COVID-19: molecular targets, drug repurposing and new avenues for drug discovery
Senger, Mario Roberto, Evangelista, Tereza Cristina Santos, Dantas, Rafael Ferreira, Santana, Marcos Vinicius da Silva, Gonçalves, Luiz Carlos Saramago, de Souza Neto, Lauro Ribeiro, Ferreira, Sabrina Baptista, Silva-Junior, Floriano Paes
Published in Memórias do Instituto Oswaldo Cruz (01.01.2020)
Published in Memórias do Instituto Oswaldo Cruz (01.01.2020)
Get full text
Journal Article
Design, synthesis, cholinesterase inhibition and molecular modelling study of novel tacrine hybrids with carbohydrate derivatives
Lopes, João Paulo Bizarro, Silva, Luana, da Costa Franarin, Gabriela, Antonio Ceschi, Marco, Seibert Lüdtke, Diogo, Ferreira Dantas, Rafael, de Salles, Cristiane Martins Cardoso, Paes Silva-Jr, Floriano, Roberto Senger, Mario, Alvim Guedes, Isabella, Emmanuel Dardenne, Laurent
Published in Bioorganic & medicinal chemistry (01.11.2018)
Published in Bioorganic & medicinal chemistry (01.11.2018)
Get full text
Journal Article
Schistosoma mansoni infection causes oxidative stress and alters receptor for advanced glycation endproduct (RAGE) and tau levels in multiple organs in mice
de Oliveira, Ramatis Birnfeld, Senger, Mario Roberto, Vasques, Laura Milan, Gasparotto, Juciano, dos Santos, João Paulo Almeida, de Bittencourt Pasquali, Matheus Augusto, Moreira, José Claudio Fonseca, Silva, Floriano Paes, Gelain, Daniel Pens
Published in International journal for parasitology (01.04.2013)
Published in International journal for parasitology (01.04.2013)
Get full text
Journal Article
N-acetyl-cysteine inhibits liver oxidative stress markers in BALB/c mice infected with Leishmania amazonensis
Gasparotto, Juciano, Kunzler, Alice, Senger, Mario Roberto, Souza, Celeste da Silva Freitas de, Simone, Salvatore Giovanni de, Bortolin, Rafael Calixto, Somensi, Nauana, Dal-Pizzol, Felipe, Moreira, José Claudio Fonseca, Abreu-Silva, Ana Lúcia, Calabrese, Kátia da Silva, Silva, Jr, Floriano Paes, Gelain, Daniel Pens
Published in Memórias do Instituto Oswaldo Cruz (01.02.2017)
Published in Memórias do Instituto Oswaldo Cruz (01.02.2017)
Get full text
Journal Article
Methanol alters ecto-nucleotidases and acetylcholinesterase in zebrafish brain
Rico, Eduardo Pacheco, Rosemberg, Denis Broock, Senger, Mario Roberto, de Bem Arizi, Marcelo, Bernardi, Giovana Farinon, Dias, Renato Dutra, Bogo, Maurício Reis, Bonan, Carla Denise
Published in Neurotoxicology and teratology (01.07.2006)
Published in Neurotoxicology and teratology (01.07.2006)
Get full text
Journal Article
Ethanol and acetaldehyde alter NTPDase and 5′-nucleotidase from zebrafish brain membranes
Rico, Eduardo Pacheco, Rosemberg, Denis Broock, Senger, Mario Roberto, Arizi, Marcelo de Bem, Dias, Renato Dutra, Souto, André Arigony, Bogo, Maurício Reis, Bonan, Carla Denise
Published in Neurochemistry international (01.01.2008)
Published in Neurochemistry international (01.01.2008)
Get full text
Journal Article
Ecto-nucleotidase pathway is altered by different treatments with fluoxetine and nortriptyline
Pedrazza, Eduardo Luiz, Rico, Eduardo Pacheco, Senger, Mario Roberto, Pedrazza, Leonardo, Zimmermann, Fernanda Francine, Sarkis, João José Freitas, Bogo, Maurício Reis, Bonan, Carla Denise
Published in European journal of pharmacology (31.03.2008)
Published in European journal of pharmacology (31.03.2008)
