Targeted clearance of senescent cells using an antibody-drug conjugate against a specific membrane marker
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Published in Scientific reports (13.10.2021)
Published in Scientific reports (13.10.2021)
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Bridging Disulfides for Stable and Defined Antibody Drug Conjugates
Badescu, George, Bryant, Penny, Bird, Matthew, Henseleit, Korinna, Swierkosz, Julia, Parekh, Vimal, Tommasi, Rita, Pawlisz, Estera, Jurlewicz, Kosma, Farys, Monika, Camper, Nicolas, Sheng, XiaoBo, Fisher, Martin, Grygorash, Ruslan, Kyle, Andrew, Abhilash, Amrita, Frigerio, Mark, Edwards, Jeff, Godwin, Antony
Published in Bioconjugate chemistry (18.06.2014)
Published in Bioconjugate chemistry (18.06.2014)
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Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion
Golding, Sarah E, Rosenberg, Elizabeth, Valerie, Nicholas, Hussaini, Isa, Frigerio, Mark, Cockcroft, Xiaoling F, Chong, Wei Yee, Hummersone, Marc, Rigoreau, Laurent, Menear, Keith A, O'Connor, Mark J, Povirk, Lawrence F, van Meter, Timothy, Valerie, Kristoffer
Published in Molecular cancer therapeutics (01.10.2009)
Published in Molecular cancer therapeutics (01.10.2009)
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Half-life extension and non-human primate pharmacokinetic safety studies of i-body AD-114 targeting human CXCR4
Griffiths, Katherine, Binder, Uli, McDowell, William, Tommasi, Rita, Frigerio, Mark, Darby, William G, Hosking, Chris G, Renaud, Lionel, Machacek, Matthias, Lloyd, Peter, Skerra, Arne, Foley, Michael
Published in mAbs (03.10.2019)
Published in mAbs (03.10.2019)
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Incorporation of Hydrophilic Macrocycles Into Drug-Linker Reagents Produces Antibody-Drug Conjugates With Enhanced in vivo Performance
Evans, Nick, Grygorash, Ruslan, Williams, Paul, Kyle, Andrew, Kantner, Terrence, Pathak, Ravindra, Sheng, XiaoBo, Simoes, Fabio, Makwana, Hiteshri, Resende, Ricardo, de Juan, Elena, Jenkins, Alan, Morris, David, Michelet, Aurelie, Jewitt, Frances, Rudge, Felicity, Camper, Nicolas, Manin, Anaïs, McDowell, William, Pabst, Martin, Godwin, Antony, Frigerio, Mark, Bird, Matthew
Published in Frontiers in pharmacology (17.06.2022)
Published in Frontiers in pharmacology (17.06.2022)
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The chemistry and biology of the bryostatin antitumour macrolides
Hale, Karl J, Hummersone, Marc G, Manaviazar, Soraya, Frigerio, Mark
Published in Natural product reports (01.08.2002)
Published in Natural product reports (01.08.2002)
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Enantioselective Formal Total Synthesis of the Antitumor Macrolide Bryostatin 7
Manaviazar, Soraya, Frigerio, Mark, Bhatia, Gurpreet S, Hummersone, Marc G, Aliev, Abil E, Hale, Karl J
Published in Organic letters (28.09.2006)
Published in Organic letters (28.09.2006)
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Bridged Cysteine Conjugations
Bird, Matthew, Nunes, Joao, Frigerio, Mark
Published in Methods in molecular biology (Clifton, N.J.) (01.01.2020)
Published in Methods in molecular biology (Clifton, N.J.) (01.01.2020)
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In Vitro and In Vivo Evaluation of Cysteine Rebridged Trastuzumab–MMAE Antibody Drug Conjugates with Defined Drug-to-Antibody Ratios
Bryant, Penny, Pabst, Martin, Badescu, George, Bird, Matthew, McDowell, William, Jamieson, Estera, Swierkosz, Julia, Jurlewicz, Kosma, Tommasi, Rita, Henseleit, Korinna, Sheng, XiaoBo, Camper, Nicolas, Manin, Anais, Kozakowska, Katarzyna, Peciak, Karolina, Laurine, Emmanuelle, Grygorash, Ruslan, Kyle, Andrew, Morris, David, Parekh, Vimal, Abhilash, Amrita, Choi, Ji-won, Edwards, Jeff, Frigerio, Mark, Baker, Matthew P, Godwin, Antony
Published in Molecular pharmaceutics (01.06.2015)
Published in Molecular pharmaceutics (01.06.2015)
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Modulation of drug-linker design to enhance in vivo potency of homogeneous antibody-drug conjugates
Pabst, Martin, McDowell, William, Manin, Anaïs, Kyle, Andrew, Camper, Nicolas, De Juan, Elena, Parekh, Vimal, Rudge, Felicity, Makwana, Hiteshri, Kantner, Terrence, Parekh, Hemal, Michelet, Aurelie, Sheng, XiaoBo, Popa, Gina, Tucker, Carolyn, Khayrzad, Farzad, Pollard, Derek, Kozakowska, Katarzyna, Resende, Ricardo, Jenkins, Alan, Simoes, Fabio, Morris, Dave, Williams, Paul, Badescu, George, Baker, Matthew P., Bird, Matthew, Frigerio, Mark, Godwin, Antony
Published in Journal of controlled release (10.05.2017)
Published in Journal of controlled release (10.05.2017)
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1-Substituted (Dibenzo[ b,d ]thiophen-4-yl)-2-morpholino-4 H -chromen-4-ones Endowed with Dual DNA-PK/PI3-K Inhibitory Activity
Cano, Céline, Saravanan, Kappusamy, Bailey, Chris, Bardos, Julia, Curtin, Nicola J., Frigerio, Mark, Golding, Bernard T., Hardcastle, Ian R., Hummersone, Marc G., Menear, Keith A., Newell, David R., Richardson, Caroline J., Shea, K., Smith, Graeme C. M., Thommes, Pia, Ting, Attilla, Griffin, Roger J.
