Combining the FtsZ-Targeting Prodrug TXA709 and the Cephalosporin Cefdinir Confers Synergy and Reduces the Frequency of Resistance in Methicillin-Resistant Staphylococcus aureus
Kaul, Malvika, Mark, Lilly, Parhi, Ajit K, LaVoie, Edmond J, Pilch, Daniel S
Published in Antimicrobial agents and chemotherapy (01.07.2016)
Published in Antimicrobial agents and chemotherapy (01.07.2016)
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Loss of Retrograde Endocannabinoid Signaling and Reduced Adult Neurogenesis in Diacylglycerol Lipase Knock-out Mice
Gao, Ying, Vasilyev, Dmitry V, Goncalves, Maria Beatriz, Howell, Fiona V, Hobbs, Carl, Reisenberg, Melina, Shen, Ru, Zhang, Mei-Yi, Strassle, Brian W, Lu, Peimin, Mark, Lilly, Piesla, Michael J, Deng, Kangwen, Kouranova, Evguenia V, Ring, Robert H, Whiteside, Garth T, Bates, Brian, Walsh, Frank S, Williams, Gareth, Pangalos, Menelas N, Samad, Tarek A, Doherty, Patrick
Published in The Journal of neuroscience (10.02.2010)
Published in The Journal of neuroscience (10.02.2010)
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An FtsZ-Targeting Prodrug with Oral Antistaphylococcal Efficacy In Vivo
KAUL, Malvika, MARK, Lilly, YONGZHENG ZHANG, PARHI, Ajit K, LAVOIE, Edmond J, PILCH, Daniel S
Published in Antimicrobial Agents and Chemotherapy (01.12.2013)
Published in Antimicrobial Agents and Chemotherapy (01.12.2013)
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Monoacylglycerol lipase activity is a critical modulator of the tone and integrity of the endocannabinoid system
Chanda, Pranab K, Gao, Ying, Mark, Lilly, Btesh, Joan, Strassle, Brian W, Lu, Peimin, Piesla, Michael J, Zhang, Mei-Yi, Bingham, Brendan, Uveges, Albert, Kowal, Dianne, Garbe, David, Kouranova, Evguenia V, Ring, Robert H, Bates, Brian, Pangalos, Menelas N, Kennedy, Jeffrey D, Whiteside, Garth T, Samad, Tarek A
Published in Molecular pharmacology (01.12.2010)
Published in Molecular pharmacology (01.12.2010)
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The pharmacokinetic profile of brensocatib and its effect on pharmacodynamic biomarkers including NE, PR3, and CatG in various rodent species
Basso, Jessica, Chen, Kuan-Ju, Zhou, Yuchen, Mark, Lilly, LaSala, Daniel, Dorfman, Arielle, Atalla, Mary, Chun, Donald, Viramontes, Veronica, Chang, Christina, Leifer, Franziska, McDonald, Patrick P, Cipolla, David C
Published in Frontiers in pharmacology (19.07.2023)
Published in Frontiers in pharmacology (19.07.2023)
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Journal Article
Pharmacokinetics and in vivo antistaphylococcal efficacy of TXY541, a 1-methylpiperidine-4-carboxamide prodrug of PC190723
Kaul, Malvika, Mark, Lilly, Zhang, Yongzheng, Parhi, Ajit K., LaVoie, Edmond J., Pilch, Daniel S.
Published in Biochemical pharmacology (15.12.2013)
Published in Biochemical pharmacology (15.12.2013)
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N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a Novel, Orally Effective Vanilloid Receptor 1 Antagonist with Analgesic Properties: II. In Vivo Characterization in Rat Models of Inflammatory and Neuropathic Pain
Pomonis, James D, Harrison, James E, Mark, Lilly, Bristol, David R, Valenzano, Kenneth J, Walker, Katharine
Published in The Journal of pharmacology and experimental therapeutics (01.07.2003)
Published in The Journal of pharmacology and experimental therapeutics (01.07.2003)
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Journal Article
Pharmacological characterisation of a rat model of incisional pain
Whiteside, Garth T, Harrison, James, Boulet, Jamie, Mark, Lilly, Pearson, Michelle, Gottshall, Susan, Walker, Katharine
Published in British journal of pharmacology (01.01.2004)
Published in British journal of pharmacology (01.01.2004)
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Pharmacology of 2-[4-(4-Chloro-2-fluorophenoxy)phenyl]-pyrimidine-4-carboxamide: A Potent, Broad-Spectrum State-Dependent Sodium Channel Blocker for Treating Pain States
Ilyin, Victor I, Pomonis, James D, Whiteside, Garth T, Harrison, James E, Pearson, Michelle S, Mark, Lilly, Turchin, Paul I, Gottshall, Susan, Carter, Richard B, Nguyen, Phong, Hogenkamp, Derk J, Olanrewaju, Shakira, Benjamin, Elfrida, Woodward, Richard M
Published in The Journal of pharmacology and experimental therapeutics (01.09.2006)
Published in The Journal of pharmacology and experimental therapeutics (01.09.2006)
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Journal Article
DiPOA ([8-(3,3-Diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl]-acetic Acid), a Novel, Systemically Available, and Peripherally Restricted Mu Opioid Agonist with Antihyperalgesic Activity: II. In Vivo Pharmacological Characterization in the Rat
Whiteside, Garth T, Harrison, James E, Pearson, Michelle S, Chen, Zhengming, Fundytus, Marian E, Rotshteyn, Yakov, Turchin, Paul I, Pomonis, James D, Mark, Lilly, Walker, Katharine, Broglé, Kevin C
Published in The Journal of pharmacology and experimental therapeutics (01.08.2004)
Published in The Journal of pharmacology and experimental therapeutics (01.08.2004)
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Journal Article
TXA709, an FtsZ-Targeting Benzamide Prodrug with Improved Pharmacokinetics and Enhanced In Vivo Efficacy against Methicillin-Resistant Staphylococcus aureus
Kaul, Malvika, Mark, Lilly, Zhang, Yongzheng, Parhi, Ajit K, Lyu, Yi Lisa, Pawlak, Joan, Saravolatz, Stephanie, Saravolatz, Louis D, Weinstein, Melvin P, LaVoie, Edmond J, Pilch, Daniel S
Published in Antimicrobial agents and chemotherapy (01.08.2015)
Published in Antimicrobial agents and chemotherapy (01.08.2015)
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Journal Article
Structural and Antibacterial Characterization of a New Benzamide FtsZ Inhibitor with Superior Bactericidal Activity and In Vivo Efficacy Against Multidrug-Resistant Staphylococcus aureus
Bryan, Eric, Ferrer-González, Edgar, Sagong, Hye Yeon, Fujita, Junso, Mark, Lilly, Kaul, Malvika, LaVoie, Edmond J., Matsumura, Hiroyoshi, Pilch, Daniel S.
