The imidazo[1,2-a]pyridine ring system as a scaffold for potent dual phosphoinositide-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitors
Stec, Markian M., Andrews, Kristin L., Bo, Yunxin, Caenepeel, Sean, Liao, Hongyu, McCarter, John, Mullady, Erin L., San Miguel, Tisha, Subramanian, Raju, Tamayo, Nuria, Whittington, Douglas A., Wang, Ling, Wu, Tian, Zalameda, Leeanne P., Zhang, Nancy, Hughes, Paul E., Norman, Mark H.
Published in Bioorganic & medicinal chemistry letters (01.10.2015)
Published in Bioorganic & medicinal chemistry letters (01.10.2015)
Get full text
Journal Article
Structure–Activity Relationships of Phosphoinositide 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitors: Investigations of Various 6,5-Heterocycles to Improve Metabolic Stability
Stec, Markian M, Andrews, Kristin L, Booker, Shon K, Caenepeel, Sean, Freeman, Daniel J, Jiang, Jian, Liao, Hongyu, McCarter, John, Mullady, Erin L, San Miguel, Tisha, Subramanian, Raju, Tamayo, Nuria, Wang, Ling, Yang, Kevin, Zalameda, Leeanne P, Zhang, Nancy, Hughes, Paul E, Norman, Mark H
Published in Journal of medicinal chemistry (28.07.2011)
Published in Journal of medicinal chemistry (28.07.2011)
Get full text
Journal Article
Small Molecule Disruptors of the Glucokinase–Glucokinase Regulatory Protein Interaction: 2. Leveraging Structure-Based Drug Design to Identify Analogues with Improved Pharmacokinetic Profiles
St. Jean, David J., Ashton, Kate S., Bartberger, Michael D., Chen, Jie, Chmait, Samer, Cupples, Rod, Galbreath, Elizabeth, Helmering, Joan, Hong, Fang-Tsao, Jordan, Steven R., Liu, Longbin, Kunz, Roxanne K., Michelsen, Klaus, Nishimura, Nobuko, Pennington, Lewis D., Poon, Steve F., Reid, Darren, Sivits, Glenn, Stec, Markian M., Tadesse, Seifu, Tamayo, Nuria, Van, Gwyneth, Yang, Kevin C., Zhang, Jiandong, Norman, Mark H., Fotsch, Christopher, Lloyd, David J., Hale, Clarence
Published in Journal of medicinal chemistry (23.01.2014)
Published in Journal of medicinal chemistry (23.01.2014)
Get full text
Journal Article
Selective Class I Phosphoinositide 3‑Kinase Inhibitors: Optimization of a Series of Pyridyltriazines Leading to the Identification of a Clinical Candidate, AMG 511
Norman, Mark H, Andrews, Kristin L, Bo, Yunxin Y, Booker, Shon K, Caenepeel, Sean, Cee, Victor J, D’Angelo, Noel D, Freeman, Daniel J, Herberich, Bradley J, Hong, Fang-Tsao, Jackson, Claire L. M, Jiang, Jian, Lanman, Brian A, Liu, Longbin, McCarter, John D, Mullady, Erin L, Nishimura, Nobuko, Pettus, Liping H, Reed, Anthony B, Miguel, Tisha San, Smith, Adrian L, Stec, Markian M, Tadesse, Seifu, Tasker, Andrew, Aidasani, Divesh, Zhu, Xiaochun, Subramanian, Raju, Tamayo, Nuria A, Wang, Ling, Whittington, Douglas A, Wu, Bin, Wu, Tian, Wurz, Ryan P, Yang, Kevin, Zalameda, Leeanne, Zhang, Nancy, Hughes, Paul E
Published in Journal of medicinal chemistry (13.09.2012)
Published in Journal of medicinal chemistry (13.09.2012)
Get full text
Journal Article
