Discovery of ABT-267, a Pan-Genotypic Inhibitor of HCV NS5A
DeGoey, David A., Randolph, John T., Liu, Dachun, Pratt, John, Hutchins, Charles, Donner, Pamela, Krueger, A. Chris, Matulenko, Mark, Patel, Sachin, Motter, Christopher E., Nelson, Lissa, Keddy, Ryan, Tufano, Michael, Caspi, Daniel D., Krishnan, Preethi, Mistry, Neeta, Koev, Gennadiy, Reisch, Thomas J., Mondal, Rubina, Pilot-Matias, Tami, Gao, Yi, Beno, David W. A., Maring, Clarence J., Molla, Akhter, Dumas, Emily, Campbell, Andrew, Williams, Laura, Collins, Christine, Wagner, Rolf, Kati, Warren M.
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
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Journal Article
Identification of aryl dihydrouracil derivatives as palm initiation site inhibitors of HCV NS5B polymerase
Liu, Yaya, Lim, Ben Hock, Jiang, Wen W., Flentge, Charles A., Hutchinson, Douglas K., Madigan, Darold L., Randolph, John T., Wagner, Rolf, Maring, Clarence J., Kati, Warren M., Molla, Akhteruzzaman
Published in Bioorganic & medicinal chemistry letters (01.06.2012)
Published in Bioorganic & medicinal chemistry letters (01.06.2012)
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Journal Article
Highlights of the Structure–Activity Relationships of Benzimidazole Linked Pyrrolidines Leading to the Discovery of the Hepatitis C Virus NS5A Inhibitor Pibrentasvir (ABT-530)
Wagner, Rolf, Randolph, John T, Patel, Sachin V, Nelson, Lissa, Matulenko, Mark A, Keddy, Ryan, Pratt, John K, Liu, Dachun, Krueger, A. Chris, Donner, Pamela L, Hutchinson, Douglas K, Flentge, Charles, Betebenner, David, Rockway, Todd, Maring, Clarence J, Ng, Teresa I, Krishnan, Preethi, Pilot-Matias, Tami, Collins, Christine, Panchal, Neeta, Reisch, Thomas, Dekhtyar, Tatyana, Mondal, Rubina, Stolarik, DeAnne F, Gao, Yi, Gao, Wenqing, Beno, David A, Kati, Warren M
Published in Journal of medicinal chemistry (10.05.2018)
Published in Journal of medicinal chemistry (10.05.2018)
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Journal Article
Discovery of pyrido[2,3-d]pyrimidine-based inhibitors of HCV NS5A
DeGoey, David A., Betebenner, David A., Grampovnik, David J., Liu, Dachun, Pratt, John K., Tufano, Michael D., He, Wenping, Krishnan, Preethi, Pilot-Matias, Tami J., Marsh, Kennan C., Molla, Akhteruzzaman, Kempf, Dale J., Maring, Clarence J.
Published in Bioorganic & medicinal chemistry letters (15.06.2013)
Published in Bioorganic & medicinal chemistry letters (15.06.2013)
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Journal Article
Synthesis and Biological Characterization of Aryl Uracil Inhibitors of Hepatitis C Virus NS5B Polymerase: Discovery of ABT-072, a trans-Stilbene Analog with Good Oral Bioavailability
Randolph, John T, Krueger, A. Chris, Donner, Pamela L, Pratt, John K, Liu, Dachun, Motter, Christopher E, Rockway, Todd W, Tufano, Michael D, Wagner, Rolf, Lim, Hock B, Beyer, Jill M, Mondal, Rubina, Panchal, Neeta S, Colletti, Lynn, Liu, Yaya, Koev, Gennadiy, Kati, Warren M, Hernandez, Lisa E, Beno, David W. A, Longenecker, Kenton L, Stewart, Kent D, Dumas, Emily O, Molla, Akhteruzzaman, Maring, Clarence J
Published in Journal of medicinal chemistry (08.02.2018)
Published in Journal of medicinal chemistry (08.02.2018)
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Journal Article
Novel Hepatitis C virus replicon inhibitors: Synthesis and structure–activity relationships of fused pyrimidine derivatives
Chris Krueger, A., Madigan, Darold L., Beno, David W., Betebenner, David A., Carrick, Robert, Green, Brian E., He, Wenping, Liu, Dachun, Maring, Clarence J., McDaniel, Keith F., Mo, Hongmei, Molla, Akhteruzzaman, Motter, Christopher E., Pilot-Matias, Tami J., Tufano, Michael D., Kempf, Dale J.
