Analysis of reproducibility and robustness of a human microfluidic four-cell liver acinus microphysiology system (LAMPS)
Sakolish, Courtney, Reese, Celeste E., Luo, Yu-Syuan, Valdiviezo, Alan, Schurdak, Mark E., Gough, Albert, Taylor, D. Lansing, Chiu, Weihsueh A., Vernetti, Lawrence A., Rusyn, Ivan
Published in Toxicology (Amsterdam) (30.01.2021)
Published in Toxicology (Amsterdam) (30.01.2021)
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Journal Article
A systems‐level study reveals host‐targeted repurposable drugs against SARS‐CoV‐2 infection
Chen, Fangyuan, Shi, Qingya, Pei, Fen, Vogt, Andreas, Porritt, Rebecca A, Garcia, Gustavo, Gomez, Angela C, Cheng, Mary Hongying, Schurdak, Mark E, Liu, Bing, Chan, Stephen Y, Arumugaswami, Vaithilingaraja, Stern, Andrew M, Taylor, D Lansing, Arditi, Moshe, Bahar, Ivet
Published in Molecular systems biology (01.08.2021)
Published in Molecular systems biology (01.08.2021)
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Journal Article
Identifying and quantifying heterogeneity in high content analysis: application of heterogeneity indices to drug discovery
Gough, Albert H, Chen, Ning, Shun, Tong Ying, Lezon, Timothy R, Boltz, Robert C, Reese, Celeste E, Wagner, Jacob, Vernetti, Lawrence A, Grandis, Jennifer R, Lee, Adrian V, Stern, Andrew M, Schurdak, Mark E, Taylor, D Lansing
Published in PloS one (18.07.2014)
Published in PloS one (18.07.2014)
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Journal Article
Validation of a high throughput screening assay to identify small molecules that target the eukaryotic replicative helicase
Sanders, Jordan, Castiglione, Michael, Shun, Tongying, Vollmer, Laura L., Schurdak, Mark E., Vogt, Andreas, Schwacha, Anthony
Published in SLAS discovery (01.06.2022)
Published in SLAS discovery (01.06.2022)
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Journal Article
A metabolic dysfunction-associated steatotic liver acinus biomimetic induces pancreatic islet dysfunction in a coupled microphysiology system
Aleman, Julio, K, Ravikumar, Wiegand, Connor, Schurdak, Mark E., Vernetti, Lawrence, Gavlock, Dillon, Reese, Celeste, DeBiasio, Richard, LaRocca, Greg, Angarita, Yulder Daniel, Gough, Albert, Soto-Gutierrez, Alejandro, Behari, Jaideep, Yechoor, Vijay K., Miedel, Mark T., Stern, Andrew M., Banerjee, Ipsita, Taylor, D. Lansing
Published in Communications biology (14.10.2024)
Published in Communications biology (14.10.2024)
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Journal Article
Biologically Relevant Heterogeneity: Metrics and Practical Insights
Gough, Albert, Stern, Andrew M., Maier, John, Lezon, Timothy, Shun, Tong-Ying, Chennubhotla, Chakra, Schurdak, Mark E., Haney, Steven A., Taylor, D. Lansing
Published in SLAS Discovery (01.03.2017)
Published in SLAS Discovery (01.03.2017)
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Book Review
Journal Article
High content screen microscopy analysis of Aβ1–42 -induced neurite outgrowth reduction in rat primary cortical neurons: Neuroprotective effects of α7 neuronal nicotinic acetylcholine receptor ligands
Hu, Min, Schurdak, Mark E, Puttfarcken, Pamela S, El Kouhen, Rachid, Gopalakrishnan, Murali, Li, Jinhe
Published in Brain research (04.09.2007)
Published in Brain research (04.09.2007)
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Journal Article
Statin-induced mevalonate pathway inhibition attenuates the growth of mesenchymal-like cancer cells that lack functional E-cadherin mediated cell cohesion
Warita, Katsuhiko, Warita, Tomoko, Beckwitt, Colin H., Schurdak, Mark E., Vazquez, Alexei, Wells, Alan, Oltvai, Zoltán N.
Published in Scientific reports (23.12.2014)
Published in Scientific reports (23.12.2014)
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Journal Article
Mutant huntingtin disrupts mitochondrial proteostasis by interacting with TIM23
Yablonska, Svitlana, Ganesan, Vinitha, Ferrando, Lisa M., Kim, JinHo, Pyzel, Anna, Baranova, Oxana V., Khattar, Nicolas K., Larkin, Timothy M., Baranov, Sergei V., Chen, Ning, Strohlein, Colleen E., Stevens, Donté A., Wang, Xiaomin, Chang, Yue-Fang, Schurdak, Mark E., Carlisle, Diane L., Minden, Jonathan S., Friedlander, Robert M.