Published in ACS chemical biology (17.03.2023)
Published in ACS chemical biology (17.03.2023)
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Journal Article
Development and Preclinical Evaluation of New Inhaled Lipoglycopeptides for the Treatment of Persistent Pulmonary Methicillin-Resistant Staphylococcus aureus Infections
Plaunt, Adam J, Rose, Sasha J, Kang, Jeong Yeon, Chen, Kuan-Ju, LaSala, Daniel, Heckler, Ryan P, Dorfman, Arielle, Smith, Barrett T, Chun, Donald, Viramontes, Veronica, Macaluso, Antonio, Li, Zhili, Zhou, Yuchen, Mark, Lilly, Basso, Jessica, Leifer, Franziska G, Corboz, Michel R, Chapman, Richard W, Cipolla, David, Perkins, Walter R, Malinin, Vladimir S, Konicek, Donna M
Published in Antimicrobial agents and chemotherapy (17.06.2021)
Published in Antimicrobial agents and chemotherapy (17.06.2021)
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Journal Article
Correction for Plaunt et al., “Development and Preclinical Evaluation of New Inhaled Lipoglycopeptides for the Treatment of Persistent Pulmonary Methicillin-Resistant Staphylococcus aureus Infections”
Plaunt, Adam J., Rose, Sasha J., Kang, Jeong Yeon, Chen, Kuan-Ju, LaSala, Daniel, Heckler, Ryan P., Dorfman, Arielle, Smith, Barrett T., Chun, Donald, Viramontes, Veronica, Macaluso, Antonio, Li, Zhili, Zhou, Yuchen, Mark, Lilly, Basso, Jessica, Leifer, Franziska G., Corboz, Michel R., Chapman, Richard W., Cipolla, David, Perkins, Walter R., Malinin, Vladimir S., Konicek, Donna M.
Published in Antimicrobial agents and chemotherapy (15.11.2022)
Published in Antimicrobial agents and chemotherapy (15.11.2022)
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Pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist, GW405833, utilizing rodent models of acute and chronic pain, anxiety, ataxia and catalepsy
Valenzano, Kenneth J., Tafesse, Laykea, Lee, Gary, Harrison, James E., Boulet, Jamie M., Gottshall, Susan L., Mark, Lilly, Pearson, Michelle S., Miller, Wendy, Shan, Shen, Rabadi, Leyana, Rotshteyn, Yakov, Chaffer, Suzanne M., Turchin, Paul I., Elsemore, David A., Toth, Mathew, Koetzner, Lee, Whiteside, Garth T.
Published in Neuropharmacology (01.04.2005)
Published in Neuropharmacology (01.04.2005)
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A role for cannabinoid receptors, but not endogenous opioids, in the antinociceptive activity of the CB2-selective agonist, GW405833
WHITESIDE, Garth T, GOTTSHALL, Susan L, BOULET, Jamie M, CHAFFER, Suzanne M, HARRISON, James E, PEARSON, Michelle S, TURCHIN, Paul I, MARK, Lilly, GARRISON, Augusta E, VALENZANO, Kenneth J
Published in European journal of pharmacology (28.12.2005)
Published in European journal of pharmacology (28.12.2005)
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Discovery of Novel Selective Norepinephrine Inhibitors: 1-(2-Morpholin-2-ylethyl)-3-aryl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-Dioxides (WYE-114152)
O’Neill, David J, Adedoyin, Adedayo, Bray, Jenifer A, Deecher, Darlene C, Fensome, Andrew, Goldberg, Joel A, Harrison, Jim, Leventhal, Liza, Mann, Charles, Mark, Lilly, Nogle, Lisa, Sullivan, Nicole R, Spangler, Taylor B, Terefenko, Eugene A, Trybulski, Eugene J, Uveges, Albert J, Vu, An, Whiteside, Garth T, Zhang, Puwen
Published in Journal of medicinal chemistry (13.10.2011)
Published in Journal of medicinal chemistry (13.10.2011)
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