Osimertinib or Platinum–Pemetrexed in EGFR T790M–Positive Lung Cancer
Mok, Tony S, Wu, Yi-Long, Ahn, Myung-Ju, Garassino, Marina C, Kim, Hye R, Ramalingam, Suresh S, Shepherd, Frances A, He, Yong, Akamatsu, Hiroaki, Theelen, Willemijn S.M.E, Lee, Chee K, Sebastian, Martin, Templeton, Alison, Mann, Helen, Marotti, Marcelo, Ghiorghiu, Serban, Papadimitrakopoulou, Vassiliki A
Published in The New England journal of medicine (16.02.2017)
Published in The New England journal of medicine (16.02.2017)
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A Phase 1 study of gefitinib combined with durvalumab in EGFR TKI-naive patients with EGFR mutation-positive locally advanced/metastatic non-small-cell lung cancer
Creelan, Benjamin C., Yeh, Tammie C., Kim, Sang-We, Nogami, Naoyuki, Kim, Dong-Wan, Chow, Laura Q. M., Kanda, Shintaro, Taylor, Rosemary, Tang, Weifeng, Tang, Mei, Angell, Helen K., Roudier, Martine P., Marotti, Marcelo, Gibbons, Don L.
Published in British journal of cancer (19.01.2021)
Published in British journal of cancer (19.01.2021)
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ADAURA: Phase III, Double-blind, Randomized Study of Osimertinib Versus Placebo in EGFR Mutation-positive Early-stage NSCLC After Complete Surgical Resection
Wu, Yi-Long, Herbst, Roy S., Mann, Helen, Rukazenkov, Yuri, Marotti, Marcelo, Tsuboi, Masahiro
Published in Clinical lung cancer (01.07.2018)
Published in Clinical lung cancer (01.07.2018)
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A Phase 1 Trial and Pharmacokinetic Study of Cediranib, an Orally Bioavailable Pan–Vascular Endothelial Growth Factor Receptor Inhibitor, in Children and Adolescents With Refractory Solid Tumors
FOX, Elizabeth, APLENC, Richard, BROWN, Kathryn H, WENRICH, Barbara, ADAMSON, Peter C, WIDEMANN, Brigitte C, BALIS, Frank M, BAGATELL, Rochelle, CHUK, Meredith K, DOMBI, Eva, GOODSPEED, Wendy, GOODWIN, Anne, KROMPLEWSKI, Marie, JAYAPRAKASH, Nalini, MAROTTI, Marcelo
Published in Journal of clinical oncology (10.12.2010)
Published in Journal of clinical oncology (10.12.2010)
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A multicenter, phase I, pharmacokinetic study of osimertinib in cancer patients with normal renal function or severe renal impairment
Vishwanathan, Karthick, Sanchez‐Simon, Inmaculada, Keam, Bhumsuk, Penel, Nicolas, Miguel‐Luken, Maria, Weilert, Doris, Mills, Andrew, Marotti, Marcelo, Johnson, Martin, Ravaud, Alain
Published in Pharmacology research & perspectives (01.08.2020)
Published in Pharmacology research & perspectives (01.08.2020)
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MA08.03 Osimertinib vs Platinum-Pemetrexed for T790M-Mutation Positive Advanced NSCLC (AURA3): Plasma ctDNA Analysis
Wu, Yi Long, Jenkins, Suzanne, Ramalingam, Suresh, Han, Ji-Youn, Delmonte, Angelo, Hsia, Te-Chun, Laskin, Janessa, Kim, Sang-We, He, Yong, Patel, Sabina, Hodge, Rachel, Marotti, Marcelo, Papadimitrakopoulou, Vassiliki, Mok, Tony
Published in Journal of thoracic oncology (01.01.2017)
Published in Journal of thoracic oncology (01.01.2017)
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Concomitant use of statins and CYP3A4 inhibitors in administrative claims and electronic medical records databases
Ming, Eileen E., MPH, ScD, Davidson, Michael H., MD, Gandhi, Sanjay K., PhD, Marotti, Marcelo, MD, PhD, Miles, Carolyn G., MPH, Ke, Xiongkan, MS, McKenney, James M., PharmD
Published in Journal of clinical lipidology (01.12.2008)
Published in Journal of clinical lipidology (01.12.2008)
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Phase II Study of Cediranib in Patients with Advanced Gastrointestinal Stromal Tumors or Soft-Tissue Sarcoma
JUDSON, Ian, SCURR, Michelle, GARDNER, Kate, BARQUIN, Elizabeth, MAROTTI, Marcelo, COLLINS, Barbara, YOUNG, Helen, JÜRGENSMEIER, Juliane M, LEAHY, Michael
Published in Clinical cancer research (01.07.2014)
Published in Clinical cancer research (01.07.2014)
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A Phase I Open-Label Study of Cediranib Plus Etoposide and Cisplatin as First-Line Therapy for Patients With Extensive-Stage Small-Cell Lung Cancer or Metastatic Neuroendocrine Non–Small-Cell Lung Cancer
Concannon, Kyle F., Glisson, Bonnie S., Doebele, Robert C., Huang, Chao, Marotti, Marcelo, Camidge, D. Ross, Heymach, John V.
