Rational Design and Synthesis of 4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a Novel, Nonsteroidal Androgen Receptor Antagonist Devoid of Phototoxicity for Dermatological Indications
Li, Jie Jack, Iula, Donna M, Nguyen, Maria N, Hu, Lain-Yen, Dettling, Danielle, Johnson, Theodore R, Du, Daniel Y, Shanmugasundaram, Veerabahu, Van Camp, Jennifer A, Wang, Zhi, Harter, William G, Yue, Wen-Song, Boys, Mark L, Wade, Kimberly J, Drummond, Elena M, Samas, Brian M, Lefker, Bruce A, Hoge, Garrett S, Lovdahl, Mark J, Asbill, Jeffrey, Carroll, Matthew, Meade, Mary Ann, Ciotti, Susan M, Krieger-Burke, Theresa
Published in Journal of medicinal chemistry (13.11.2008)
Published in Journal of medicinal chemistry (13.11.2008)
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Discovery of 5‑Azaquinoxaline Derivatives as Potent and Orally Bioavailable Allosteric SHP2 Inhibitors
Elsayed, Mohamed S. A., Blake, James F., Boys, Mark L., Brown, Eric, Chapsal, Bruno D., Chicarelli, Mark J., Cook, Adam W., Fell, Jay B., Fischer, John P., Hanson, Lauren, Lemieux, Christine, Martinson, Matthew C., McCown, Joseph, McNulty, Oren T., Mejia, Macedonio J., Neitzel, Nickolas A., Otten, Jennifer N., Rodriguez, Martha E., Wilcox, Daniel, Wong, Christina E., Zhou, Yeyun, Hinklin, Ronald J.
Published in ACS medicinal chemistry letters (14.12.2023)
Published in ACS medicinal chemistry letters (14.12.2023)
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5‑Alkyl-2-urea-Substituted Pyridines: Identification of Efficacious Glucokinase Activators with Improved Properties
Kohn, Todd J, Du, Xiaohui, Lai, SuJen, Xiong, YuMei, Komorowski, Renee, Veniant, Murielle, Fu, Zice, Jiao, Xianyun, Pattaropong, Vatee, Chow, David, Cardozo, Mario, Jin, Lixia, Conn, Marion, DeWolf, Walter E, Kraser, Christopher F, Hinklin, Ronald J, Boys, Mark L, Medina, Julio C, Houze, Jonathan, Dransfield, Paul, Coward, Peter
Published in ACS medicinal chemistry letters (14.07.2016)
Published in ACS medicinal chemistry letters (14.07.2016)
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Discovery of a series of 2-(1H-pyrazol-1-yl)pyridines as ALK5 inhibitors with potential utility in the prevention of dermal scarring
Boys, Mark L., Bian, Feng, Kramer, James B., Chio, Christopher L., Ren, Xiao-Dan, Chen, Huifen, Barrett, Stephen D., Sexton, Karen E., Iula, Donna M., Filzen, Gary F., Nguyen, Maria N., Angell, Paul, Downs, Victoria L., Wang, Zhi, Raheja, Neil, Ellsworth, Edmund L., Fakhoury, Stephen, Bratton, Larry D., Keller, Paul R., Gowan, Richard, Drummond, Elena M., Maiti, Samarendra N., Hena, Mostofa A., Lu, Leroy, McConnell, Patrick, Knafels, John D., Thanabal, Venkataraman, Sun, Fang, Alessi, Diane, McCarthy, Ann, Zhang, Erli, Finzel, Barry C., Patel, Sneha, Ciotti, Susan M., Eisma, Rone, Payne, N.A., Gilbertsen, Richard B., Kostlan, Catherine R., Pocalyko, David J., Lala, Deepak S.