P450-mediated O-demethylated metabolite is responsible for rat hepatobiliary toxicity of pyridyltriazine-containing PI3K inhibitors
Subramanian, Raju, Aidasani, Divesh, Bailey, Keith, Branstetter, Dan, Everds, Nancy, Jiang, Jian, Norman, Mark H, Primack, Ronya, Skiles, Gary L, Soto, Irene, Stec, Markian M, Wagner, Mylo, Wu, Tian, Zhu, Xiaochun, Lebrec, Hervé
Published in Toxicological sciences (01.11.2014)
Published in Toxicological sciences (01.11.2014)
Get full text
Journal Article
Design and Synthesis of Peripherally Restricted Transient Receptor Potential Vanilloid 1 (TRPV1) Antagonists
Tamayo, Nuria, Liao, Hongyu, Stec, Markian M, Wang, Xianghong, Chakrabarti, Partha, Retz, Dan, Doherty, Elizabeth M, Surapaneni, Sekhar, Tamir, Rami, Bannon, Anthony W, Gavva, Narender R, Norman, Mark H
Published in Journal of medicinal chemistry (08.05.2008)
Published in Journal of medicinal chemistry (08.05.2008)
Get full text
Journal Article
Correction to Selective Class I Phosphoinositide 3‑Kinase Inhibitors: Optimization of a Series of Pyridyltriazines Leading to the Identification of a Clinical Candidate, AMG 511
Norman, Mark H, Andrews, Kristin L, Bo, Yunxin Y, Booker, Shon K, Caenepeel, Sean, Cee, Victor J, D’Angelo, Noel D, Freeman, Daniel J, Herberich, Bradley J, Hong, Fang-Tsao, Jackson, Claire L. M, Jiang, Jian, Lanman, Brian A, Liu, Longbin, McCarter, John D, Mullady, Erin L, Nishimura, Nobuko, Pettus, Liping H, Reed, Anthony B, Miguel, Tisha San, Smith, Adrian L, Stec, Markian M, Tadesse, Seifu, Tasker, Andrew, Aidasani, Divesh, Zhu, Xiaochun, Subramanian, Raju, Tamayo, Nuria A, Wang, Ling, Whittington, Douglas A, Wu, Bin, Wu, Tian, Wurz, Ryan P, Yang, Kevin, Zalameda, Leeanne, Zhang, Nancy, Hughes, Paul E
Published in Journal of medicinal chemistry (25.10.2012)
Published in Journal of medicinal chemistry (25.10.2012)
Get full text
Journal Article
Substituted aryl pyrimidines as potent and soluble TRPV1 antagonists
Stec, Markian M., Bo, Yunxin, Chakrabarti, Partha P., Liao, Lillian, Ncube, Mqhele, Tamayo, Nuria, Tamir, Rami, Gavva, Narender R., Treanor, James J.S., Norman, Mark H.
Published in Bioorganic & medicinal chemistry (15.09.2008)
Published in Bioorganic & medicinal chemistry (15.09.2008)
Get full text
Journal Article
Synthesis of novel melanocortin 4 receptor agonists and antagonists containing a succinamide core
Xi, Ning, Hale, Clarence, Kelly, Michael G., Norman, Mark H., Stec, Markian, Xu, Shimin, Baumgartner, James W., Fotsch, Christopher
Published in Bioorganic & medicinal chemistry letters (2004)
Published in Bioorganic & medicinal chemistry letters (2004)
Get full text
Journal Article
MCL-1 INHIBITOR FORMULATIONS
SEAN BROWN, DARREN L REID, JAMES E HUCKLE, MARKIAN STEC, WU TIAN, FERNANDO ANTONIO AVAREZ-NUNEZ
Year of Publication 10.03.2022
Get full text
Year of Publication 10.03.2022
Patent
METHYLATION OF Mcl-1 COMPOUND
SEAN BROWN, HWANG TSANG-LIN, JANINE K TOM, JAMES E HUCKLE, MICHAEL ACHMATOWICZ, NEIL FRED LANGILLE, MARKIAN STEC, CUI SHENG, WU TIAN
Year of Publication 11.10.2021
Get full text
Year of Publication 11.10.2021
