, Hales, Eric, Polin, Lisa, White, Kathryn, Kushner, Juiwanna, Stout, Mark, Hou, Zhanjun, Cherian, Christina, Gangjee, Aleem, Matherly, Larry H
Published in Molecular pharmacology (01.12.2011)
Published in Molecular pharmacology (01.12.2011)
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Journal Article
Pattern Analysis of Organellar Maps for Interpretation of Proteomic Data
Burton, Jordan B, Carruthers, Nicholas J, Hou, Zhanjun, Matherly, Larry H, Stemmer, Paul M
Published in Proteomes (23.05.2022)
Published in Proteomes (23.05.2022)
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Journal Article
RX-3117 (Fluorocyclopentenyl-Cytosine)-Mediated Down-Regulation of DNA Methyltransferase 1 Leads to Protein Expression of Tumor-Suppressor Genes and Increased Functionality of the Proton-Coupled Folate Carrier
Sarkisjan, Dzjemma, Julsing, Joris R, El Hassouni, Btissame, Honeywell, Richard J, Kathmann, Ietje, Matherly, Larry H, Lee, Young B, Kim, Deog J, Peters, Godefridus J
Published in International journal of molecular sciences (14.04.2020)
Published in International journal of molecular sciences (14.04.2020)
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Journal Article
Discovery of 5‑Substituted Pyrrolo[2,3‑d]pyrimidine Antifolates as Dual-Acting Inhibitors of Glycinamide Ribonucleotide Formyltransferase and 5‑Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase in De Novo Purine Nucleotide Biosynthesis: Implications of Inhibiting 5‑Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase to AMPK Activation and Antitumor Activity
Mitchell-Ryan, Shermaine, Wang, Yiqiang, Raghavan, Sudhir, Ravindra, Manasa Punaha, Hales, Eric, Orr, Steven, Cherian, Christina, Hou, Zhanjun, Matherly, Larry H, Gangjee, Aleem
Published in Journal of medicinal chemistry (27.12.2013)
Published in Journal of medicinal chemistry (27.12.2013)
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Journal Article
Rodent intestinal folate transporters (SLC46A1): secondary structure, functional properties, and response to dietary folate restriction
Qiu, Andong, Min, Sang Hee, Jansen, Michaela, Malhotra, Usha, Tsai, Eugenia, Cabelof, Diane C, Matherly, Larry H, Zhao, Rongbao, Akabas, Myles H, Goldman, I. David
Published in American Journal of Physiology: Cell Physiology (01.11.2007)
Published in American Journal of Physiology: Cell Physiology (01.11.2007)
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Journal Article
Gene Signature of High White Blood Cell Count in B-Precursor Acute Lymphoblastic Leukemia
Edwards, Holly, Rubenstein, Mara, Dombkowski, Alan A, Caldwell, J Timothy, Chu, Roland, Xavier, Ana C, Thummel, Ryan, Neely, Melody, Matherly, Larry H, Ge, Yubin, Taub, Jeffrey W
Published in PloS one (18.08.2016)
Published in PloS one (18.08.2016)
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Journal Article
Identification and Functional Impact of Homo-oligomers of the Human Proton-coupled Folate Transporter
Hou, Zhanjun, Kugel Desmoulin, Sita, Etnyre, Erika, Olive, Mary, Hsiung, Benjamin, Cherian, Christina, Wloszczynski, Patrick A., Moin, Kamiar, Matherly, Larry H.
Published in The Journal of biological chemistry (10.02.2012)
Published in The Journal of biological chemistry (10.02.2012)
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Journal Article
Overexpression of GATA1 confers resistance to chemotherapy in acute megakaryocytic Leukemia
Caldwell, John Timothy, Edwards, Holly, Dombkowski, Alan A, Buck, Steven A, Matherly, Larry H, Ge, Yubin, Taub, Jeffrey W
Published in PloS one (10.07.2013)
Published in PloS one (10.07.2013)
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