Search Results - "MARK, E. LAYTON" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Optimization of Novel Aza-benzimidazolone mGluR2 PAMs with Respect to LLE and PK Properties and Mitigation of CYP TDI

Optimization of Novel Aza-benzimidazolone mGluR2 PAMs with Respect to LLE and PK Properties and Mitigation of CYP TDI

by Pero, Joseph E, Rossi, Michael A, Kelly, Michael J, Lehman, Hannah D. G. F, Layton, Mark E, Garbaccio, Robert M, O’Brien, Julie A, Magliaro, Brian C, Uslaner, Jason M, Huszar, Sarah L, Fillgrove, Kerry L, Tang, Cuyue, Kuo, Yuhsin, Joyce, Leo A, Sherer, Edward C, Jacobson, Marlene A
Published in ACS medicinal chemistry letters (10.03.2016)

Get full text

Journal Article

Recent advances in the development of NR2B subtype-selective NMDA receptor antagonists

Recent advances in the development of NR2B subtype-selective NMDA receptor antagonists

by Layton, Mark E, Kelly, 3rd, Michael J, Rodzinak, Kevin J
Published in Current topics in medicinal chemistry (01.04.2006)

Get more information

Journal Article

Synthesis of (+)-CP-263,114

Synthesis of (+)-CP-263,114

by Chen, Chuo, Layton, Mark E, Sheehan, Scott M, Shair, Matthew D
Published in Journal of the American Chemical Society (02.08.2000)

Get full text

Journal Article

Subtype-selective noncompetitive modulators of metabotropic glutamate receptor subtype 1 (mGluR1)

Subtype-selective noncompetitive modulators of metabotropic glutamate receptor subtype 1 (mGluR1)

by Layton, Mark E
Published in Current topics in medicinal chemistry (01.08.2005)

Get more information

Journal Article

2-OXOIMIDAZOLIDINE-4-CARBOXAMIDES AS NAV1.8 INHIBITORS

2-OXOIMIDAZOLIDINE-4-CARBOXAMIDES AS NAV1.8 INHIBITORS

by JASON M COX, CHRISTOPHER JAMES BUNGARD, LIU JIAN, MICHAEL J KELLY III, JAMES J PERKINS, AKSHAY A SHAH, IAN M BELL, LIU HONG, CHRISTOPHER S BURGEY, MARK E LAYTON, WU ZHE, ASHOK ARASAPPAN, MICHAEL DAVID VANHEYST
Year of Publication 03.10.2023

Get full text

Patent

2-OXOIMIDAZOLIDINE-4-CARBOXAMIDES AS NAV1.8 INHIBITORS

2-OXOIMIDAZOLIDINE-4-CARBOXAMIDES AS NAV1.8 INHIBITORS

by JASON M COX, CHRISTOPHER JAMES BUNGARD, LIU JIAN, MICHAEL J KELLY III, JAMES J PERKINS, AKSHAY A SHAH, IAN M BELL, LIU HONG, CHRISTOPHER S BURGEY, MARK E LAYTON, WU ZHE, ASHOK ARASAPPAN, MICHAEL DAVID VANHEYST
Year of Publication 04.07.2023

Get full text

Patent

Stereospecific Synthesis of the CP-263,114 Core Structure

Stereospecific Synthesis of the CP-263,114 Core Structure

by Chen, Chuo, Layton, Mark E, Shair, Matthew D
Published in Journal of the American Chemical Society (21.10.1998)

Get full text

Journal Article

Discovery of selective, orally bioavailable, N-linked arylsulfonamide Na(v)1.7 inhibitors with pain efficacy in mice

Discovery of selective, orally bioavailable, N-linked arylsulfonamide Na(v)1.7 inhibitors with pain efficacy in mice

by Roecker, Anthony J., Egbertson, Melissa, Jones, Kristen L. G., Gomez, Robert, Kraus, Richard L., Li, Yuxing, Koser, Amy Jo, Urban, Mark O., Klein, Rebecca, Clements, Michelle, Panigel, Jacqueline, Daley, Christopher, Wang, Jixin, Finger, Eleftheria N., Majercak, John, Santarelli, Vincent, Gregan, Irene, Cato, Matthew, Filzen, Tracey, Jovanovska, Aneta, Wang, Ying-Hong, Wang, Deping, Joyce, Leo A., Sherer, Edward C., Peng, Xuanjia, Wang, Xiu, Sun, Haiyan, Coleman, Paul J., Houghton, Andrea K., Layton, Mark E.
Published in Bioorganic & medicinal chemistry letters (15.05.2017)

Get full text

Journal Article

Benzoxazolinone aryl sulfonamides as potent, selective Na(v)1.7 inhibitors with in vivo efficacy in a preclinical pain model

Benzoxazolinone aryl sulfonamides as potent, selective Na(v)1.7 inhibitors with in vivo efficacy in a preclinical pain model

by Pero, Joseph E., Rossi, Michael A., Lehman, Hannah D. G. F., Kelly, Michael J., Mulhearn, James J., Wolkenberg, Scott E., Cato, Matthew J., Clements, Michelle K., Daley, Christopher J., Filzen, Tracey, Finger, Eleftheria N., Gregan, Yun, Henze, Darrell A., Jovanovska, Aneta, Klein, Rebecca, Kraus, Richard L., Li, Yuxing, Liang, Annie, Majercak, John M., Panigel, Jacqueline, Urban, Mark O., Wang, Jixin, Wang, Ying-Hong, Houghton, Andrea K., Layton, Mark E.
Published in Bioorganic & medicinal chemistry letters (15.06.2017)

