Development of a Zinc-Mediated Approach to a 2,3-cis-Pyrrolidine Arginase Inhibitor
Lyons, Thomas W, Martinot, Theodore A, He, Cyndi Qixin, Qi, Ji, Shao, Guangxin
Published in Organic process research & development (21.08.2020)
Published in Organic process research & development (21.08.2020)
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Discovery of Amino-cyclobutarene-derived Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitors for Cancer Immunotherapy
Zhang, Hongjun, Liu, Kun, Pu, Qinglin, Achab, Abdelghani, Ardolino, Michael J, Cheng, Mangeng, Deng, Yongqi, Doty, Amy C, Ferguson, Heidi, Fradera, Xavier, Knemeyer, Ian, Kurukulasuriya, Ravi, Lam, Yu-hong, Lesburg, Charles A, Martinot, Theodore A, McGowan, Meredeth A, Miller, J. Richard, Otte, Karin, Biju, Purakattle J, Sciammetta, Nunzio, Solban, Nicolas, Yu, Wensheng, Zhou, Hua, Wang, Xiao, Bennett, David Jonathan, Han, Yongxin
Published in ACS medicinal chemistry letters (14.11.2019)
Published in ACS medicinal chemistry letters (14.11.2019)
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Oxetane Promise Delivered: Discovery of Long-Acting IDO1 Inhibitors Suitable for Q3W Oral or Parenteral Dosing
Li, Derun, Sloman, David L, Achab, Abdelghani, Zhou, Hua, McGowan, Meredeth A, White, Catherine, Gibeau, Craig, Zhang, Hongjun, Pu, Qinglin, Bharathan, Indu, Hopkins, Brett, Liu, Kun, Ferguson, Heidi, Fradera, Xavier, Lesburg, Charles A, Martinot, Theodore A, Qi, Ji, Song, Zhiguo J, Yin, Jingjun, Zhang, Huangguang, Song, Licheng, Wan, Baoqiang, DAddio, Suzanne, Solban, Nicolas, Miller, J Richard, Zamlynny, Beata, Bass, Alan, Freeland, Elizabeth, Ykoruk, Bridget, Hilliard, Catherine, Ferraro, Jude, Zhai, Jin, Knemeyer, Ian, Otte, Karin M, Vincent, Stella, Sciammetta, Nunzio, Pasternak, Alexander, Bennett, David Jonathan, Han, Yongxin
Published in Journal of medicinal chemistry (28.04.2022)
Published in Journal of medicinal chemistry (28.04.2022)
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Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1‑Heteroaryl‑1H‑Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson’s Disease
Candito, David A., Simov, Vladimir, Gulati, Anmol, Kattar, Solomon, Chau, Ryan W., Lapointe, Blair T., Methot, Joey L., DeMong, Duane E., Graham, Thomas H., Kurukulasuriya, Ravi, Keylor, Mitchell H., Tong, Ling, Morriello, Gregori J., Acton, John J., Pio, Barbara, Liu, Weiguo, Scott, Jack D., Ardolino, Michael J., Martinot, Theodore A., Maddess, Matthew L., Yan, Xin, Gunaydin, Hakan, Palte, Rachel L., McMinn, Spencer E., Nogle, Lisa, Yu, Hongshi, Minnihan, Ellen C., Lesburg, Charles A., Liu, Ping, Su, Jing, Hegde, Laxminarayan G., Moy, Lily Y., Woodhouse, Janice D., Faltus, Robert, Xiong, Tina, Ciaccio, Paul, Piesvaux, Jennifer A., Otte, Karin M., Kennedy, Matthew E., Bennett, David Jonathan, DiMauro, Erin F., Fell, Matthew J., Neelamkavil, Santhosh, Wood, Harold B., Fuller, Peter H., Ellis, J. Michael
Published in Journal of medicinal chemistry (22.12.2022)
Published in Journal of medicinal chemistry (22.12.2022)
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PI3Kγ inhibition circumvents inflammation and vascular leak in SARS-CoV-2 and other infections
Shepard, Ryan M, Ghebremedhin, Anghesom, Pratumchai, Isaraphorn, Robinson, Sally R, Betts, Courtney, Hu, Jingjing, Sasik, Roman, Fisch, Kathleen M, Zak, Jaroslav, Chen, Hui, Paradise, Marc, Rivera, Jason, Amjad, Mohammad, Uchiyama, Satoshi, Seo, Hideya, Campos, Alejandro D, Dayao, Denise Ann, Tzipori, Saul, Piedra-Mora, Cesar, Das, Soumita, Hasteh, Farnaz, Russo, Hana, Sun, Xin, Xu, Le, E Alexander, Laura Crotty, Duran, Jason M, Odish, Mazen, Pretorius, Victor, Kirchberger, Nell C, Chin, Shao-Ming, Von Schalscha, Tami, Cheresh, David, Morrey, John D, Alargova, Rossitza, O'Connell, Brenda, Martinot, Theodore A, Patel, Sandip P, Nizet, Victor, Martinot, Amanda J, Coussens, Lisa M, Teijaro, John R, Varner, Judith A