Published in Bioorganic & medicinal chemistry letters (15.05.2012)
Published in Bioorganic & medicinal chemistry letters (15.05.2012)
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Synthesis of pyrazoles and isoxazoles as potent αvβ3 receptor antagonists
PENNING, Thomas D, KHILEVICH, Albert, HANNEKE, Melanie L, KEENE, Jeffery L, KLOVER, Jon A, NICKOLS, G. Allen, NICKOLS, Maureen A, RADER, Randall K, SETTLE, Steven L, SHANNON, Kristen E, STEININGER, Christina N, WESTLIN, Marisa M, CHEN, Barbara B, WESTLIN, William F, RUSSELL, Mark A, BOYS, Mark L, YAPING WANG, DUFFIN, Tiffany, ENGLEMAN, V. Wayne, FINN, Mary Beth, FREEMAN, Sandra K
Published in Bioorganic & medicinal chemistry letters (15.06.2006)
Published in Bioorganic & medicinal chemistry letters (15.06.2006)
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(−)-Sparteine-Mediated α-Lithiation of N-Boc-N-(p-methoxyphenyl)benzylamine: Enantioselective Syntheses of (S) and (R) Mono- and Disubstituted N-Boc-benzylamines
Park, Yong Sun, Boys, Mark L, Beak, Peter
Published in Journal of the American Chemical Society (17.04.1996)
Published in Journal of the American Chemical Society (17.04.1996)
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Convergent, parallel synthesis of a series of β-substituted 1,2,4-oxadiazole butanoic acids as potent and selective αvβ3 receptor antagonists
BOYS, Mark L, SCHRETZMAN, Lori A, STENMARK, Heather G, HONGWEI WU, SPANGLER, Dale P, CLARE, Michael, DESAI, Bipin N, KHANNA, Ish K, NGUYEN, Maria N, DUFFIN, Tiffany, WAYNE ENGLEMAN, V, FINN, Mary Beth, CHANDRAKUMAR, Nizal S, FREEMAN, Sandra K, HANNEKE, Melanie L, KEENE, Jeffery L, KLOVER, Jon A, NICKOLS, G. Allen, NICKOLS, Maureen A, STEININGER, Christina N, WESTLIN, Marisa, WESTLIN, William, YU, Yi X, TOLLEFSON, Michael B, YAPING WANG, DALTON, Christopher R, NORRING, Sarah A, MOHLER, Scott B, DOWNS, Victoria L, PENNING, Thomas D, RUSSELL, Mark A, WENDT, John A, CHEN, Barbara B
Published in Bioorganic & medicinal chemistry letters (15.02.2006)
Published in Bioorganic & medicinal chemistry letters (15.02.2006)
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Journal Article
Synthesis of 2,5-thiazole butanoic acids as potent and selective αvβ3 integrin receptor antagonists with improved oral pharmacokinetic properties
WENDT, John A, HONGWEI WU, KEENE, Jeffery L, WAYNE ENGLEMAN, V, FREEMAN, Sandra K, HANNEKE, Melanie L, SHANNON, Kristen E, NICKOLS, Maureen A, STEININGER, Christina N, WESTLIN, Marissa, KLOVER, Jon A, WESTLIN, William, STENMARK, Heather G, NICKOLS, G. Allen, RUSSELL, Mark A, BOYS, Mark L, DOWNS, Victoria L, PENNING, Thomas D, CHEN, Barbara B, YAPING WANG, DUFFIN, Tiffany, FINN, Mary Beth
Published in Bioorganic & medicinal chemistry letters (15.02.2006)
Published in Bioorganic & medicinal chemistry letters (15.02.2006)
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Journal Article
Total Synthesis of (+)-Papuamine: An Antifungal Pentacyclic Alkaloid from a Marine Sponge, Haliclona sp
Barrett, Anthony G. M, Boys, Mark L, Boehm, Terri L
Published in Journal of organic chemistry (26.01.1996)
Published in Journal of organic chemistry (26.01.1996)
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Abstract 1635: OKI-1546 is a selective, orally bioavailable inhibitor of CDK12 that causes tumor regression in multiple preclinical cancer models
Strait, Alexander A., Mareska, David A., Mahadevan, Jyothi, Schulte, Christie A., Izrayelit, Yevgeniy, Boys, Mark L., Woessner, Richard
