Quantitative Signaling and Structure-Activity Analyses Demonstrate Functional Selectivity at the Nociceptin/Orphanin FQ Opioid Receptor
Chang, Steven D, Mascarella, S Wayne, Spangler, Skylar M, Gurevich, Vsevolod V, Navarro, Hernan A, Carroll, F Ivy, Bruchas, Michael R
Published in Molecular pharmacology (01.09.2015)
Published in Molecular pharmacology (01.09.2015)
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Novel Synthesis and Pharmacological Characterization of NOP Receptor Agonist 8-[(1S,3aS)-2,3,3a,4,5,6-Hexahydro-1H-phenalen-1-yl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one (Ro 64-6198)
Chang, Steven D, Brieaddy, Lawrence E, Harvey, Joseph D, Lewin, Anita H, Mascarella, S. Wayne, Seltzman, Herbert H, Reddy, P. Anantha, Decker, Ann M, McElhinny, Charles J, Zhong, Desong, Peterson, Elisha E, Navarro, Hernán A, Bruchas, Michael R, Carroll, F. Ivy
Published in ACS chemical neuroscience (16.12.2015)
Published in ACS chemical neuroscience (16.12.2015)
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Identification of (3R)-7-Hydroxy-N-((1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)- 3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro- 3-isoquinolinecarboxamide as a Novel Potent and Selective Opioid κ Receptor Antagonist
Thomas, James B, Atkinson, Robert N, Vinson, N. Ariane, Catanzaro, Jennifer L, Perretta, Carin L, Fix, Scott E, Mascarella, S. Wayne, Rothman, Richard B, Xu, Heng, Dersch, Christina M, Cantrell, Buddy E, Zimmerman, Dennis M, Carroll, F. Ivy
Published in Journal of medicinal chemistry (03.07.2003)
Published in Journal of medicinal chemistry (03.07.2003)
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N-Substituted 4β-Methyl-5-(3-hydroxyphenyl)-7α-amidomorphans Are Potent, Selective κ Opioid Receptor Antagonists
Carroll, F. Ivy, Melvin, Matt S, Nuckols, Michel C, Mascarella, S. Wayne, Navarro, Hernán A, Thomas, James B
Published in Journal of medicinal chemistry (09.03.2006)
Published in Journal of medicinal chemistry (09.03.2006)
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Identification of the First trans-(3R,4R)- Dimethyl-4-(3-hydroxyphenyl)piperidine Derivative To Possess Highly Potent and Selective Opioid κ Receptor Antagonist Activity
Thomas, James B, Atkinson, Robert N, Rothman, Richard B, Fix, Scott E, Mascarella, S. Wayne, Vinson, N. Ariane, Xu, Heng, Dersch, Christina M, Lu, Y. -F, Cantrell, Buddy E, Zimmerman, Dennis M, Carroll, F. Ivy
Published in Journal of medicinal chemistry (16.08.2001)
Published in Journal of medicinal chemistry (16.08.2001)
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N-Substituted cis-4a-(3-Hydroxyphenyl)-8a-methyloctahydroisoquinolines Are Opioid Receptor Pure Antagonists
Carroll, F. Ivy, Chaudhari, Sachin, Thomas, James B, Mascarella, S. Wayne, Gigstad, Kenneth M, Deschamps, Jeffrey, Navarro, Hernán A
Published in Journal of medicinal chemistry (29.12.2005)
Published in Journal of medicinal chemistry (29.12.2005)
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Importance of Phenolic Address Groups in Opioid Kappa Receptor Selective Antagonists
Thomas, James B, Fix, Scott E, Rothman, Richard B, Mascarella, S. Wayne, Dersch, Christina M, Cantrell, Buddy E, Zimmerman, Dennis M, Carroll, F. Ivy
Published in Journal of medicinal chemistry (12.02.2004)
Published in Journal of medicinal chemistry (12.02.2004)
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Discovery of the First N-Substituted 4β-Methyl-5-(3-hydroxyphenyl)morphan To Possess Highly Potent and Selective Opioid δ Receptor Antagonist Activity
Carroll, F. Ivy, Zhang, Li, Mascarella, S. Wayne, Navarro, Hernán A, Rothman, Richard B, Cantrell, Buddy E, Zimmerman, Dennis M, Thomas, James B
Published in Journal of medicinal chemistry (15.01.2004)
Published in Journal of medicinal chemistry (15.01.2004)
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Synthesis, ligand binding, and quantitative structure-activity relationship study of 3 beta-(4'-substituted phenyl)-2 beta-heterocyclic tropanes: Evidence for an electrostatic interaction at the 2 beta-position
Kotian, P, Mascarella, SW, Abraham, P, Lewin, AH, Boja, JW, Kuhar, MJ, Carroll, FI
Published in Journal of medicinal chemistry (05.07.1996)
Published in Journal of medicinal chemistry (05.07.1996)
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SYNTHESIS, LIGAND-BINDING, AND QSAR (COMFA AND CLASSICAL) STUDY OF 3-BETA-(3'-SUBSTITUTED PHENYL), 3-BETA-(4'-SUBSTITUTED PHENYL), AND 3-BETA-(3',4'-DISUBSTITUTED PHENYL)TROPANE-2-BETA-CARBOXYLIC ACID METHYL-ESTERS