Get full text
Journal Article
Ecto-5′-nucleotidase activity in brain membranes of zebrafish ( Danio rerio)
Senger, Mario Roberto, Rico, Eduardo Pacheco, Dias, Renato Dutra, Bogo, Maurício Reis, Bonan, Carla Denise
Published in Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology (01.10.2004)
Published in Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology (01.10.2004)
Get full text
Journal Article
1-Phenyl-1H- and 2-phenyl-2H-1,2,3-triazol derivatives: Design, synthesis and inhibitory effect on alpha-glycosidases
Gonzaga, Daniel, Senger, Mario Roberto, da Silva, Fernando de Carvalho, Ferreira, Vitor Francisco, Silva, Floriano Paes
Published in European journal of medicinal chemistry (03.03.2014)
Published in European journal of medicinal chemistry (03.03.2014)
Get full text
Journal Article
Kinetics and molecular modeling studies on the inhibition mechanism of GH13 α-glycosidases by small molecule ligands
Senger, Mario Roberto, da Costa Latgé, Samara Graciane, von Ranke, Natalia Lidmar, de Aquino, Gabriel Alves Souto, Dantas, Rafael Ferreira, Genta, Fernando Ariel, Ferreira, Sabrina Baptista, Junior, Floriano Paes Silva
Published in International journal of biological macromolecules (01.06.2024)
Published in International journal of biological macromolecules (01.06.2024)
Get full text
Journal Article
Dealing with frequent hitters in drug discovery: a multidisciplinary view on the issue of filtering compounds on biological screenings
Dantas, Rafael Ferreira, Evangelista, Tereza Cristina Santos, Neves, Bruno Junior, Senger, Mario Roberto, Andrade, Carolina Horta, Ferreira, Sabrina Baptista, Silva-Junior, Floriano Paes
Published in Expert opinion on drug discovery (02.12.2019)
Published in Expert opinion on drug discovery (02.12.2019)
Get more information
Journal Article
Neurological impairment caused by Schistosoma mansoni systemic infection exhibits early features of idiopathic neurodegenerative disease
Gasparotto, Juciano, Senger, Mario Roberto, Telles de Sá Moreira, Emilio, Brum, Pedro Ozorio, Carazza Kessler, Flávio Gabriel, Peixoto, Daniel Oppermann, Panzenhagen, Alana Castro, Ong, Lin Kooi, Campos Soares, Marlene, Reis, Patricia Alves, Schirato, Giuliana Viegas, Góes Valente, Walter César, Araújo Montoya, Bogar Omar, Silva, Floriano P., Fonseca Moreira, José Claudio, Dal-Pizzol, Felipe, Castro-Faria-Neto, Hugo C., Gelain, Daniel Pens
Published in The Journal of biological chemistry (01.08.2021)
Published in The Journal of biological chemistry (01.08.2021)
Get full text
Journal Article
Aluminum exposure alters behavioral parameters and increases acetylcholinesterase activity in zebrafish (Danio rerio) brain
Senger, Mario Roberto, Seibt, Kelly Juliana, Ghisleni, Gabriele Cordenonzi, Dias, Renato Dutra, Bogo, Mauricio Reis, Bonan, Carla Denise
Published in Cell biology and toxicology (01.06.2011)
Published in Cell biology and toxicology (01.06.2011)
Get full text
Journal Article
Kinetics Studies on the Inhibition Mechanism of Pancreatic α-Amylase by Glycoconjugated 1H-1,2,3-Triazoles: A New Class of Inhibitors with Hypoglycemiant Activity
Senger, Mario Roberto, Gomes, Lucas da Costa Andrade, Ferreira, Sabrina Baptista, Kaiser, Carlos Roland, Ferreira, Vitor Francisco, Silva Jr, Floriano Paes
Published in Chembiochem : a European journal of chemical biology (23.07.2012)