Published in Proceedings of the National Academy of Sciences - PNAS (13.08.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (13.08.2019)
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Journal Article
An ultraefficient affinity-based high-throughout screening process: application to bacterial cell wall biosynthesis enzyme MurF
Comess, Kenneth M, Schurdak, Mark E, Voorbach, Martin J, Coen, Michael, Trumbull, Jonathan D, Yang, Houjun, Gao, Lan, Tang, Hua, Cheng, Xueheng, Lerner, Claude G, McCall, J Owen, Burns, David J, Beutel, Bruce A
Published in Journal of biomolecular screening (01.10.2006)
Published in Journal of biomolecular screening (01.10.2006)
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Journal Article
Targeting NAD + Biosynthesis Overcomes Panobinostat and Bortezomib-Induced Malignant Glioma Resistance
Jane, Esther P, Premkumar, Daniel R, Thambireddy, Swetha, Golbourn, Brian, Agnihotri, Sameer, Bertrand, Kelsey C, Mack, Stephen C, Myers, Max I, Chattopadhyay, Ansuman, Taylor, D Lansing, Schurdak, Mark E, Stern, Andrew M, Pollack, Ian F
Published in Molecular cancer research (01.07.2020)
Published in Molecular cancer research (01.07.2020)
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Journal Article
A Perspective on Implementing a Quantitative Systems Pharmacology Platform for Drug Discovery and the Advancement of Personalized Medicine
Stern, Andrew M, Schurdak, Mark E, Bahar, Ivet, Berg, Jeremy M, Taylor, D Lansing
Published in Journal of biomolecular screening (01.07.2016)
Published in Journal of biomolecular screening (01.07.2016)
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Journal Article
Comparison of three cell-based drug screening platforms for HSV-1 infection
D'Aiuto, Leonardo, Williamson, Kelly, Dimitrion, Peter, McNulty, James, Brown, Carla E., Dokuburra, Chanti Babu, Nielsen, Alexander J., Lin, Wen Jing, Piazza, Paolo, Schurdak, Mark E., Wood, Joel, Yolken, Robert H., Kinchington, Paul R., Bloom, David C., Nimgaonkar, Vishwajit L.
Published in Antiviral research (01.06.2017)
Published in Antiviral research (01.06.2017)
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Journal Article
Harnessing Human Microphysiology Systems as Key Experimental Models for Quantitative Systems Pharmacology
Taylor, D Lansing, Gough, Albert, Schurdak, Mark E, Vernetti, Lawrence, Chennubhotla, Chakra S, Lefever, Daniel, Pei, Fen, Faeder, James R, Lezon, Timothy R, Stern, Andrew M, Bahar, Ivet
Published in Handbook of experimental pharmacology (2019)
Published in Handbook of experimental pharmacology (2019)
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Journal Article
Optimization of pyrazole-containing 1,2,4-triazolo-[3,4-b]thiadiazines, a new class of STAT3 pathway inhibitors
LaPorte, Matthew G., Wang, Zhuzhu, Colombo, Raffaele, Garzan, Atefeh, Peshkov, Vsevolod A., Liang, Mary, Johnston, Paul A., Schurdak, Mark E., Sen, Malabika, Camarco, Daniel P., Hua, Yun, Pollock, Netanya I., Lazo, John S., Grandis, Jennifer R., Wipf, Peter, Huryn, Donna M.
Published in Bioorganic & medicinal chemistry letters (01.08.2016)
Published in Bioorganic & medicinal chemistry letters (01.08.2016)
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Journal Article
Connecting Neuronal Cell Protective Pathways and Drug Combinations in a Huntington’s Disease Model through the Application of Quantitative Systems Pharmacology
Pei, Fen, Li, Hongchun, Henderson, Mark J., Titus, Steven A., Jadhav, Ajit, Simeonov, Anton, Cobanoglu, Murat Can, Mousavi, Seyed H., Shun, Tongying, McDermott, Lee, Iyer, Prema, Fioravanti, Michael, Carlisle, Diane, Friedlander, Robert M., Bahar, Ivet, Taylor, D. Lansing, Lezon, Timothy R., Stern, Andrew M., Schurdak, Mark E.
Published in Scientific reports (19.12.2017)
Published in Scientific reports (19.12.2017)
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Journal Article
Large-scale generation of human iPSC-derived neural stem cells/early neural progenitor cells and their neuronal differentiation
D'Aiuto, Leonardo, Zhi, Yun, Kumar Das, Dhanjit, Wilcox, Madeleine R, Johnson, Jon W, McClain, Lora, MacDonald, Matthew L, Di Maio, Roberto, Schurdak, Mark E, Piazza, Paolo, Viggiano, Luigi, Sweet, Robert, Kinchington, Paul R, Bhattacharjee, Ayantika G, Yolken, Robert, Nimgaonka, Vishwajit L
Published in Organogenesis (2014)
Published in Organogenesis (2014)
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Journal Article
A Quantitative Systems Pharmacology Approach to Infer Pathways Involved in Complex Disease Phenotypes
Schurdak, Mark E, Pei, Fen, Lezon, Timothy R, Carlisle, Diane, Friedlander, Robert, Taylor, D Lansing, Stern, Andrew M
Published in Methods in molecular biology (Clifton, N.J.) (2018)
Published in Methods in molecular biology (Clifton, N.J.) (2018)
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Journal Article
Selection of a potential diagnostic biomarker for HIV infection from a random library of non-biological synthetic peptoid oligomers
Gearhart, Tricia L., Montelaro, Ronald C., Schurdak, Mark E., Pilcher, Chris D., Rinaldo, Charles R., Kodadek, Thomas, Park, Yongseok, Islam, Kazi, Yurko, Raymond, Marques, Ernesto T.A., Burke, Donald S.
Published in Journal of immunological methods (01.08.2016)
Published in Journal of immunological methods (01.08.2016)
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Journal Article