Published in Bioorganic & medicinal chemistry letters (15.03.2012)
Published in Bioorganic & medicinal chemistry letters (15.03.2012)
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Journal Article
Aryl uracil inhibitors of hepatitis C virus NS5B polymerase: Synthesis and characterization of analogs with a fused 5,6-bicyclic ring motif
Krueger, A. Chris, Randolph, John T., DeGoey, David A., Donner, Pamela L., Flentge, Charles A., Hutchinson, Douglas K., Liu, Dachun, Motter, Christopher E., Rockway, Todd W., Wagner, Rolf, Beno, David W.A., Koev, Gennadiy, Lim, Hock B., Beyer, Jill M., Mondal, Rubina, Liu, Yaya, Kati, Warren M., Longenecker, Kenton L., Molla, Akhteruzzaman, Stewart, Kent D., Maring, Clarence J.
Published in Bioorganic & medicinal chemistry letters (15.06.2013)
Published in Bioorganic & medicinal chemistry letters (15.06.2013)
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Journal Article
Influenza Neuraminidase Inhibitors: Structure-Based Design of a Novel Inhibitor Series
Stoll, Vincent, Stewart, Kent D, Maring, Clarence J, Muchmore, Steven, Giranda, Vincent, Gu, Yu-gui Y, Wang, Gary, Chen, Yuanwei, Sun, Minghua, Zhao, Chen, Kennedy, April L, Madigan, Darold L, Xu, Yibo, Saldivar, Ayda, Kati, Warren, Laver, Graeme, Sowin, Thomas, Sham, Hing L, Greer, Jonathan, Kempf, Dale
Published in Biochemistry (Easton) (28.01.2003)
Published in Biochemistry (Easton) (28.01.2003)
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Journal Article
Des-A-ring benzothiadiazines: Inhibitors of HCV genotype 1 NS5B RNA-dependent RNA polymerase
Donner, Pamela L., Xie, Qinghua, Pratt, John K., Maring, Clarence J., Kati, Warren, Jiang, Wen, Liu, Yaya, Koev, Gennadiy, Masse, Sherie, Montgomery, Debra, Molla, Akhter, Kempf, Dale J.
Published in Bioorganic & medicinal chemistry (15.04.2008)
Published in Bioorganic & medicinal chemistry (15.04.2008)
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Journal Article
Hepatitis C NS5B polymerase inhibitors: Functional equivalents for the benzothiadiazine moiety
Hutchinson, Douglas K., Flentge, Charles A., Donner, Pamela L., Wagner, Rolf, Maring, Clarence J., Kati, Warren M., Liu, Yaya, Masse, Sherie V., Middleton, Tim, Mo, Hongmei, Montgomery, Debra, Jiang, Wen W., Koev, Gennadiy, Beno, David W.A., Stewart, Kent D., Stoll, Vincent S., Molla, Akhteruzzaman, Kempf, Dale J.
Published in Bioorganic & medicinal chemistry letters (15.03.2011)
Published in Bioorganic & medicinal chemistry letters (15.03.2011)
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Journal Article
Structure-Based Characterization and Optimization of Novel Hydrophobic Binding Interactions in a Series of Pyrrolidine Influenza Neuraminidase Inhibitors
Maring, Clarence J, Stoll, Vincent S, Zhao, Chen, Sun, Minghua, Krueger, Allan C, Stewart, Kent D, Madigan, Darold L, Kati, Warren M, Xu, Yibo, Carrick, Robert J, Montgomery, Debra A, Kempf-Grote, Anita, Marsh, Kennan C, Molla, Akhteruzzaman, Steffy, Kevin R, Sham, Hing L, Laver, W. Graeme, Gu, Yu-gui, Kempf, Dale J, Kohlbrenner, William E
Published in Journal of medicinal chemistry (16.06.2005)
Published in Journal of medicinal chemistry (16.06.2005)
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Journal Article
Inhibitors of HCV NS5B polymerase: synthesis and structure–activity relationships of N-1-heteroalkyl-4-hydroxyquinolon-3-yl-benzothiadiazines
Pratt, John K., Donner, Pamela, McDaniel, Keith F., Maring, Clarence J., Kati, Warren M., Mo, Hongmei, Middleton, Tim, Liu, Yaya, Ng, Teresa, Xie, Qinghua, Zhang, Rong, Montgomery, Debra, Molla, Akhteruzzaman, Kempf, Dale J., Kohlbrenner, William
Published in Bioorganic & medicinal chemistry letters (15.03.2005)
Published in Bioorganic & medicinal chemistry letters (15.03.2005)
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Journal Article
Inhibitors of HCV NS5B polymerase: Synthesis and structure–activity relationships of N-1-benzyl and N-1-[3-methylbutyl]-4-hydroxy-1,8-naphthyridon-3-yl benzothiadiazine analogs containing substituents on the aromatic ring
Rockway, Todd W., Zhang, Rong, Liu, Dachun, Betebenner, David A., McDaniel, Keith F., Pratt, John K., Beno, David, Montgomery, Debra, Jiang, Wen W., Masse, Sherie, Kati, Warren M., Middleton, Tim, Molla, Akhteruzzaman, Maring, Clarence J., Kempf, Dale J.
