Search Results - "MARK G. SAULNIER" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

In vitro and in vivo antitumor effects of the dual insulin-like growth factor-I/insulin receptor inhibitor, BMS-554417

In vitro and in vivo antitumor effects of the dual insulin-like growth factor-I/insulin receptor inhibitor, BMS-554417

by Haluska, Paul, Carboni, Joan M, Loegering, David A, Lee, Francis Y, Wittman, Mark, Saulnier, Mark G, Frennesson, David B, Kalli, Kimberly R, Conover, Cheryl A, Attar, Ricardo M, Kaufmann, Scott H, Gottardis, Marco, Erlichman, Charles
Published in Cancer research (Chicago, Ill.) (01.01.2006)

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5‑Bromo-2-chloro-4-fluoro-3-iodopyridine as a Halogen-rich Intermediate for the Synthesis of Pentasubstituted Pyridines

5‑Bromo-2-chloro-4-fluoro-3-iodopyridine as a Halogen-rich Intermediate for the Synthesis of Pentasubstituted Pyridines

by Wu, Yong-Jin, Porter, Gerard J, Frennesson, David B, Saulnier, Mark G
Published in Journal of organic chemistry (04.03.2022)

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Discovery and Preclinical Profiling of GSK3839919, a Potent HIV‑1 Allosteric Integrase Inhibitor

Discovery and Preclinical Profiling of GSK3839919, a Potent HIV‑1 Allosteric Integrase Inhibitor

by Parcella, Kyle, Wang, Tao, Eastman, Kyle, Zhang, Zhongxing, Yin, Zhiwei, Patel, Manoj, Tu, Yong, Zheng, Barbara Zhizhen, Walker, Michael A., Saulnier, Mark G., Frennesson, David, Bowsher, Michael, Gillis, Eric, Peese, Kevin, Belema, Makonen, Cianci, Christopher, Dicker, Ira B., McAuliffe, Brian, Ding, Bo, Falk, Paul, Simmermacher, Jean, Parker, Dawn D., Sivaprakasam, Prasanna, Kish, Kevin, Lewis, Hal, Hanumegowda, Umesh, Jenkins, Susan, Kadow, John F., Krystal, Mark, Meanwell, Nicholas A., Naidu, B. Narasimhulu
Published in ACS medicinal chemistry letters (09.06.2022)

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Discovery of a 1H-Benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) Inhibitor of Insulin-like Growth Factor I Receptor Kinase with in Vivo Antitumor Activity

Discovery of a 1H-Benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) Inhibitor of Insulin-like Growth Factor I Receptor Kinase with in Vivo Antitumor Activity

by Wittman, Mark, Carboni, Joan, Attar, Ricardo, Balasubramanian, Balu, Balimane, Praveen, Brassil, Patrick, Beaulieu, Francis, Chang, Chiehying, Clarke, Wendy, Dell, Janet, Eummer, Jeffrey, Frennesson, David, Gottardis, Marco, Greer, Ann, Hansel, Steven, Hurlburt, Warren, Jacobson, Bruce, Krishnananthan, Subramaniam, Lee, Francis Y, Li, Aixin, Lin, Tai-An, Liu, Peiying, Ouellet, Carl, Sang, Xiaopeng, Saulnier, Mark G, Stoffan, Karen, Sun, Yax, Velaparthi, Upender, Wong, Henry, Yang, Zheng, Zimmermann, Kurt, Zoeckler, Mary, Vyas, Dolatrai
Published in Journal of medicinal chemistry (08.09.2005)

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Nucleophilic Capture of the Imino-Quinone Methide Type Intermediates Generated from 2-Aminothiazol-5-yl Carbinols

Nucleophilic Capture of the Imino-Quinone Methide Type Intermediates Generated from 2-Aminothiazol-5-yl Carbinols

by Saulnier, Mark G, Dodier, Marco, Frennesson, David B, Langley, David R, Vyas, Dolatrai M
Published in Organic letters (19.11.2009)

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Insulin-like growth factor-1 receptor (IGF-1R) kinase inhibitors: SAR of a series of 3-[6-(4-substituted-piperazin-1-yl)-4-methyl-1H-benzimidazol-2-yl]-1H-pyridine-2-one

Insulin-like growth factor-1 receptor (IGF-1R) kinase inhibitors: SAR of a series of 3-[6-(4-substituted-piperazin-1-yl)-4-methyl-1H-benzimidazol-2-yl]-1H-pyridine-2-one

by VELAPARTHI, Upender, SAULNIER, Mark G, CLARKE, Wendy, ZHENG YANG, MENARD, Krista, LEE, Francis Y, TRAINOR, George, VYAS, Dolatrai, WITTMAN, Mark D, PEIYING LIU, FRENNESSON, David B, ZIMMERMANN, Kurt, CARBONI, Joan M, GOTTARDIS, Marco, AIXIN LI, GREER, Ann
Published in Bioorganic & medicinal chemistry letters (15.05.2010)

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SAR of PXR transactivation in benzimidazole-based IGF-1R kinase inhibitors

