Small Molecule IL-36γ Antagonist as a Novel Therapeutic Approach for Plaque Psoriasis
Todorović, Viktor, Su, Zhi, Putman, C. Brent, Kakavas, Stevan J., Salte, Katherine M., McDonald, Heath A., Wetter, Joseph B., Paulsboe, Stephanie E., Sun, Qi, Gerstein, Clare E., Medina, Limary, Sielaff, Bernhard, Sadhukhan, Ramkrishna, Stockmann, Henning, Richardson, Paul L., Qiu, Wei, Argiriadi, Maria A., Henry, Rodger F., Herold, J. Martin, Shotwell, J. Brad, McGaraughty, Steve P., Honore, Prisca, Gopalakrishnan, Sujatha M., Sun, Chaohong C., Scott, Victoria E.
Published in Scientific reports (24.06.2019)
Published in Scientific reports (24.06.2019)
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Journal Article
Optimization of Cellular Activity of G9a Inhibitors 7-Aminoalkoxy-quinazolines
Liu, Feng, Barsyte-Lovejoy, Dalia, Allali-Hassani, Abdellah, He, Yunlong, Herold, J. Martin, Chen, Xin, Yates, Christopher M, Frye, Stephen V, Brown, Peter J, Huang, Jing, Vedadi, Masoud, Arrowsmith, Cheryl H, Jin, Jian
Published in Journal of medicinal chemistry (08.09.2011)
Published in Journal of medicinal chemistry (08.09.2011)
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Journal Article
Discovery of a Selective, Substrate-Competitive Inhibitor of the Lysine Methyltransferase SETD8
Ma, Anqi, Yu, Wenyu, Li, Fengling, Bleich, Rachel M, Herold, J. Martin, Butler, Kyle V, Norris, Jacqueline L, Korboukh, Victoria, Tripathy, Ashutosh, Janzen, William P, Arrowsmith, Cheryl H, Frye, Stephen V, Vedadi, Masoud, Brown, Peter J, Jin, Jian
Published in Journal of medicinal chemistry (14.08.2014)
Published in Journal of medicinal chemistry (14.08.2014)
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Journal Article
Discovery of a 2,4-Diamino-7-aminoalkoxyquinazoline as a Potent and Selective Inhibitor of Histone Lysine Methyltransferase G9a
Liu, Feng, Chen, Xin, Allali-Hassani, Abdellah, Quinn, Amy M, Wasney, Gregory A, Dong, Aiping, Barsyte, Dalia, Kozieradzki, Ivona, Senisterra, Guillermo, Chau, Irene, Siarheyeva, Alena, Kireev, Dmitri B, Jadhav, Ajit, Herold, J. Martin, Frye, Stephen V, Arrowsmith, Cheryl H, Brown, Peter J, Simeonov, Anton, Vedadi, Masoud, Jin, Jian
Published in Journal of medicinal chemistry (24.12.2009)
Published in Journal of medicinal chemistry (24.12.2009)
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Journal Article
Protein Lysine Methyltransferase G9a Inhibitors: Design, Synthesis, and Structure Activity Relationships of 2,4-Diamino-7-aminoalkoxy-quinazolines
Liu, Feng, Chen, Xin, Allali-Hassani, Abdellah, Quinn, Amy M, Wigle, Tim J, Wasney, Gregory A, Dong, Aiping, Senisterra, Guillermo, Chau, Irene, Siarheyeva, Alena, Norris, Jacqueline L, Kireev, Dmitri B, Jadhav, Ajit, Herold, J. Martin, Janzen, William P, Arrowsmith, Cheryl H, Frye, Stephen V, Brown, Peter J, Simeonov, Anton, Vedadi, Masoud, Jin, Jian
Published in Journal of medicinal chemistry (12.08.2010)
Published in Journal of medicinal chemistry (12.08.2010)
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Journal Article
Screening for Inhibitors of Low-Affinity Epigenetic Peptide-Protein Interactions: An AlphaScreen™-Based Assay for Antagonists of Methyl-Lysine Binding Proteins
Wigle, Tim J., Herold, J. Martin, Senisterra, Guillermo A., Vedadi, Masoud, Kireev, Dmitri B., Arrowsmith, Cheryl H., Frye, Stephen V., Janzen, William P.
