A circular RNA generated from an intron of the insulin gene controls insulin secretion
Stoll, Lisa, Rodríguez-Trejo, Adriana, Guay, Claudiane, Brozzi, Flora, Bayazit, Mustafa Bilal, Gattesco, Sonia, Menoud, Véronique, Sobel, Jonathan, Marques, Ana Claudia, Venø, Morten Trillingsgaard, Esguerra, Jonathan Lou S., Barghouth, Mohammad, Suleiman, Mara, Marselli, Lorella, Kjems, Jørgen, Eliasson, Lena, Renström, Erik, Bouzakri, Karim, Pinget, Michel, Marchetti, Piero, Regazzi, Romano
Published in Nature communications (05.11.2020)
Published in Nature communications (05.11.2020)
Get full text
Journal Article
SARS-CoV-2 Receptor Angiotensin I-Converting Enzyme Type 2 (ACE2) Is Expressed in Human Pancreatic β -Cells and in the Human Pancreas Microvasculature
Fignani, Daniela, Licata, Giada, Brusco, Noemi, Nigi, Laura, Grieco, Giuseppina E, Marselli, Lorella, Overbergh, Lut, Gysemans, Conny, Colli, Maikel L, Marchetti, Piero, Mathieu, Chantal, Eizirik, Decio L, Sebastiani, Guido, Dotta, Francesco
Published in Frontiers in endocrinology (Lausanne) (13.11.2020)
Published in Frontiers in endocrinology (Lausanne) (13.11.2020)
Get full text
Journal Article
RNA Sequencing Identifies Dysregulation of the Human Pancreatic Islet Transcriptome by the Saturated Fatty Acid Palmitate
CNOP, Miriam, ABDULKARIM, Baroj, BUGLIANI, Marco, LADRIERE, Laurence, MARSELLI, Lorella, MCCARTHY, Mark I, MARCHETTI, Piero, SAMMETH, Michael, EIZIRIK, Décio L, BOTTU, Guy, CUNHA, Daniel A, IGOILLO-ESTEVE, Mariana, MASINI, Matilde, TURATSINZE, Jean-Valery, GRIEBEL, Thasso, VILLATE, Olatz, SANTIN, Izortze
Published in Diabetes (New York, N.Y.) (01.06.2014)
Published in Diabetes (New York, N.Y.) (01.06.2014)
Get full text
Journal Article
The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines
Eizirik, Décio L, Sammeth, Michael, Bouckenooghe, Thomas, Bottu, Guy, Sisino, Giorgia, Igoillo-Esteve, Mariana, Ortis, Fernanda, Santin, Izortze, Colli, Maikel L, Barthson, Jenny, Bouwens, Luc, Hughes, Linda, Gregory, Lorna, Lunter, Gerton, Marselli, Lorella, Marchetti, Piero, McCarthy, Mark I, Cnop, Miriam
Published in PLoS genetics (01.03.2012)
Published in PLoS genetics (01.03.2012)
Get full text
Journal Article
An integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of human pancreatic beta cells
Colli, Maikel L., Ramos-Rodríguez, Mireia, Nakayasu, Ernesto S., Alvelos, Maria I., Lopes, Miguel, Hill, Jessica L. E., Turatsinze, Jean-Valery, Coomans de Brachène, Alexandra, Russell, Mark A., Raurell-Vila, Helena, Castela, Angela, Juan-Mateu, Jonàs, Webb-Robertson, Bobbie-Jo M., Krogvold, Lars, Dahl-Jorgensen, Knut, Marselli, Lorella, Marchetti, Piero, Richardson, Sarah J., Morgan, Noel G., Metz, Thomas O., Pasquali, Lorenzo, Eizirik, Décio L.
Published in Nature communications (22.05.2020)
Published in Nature communications (22.05.2020)
Get full text
Journal Article
Gene expression profiles of Beta-cell enriched tissue obtained by laser capture microdissection from subjects with type 2 diabetes
Marselli, Lorella, Thorne, Jeffrey, Dahiya, Sonika, Sgroi, Dennis C, Sharma, Arun, Bonner-Weir, Susan, Marchetti, Piero, Weir, Gordon C
Published in PloS one (13.07.2010)
Published in PloS one (13.07.2010)
Get full text
Journal Article
Palmitate activates autophagy in INS-1E β-cells and in isolated rat and human pancreatic islets
Martino, Luisa, Masini, Matilde, Novelli, Michela, Beffy, Pascale, Bugliani, Marco, Marselli, Lorella, Masiello, Pellegrino, Marchetti, Piero, De Tata, Vincenzo
Published in PloS one (01.05.2012)
Published in PloS one (01.05.2012)
Get full text
Journal Article
The expression of genes in top obesity-associated loci is enriched in insula and substantia nigra brain regions involved in addiction and reward
Ndiaye, Fatou K., Huyvaert, Marlène, Ortalli, Ana, Canouil, Mickaël, Lecoeur, Cécile, Verbanck, Marie, Lobbens, Stéphane, Khamis, Amna, Marselli, Lorella, Marchetti, Piero, Kerr-Conte, Julie, Pattou, François, Marre, Michel, Roussel, Ronan, Balkau, Beverley, Froguel, Philippe, Bonnefond, Amélie
Published in International Journal of Obesity (01.02.2020)
Published in International Journal of Obesity (01.02.2020)
Get full text
Journal Article
Ultrastructural alterations of pancreatic beta cells in human diabetes mellitus
Masini, Matilde, Martino, Luisa, Marselli, Lorella, Bugliani, Marco, Boggi, Ugo, Filipponi, Franco, Marchetti, Piero, De Tata, Vincenzo
Published in Diabetes/metabolism research and reviews (01.09.2017)
Published in Diabetes/metabolism research and reviews (01.09.2017)
Get full text
Journal Article
The Role of Beta Cell Recovery in Type 2 Diabetes Remission
Suleiman, Mara, Marselli, Lorella, Cnop, Miriam, Eizirik, Decio L, De Luca, Carmela, Femia, Francesca R, Tesi, Marta, Del Guerra, Silvia, Marchetti, Piero
Published in International journal of molecular sciences (04.07.2022)
Published in International journal of molecular sciences (04.07.2022)
Get full text
Journal Article
Arginase 2 and Polyamines in Human Pancreatic Beta Cells: Possible Role in the Pathogenesis of Type 2 Diabetes
Marselli, Lorella, Bosi, Emanuele, De Luca, Carmela, Del Guerra, Silvia, Tesi, Marta, Suleiman, Mara, Marchetti, Piero
Published in International journal of molecular sciences (09.11.2021)
Published in International journal of molecular sciences (09.11.2021)
Get full text
Journal Article
A nanobody-based nuclear imaging tracer targeting dipeptidyl peptidase 6 to determine the mass of human beta cell grafts in mice
Demine, Stéphane, Garcia Ribeiro, Rita, Thevenet, Julien, Marselli, Lorella, Marchetti, Piero, Pattou, François, Kerr-Conte, Julie, Devoogdt, Nick, Eizirik, Decio L.
