Diversity oriented biosynthesis via accelerated evolution of modular gene clusters
Wlodek, Aleksandra, Kendrew, Steve G., Coates, Nigel J., Hold, Adam, Pogwizd, Joanna, Rudder, Steven, Sheehan, Lesley S., Higginbotham, Sarah J., Stanley-Smith, Anna E., Warneck, Tony, Nur-E-Alam, Mohammad, Radzom, Markus, Martin, Christine J., Overvoorde, Lois, Samborskyy, Markiyan, Alt, Silke, Heine, Daniel, Carter, Guy T., Graziani, Edmund I., Koehn, Frank E., McDonald, Leonard, Alanine, Alexander, Rodríguez Sarmiento, Rosa María, Chao, Suzan Keen, Ratni, Hasane, Steward, Lucinda, Norville, Isobel H., Sarkar-Tyson, Mitali, Moss, Steven J., Leadlay, Peter F., Wilkinson, Barrie, Gregory, Matthew A.
Published in Nature communications (31.10.2017)
Published in Nature communications (31.10.2017)
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Journal Article
Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate
Andexer, Jennifer N, Kendrew, Steven G, Nur-e-Alam, Mohammad, Lazos, Orestis, Foster, Teresa A, Zimmermann, Anna-Sophie, Warneck, Tony D, Suthar, Dipen, Coates, Nigel J, Koehn, Frank E, Skotnicki, Jerauld S, Carter, Guy T, Gregory, Matthew A, Martin, Christine J, Moss, Steven J, Leadlay, Peter F, Wilkinson, Barrie
Published in Proceedings of the National Academy of Sciences - PNAS (22.03.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (22.03.2011)
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Journal Article
Loss of co-linearity by modular polyketide synthases: a mechanism for the evolution of chemical diversity
Moss, Steven J, Martin, Christine J, Wilkinson, Barrie
Published in Natural product reports (01.10.2004)
Published in Natural product reports (01.10.2004)
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Journal Article
Rapamycin biosynthesis: elucidation of gene product function
Gregory, Matthew A., Hong, Hui, Lill, Rachel E., Gaisser, Sabine, Petkovic, Hrvoje, Low, Lindsey, Sheehan, Lesley S., Carletti, Isabelle, Ready, Sarah J., Ward, Michael J., Kaja, Andrew L., Weston, Alison J., Challis, Iain R., Leadlay, Peter F., Martin, Christine J., Wilkinson, Barrie, Sheridan, Rose M.
Published in Organic & biomolecular chemistry (01.01.2006)
Published in Organic & biomolecular chemistry (01.01.2006)
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Journal Article
Optimizing Natural Products by Biosynthetic Engineering: Discovery of Nonquinone Hsp90 Inhibitors
Zhang, Ming-Qiang, Gaisser, Sabine, Nur-E-Alam, Mohammad, Sheehan, Lesley S, Vousden, William A, Gaitatzis, Nikolaos, Peck, Gerrard, Coates, Nigel J, Moss, Steven J, Radzom, Markus, Foster, Teresa A, Sheridan, Rose M, Gregory, Matthew A, Roe, S. Mark, Prodromou, Chrisostomos, Pearl, Laurence, Boyd, Susan M, Wilkinson, Barrie, Martin, Christine J
Published in Journal of medicinal chemistry (25.09.2008)
Published in Journal of medicinal chemistry (25.09.2008)
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Journal Article
Molecular Characterization of Macbecin as an Hsp90 Inhibitor
Martin, Christine J, Gaisser, Sabine, Challis, Iain R, Carletti, Isabelle, Wilkinson, Barrie, Gregory, Matthew, Prodromou, Chrisostomos, Roe, S. Mark, Pearl, Laurence H, Boyd, Susan M, Zhang, Ming-Qiang
Published in Journal of medicinal chemistry (08.05.2008)
Published in Journal of medicinal chemistry (08.05.2008)
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Journal Article
Structure guided design of improved anti-proliferative rapalogs through biosynthetic medicinal chemistry
Gregory, Matthew A, Kaja, Andrew L, Kendrew, Steven G, Coates, Nigel J, Warneck, Tony, Nur-e-Alam, Mohammad, Lill, Rachel E, Sheehan, Lesley S, Chudley, Lindsey, Moss, Steven J, Sheridan, Rose M, Quimpere, Miguel, Zhang, Ming-Qiang, Martin, Christine J, Wilkinson, Barrie
Published in Chemical science (Cambridge) (01.01.2013)
Published in Chemical science (Cambridge) (01.01.2013)
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Journal Article
Recombinant strains for the enhanced production of bioengineered rapalogs
Kendrew, Steven G., Petkovic, Hrvoje, Gaisser, Sabine, Ready, Sarah J., Gregory, Matthew A., Coates, Nigel J., Nur-e-Alam, Mohammad, Warneck, Tony, Suthar, Dipen, Foster, Teresa A., McDonald, Leonard, Schlingman, Gerhard, Koehn, Frank E., Skotnicki, Jerauld S., Carter, Guy T., Moss, Steven J., Zhang, Ming-Qiang, Martin, Christine J., Sheridan, Rose M., Wilkinson, Barrie
Published in Metabolic engineering (01.01.2013)
Published in Metabolic engineering (01.01.2013)
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Journal Article
Borrelidin modulates the alternative splicing of VEGF in favour of anti-angiogenic isoforms
Woolard, Jeanette, Vousden, William, Moss, Steven J, Krishnakumar, Arjun, Gammons, Melissa Vr, Nowak, David G, Dixon, Neil, Micklefield, Jason, Spannhoff, Astrid, Bedford, Mark T, Gregory, Matthew A, Martin, Christine J, Leadlay, Peter F, Zhang, Ming Q, Harper, Steven J, Bates, David O, Wilkinson, Barrie