SAR of PXR transactivation in benzimidazole-based IGF-1R kinase inhibitors

by Zimmermann, Kurt, Wittman, Mark D., Saulnier, Mark G., Velaparthi, Upender, Sang, Xiaopeng, Frennesson, David B., Struzynski, Charles, Seitz, Steven P., He, Liqi, Carboni, Joan M., Li, Aixin, Greer, Ann F., Gottardis, Marco, Attar, Ricardo M., Yang, Zheng, Balimane, Praveen, Discenza, Lorell N., Lee, Francis Y., Sinz, Michael, Kim, Sean, Vyas, Dolatrai
Published in Bioorganic & medicinal chemistry letters (01.03.2010)

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An unusual oxidative cyclization. A synthesis and absolute stereochemical assignment of (-)-rocaglamide

An unusual oxidative cyclization. A synthesis and absolute stereochemical assignment of (-)-rocaglamide

by Trost, Barry M, Greenspan, Paul D, Yang, Bingwei V, Saulnier, Mark G
Published in Journal of the American Chemical Society (01.11.1990)

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Balancing oral exposure with Cyp3A4 inhibition in benzimidazole-based IGF-IR inhibitors

Balancing oral exposure with Cyp3A4 inhibition in benzimidazole-based IGF-IR inhibitors

by Zimmermann, Kurt, Wittman, Mark D., Saulnier, Mark G., Velaparthi, Upender, Langley, David R., Sang, Xiaopeng, Frennesson, David, Carboni, Joan, Li, Aixin, Greer, Ann, Gottardis, Marco, Attar, Ricardo M., Yang, Zheng, Balimane, Praveen, Discenza, Lorell N., Vyas, Dolatrai
Published in Bioorganic & medicinal chemistry (15.07.2008)

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2-(1 H-Imidazol-4-yl)ethanamine and 2-(1 H-pyrazol-1-yl)ethanamine side chain variants of the IGF-1R inhibitor BMS-536924

2-(1 H-Imidazol-4-yl)ethanamine and 2-(1 H-pyrazol-1-yl)ethanamine side chain variants of the IGF-1R inhibitor BMS-536924

by Saulnier, Mark G., Frennesson, David B., Wittman, Mark D., Zimmermann, Kurt, Velaparthi, Upender, Langley, David R., Struzynski, Charles, Sang, Xiaopeng, Carboni, Joan, Li, Aixin, Greer, Ann, Yang, Zheng, Balimane, Praveen, Gottardis, Marco, Attar, Ricardo, Vyas, Dolatrai
Published in Bioorganic & medicinal chemistry (01.03.2008)

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Generation and reactions of 3-lithio-1-(phenylsulfonyl)indole

Generation and reactions of 3-lithio-1-(phenylsulfonyl)indole

by Saulnier, Mark G, Gribble, Gordon W
Published in Journal of organic chemistry (01.02.1982)

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Discovery of a Fluoroindolo[2,3-a]carbazole Clinical Candidate with Broad Spectrum Antitumor Activity in Preclinical Tumor Models Superior to the Marketed Oncology Drug, CPT-11

Discovery of a Fluoroindolo[2,3-a]carbazole Clinical Candidate with Broad Spectrum Antitumor Activity in Preclinical Tumor Models Superior to the Marketed Oncology Drug, CPT-11

by Saulnier, Mark G, Balasubramanian, Balu N, Long, Byron H, Frennesson, David B, Ruediger, Edward, Zimmermann, Kurt, Eummer, Jeffrey T, St. Laurent, Denis R, Stoffan, Karen M, Naidu, B. Narasimhulu, Mahler, Mikael, Beaulieu, Francis, Bachand, Carol, Lee, Frank Y, Fairchild, Craig R, Stadnick, Linda K, Rose, William C, Solomon, Carola, Wong, Henry, Martel, Alain, Wright, John J, Kramer, Robert, Langley, David R, Vyas, Dolatrai M
Published in Journal of medicinal chemistry (07.04.2005)

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Synthesis and Diels-Alder reactions of 1,3-dimethyl-4-(phenylsulfonyl)-4H-furo[3,4-b]indole. A new annulation strategy for the construction of ellipticine and isoellipticine

Synthesis and Diels-Alder reactions of 1,3-dimethyl-4-(phenylsulfonyl)-4H-furo[3,4-b]indole. A new annulation strategy for the construction of ellipticine and isoellipticine

by Gribble, Gordon W, Saulnier, Mark G, Sibi, Mukund P, Obaza-Nutaitis, Judy A
Published in Journal of organic chemistry (01.11.1984)

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Design and Synthesis of a Fluoroindolocarbazole Series as Selective Topoisomerase I Active Agents. Discovery of Water-Soluble 3,9-Difluoro-12,13-dihydro-13-[6-amino-β- d-glucopyranosyl]-5H,13H-benzo[b]- thienyl[2,3-a]pyrrolo[3,4-c]carbazole- 5,7(6H)-dione (BMS-251873) with Curative Antitumor Activity against Prostate Carcinoma Xenograft Tumor Model