Published in Science translational medicine (03.07.2024)
Published in Science translational medicine (03.07.2024)
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Synthesis of the Bis-tetrahydropyran Core of Amphidinol 3
Crimmins, Michael T, Martin, Timothy J, Martinot, Theodore A
Published in Organic letters (03.09.2010)
Published in Organic letters (03.09.2010)
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Utilization of Metabolite Identification and Structural Data to Guide Design of Low-Dose IDO1 Inhibitors
Hopkins, Brett, Zhang, Hongjun, Bharathan, Indu, Li, Derun, Pu, Qinglin, Zhou, Hua, Martinot, Theodore A, Fradera, Xavier, Lammens, Alfred, Lesburg, Charles A, Cohen, Ryan D, Ballard, Jeanine, Knemeyer, Ian, Otte, Karin, Vincent, Stella, Miller, J. Richard, Solban, Nicolas, Cheng, Mangeng, Geda, Prasanthi, Smotrov, Nadya, Song, Xuelei, Bennett, David Jonathan, Han, Yongxin
Published in ACS medicinal chemistry letters (09.09.2021)
Published in ACS medicinal chemistry letters (09.09.2021)
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Carbamate and N‑Pyrimidine Mitigate Amide Hydrolysis: Structure-Based Drug Design of Tetrahydroquinoline IDO1 Inhibitors
Li, Derun, Deng, Yongqi, Achab, Abdelghani, Bharathan, Indu, Hopkins, Brett Andrew, Yu, Wensheng, Zhang, Hongjun, Sanyal, Sulagna, Pu, Qinglin, Zhou, Hua, Liu, Kun, Lim, Jongwon, Fradera, Xavier, Lesburg, Charles A, Lammens, Alfred, Martinot, Theodore A, Cohen, Ryan D, Doty, Amy C, Ferguson, Heidi, Nickbarg, Elliott B, Cheng, Mangeng, Spacciapoli, Peter, Geda, Prasanthi, Song, Xuelei, Smotrov, Nadya, Abeywickrema, Pravien, Andrews, Christine, Chamberlin, Chad, Mabrouk, Omar, Curran, Patrick, Richards, Matthew, Saradjian, Peter, Miller, J. Richard, Knemeyer, Ian, Otte, Karin M, Vincent, Stella, Sciammetta, Nunzio, Pasternak, Alexander, Bennett, David Jonathan, Han, Yongxin
Published in ACS medicinal chemistry letters (11.03.2021)
Published in ACS medicinal chemistry letters (11.03.2021)
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Process Safety Considerations for the Supply of a High-Energy Oxadiazole IDO1-Selective Inhibitor
Martinot, Theodore A, Ardolino, Michael, Chen, Lu, Lam, Yu-hong, Li, Chaomin, Maddess, Matthew L, Muzzio, Daniel, Qi, Ji, Saurí, Josep, Song, Zhiguo J, Tan, Lushi, Vickery, Thomas, Yin, Jingjun, Zhao, Ralph
Published in Organic process research & development (21.06.2019)
Published in Organic process research & development (21.06.2019)
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Discovery and Optimization of Rationally Designed Bicyclic Inhibitors of Human Arginase to Enhance Cancer Immunotherapy
Mitcheltree, Matthew J, Li, Derun, Achab, Abdelghani, Beard, Adam, Chakravarthy, Kalyan, Cheng, Mangeng, Cho, Hyelim, Eangoor, Padmanabhan, Fan, Peter, Gathiaka, Symon, Kim, Hai-Young, Lesburg, Charles A, Lyons, Thomas W, Martinot, Theodore A, Miller, J. Richard, McMinn, Spencer, O’Neil, Jennifer, Palani, Anandan, Palte, Rachel L, Saurí, Josep, Sloman, David L, Zhang, Hongjun, Cumming, Jared N, Fischer, Christian
Published in ACS medicinal chemistry letters (09.04.2020)
Published in ACS medicinal chemistry letters (09.04.2020)
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Comprehensive Strategies to Bicyclic Prolines: Applications in the Synthesis of Potent Arginase Inhibitors