Get full text

Journal Article

Discovery of Arylsulfonamide Na(v)1.7 Inhibitors: IVIVC, MPO Methods, and Optimization of Selectivity Profile

by Roecker, Anthony J., Layton, Mark E., Pero, Joseph E., Kelly, Michael J., Greshock, Thomas J., Kraus, Richard L., Li, Yuxing, Klein, Rebecca, Clements, Michelle, Daley, Christopher, Jovanovska, Aneta, Ballard, Jeanine E., Wang, Deping, Zhao, Fuqiang, Brunskill, Andrew P. J., Peng, Xuanjia, Wang, Xiu, Sun, Haiyan, Houghton, Andrea K., Burgey, Christopher S.
Published in ACS medicinal chemistry letters (10.06.2021)

Get full text

Journal Article

PRODRUGS OF 4'-SUBSTITUTED NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS

PRODRUGS OF 4'-SUBSTITUTED NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS

by Layton, Mark E, Embrey, Mark W, Grobler, Jay A, Raheem, Izzat T
Year of Publication 29.08.2024

Get full text

Patent

PRODRUGS OF 4'-SUBSTITUTED NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS

PRODRUGS OF 4'-SUBSTITUTED NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS

by GROBLER, Jay A, RAHEEM, Izzat T, LAYTON, Mark E, EMBREY, Mark W
Year of Publication 08.08.2024

Get full text

Patent

N-SUBSTITUTED INDAZOLE SULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS BACKGROUND

N-SUBSTITUTED INDAZOLE SULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS BACKGROUND

by GILBERT, Kevin F, PERO, Joseph E, KELLY III, Michael J, LAYTON, Mark E
Year of Publication 02.08.2024

Get full text

Patent

HYDROXYPYRROLIDINE-SUBSTITUTED ARYLSULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS

HYDROXYPYRROLIDINE-SUBSTITUTED ARYLSULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS

by WANG, Deping, WANG, Xiu, LAYTON, Mark, E, PENG, Xuanjia, ROECKER, Anthony, J
Year of Publication 05.07.2023

Get full text

Patent

5-OXOPYRROLIDINE-3-CARBOXAMIDES AS NAV1.8 INHIBITORS

5-OXOPYRROLIDINE-3-CARBOXAMIDES AS NAV1.8 INHIBITORS

by BELL, Ian, M, SHAH, Akshay, A, LAYTON, Mark, E, KELLY, Michael, J., III, COX, Jason, M, LIU, Hong, LIU, Jian, ARASAPPAN, Ashok, VANHEYST, Michael, D
Year of Publication 24.07.2024

Get full text

Patent

HYDROXYPYRROLIDINE-SUBSTITUTED ARYLSULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS

HYDROXYPYRROLIDINE-SUBSTITUTED ARYLSULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS

by Peng, Xuanjia, Layton, Mark E, Wang, Deping, Wang, Xiu, Roecker, Anthony J
Year of Publication 29.09.2022

Get full text

Patent

HYDROXYPYRROLIDINE-SUBSTITUTED ARYLSULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS

HYDROXYPYRROLIDINE-SUBSTITUTED ARYLSULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS

by WANG, Deping, WANG, Xiu, LAYTON, Mark, E, PENG, Xuanjia, ROECKER, Anthony, J
Year of Publication 20.04.2022

Get full text

Patent

2-OXOIMIDAZOLIDINE-4-CARBOXAMIDES AS NAV1.8 INHIBITORS

2-OXOIMIDAZOLIDINE-4-CARBOXAMIDES AS NAV1.8 INHIBITORS

by SHAH, Akshay A, BELL, Ian M, BURGEY, Christopher S, PERKINS, James J, COX, Jason M, LIU, Jian, ARASAPPAN, Ashok, WU, Zhe, KELLY III, Michael J, LAYTON, Mark E, LIU, Hong, BUNGARD, Christopher James, VANHEYST, Michael David
Year of Publication 31.07.2024

Get full text

Patent

PROTEASE INHIBITORS FOR TREATING OR PREVENTING CORONAVIRUS INFECTION

PROTEASE INHIBITORS FOR TREATING OR PREVENTING CORONAVIRUS INFECTION

by MCCAULEY, John A, ACTON, III, DE LERA RUIZ, Manuel, PARISH, Craig, ROECKER, Anthony J, MORRIELLO, Gregori J, KLINGLER, Franca-Maria, GUPTA, Mayuri, KRISHNAMURTHY, Harini, KELLY III, Michael J, SHURTLEFF, Valerie W, LAYTON, Mark E, PERKINS, James
Year of Publication 18.07.2024

Get full text

Patent

5-OXOPYRROLIDINE-3-CARBOXAMIDES AS NAV1.8 INHIBITORS

5-OXOPYRROLIDINE-3-CARBOXAMIDES AS NAV1.8 INHIBITORS

by Liu, Jian, Layton, Mark E, Cox, Jason Michael, Shah, Akshay A, VanHeyst, Michael David, Bell, Ian M, Kelly, III, Michael J, Arasappan, Ashok, Liu, Hong
Year of Publication 20.07.2023

Get full text

Patent

[1]
Prev
1
2
3
4
5
6
7
8
9
10
11
Next
[20]