Published in Clinical lung cancer (01.11.2024)
Published in Clinical lung cancer (01.11.2024)
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Abstract CT210: Trial in Process: Phase 1 studies of BI 1701963, a SOS1::KRAS Inhibitor, in combination with MEK inhibitors, irreversible KRASG12C inhibitors or irinotecan
Hofmann, Marco H., Lu, Hengyu, Duenzinger, Ulrich, Gerlach, Daniel, Trapani, Francesca, Machado, Annette A., Daniele, Joseph R., Waizenegger, Irene, Gmachl, Michael, Rudolph, Dorothea, Vellano, Christopher P., Marotti, Marcelo, Vucenovic, Vitomir, Heffernan, Timothy P., Marszalek, Joseph R., Petronczki, Mark P., Kraut, Norbert
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Paediatric Strategy Forum for medicinal product development in mitogen-activated protein kinase pathway inhibitors: ACCELERATE in collaboration with the European Medicines Agency with participation of the Food and Drug Administration
Pearson, Andrew Dj, Allen, Carl, Fangusaro, Jason, Hutter, Caroline, Witt, Olaf, Weiner, Susan, Reaman, Gregory, Russo, Mark, Bandopadhayay, Pratiti, Ahsan, Sama, Barone, Amy, Barry, Elly, de Rojas, Teresa, Fisher, Michael, Fox, Elizabeth, Bender, Julia Glade, Gore, Lia, Hargrave, Darren, Hawkins, Doug, Kreider, Brent, Langseth, Abraham J, Lesa, Giovanni, Ligas, Franca, Marotti, Marcelo, Marshall, Lynley V, Nasri, Kahina, Norga, Koen, Nysom, Karsten, Pappo, Alberto, Rossato, Gianluca, Scobie, Nicole, Smith, Malcolm, Stieglitz, Elliot, Weigel, Brenda, Weinstein, Amy, Viana, Ruth, Karres, Dominik, Vassal, Gilles
Published in European journal of cancer (1990) (01.12.2022)
Published in European journal of cancer (1990) (01.12.2022)
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Paediatric Strategy Forum for medicinal product development in mitogen-activated protein kinase pathway inhibitors
Pearson, Andrew DJ, Allen, Carl, Fangusaro, Jason, Hutter, Caroline, Witt, Olaf, Weiner, Susan, Reaman, Gregory, Russo, Mark, Bandopadhayay, Pratiti, Ahsan, Sama, Barone, Amy, Barry, Elly, de Rojas, Teresa, Fisher, Michael, Fox, Elizabeth, Bender, Julia Glade, Gore, Lia, Hargrave, Darren, Hawkins, Doug, Kreider, Brent, Langseth, Abraham J., Lesa, Giovanni, Ligas, Franca, Marotti, Marcelo, Marshall, Lynley V., Nasri, Kahina, Norga, Koen, Nysom, Karsten, Pappo, Alberto, Rossato, Gianluca, Scobie, Nicole, Smith, Malcolm, Stieglitz, Elliot, Weigel, Brenda, Weinstein, Amy, Viana, Ruth, Karres, Dominik, Vassal, Gilles
Published in European journal of cancer (1990) (01.12.2022)
Published in European journal of cancer (1990) (01.12.2022)
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Abstract 2667: Trial in progress: Phase 1 study of BI 1823911, an irreversible KRASG12C inhibitor targeting KRAS in its GDP-loaded state, as monotherapy and in combination with the pan-KRAS SOS1 inhibitor BI 1701963 in solid tumors expressing KRASG12C mutation
Waizenegger, Irene C., Lu, Hengyu, Thamer, Claus, Savarese, Fabio, Gerlach, Daniel, Rudolph, Dorothea, Vellano, Christopher P., Marotti, Marcelo, Heymach, John, Kopetz, Scott, Heffernan, Timothy P., Marszalek, Joseph R., Petronczki, Mark P., Hofmann, Marco H., Kraut, Norbert