Published in Bioorganic & medicinal chemistry letters (15.07.2006)
Published in Bioorganic & medicinal chemistry letters (15.07.2006)
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Journal Article
Synthesis of potent pyrrolidine influenza neuraminidase inhibitors
Krueger, A. Chris, Xu, Yibo, Kati, Warren M., Kempf, Dale J., Maring, Clarence J., McDaniel, Keith F., Molla, Akhteruzzaman, Montgomery, Debra, Kohlbrenner, William E.
Published in Bioorganic & medicinal chemistry (01.03.2008)
Published in Bioorganic & medicinal chemistry (01.03.2008)
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Journal Article
Inhibitors of Hepatitis C Virus Polymerase: Synthesis and Biological Characterization of Unsymmetrical Dialkyl-Hydroxynaphthalenoyl-benzothiadiazines
Wagner, Rolf, Larson, Daniel P, Beno, David W. A, Bosse, Todd D, Darbyshire, John F, Gao, Yi, Gates, Bradley D, He, Wenping, Henry, Rodger F, Hernandez, Lisa E, Hutchinson, Douglas K, Jiang, Wen W, Kati, Warren M, Klein, Larry L, Koev, Gennadiy, Kohlbrenner, William, Krueger, A. Chris, Liu, Jinrong, Liu, Yaya, Long, Michelle A, Maring, Clarence J, Masse, Sherie V, Middleton, Tim, Montgomery, Debra A, Pratt, John K, Stuart, Patricia, Molla, Akhteruzzaman, Kempf, Dale J
Published in Journal of medicinal chemistry (26.03.2009)
Published in Journal of medicinal chemistry (26.03.2009)
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Journal Article
Inhibitors of HCV NS5B polymerase: Synthesis and structure–activity relationships of unsymmetrical 1-hydroxy-4,4-dialkyl-3-oxo-3,4-dihydronaphthalene benzothiadiazine derivatives
Krueger, A. Chris, Madigan, Darold L., Green, Brian E., Hutchinson, Douglas K., Jiang, Wen W., Kati, Warren M., Liu, Yaya, Maring, Clarence J., Masse, Sherie V., McDaniel, Keith F., Middleton, Tim R., Mo, Hongmei, Molla, Akhteruzzaman, Montgomery, Debra A., Ng, Teresa I., Kempf, Dale J.
Published in Bioorganic & medicinal chemistry letters (15.04.2007)
Published in Bioorganic & medicinal chemistry letters (15.04.2007)
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Journal Article
Inhibitors of HCV NS5B polymerase: Synthesis and structure–activity relationships of N-alkyl-4-hydroxyquinolon-3-yl-benzothiadiazine sulfamides
Chris Krueger, A., Madigan, Darold L., Jiang, Wen W., Kati, Warren M., Liu, Dachun, Liu, Yaya, Maring, Clarence J., Masse, Sherie, McDaniel, Keith F., Middleton, Tim, Mo, Hongmei, Molla, Akhteruzzaman, Montgomery, Debra, Pratt, John K., Rockway, Todd W., Zhang, Rong, Kempf, Dale J.
Published in Bioorganic & medicinal chemistry letters (01.07.2006)
Published in Bioorganic & medicinal chemistry letters (01.07.2006)
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Journal Article
Design, synthesis, and structural analysis of inhibitors of influenza neuraminidase containing a 2,3-disubstituted tetrahydrofuran-5-carboxylic acid core
Wang, Gary T., Wang, Sheldon, Gentles, Robert, Sowin, Thomas, Maring, Clarence J., Kempf, Dale J., Kati, Warren M., Stoll, Vincent, Stewart, Kent D., Laver, Graeme
Published in Bioorganic & medicinal chemistry letters (03.01.2005)
Published in Bioorganic & medicinal chemistry letters (03.01.2005)
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Journal Article
A stereoselective totally synthetic route to methyl .alpha.-peracetylhikosaminide
Danishefsky, Samuel J, Maring, Clarence J
Published in Journal of the American Chemical Society (01.03.1989)
Published in Journal of the American Chemical Society (01.03.1989)
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Journal Article
ANTI-VIRAL COMPOUNDS
ALLAN C KRUEGER, BETEBENNER DAVID A, HUTCHINSON DOUGLAS K, ROCKWAY TODD W, JEAN C CALIFANO, FLENTGE CHARLES A, CHARLES W HUTCHINS, SARRIS KATHY, GAO YI, DEGOEY DAVID A, KATI WARREN M, KEDDY RYAN G, MATULENKO MARK A, TAMMIE K JINKERSON, MARING CLARENCE J, DONNER PAMELA L, PRATT JOHN K, NELSON LISSA T, WAGNER ROLF, SACHIN V PATEL, WAGAW SABLE H, RANDOLPH JOHN T, TUFANO MICHAEL D, WILLIAM A CARROLL, MOTTER CHRISTOPHER E, LIU DACHUN, DANIEL D CASPI, LI WENKE, BELLIZZI MARY E, KEVIN R WOLLER
Year of Publication 04.03.2021
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Year of Publication 04.03.2021
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