1,2,3-Triazolyl ester of Ketorolac: A “Click Chemistry”-based highly potent PAK1-blocking cancer-killer
Nguyen, Binh Cao Quan, Takahashi, Hideaki, Uto, Yoshihiro, Shahinozzaman, M.d., Tawata, Shinkichi, Maruta, Hiroshi
Published in European journal of medicinal chemistry (27.01.2017)
Published in European journal of medicinal chemistry (27.01.2017)
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Journal Article
FREEZE-THAW RESISTANCE AND CHLORIDE ION PENETRATION RESISTANCE OF CONCRETE BY INCORPORATION OF SOLID PARAFFIN EMULSION UNDER DIFFERENT FREEZE-THAW CONDITIONS
MARUTA, Hiroshi, HAZEHARA, Hirotaka, SOEDA, Masashi
Published in Cement Science and Concrete Technology (29.03.2024)
Published in Cement Science and Concrete Technology (29.03.2024)
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Journal Article
Frondoside A from sea cucumber and nymphaeols from Okinawa propolis: Natural anti-cancer agents that selectively inhibit PAK1 in vitro
Nguyen, Binh Cao Quan, Yoshimura, Kazuki, Kumazawa, Shigenori, Tawata, Shinkichi, Maruta, Hiroshi
Published in Drug Discoveries & Therapeutics (30.05.2017)
Published in Drug Discoveries & Therapeutics (30.05.2017)
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Journal Article
Alert Regarding Cisplatin-induced Severe Adverse Events in Cancer Patients with Xeroderma Pigmentosum
Sumiyoshi, Makoto, Soda, Hiroshi, Sadanaga, Noriaki, Taniguchi, Hirokazu, Ikeda, Takaya, Maruta, Hiroshi, Dotsu, Yosuke, Ogawara, Daiki, Fukuda, Yuichi, Mukae, Hiroshi
Published in Internal Medicine (01.01.2017)
Published in Internal Medicine (01.01.2017)
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Journal Article
1,2,3-Triazolyl esterization of PAK1-blocking propolis ingredients, artepillin C (ARC) and caffeic acid (CA), for boosting their anti-cancer/anti-PAK1 activities along with cell-permeability
Takahashi, Hideaki, Nguyen, Binh Cao Quan, Uto, Yoshihiro, Shahinozzaman, Md, Tawata, Shinkichi, Maruta, Hiroshi
Published in Drug Discoveries & Therapeutics (30.05.2017)
Published in Drug Discoveries & Therapeutics (30.05.2017)
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Journal Article
1,2,3-Triazolyl ester of ketorolac (15K), a potent PAK1 blocker, inhibits both growth and metastasis of orthotopic human pancreatic cancer xenografts in mice
Hennig, Rene, Albawardi, Alia, Almarzooqi, Saeeda, Haneefa, Shoja, Imbaraj, Edward, Zaaba, Nur Elena, Nemmar, Abderrahim, Subramanya, Sandeep, Maruta, Hiroshi, Adrian, Thomas E.
Published in Drug Discoveries & Therapeutics (31.10.2019)
Published in Drug Discoveries & Therapeutics (31.10.2019)
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Journal Article
Artepillin C (ARC) in Brazilian green propolis selectively blocks oncogenic PAK1 signaling and suppresses the growth of NF tumors in mice
Messerli, Shanta M, Ahn, Mok-Ryeon, Kunimasa, Kazuhiro, Yanagihara, Miyako, Tatefuji, Tomoki, Hashimoto, Ken, Mautner, Victor, Uto, Yoshihiro, Hori, Hitoshi, Kumazawa, Shigenori, Kaji, Kazuhiko, Ohta, Toshiro, Maruta, Hiroshi
Published in Phytotherapy research (01.03.2009)
Published in Phytotherapy research (01.03.2009)
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1,2,3-Triazolyl ester of ketorolac (15K): Boosting both heat-endurance and lifespan of C. elegans by down-regulating PAK1 at nM levels
Nguyen, Binh C., Kim, Sung-A, Won, Seong-Min, Park, Sang-Kyu, Uto, Yoshihiro, Maruta, Hiroshi
Published in Drug Discoveries & Therapeutics (30.04.2018)
Published in Drug Discoveries & Therapeutics (30.04.2018)
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Journal Article
Both triazolyl ester of ketorolac (15K) and YM155 inhibit the embryonic angiogenesis in ovo (fertilized eggs) via their common PAK1-survivin/VEGF signaling pathway
Ahn, Mok-Ryeon, Bae, Ji-Yeon, Jeong, Da-Hye, Takahashi, Hideaki, Uto, Yoshihiro, Maruta, Hiroshi
Published in Drug Discoveries & Therapeutics (2017)
Published in Drug Discoveries & Therapeutics (2017)
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