Published in Chemical science (Cambridge) (01.02.2011)
Published in Chemical science (Cambridge) (01.02.2011)
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Journal Article
Engineering of the Spinosyn PKS: Directing Starter Unit Incorporation
Sheehan, Lesley S, Lill, Rachel E, Wilkinson, Barrie, Sheridan, Rose M, Vousden, William A, Kaja, Andrew L, Crouse, Gary D, Gifford, James, Graupner, Paul R, Karr, Laura, Lewer, Paul, Sparks, Thomas C, Leadlay, Peter F, Waldron, Clive, Martin, Christine J
Published in Journal of natural products (Washington, D.C.) (01.12.2006)
Published in Journal of natural products (Washington, D.C.) (01.12.2006)
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Journal Article
Heterologous expression in Saccharopolyspora erythraea of a pentaketide synthase derived from the spinosyn polyketide synthase
Martin, CJ, Timoney, MC, Sheridan, RM, Kendrew, SG, Wilkinson, B, Staunton, J, Leadlay, PF
Published in Organic & biomolecular chemistry (07.12.2003)
Published in Organic & biomolecular chemistry (07.12.2003)
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Journal Article
Engineered biosynthesis of novel spinosyns bearing altered deoxyhexose substituents
Gaisser, S, Martin, CJ, Wilkinson, B, Sheridan, RM, Lill, RE, Weston, AJ, Ready, SJ, Waldron, C, Crouse, GD, Leadlay, PF, Staunton, J
Published in Chemical communications (Cambridge, England) (21.03.2002)
Published in Chemical communications (Cambridge, England) (21.03.2002)
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Heterologous expression in Saccharopolyspora erythraea of a pentaketide synthase derived from the spinosyn polyketide synthaseElectronic supplementary information (ESI) available: Further details of the construction of pCJR308, the fermentation of BIOT-0966 and the isolation of pentaketide lactone, 3, and figures showing the13C NMR and 1H COSY spectra of 3. See http://www.rsc.org/suppdata/ob/b3/b310740j
Martin, Christine J., Timoney, M ire C., Sheridan, Rose M., Kendrew, Steven G., Wilkinson, Barrie, Staunton, James, Leadlay, Peter F.
Published in Organic & biomolecular chemistry (18.11.2003)
Published in Organic & biomolecular chemistry (18.11.2003)
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Journal Article
Increasing the efficiency of heterologous promoters in actinomycetes
Wilkinson, Christopher J, Hughes-Thomas, Zoë A, Martin, Christine J, Böhm, Ines, Mironenko, Tatiana, Deacon, Matthew, Wheatcroft, Michael, Wirtz, Gabriele, Staunton, James, Leadlay, Peter F
Published in Journal of molecular microbiology and biotechnology (01.07.2002)
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Published in Journal of molecular microbiology and biotechnology (01.07.2002)
Journal Article
Engineered biosynthesis of novel spinosyns bearing altered deoxyhexose substituentsElectronic supplementary information (ESI) available: 1H and 13C NMR data for compounds 5–8. See http://www.rsc.org/suppdata/cc/b2/b200536k
Gaisser, Sabine, Martin, Christine J., Wilkinson, Barrie, Sheridan, Rose M., Lill, Rachel E., Weston, Alison J., Ready, Sarah J., Waldron, Clive, Crouse, Gary D., Leadlay, Peter F., Staunton, James
Published in Chemical communications (Cambridge, England) (07.03.2002)
Published in Chemical communications (Cambridge, England) (07.03.2002)
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Journal Article
Skipping in a Hybrid Polyketide Synthase: Evidence for ACP-to-ACP Chain Transfer
Thomas, Iain, Martin, Christine J, Wilkinson, Christopher J, Staunton, James, Leadlay, Peter F
Published in Chemistry & biology (01.07.2002)
Published in Chemistry & biology (01.07.2002)
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Journal Article
Novel FK506 and FK520 analogues via mutasynthesis: mutasynthon scope and product characteristics
Moss, Steven J., Stanley-Smith, Anna E., Schell, Ursula, Coates, Nigel J., Foster, Teresa A., Gaisser, Sabine, Gregory, Matthew A., Martin, Christine J., Nur-e-Alam, Mohammad, Piraee, Mahmood, Radzom, Markus, Suthar, Dipen, Thexton, David G., Warneck, Tony D., Zhang, Ming-Qiang, Wilkinson, Barrie
Published in MedChemComm (01.02.2013)
Published in MedChemComm (01.02.2013)
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Journal Article
Novel FK506 and FK520 analogues via mutasynthesis: mutasynthon scope and product characteristicsElectronic supplementary information (ESI) available: Materials and methods for generating strains and experimental data for compounds assayed, materials and methods for in vitro and in vivo assays. See DOI: 10.1039/c2md20266b
Moss, Steven J, Stanley-Smith, Anna E, Schell, Ursula, Coates, Nigel J, Foster, Teresa A, Gaisser, Sabine, Gregory, Matthew A, Martin, Christine J, Nur-e-Alam, Mohammad, Piraee, Mahmood, Radzom, Markus, Suthar, Dipen, Thexton, David G, Warneck, Tony D, Zhang, Ming-Qiang, Wilkinson, Barrie
Year of Publication 30.01.2013
Year of Publication 30.01.2013
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