Published in Journal of medicinal chemistry (22.08.2013)
Published in Journal of medicinal chemistry (22.08.2013)
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1‑Substituted (Dibenzo[b,d]thiophen-4-yl)-2-morpholino‑4H‑chromen-4-ones Endowed with Dual DNA-PK/PI3‑K Inhibitory Activity
Cano, Céline, Saravanan, Kappusamy, Bailey, Chris, Bardos, Julia, Curtin, Nicola J, Frigerio, Mark, Golding, Bernard T, Hardcastle, Ian R, Hummersone, Marc G, Menear, Keith A, Newell, David R, Richardson, Caroline J, Shea, K, Smith, Graeme C. M, Thommes, Pia, Ting, Attilla, Griffin, Roger J
Published in Journal of medicinal chemistry (22.08.2013)
Published in Journal of medicinal chemistry (22.08.2013)
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Abstract 1217: Preclinical evaluation of a next-generation, EGFR targeting ADC that promotes regression in KRAS or BRAF mutant tumors
Huang, Lei, Veneziale, Bob, Frigerio, Mark, Badescu, George, Li, Xiaoming, Zhao, Qiping, Bahn, Jesse, Souratha, Jennifer, Osgood, Ryan, Zhao, Chunmei, Phan, Kim, Cowell, Jessica, Rosengren, Sanna, Parise, Jason, Pabst, Martin, Bird, Mathew, McDowell, William, Wei, Gina, Thompson, Curtis, Godwin, Antony, Shepard, Michael, Thanos, Christopher
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Antitumor imidazo[5,1-d]-1,2,3,5-tetrazines: compounds modified at the 3-position overcome resistance in human glioblastoma cell linesPart 43 in the series 'Antitumour Imidazotetrazines', part 42 is ref. 18. MFGS and TDB were consultants to, and MFGS was a shareholder of, Pharminox Ltd.Electronic supplementary information (ESI) available. See DOI: 10.1039/c6md00384b
Cousin, David, Zhang, Jihong, Hummersone, Marc G, Matthews, Charles S, Frigerio, Mark, Bradshaw, Tracey D, Stevens, Malcolm F. G
Year of Publication 07.12.2016
Year of Publication 07.12.2016
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Antitumor imidazo[5,1-d]-1,2,3,5-tetrazines: compounds modified at the 3-position overcome resistance in human glioblastoma cell lines
Cousin, David, Zhang, Jihong, Hummersone, Marc G., Matthews, Charles S., Frigerio, Mark, Bradshaw, Tracey D., Stevens, Malcolm F. G.
Published in MedChemComm (01.01.2016)
Published in MedChemComm (01.01.2016)
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DNA-Dependent Protein Kinase (DNA-PK) Inhibitors. Synthesis and Biological Activity of Quinolin-4-one and Pyridopyrimidin-4-one Surrogates for the Chromen-4-one Chemotype
Cano, Céline, Barbeau, Olivier R, Bailey, Christine, Cockcroft, Xiao-Ling, Curtin, Nicola J, Duggan, Heather, Frigerio, Mark, Golding, Bernard T, Hardcastle, Ian R, Hummersone, Marc G, Knights, Charlotte, Menear, Keith A, Newell, David R, Richardson, Caroline J, Smith, Graeme C. M, Spittle, Ben, Griffin, Roger J
Published in Journal of medicinal chemistry (23.12.2010)
Published in Journal of medicinal chemistry (23.12.2010)
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On and off-target effects of telomere uncapping G-quadruplex selective ligands based on pentacyclic acridinium salts
Iachettini, Sara, Stevens, Malcolm Fg, Frigerio, Mark, Hummersone, Marc G, Hutchinson, Ian, Garner, Thomas P, Searle, Mark S, Wilson, David W, Munde, Manoj, Nanjunda, Rupesh, D'Angelo, Carmen, Zizza, Pasquale, Rizzo, Angela, Cingolani, Chiara, De Cicco, Federica, Porru, Manuela, D'Incalci, Maurizio, Leonetti, Carlo, Biroccio, Annamaria, Salvati, Erica
Published in Journal of experimental & clinical cancer research (19.09.2013)
Published in Journal of experimental & clinical cancer research (19.09.2013)
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