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Abstract PO3-25-09: OKI-219, a PI3KαH1047R-mutant-selective inhibitor demonstrates efficacy as a single agent and drives combination responses with standard of care therapies in pre-clinical PI3KαH1047R mutant breast cancer models
Taylor, Molly A., Zhao, Qian, Mareska, David, Hoh, Maria, Izrayelit, Yevgeniy, Litwiler, Kevin, Boys, Mark L, Woessner, Rich, Walker, Duncan, Winkler, James D, Diamond, Jennifer
Published in Cancer research (Chicago, Ill.) (02.05.2024)
Published in Cancer research (Chicago, Ill.) (02.05.2024)
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Journal Article
Abstract LB174: OKI-219 is an inhibitor of PI3Kα H1047R that has brain penetrance and anti-tumor activity in a preclinical intracranial model of metastatic breast cancer
Strait, Alexander A., Taylor, Molly A., Litwiler, Kevin S., Zhao, Qian, Mareska, David A., Boys, Mark L., Izrayelit, Yevgeniy, Woessner, Richard, Winkler, James D.
Published in Cancer research (Chicago, Ill.) (05.04.2024)
Published in Cancer research (Chicago, Ill.) (05.04.2024)
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Journal Article
Abstract B163: Discovery and characterization of OKI-219, an orally bioavailable H1047R-mutant-selective inhibitor of PI3Kα
Taylor, Molly A, Zhao, Qian, Mareska, David, Hoh, Maria, Izrayelit, Yevgeniy, Litwiler, Kevin, Boys, Mark L, Woessner, Rich, Walker, Duncan, Diamond, Jennifer, Winkler, James D
Published in Molecular cancer therapeutics (01.12.2023)
Published in Molecular cancer therapeutics (01.12.2023)
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Journal Article
One-Pot Process for the Preparation of a β-Alkynyl β-Amino Acid Ester
Boys, Mark L, Cain-Janicki, Kimberly J, Doubleday, Wendel W, Farid, Payman N, Kar, Mangalya, Nugent, Sean T, Behling, James R, Pilipauskas, Daniel R
Published in Organic process research & development (01.05.1997)
Published in Organic process research & development (01.05.1997)
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Abstract 551: A potent and selective cFMS inhibitor regulates the tumor macrophage microenvironment leading to tumor growth inhibition
Wright, Albion D., Willis, Brandon S., Gomez, Anna, Boys, Mark L., DeLisle, Robert K., Burgess, Laurence E., Munson, Mark C., Kennedy, April L., Topalov, George T., Zhao, Qian, Rodriguez, Martha E., Rast, Bryson, Rizzi, James P., DeWolf, Walter E., Lemieux, Christine, Anderson, Deborah, Neale, Jason R., Martinson, Matthew, Gross, Stefan D., Callejo, Michele, Risom, Tyler, Lee, Patrice A.
Published in Cancer research (Chicago, Ill.) (15.04.2011)
Published in Cancer research (Chicago, Ill.) (15.04.2011)
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Journal Article
Synthesis of pyrazoles and isoxazoles as potent alpha(v)beta3 receptor antagonists
Penning, Thomas D, Khilevich, Albert, Chen, Barbara B, Russell, Mark A, Boys, Mark L, Wang, Yaping, Duffin, Tiffany, Engleman, V Wayne, Finn, Mary Beth, Freeman, Sandra K, Hanneke, Melanie L, Keene, Jeffery L, Klover, Jon A, Nickols, G Allen, Nickols, Maureen A, Rader, Randall K, Settle, Steven L, Shannon, Kristen E, Steininger, Christina N, Westlin, Marisa M, Westlin, William F
Published in Bioorganic & medicinal chemistry letters (15.06.2006)
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Published in Bioorganic & medicinal chemistry letters (15.06.2006)
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