Published in Chembiochem : a European journal of chemical biology (23.07.2012)
Get full text
Journal Article
Synthesis of new lophine-carbohydrate hybrids as cholinesterase inhibitors: cytotoxicity evaluation and molecular modeling
Lopes, João Paulo Bizarro, Silva, Luana, Ceschi, Marco Antonio, Lüdtke, Diogo Seibert, Zimmer, Aline Rigon, Ruaro, Thais Carine, Dantas, Rafael Ferreira, de Salles, Cristiane Martins Cardoso, Silva-Jr, Floriano Paes, Senger, Mario Roberto, Barbosa, Gisele, Lima, Lídia Moreira, Guedes, Isabella Alvim, Dardenne, Laurent Emmanuel
Published in MedChemComm (01.12.2019)
Published in MedChemComm (01.12.2019)
Get full text
Journal Article
Investigation into effects of antipsychotics on ectonucleotidase and adenosine deaminase in zebrafish brain
Seibt, Kelly Juliana, da Luz Oliveira, Renata, Bogo, Mauricio Reis, Senger, Mario Roberto, Bonan, Carla Denise
Published in Fish physiology and biochemistry (01.12.2015)
Published in Fish physiology and biochemistry (01.12.2015)
Get full text
Journal Article
Synthesis of new lophine–carbohydrate hybrids as cholinesterase inhibitors: cytotoxicity evaluation and molecular modeling† †Electronic supplementary information (ESI) available: Graphics and extra data of in vitro and in silico experiments and detailed spectroscopic characterization. See DOI: 10.1039/c9md00358d
Lopes, João Paulo Bizarro, Silva, Luana, Ceschi, Marco Antonio, Lüdtke, Diogo Seibert, Zimmer, Aline Rigon, Ruaro, Thais Carine, Dantas, Rafael Ferreira, de Salles, Cristiane Martins Cardoso, Silva-Jr, Floriano Paes, Senger, Mario Roberto, Barbosa, Gisele, Lima, Lídia Moreira, Guedes, Isabella Alvim, Dardenne, Laurent Emmanuel
Published in MedChemComm (08.11.2019)
Published in MedChemComm (08.11.2019)
Get full text
Journal Article
Increased tau phosphorylation and receptor for advanced glycation endproducts (RAGE) in the brain of mice infected with Leishmania amazonensis
Gasparotto, Juciano, Senger, Mario Roberto, Kunzler, Alice, Degrossoli, Adriana, de Simone, Salvatore Giovanni, Bortolin, Rafael Calixto, Somensi, Nauana, Girardi, Carolina Saibro, de Souza, Celeste da Silva Freitas, Calabrese, Kátia da Silva, Dal-Pizzol, Felipe, Moreira, José Claudio Fonseca, Silva-Jr, Floriano Paes, Gelain, Daniel Pens
Published in Brain, behavior, and immunity (01.01.2015)
Published in Brain, behavior, and immunity (01.01.2015)
Get full text
Journal Article
The antidepressant drug paroxetine as a new lead candidate in schistosome drug discovery
Neves, Bruno Junior, Dantas, Rafael Ferreira, Senger, Mario Roberto, Valente, Walter César Góes, Rezende-Neto, João de Mello, Chaves, Willian Távora, Kamentsky, Lee, Carpenter, Anne, Silva-Junior, Floriano Paes, Andrade, Carolina Horta
Published in MedChemComm (01.01.2016)
Published in MedChemComm (01.01.2016)
Get full text
Journal Article
Kinetics Studies on the Inhibition Mechanism of Pancreatic α‐Amylase by Glycoconjugated 1 H ‐1,2,3‐Triazoles: A New Class of Inhibitors with Hypoglycemiant Activity
Senger, Mario Roberto, Gomes, Lucas da Costa Andrade, Ferreira, Sabrina Baptista, Kaiser, Carlos Roland, Ferreira, Vitor Francisco, Silva, Floriano Paes
Published in Chembiochem : a European journal of chemical biology (23.07.2012)
Published in Chembiochem : a European journal of chemical biology (23.07.2012)
Get full text
Journal Article