Patent
Novel Vanilloid Receptor-1 Antagonists: 2. Structure−Activity Relationships of 4-Oxopyrimidines Leading to the Selection of a Clinical Candidate
Doherty, Elizabeth M, Fotsch, Christopher, Bannon, Anthony W, Bo, Yunxin, Chen, Ning, Dominguez, Celia, Falsey, James, Gavva, Narender R, Katon, Jodie, Nixey, Thomas, Ognyanov, Vassil I, Pettus, Liping, Rzasa, Robert M, Stec, Markian, Surapaneni, Sekhar, Tamir, Rami, Zhu, Jiawang, Treanor, James J. S, Norman, Mark H
Published in Journal of medicinal chemistry (26.07.2007)
Published in Journal of medicinal chemistry (26.07.2007)
Get full text
Journal Article
Novel Vanilloid Receptor-1 Antagonists: 1. Conformationally Restricted Analogues of trans-Cinnamides
Norman, Mark H, Zhu, Jiawang, Fotsch, Christopher, Bo, Yunxin, Chen, Ning, Chakrabarti, Partha, Doherty, Elizabeth M, Gavva, Narender R, Nishimura, Nobuko, Nixey, Thomas, Ognyanov, Vassil I, Rzasa, Robert M, Stec, Markian, Surapaneni, Sekhar, Tamir, Rami, Viswanadhan, Vellarkad N, Treanor, James J. S
Published in Journal of medicinal chemistry (26.07.2007)
Published in Journal of medicinal chemistry (26.07.2007)
Get full text
Journal Article
Melanocortin subtype-4 receptor agonists containing a piperazine core with substituted aryl sulfonamides
Fotsch, Christopher, Han, Nianhe, Arasasingham, Premilla, Bo, Yunxin, Carmouche, Michelle, Chen, Ning, Davis, James, Goldberg, Martin H., Hale, Clarence, Hsieh, Feng-Yin, Kelly, Michael G., Liu, Qingyian, Norman, Mark H., Smith, Duncan M., Stec, Markian, Tamayo, Nuria, Xi, Ning, Xu, Shimin, Bannon, Anthony W., Baumgartner, James W.
Published in Bioorganic & medicinal chemistry letters (15.03.2005)
Published in Bioorganic & medicinal chemistry letters (15.03.2005)
Get full text
Journal Article
MCL-1 INHIBITOR FORMULATIONS
HUCKLE, JAMES E, STEC, MARKIAN M, REID, DARREN L, WU, TIAN, ALVAREZ-NUNEZ, FERNANDO A, BROWN, SEAN P
Year of Publication 05.10.2023
Get full text
Year of Publication 05.10.2023
Patent
CRYSTALLINE FORMS OF AN MCL-1 INHIBITOR
XIAO, Lingyun, HUCKLE, James, CHAVES, Mary, PARENT, Stephan, STEC, Markian, ACHMATOWICZ, Michal, TENG, Jing, FARRELL, Robert, KELLY, Ron, LUU, Van, REID, Darren, WU, Tian
Year of Publication 04.07.2024
Get full text
Year of Publication 04.07.2024
Patent
MCL-1 INHIBITOR FORMULATIONS
REID, Darren L, STEC, Markian, AVAREZ-NUNEZ, Fernando Antonio, BROWN, Sean P, HUCKLE, James E, WU, Tian
Year of Publication 05.07.2023
Get full text
Year of Publication 05.07.2023
Patent
Preparation of Mcl-1 inhibiting compound by methylation in the presence of water
TOM, Janine K, LANGILLE, Neil Fred, CUI, Sheng, HWANG, Tsang-Lin, STEC, Markian, ACHMATOWICZ, Michal, BROWN, Sean P, HUCKLE, James E, WU, Tian
Year of Publication 22.02.2024
Get full text
Year of Publication 22.02.2024
Patent
Mcl-1 inhibitor formulations
REID, Darren L, STEC, Markian, AVAREZ-NUNEZ, Fernando Antonio, BROWN, Sean P, HUCKLE, James E, WU, Tian
Year of Publication 30.03.2023
Get full text
Year of Publication 30.03.2023
Patent