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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PL03.03: Randomized Phase III Study of Osimertinib vs Platinum-Pemetrexed for EGFR T790M-Positive Advanced NSCLC (AURA3)
Papadimitrakopoulou, Vassiliki, Wu, Yi Long, Ahn, Myung-Ju, Ramalingam, Suresh, Garassino, Marina, Kim, Hye Ryun, Shepherd, Frances, Akamatsu, Hiroaki, Theelen, Willemijn, Lee, Chee Khoon, Sebastian, Martin, Templeton, Alison, Marotti, Marcelo, Ghiorghiu, Serban, Mok, Tony
Published in Journal of thoracic oncology (01.01.2017)
Published in Journal of thoracic oncology (01.01.2017)
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Phase I open-label study of cediranib, an oral inhibitor of VEGF signalling, in combination with the oral Src inhibitor saracatinib in patients with advanced solid tumours
Trarbach, Tanja, Schultheis, Beate, Gauler, Thomas C., Schneider, Vesile, Strumberg, Dirk, Eberhardt, Wilfried E. E., Le Scouiller, Stephanie, Marotti, Marcelo, Brown, Kathryn H., Drevs, Joachim
Published in Investigational new drugs (01.10.2012)
Published in Investigational new drugs (01.10.2012)
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Abstract LB-66: Results of two phase I multicenter trials of AZD5363, an inhibitor of AKT1, 2 and 3: Biomarker and early clinical evaluation in Western and Japanese patients with advanced solid tumors
Banerji, Udai, Ranson, Malcolm, Schellens, Jan HM, Esaki, Taito, Dean, Emma, Zivi, Andrea, van der Noll, Ruud, Stockman, Paul K., Marotti, Marcelo, Garrett, Michelle D., Davies, Barry R., Elvin, Paul, Hastie, Andrew, Lawrence, Peter, Cheung, SY Amy, Stephens, Christine, Tamura, Kenji
Published in Cancer research (Chicago, Ill.) (15.04.2013)
Published in Cancer research (Chicago, Ill.) (15.04.2013)
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Pharmacokinetics and tolerability of cediranib, a potent VEGF signalling inhibitor, in cancer patients with hepatic impairment
van Herpen, Carla M L, Lassen, Ulrik, Desar, Ingrid M E, Brown, Kathryn H, Marotti, Marcelo, de Jonge, Maja J A
Published in Anti-cancer drugs (01.02.2013)
Published in Anti-cancer drugs (01.02.2013)
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Abstract A5: Phase I trial and pharmacokinetic study of cediranib in children with recurrent or refractory solid tumors
Fox, Elizabeth, Aplenc, Richard, Widemann, Brigitte, Chuk, Meredith, Bagatell, Rochelle, Goodwin, Anne, Goodspeed, Wendy, Kromplewski, Marie, Wenrich, Barbara, Brown, Kathryn H., Marotti, Marcelo, Adamson, Peter C., Balis, Frank M.
Published in Molecular cancer therapeutics (10.12.2009)
Published in Molecular cancer therapeutics (10.12.2009)
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The DISCOVERY PENTA study: a DIrect Statin COmparison of LDL‐C Value – an Evaluation of Rosuvastatin therapY compared with atorvastatin
Fonseca, Francisco A. H., Ruiz, Alvaro, Cardona-Muñoz, Ernesto G., Silva, Jose M., Fuenmayor, Nery, Marotti, Marcelo
Published in Current medical research and opinion (01.08.2005)
Published in Current medical research and opinion (01.08.2005)
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