Published in Journal of biomolecular screening (01.01.2010)
Published in Journal of biomolecular screening (01.01.2010)
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Journal Article
Identification of Non-Peptide Malignant Brain Tumor (MBT) Repeat Antagonists by Virtual Screening of Commercially Available Compounds
Kireev, Dmitri, Wigle, Tim J, Norris-Drouin, Jacqueline, Herold, J. Martin, Janzen, William P, Frye, Stephen V
Published in Journal of medicinal chemistry (11.11.2010)
Published in Journal of medicinal chemistry (11.11.2010)
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Journal Article
Assessment of free energy predictors for ligand binding to a methyllysine histone code reader
Gao, Cen, Herold, J. Martin, Kireev, Dmitri
Published in Journal of computational chemistry (05.03.2012)
Published in Journal of computational chemistry (05.03.2012)
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Journal Article
Targeting the Tyrosine Kinase 2 (TYK2) Pseudokinase Domain: Discovery of the Selective TYK2 Inhibitor ABBV-712
Breinlinger, Eric, Van Epps, Stacy, Friedman, Michael, Argiriadi, Maria, Chien, Ellen, Chhor, Gekleng, Cowart, Marlon, Dunstan, Theresa, Graff, Candace, Hardee, David, Herold, J. Martin, Little, Andrew, McCarthy, Richard, Parmentier, Julie, Perham, Matthew, Qiu, Wei, Schrimpf, Michael, Vargo, Thomas, Webster, Matthew P., Wu, Fei, Bennett, Dawn, Edmunds, Jeremy
Published in Journal of medicinal chemistry (26.10.2023)
Published in Journal of medicinal chemistry (26.10.2023)
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Journal Article
Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain
James, Lindsey I, Barsyte-Lovejoy, Dalia, Zhong, Nan, Krichevsky, Liubov, Korboukh, Victoria K, Herold, J Martin, MacNevin, Christopher J, Norris, Jacqueline L, Sagum, Cari A, Tempel, Wolfram, Marcon, Edyta, Guo, Hongbo, Gao, Cen, Huang, Xi-Ping, Duan, Shili, Emili, Andrew, Greenblatt, Jack F, Kireev, Dmitri B, Jin, Jian, Janzen, William P, Brown, Peter J, Bedford, Mark T, Arrowsmith, Cheryl H, Frye, Stephen V
Published in Nature chemical biology (01.03.2013)
Published in Nature chemical biology (01.03.2013)
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Journal Article
Small-Molecule Ligands of Methyl-Lysine Binding Proteins: Optimization of Selectivity for L3MBTL3
James, Lindsey I, Korboukh, Victoria K, Krichevsky, Liubov, Baughman, Brandi M, Herold, J. Martin, Norris, Jacqueline L, Jin, Jian, Kireev, Dmitri B, Janzen, William P, Arrowsmith, Cheryl H, Frye, Stephen V
Published in Journal of medicinal chemistry (26.09.2013)
Published in Journal of medicinal chemistry (26.09.2013)
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Journal Article
Small-Molecule Ligands of Methyl-Lysine Binding Proteins
Herold, J. Martin, Wigle, Tim J, Norris, Jacqueline L, Lam, Robert, Korboukh, Victoria K, Gao, Cen, Ingerman, Lindsey A, Kireev, Dmitri B, Senisterra, Guillermo, Vedadi, Masoud, Tripathy, Ashutosh, Brown, Peter J, Arrowsmith, Cheryl H, Jin, Jian, Janzen, William P, Frye, Stephen V
Published in Journal of medicinal chemistry (14.04.2011)
Published in Journal of medicinal chemistry (14.04.2011)
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Journal Article
Structure–activity relationships of methyl-lysine reader antagonists
Herold, J. Martin, James, Lindsey Ingerman, Korboukh, Victoria K., Gao, Cen, Coil, Kaitlyn E., Bua, Dennis J., Norris, Jacqueline L., Kireev, Dmitri B., Brown, Peter J., Jin, Jian, Janzen, William P., Gozani, Or, Frye, Stephen V.