CARROLL, FI, MASCARELLA, SW, KUZEMKO, MA, GAO, YG, ABRAHAM, P, LEWIN, AH, BOJA, JW, KUHAR, MJ
Published in Journal of medicinal chemistry (02.09.1994)
Published in Journal of medicinal chemistry (02.09.1994)
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Discovery of an Opioid κ Receptor Selective Pure Antagonist from a Library of N-Substituted 4β-Methyl-5-(3-hydroxyphenyl)morphans
Thomas, James B, Atkinson, Robert N, Namdev, Nivedita, Rothman, Richard B, Gigstad, Kenneth M, Fix, Scott E, Mascarella, S. Wayne, Burgess, Jason P, Vinson, N. Ariane, Xu, Heng, Dersch, Christina M, Cantrell, Buddy E, Zimmerman, Dennis M, Carroll, F. Ivy
Published in Journal of medicinal chemistry (01.08.2002)
Published in Journal of medicinal chemistry (01.08.2002)
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QSAR analysis of Delta(8)-THC analogues: relationship of side-chain conformation to cannabinoid receptor affinity and pharmacological potency
Keimowitz, A R, Martin, B R, Razdan, R K, Crocker, P J, Mascarella, S W, Thomas, B F
Published in Journal of medicinal chemistry (13.01.2000)
Published in Journal of medicinal chemistry (13.01.2000)
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Identification of an Opioid κ Receptor Subtype-Selective N-Substituent for (+)-(3R,4R)-Dimethyl-4-(3-hydroxyphenyl)piperidine
Thomas, James B, Fall, Michael J, Cooper, Julie B, Rothman, Richard B, Mascarella, S. Wayne, Xu, Heng, Partilla, John S, Dersch, Christina M, McCullough, Karen B, Cantrell, Buddy E, Zimmerman, Dennis M, Carroll, F. Ivy
Published in Journal of medicinal chemistry (17.12.1998)
Published in Journal of medicinal chemistry (17.12.1998)
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Synthesis of bridged analogs of epibatidine. 3-Chloro-5,7,8,9,9a,10-hexahydro-7,10-methanopyrrolo[1,2- b]-2,6-naphthyridine and 2-chloro-5,5a,6,7,8,10-hexahydro-5,8-methanopyrrolo[2,1- b]-1,7-naphthyridine
Brieaddy, Lawrence E, Wayne Mascarella, S, Navarro, Hernán A, Atkinson, Robert N, Damaj, M.I, Martin, Billy R, Carroll, F.Ivy
Published in Tetrahedron letters (04.06.2001)
Published in Tetrahedron letters (04.06.2001)
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Investigation of the N-Substituent Conformation Governing Potency and μ Receptor Subtype-Selectivity in (+)-(3R,4R)-Dimethyl-4-(3-hydroxyphenyl)- piperidine Opioid Antagonists
Thomas, James B, Mascarella, S. Wayne, Rothman, Richard B, Partilla, John S, Xu, Heng, McCullough, Karen B, Dersch, Christina M, Cantrell, Buddy E, Zimmerman, Dennis M, Carroll, F. Ivy
Published in Journal of medicinal chemistry (21.05.1998)
Published in Journal of medicinal chemistry (21.05.1998)
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A comparison of (-)-deoxybenzomorphans devoid of opiate activity with their dextrorotatory phenolic counterparts suggests role of sigma 2 receptors in motor function
Walker, J M, Bowen, W D, Patrick, S L, Williams, W E, Mascarella, S W, Bai, X, Carroll, F I
Published in European journal of pharmacology (26.01.1993)
Published in European journal of pharmacology (26.01.1993)
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N-Substituted 9β-Methyl-5-(3-hydroxyphenyl)morphans Are Opioid Receptor Pure Antagonists
Thomas, James B, Zheng, Xiaoling, Mascarella, S. Wayne, Rothman, Richard B, Dersch, Christina M, Partilla, John S, Flippen-Anderson, Judith L, George, Clifford F, Cantrell, Buddy E, Zimmerman, Dennis M, Carroll, F. Ivy
Published in Journal of medicinal chemistry (08.10.1998)
Published in Journal of medicinal chemistry (08.10.1998)
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Factors Influencing Agonist Potency and Selectivity for the Opioid δ Receptor Are Revealed in Structure−Activity Relationship Studies of the 4-[(N-Substituted-4-piperidinyl)arylamino]-N,N-diethylbenzamides
Thomas, James B, Herault, Xavier M, Rothman, Richard B, Atkinson, Robert N, Burgess, Jason P, Mascarella, S. Wayne, Dersch, Christina M, Xu, Heng, Flippen-Anderson, Judith L, George, Clifford F, Carroll, F. Ivy
Published in Journal of medicinal chemistry (15.03.2001)
Published in Journal of medicinal chemistry (15.03.2001)
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A stereoselective synthetic approach to N-alkyl-4β-methyl-5-phenylmorphans
Thomas, James B., Gigstad, Kenneth M., Fix, Scott E., Burgess, Jason P., Cooper, Julie B., Mascarella, S.Wayne, Cantrell, Buddy E., Zimmerman, Dennis M., Carroll, F.Ivy
Published in Tetrahedron letters (15.01.1999)
Published in Tetrahedron letters (15.01.1999)
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