Li, Derun, Zhang, Hongjun, Lyons, Thomas W, Lu, Min, Achab, Abdelghani, Pu, Qinglin, Childers, Matthew, Mitcheltree, Matthew J, Wang, Jialiang, Martinot, Theodore A, McMinn, Spencer E, Sloman, David L, Palani, Anandan, Beard, Adam, Nogle, Lisa, Gathiaka, Symon, Saurí, Josep, Kim, Hai-Young, Adpressa, Donovon, Spacciapoli, Peter, Miller, J. Richard, Palte, Rachel L, Lesburg, Charles A, Cumming, Jared, Fischer, Christian
Published in ACS medicinal chemistry letters (11.11.2021)
Published in ACS medicinal chemistry letters (11.11.2021)
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Total synthesis and biological evaluation of Amaryllidaceae alkaloids: Narciclasine, ent-7-deoxypancratistatin, regioisomer of 7-deoxypancratistatin, 10b-epi-deoxypancratistatin, and truncated derivatives
Hudlicky, T, Rinner, U, Gonzalez, D, Akgun, H, Schilling, S, Siengalewicz, P, Martinot, TA, Pettit, GR
Published in Journal of organic chemistry (13.12.2002)
Published in Journal of organic chemistry (13.12.2002)
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A Design of Experiments Approach to a Robust Final Deprotection and Reactive Crystallization of IPI-926, A Novel Hedgehog Pathway Inhibitor
Martinot, Theodore A, Austad, Brian C, Côté, Alexandre, Depew, Kristopher M, Genov, Daniel, Grenier, Louis, Helble, Joseph, Lescarbeau, Andre, Nair, Somarajan, Trudeau, Martin, White, Priscilla, Yu, Lin-Chen
Published in Organic process research & development (20.11.2015)
Published in Organic process research & development (20.11.2015)
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Development of a Manufacturing Process for an HCV Protease Inhibitor Candidate Molecule
Littler, Benjamin J, Aizenberg, Michael, Ambhaikar, Narendra B, Blythe, Todd A, Curran, Timothy T, Dvornikovs, Vadims, Jung, Young C, Jurkauskas, Valdas, Lee, Elaine C, Looker, Adam R, Luong, Hoa, Martinot, Theodore A, Miller, David B, Neubert-Langille, Bobbianna J, Otten, Pieter A, Rose, Peter J, Ruggiero, Piero L
Published in Organic process research & development (16.01.2015)
Published in Organic process research & development (16.01.2015)
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Correction to “Development of a Manufacturing Process for an HCV Protease Inhibitor Candidate Molecule”
Littler, Benjamin J, Aizenberg, Michael, Ambhaikar, Narendra B, Blythe, Todd A, Curran, Timothy T, Dvornikovs, Vadims, Jung, Young C, Jurkauskas, Valdas, Lee, Elaine C, Looker, Adam R, Luong, Hoa, Martinot, Theodore A, Miller, David B, Neubert-Langille, Bobbianna J, Otten, Pieter A, Rose, Peter J, Ruggiero, Piero L
Published in Organic process research & development (20.02.2015)
Published in Organic process research & development (20.02.2015)
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Total Synthesis and Biological Evaluation of Amaryllidaceae Alkaloids: Narciclasine, ent-7-Deoxypancratistatin, Regioisomer of 7-Deoxypancratistatin, 10b-epi-Deoxypancratistatin, and Truncated Derivatives
Hudlicky, Tomas, Rinner, Uwe, Gonzalez, David, Akgun, Hulya, Schilling, Stefan, Siengalewicz, Peter, Martinot, Theodore A, Pettit, George R
Published in Journal of organic chemistry (24.01.2003)
Published in Journal of organic chemistry (24.01.2003)
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Racemic Synthesis of a Key 1,4-Dihydro‑2H‑spiro[isoquinoline-3,4′-piperidin]-3′-ol Building Block
Candito, David A., Martinot, Theodore A., Su, Jing, Saurí, Josep, Lam, Yu-hong, Joyce, Leo A., Silverman, Steven M., Sloman, David L., Maddess, Matthew L., Machacek, Michelle R.
Published in Organic process research & development (18.11.2022)
Published in Organic process research & development (18.11.2022)
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