Chiral scandium-catalyzed enantioselective hydroxymethylation of ketones in water
Kobayashi, Shū, Kokubo, Masaya, Kawasumi, Katsuaki, Nagano, Takashi
Published in Chemistry, an Asian journal (01.03.2010)
Published in Chemistry, an Asian journal (01.03.2010)
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Discovery, Synthesis and Characterization of a Highly Muscarinic Acetylcholine Receptor (mAChR)-Selective M5-Orthosteric Antagonist, VU0488130 (ML381): A Novel Molecular Probe
Gentry, Patrick R., Kokubo, Masaya, Bridges, Thomas M., Cho, Hyekyung P., Smith, Emery, Chase, Peter, Hodder, Peter S., Utley, Thomas J., Rajapakse, Anuruddha, Byers, Frank, Niswender, Colleen M., Morrison, Ryan D., Daniels, J. Scott, Wood, Michael R., Conn, P. Jeffrey, Lindsley, Craig W.
Published in ChemMedChem (01.08.2014)
Published in ChemMedChem (01.08.2014)
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Synthesis of a tetrabenzyl-substituted 10-membered cyclic diamide
Doi, Takayuki, Nagamiya, Hiroyuki, Kokubo, Masaya, Hirabayashi, Kazunori, Takahashi, Takashi
Published in Tetrahedron (08.04.2002)
Published in Tetrahedron (08.04.2002)
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Discovery of the First M-5-Selective and CNS Penetrant Negative Allosteric Modulator (NAM) of a Muscarinic Acetylcholine Receptor: (S)-9b-(4-Chlorophenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one (ML375)
Gentry, Patrick R., Kokubo, Masaya, Bridges, Thomas M., Kett, Nathan R., Harp, Joel M., Cho, Hyekyung P., Smith, Emery, Chase, Peter, Hodder, Peter S., Niswender, Colleen M., Daniels, J. Scott, Conn, P. Jeffrey, Wood, Michael R., Lindsley, Craig W.
Published in Journal of medicinal chemistry (28.11.2013)
Published in Journal of medicinal chemistry (28.11.2013)
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Sequential Asymmetric Hydrogenation of Symmetric Bis-Cinnamic Acid Derivatives: Syntheses of the C2-Symmetric Core Units of HIV Protease Inhibitors
DOI, Takayuki, HIRABAYASHI, Kazunori, KOKUBO, Masaya, KOMAGATA, Toshikazu, YAMAMOTO, Keiji, TAKAHASHI, Takashi
Published in Journal of organic chemistry (29.11.1996)
Published in Journal of organic chemistry (29.11.1996)
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Development of a Highly Potent, Novel M-5 Positive Allosteric Modulator (PAM) Demonstrating CNS Exposure: 1-((1H-Indazol-5-yl)sulfoneyl)-N-ethyl-N-(2-(trifluoromethyl)benzyl)piperidine-4-carboxamide (ML380)
Gentry, Patrick R., Kokubo, Masaya, Bridges, Thomas M., Noetzel, Meredith J., Cho, Hyekyung P., Lamsal, Atin, Smith, Emery, Chase, Peter, Hodder, Peter S., Niswender, Colleen M., Daniels, J. Scott, Conn, P. Jeffrey, Lindsley, Craig W., Wood, Michael R.
Published in Journal of medicinal chemistry (25.09.2014)
Published in Journal of medicinal chemistry (25.09.2014)
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Towards a TREK-1/2 (TWIK-Related K+ Channel 1 and 2) dual activator tool compound: Multi-dimensional optimization of BL-1249
Iwaki, Yuzo, Yashiro, Kentaro, Kokubo, Masaya, Mori, Takahiro, Wieting, Joshua M., McGowan, Kevin M., Bridges, Thomas M., Engers, Darren W., Denton, Jerod S., Kurata, Haruto, Lindsley, Craig W.
Published in Bioorganic & medicinal chemistry letters (01.07.2019)
Published in Bioorganic & medicinal chemistry letters (01.07.2019)
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Further optimization of the M-5 NAM MLPCN probe ML375: Tactics and challenges
Kurata, Haruto, Gentry, Patrick R., Kokubo, Masaya, Cho, Hyekyung P., Bridges, Thomas M., Niswender, Colleen M., Byers, Frank W., Wood, Michael R., Daniels, J. Scott, Conn, P. Jeffrey, Lindsley, Craig W.