Design and Synthesis of a Fluoroindolocarbazole Series as Selective Topoisomerase I Active Agents. Discovery of Water-Soluble 3,9-Difluoro-12,13-dihydro-13-[6-amino-β- d-glucopyranosyl]-5H,13H-benzo[b]- thienyl[2,3-a]pyrrolo[3,4-c]carbazole- 5,7(6H)-dione (BMS-251873) with Curative Antitumor Activity against Prostate Carcinoma Xenograft Tumor Model

by Balasubramanian, Balu N, St. Laurent, Denis R, Saulnier, Mark G, Long, Byron H, Bachand, Carol, Beaulieu, Francis, Clarke, Wendy, Deshpande, Milind, Eummer, Jeffrey, Fairchild, Craig R, Frennesson, David B, Kramer, Robert, Lee, Frank Y, Mahler, Mikael, Martel, Alain, Naidu, B. Narasimhulu, Rose, William C, Russell, John, Ruediger, Edward, Solomon, Carola, Stoffan, Karen M, Wong, Henry, Zimmermann, Kurt, Vyas, Dolatrai M
Published in Journal of medicinal chemistry (25.03.2004)

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Design and Synthesis of a Fluoroindolocarbazole Series as Selective Topoisomerase I Active Agents. Discovery of Water-Soluble 3,9-Difluoro-12,13-dihydro-13-[6-amino-β-d-glucopyranosyl]-5H,13H-benzo[b]thienyl[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione (BMS-251873) with Curative Antitumor Activity against Prostate Carcinoma Xenograft Tumor Model

Design and Synthesis of a Fluoroindolocarbazole Series as Selective Topoisomerase I Active Agents. Discovery of Water-Soluble 3,9-Difluoro-12,13-dihydro-13-[6-amino-β-d-glucopyranosyl]-5H,13H-benzo[b]thienyl[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione (BMS-251873) with Curative Antitumor Activity against Prostate Carcinoma Xenograft Tumor Model

by Balasubramanian, Balu N, St. Laurent, Denis R, Saulnier, Mark G, Long, Byron H, Bachand, Carol, Beaulieu, Francis, Clarke, Wendy, Deshpande, Milind, Eummer, Jeffrey, Fairchild, Craig R, Frennesson, David B, Kramer, Robert, Lee, Frank Y, Mahler, Mikael, Martel, Alain, Naidu, B. Narasimhulu, Rose, William C, Russell, John, Ruediger, Edward, Solomon, Carola, Stoffan, Karen M, Wong, Henry, Wright, John J, Zimmermann, Kurt, Vyas, Dolatrai M
Published in Journal of medicinal chemistry (27.01.2005)

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Intramolecular Diels-Alder Reactions of 4H-Furo[3,4-b]indoles. New Syntheses of Benzo[a]carbazoles and Benzo[c]carbazoles

Intramolecular Diels-Alder Reactions of 4H-Furo[3,4-b]indoles. New Syntheses of Benzo[a]carbazoles and Benzo[c]carbazoles

by Gribble, Gordon W., Silva, Richard A., Saulnier, Mark G.
Published in Synthetic communications (01.02.1999)

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Syntheses and Diels-Alder cycloaddition reactions of 4H-furo[3,4-b]indoles. A regiospecific Diels-Alder synthesis of ellipticine

Syntheses and Diels-Alder cycloaddition reactions of 4H-furo[3,4-b]indoles. A regiospecific Diels-Alder synthesis of ellipticine

by Gribble, Gordon W., Keavy, Daniel J., Davis, Deborah A., Saulnier, Mark G., Pelcman, Benjamin, Barden, Timothy C., Sibi, Mukund P., Olson, Erik R., BelBruno, Joseph J.
Published in Journal of organic chemistry (01.10.1992)

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Synthesis of new pyrrolo[3,4-b]indol-3-ones as latent substrates for pyrrolo[3,4-b]indoles

Synthesis of new pyrrolo[3,4-b]indol-3-ones as latent substrates for pyrrolo[3,4-b]indoles

by Saulnier, Mark G., Schreiber, Steven M., Cavanaugh, Kerri L., Perni, Robert B., Joyner, H. Howard, Gribble, and Gordon W.
Published in ARKIVOC free online journal of organic chemistry (04.10.2020)

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Synthesis of etoposide phosphate, BMY-40481: A water-soluble clinically active prodrug of etoposide

Synthesis of etoposide phosphate, BMY-40481: A water-soluble clinically active prodrug of etoposide

by Saulnier, Mark G., Langley, David R., Kadow, John F., Senter, Peter D., Knipe, Jay O, Tun, Min Min, Vyas, Dolatrai M., Doyle, Terrence W.
Published in Bioorganic & medicinal chemistry letters (10.11.1994)

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Chemoselective synthesis of allyltrimethylsilanes by cross-coupling of vinyl triflates with tris((trimethylsilyl)methyl)aluminum catalyzed by palladium(0)

Chemoselective synthesis of allyltrimethylsilanes by cross-coupling of vinyl triflates with tris((trimethylsilyl)methyl)aluminum catalyzed by palladium(0)

by Saulnier, Mark G, Kadow, John F, Tun, Min Min, Langley, David R, Vyas, Dolatrai M
Published in Journal of the American Chemical Society (01.10.1989)

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