Published in Diabetologia (01.04.2020)
Published in Diabetologia (01.04.2020)
Get full text
Journal Article
NF-κB-inducing kinase (NIK) is activated in pancreatic β-cells but does not contribute to the development of diabetes
Xiao, Peng, Takiishi, Tatiana, Violato, Natalia Moretti, Licata, Giada, Dotta, Francesco, Sebastiani, Guido, Marselli, Lorella, Singh, Sumeet Pal, Sze, Mozes, Van Loo, Geert, Dejardin, Emmanuel, Gurzov, Esteban Nicolas, Cardozo, Alessandra Kupper
Published in Cell death & disease (19.05.2022)
Published in Cell death & disease (19.05.2022)
Get full text
Journal Article
Combined transcriptome and proteome profiling of the pancreatic β-cell response to palmitate unveils key pathways of β-cell lipotoxicity
Lytrivi, Maria, Ghaddar, Kassem, Lopes, Miguel, Rosengren, Victoria, Piron, Anthony, Yi, Xiaoyan, Johansson, Henrik, Lehtiö, Janne, Igoillo-Esteve, Mariana, Cunha, Daniel A, Marselli, Lorella, Marchetti, Piero, Ortsäter, Henrik, Eizirik, Decio L, Cnop, Miriam
Published in BMC genomics (26.08.2020)
Published in BMC genomics (26.08.2020)
Get full text
Journal Article
MicroRNA-124a is hyperexpressed in type 2 diabetic human pancreatic islets and negatively regulates insulin secretion
Sebastiani, Guido, Po, Agnese, Miele, Evelina, Ventriglia, Giuliana, Ceccarelli, Elena, Bugliani, Marco, Marselli, Lorella, Marchetti, Piero, Gulino, Alberto, Ferretti, Elisabetta, Dotta, Francesco
Published in Acta diabetologica (01.06.2015)
Published in Acta diabetologica (01.06.2015)
Get full text
Journal Article
DPP-4 is expressed in human pancreatic beta cells and its direct inhibition improves beta cell function and survival in type 2 diabetes
Bugliani, Marco, Syed, Farooq, Paula, Flavia M.M., Omar, Bilal A., Suleiman, Mara, Mossuto, Sandra, Grano, Francesca, Cardarelli, Francesco, Boggi, Ugo, Vistoli, Fabio, Filipponi, Franco, De Simone, Paolo, Marselli, Lorella, De Tata, Vincenzo, Ahren, Bo, Eizirik, Decio L., Marchetti, Piero
Published in Molecular and cellular endocrinology (15.09.2018)
Published in Molecular and cellular endocrinology (15.09.2018)
Get full text
Journal Article
Coxsackie B4 virus infection of β cells and natural killer cell insulitis in recent-onset type 1 diabetic patients
Dotta, Francesco, Censini, Stefano, van Halteren, Astrid G.S, Marselli, Lorella, Masini, Matilde, Dionisi, Sabrina, Mosca, Franco, Boggi, Ugo, Muda, Andrea Onetti, Prato, Stefano Del, Elliott, John F, Covacci, Antonello, Rappuoli, Rino, Roep, Bart O, Marchetti, Piero
Published in Proceedings of the National Academy of Sciences - PNAS (20.03.2007)
Published in Proceedings of the National Academy of Sciences - PNAS (20.03.2007)
Get full text
Journal Article
Conformal coating by multilayer nano-encapsulation for the protection of human pancreatic islets: In-vitro and in-vivo studies
Syed, Farooq, Bugliani, Marco, Novelli, Michela, Olimpico, Francesco, Suleiman, Mara, Marselli, Lorella, Boggi, Ugo, Filipponi, Franco, Raffa, Vittoria, Krol, Silke, Campani, Daniela, Masiello, Pellegrino, De Tata, Vincenzo, Marchetti, Piero
Published in Nanomedicine (01.10.2018)
Published in Nanomedicine (01.10.2018)
Get full text
Journal Article
Pancreatic Beta Cell Identity in Humans and the Role of Type 2 Diabetes
Marchetti, Piero, Bugliani, Marco, De Tata, Vincenzo, Suleiman, Mara, Marselli, Lorella
Published in Frontiers in cell and developmental biology (23.05.2017)
Published in Frontiers in cell and developmental biology (23.05.2017)
Get full text
Journal Article