Published in Bioorganic & medicinal chemistry letters (01.02.2015)
Published in Bioorganic & medicinal chemistry letters (01.02.2015)
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Design, Synthesis, and Biological Evaluation of the Combinatorial Library with a New Spirodiketopiperazine Scaffold. Discovery of Novel Potent and Selective Low-Molecular-Weight CCR5 Antagonists
Habashita, Hiromu, Kokubo, Masaya, Hamano, Shin-ichi, Hamanaka, Nobuyuki, Toda, Masaaki, Shibayama, Shiro, Tada, Hideaki, Sagawa, Kenji, Fukushima, Daikichi, Maeda, Kenji, Mitsuya, Hiroaki
Published in Journal of medicinal chemistry (13.07.2006)
Published in Journal of medicinal chemistry (13.07.2006)
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Suppressive effects of a novel CC chemokine receptor 4 antagonist on Th2 cell trafficking in ligand- and antigen-induced mouse models
Komiya, Takaki, Sugiyama, Tetsuya, Takeda, Kazuhiko, Watanabe, Noriki, Imai, Masamichi, Kokubo, Masaya, Tokuda, Natsuko, Ochiai, Hiroshi, Habashita, Hiromu, Shibayama, Shiro
Published in European journal of pharmacology (15.11.2013)
Published in European journal of pharmacology (15.11.2013)
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Further optimization of the M5 NAM MLPCN probe ML375: Tactics and challenges
Kurata, Haruto, Gentry, Patrick R., Kokubo, Masaya, Cho, Hyekyung P., Bridges, Thomas M., Niswender, Colleen M., Byers, Frank W., Wood, Michael R., Daniels, J. Scott, Conn, P. Jeffrey, Lindsley, Craig W.
Published in Bioorganic & medicinal chemistry letters (01.02.2015)
Published in Bioorganic & medicinal chemistry letters (01.02.2015)
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Journal Article
Discovery, Synthesis and Characterization of a Highly Muscarinic Acetylcholine Receptor (mAChR)-Selective M-5-Orthosteric Antagonist, VU0488130 (ML381): A Novel Molecular Probe
Gentry, Patrick R., Kokubo, Masaya, Bridges, Thomas M., Cho, Hyekyung P., Smith, Emery, Chase, Peter, Hodder, Peter S., Utley, Thomas J., Rajapakse, Anuruddha, Byers, Frank, Niswender, Colleen M., Morrison, Ryan D., Daniels, J. Scott, Wood, Michael R., Conn, P. Jeffrey, Lindsley, Craig W.
Published in ChemMedChem (01.08.2014)
Published in ChemMedChem (01.08.2014)
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Journal Article
Development of a Highly Potent, Novel M5 Positive Allosteric Modulator (PAM) Demonstrating CNS Exposure: 1-((1H-Indazol-5-yl)sulfoneyl)-N-ethyl-N-(2-(trifluoromethyl)benzy l )piperidine-4-carboxamide (ML380)
Gentry, Patrick R, Kokubo, Masaya, Bridges, Thomas M, Noetzel, Meredith J, Cho, Hyekyung P, Lamsal, Atin, Smith, Emery, Chase, Peter, Hodder, Peter S, Niswender, Colleen M, Daniels, JScott, Conn, PJeffrey, Lindsley, Craig W, Wood, Michael R
Published in Journal of medicinal chemistry (22.08.2014)
Published in Journal of medicinal chemistry (22.08.2014)
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Further optimization of the M sub(5) NAM MLPCN probe ML375: Tactics and challenges
Kurata, Haruto, Gentry, Patrick R, Kokubo, Masaya, Cho, Hyekyung P, Bridges, Thomas M, Niswender, Colleen M, Byers, Frank W, Wood, Michael R, Daniels, JScott, Conn, PJeffrey, Lindsley, Craig W
Published in Bioorganic & medicinal chemistry letters (01.02.2015)
Published in Bioorganic & medicinal chemistry letters (01.02.2015)
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Journal Article
Discovery of the First M 5 -Selective and CNS Penetrant Negative Allosteric Modulator (NAM) of a Muscarinic Acetylcholine Receptor: ( S )-9b-(4-Chlorophenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydro-1 H -imidazo[2,1- a ]isoindol-5(9b H )-one (ML375)
Gentry, Patrick R., Kokubo, Masaya, Bridges, Thomas M., Kett, Nathan R., Harp, Joel M., Cho, Hyekyung P., Smith, Emery, Chase, Peter, Hodder, Peter S., Niswender, Colleen M., Daniels, J. Scott, Conn, P. Jeffrey, Wood, Michael R., Lindsley, Craig W.
Published in Journal of medicinal chemistry (27.11.2013)
Published in Journal of medicinal chemistry (27.11.2013)
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