Published in MedChemComm (01.01.2012)
Published in MedChemComm (01.01.2012)
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Journal Article
Drug discovery toward antagonists of methyl-lysine binding proteins
Herold, J Martin, Ingerman, Lindsey A, Gao, Cen, Frye, Stephen V
Published in Current chemical genomics (2011)
Published in Current chemical genomics (2011)
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Journal Article
Discovery of a chemical probe for the L3MBTL3 methyl-lysine reader domain
James, Lindsey I., Barsyte-Lovejoy, Dalia, Zhong, Nan, Krichevsky, Liubov, Korboukh, Victoria K., Herold, Martin J., MacNevin, Christopher J., Norris, Jacqueline L., Sagum, Cari A., Tempel, Wolfram, Marcon, Edyta, Guo, Hongbo, Gao, Cen, Huang, Xi-Ping, Duan, Shili, Emili, Andrew, Greenblatt, Jack F., Kireev, Dmitri B., Jin, Jian, Janzen, William P., Brown, Peter J., Bedford, Mark T., Arrowsmith, Cheryl H., Frye, Stephen V.
Published in Nature chemical biology (06.01.2013)
Published in Nature chemical biology (06.01.2013)
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Journal Article
Discovery of a 2,4-Diamino-7-aminoalkoxy-quinazoline as a Potent and Selective Inhibitor of Histone Lysine Methyltransferase G9a
Liu, Feng, Chen, Xin, Allali-Hassani, Abdellah, Quinn, Amy M., Wasney, Gregory A., Dong, Aiping, Barsyte, Dalia, Kozieradzki, Ivona, Senisterra, Guillermo, Chau, Irene, Siarheyeva, Alena, Kireev, Dmitri B., Jadhav, Ajit, Herold, J. Martin, Frye, Stephen V., Arrowsmith, Cheryl H., Brown, Peter J., Simeonov, Anton, Vedadi, Masoud, Jin, Jian
Published in Journal of medicinal chemistry (24.12.2009)
Published in Journal of medicinal chemistry (24.12.2009)
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Journal Article
Structureactivity relationships of methyl-lysine reader antagonistsThis article is part of a MedChemComm web theme issue on epigenetics.Electronic supplementary information (ESI) available: In vitro assay conditions, representative AlphaScreen and ITC binding curves, experimental procedures including spectra for all final compounds. See DOI: 10.1039/c1md00195g
Herold, J. Martin, James, Lindsey Ingerman, Korboukh, Victoria K, Gao, Cen, Coil, Kaitlyn E, Bua, Dennis J, Norris, Jacqueline L, Kireev, Dmitri B, Brown, Peter J, Jin, Jian, Janzen, William P, Gozani, Or, Frye, Stephen V
Year of Publication 01.01.2012
Year of Publication 01.01.2012
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Journal Article
PRIMARY CARBOXAMIDES AS BTK INHIBITORS
BONAFOUX, Dominique, OSUMA, Augustine, HUNTLEY, Raymond, SOMAL, Gagandeep, K, WALLACE, Grier, A, FRIEDMAN, Michael, M, VASUDEVAN, Anil, HOEMANN, Michael, Z, HEROLD, J. Martin, VAN CAMP, Jennifer, VAN EPPS, Stacy, A, SHEPPARD, George, FRANK, Kristine, E, XU, Xiangdong, DAVIS, Heather, M, WANG, Lu, WANG, Zhi, WILSON, Noel, S
Year of Publication 08.06.2022
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Year of Publication 08.06.2022
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