A Highly Selective Hydantoin Inhibitor of Aggrecanase‑1 and Aggrecanase‑2 with a Low Projected Human Dose
Durham, Timothy B, Marimuthu, Jothirajah, Toth, James L, Liu, Chin, Adams, Lisa, Mudra, Daniel R, Swearingen, Craig, Lin, Chaohua, Chambers, Mark G, Thirunavukkarasu, Kannan, Wiley, Michael R
Published in Journal of medicinal chemistry (13.07.2017)
Published in Journal of medicinal chemistry (13.07.2017)
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Journal Article
Use of Osmotic Pumps to Establish the Pharmacokinetic–Pharmacodynamic Relationship and Define Desirable Human Performance Characteristics for Aggrecanase Inhibitors
Wiley, Michael R, Durham, Timothy B, Adams, Lisa A, Chambers, Mark G, Lin, Chaohua, Liu, Chin, Marimuthu, Jothirajah, Mitchell, Peter G, Mudra, Daniel R, Swearingen, Craig A, Toth, James L, Weller, Jennifer M, Thirunavukkarasu, Kannan
Published in Journal of medicinal chemistry (23.06.2016)
Published in Journal of medicinal chemistry (23.06.2016)
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Journal Article
Identification of Potent and Selective Hydantoin Inhibitors of Aggrecanase‑1 and Aggrecanase‑2 That Are Efficacious in Both Chemical and Surgical Models of Osteoarthritis
Durham, Timothy B, Klimkowski, Valentine J, Rito, Christopher J, Marimuthu, Jothirajah, Toth, James L, Liu, Chin, Durbin, Jim D, Stout, Stephanie L, Adams, Lisa, Swearingen, Craig, Lin, Chaohua, Chambers, Mark G, Thirunavukkarasu, Kannan, Wiley, Michael R
Published in Journal of medicinal chemistry (26.12.2014)
Published in Journal of medicinal chemistry (26.12.2014)
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Journal Article
d-Phenylglycinol-derived non-covalent factor Xa inhibitors: Effect of non-peptidic S4 linkage elements on affinity and anticoagulant activity
Klimkowski, Valentine J., Watson, Brian M., Wiley, Michael R., Liebeschuetz, John, Franciskovich, Jeffry B., Marimuthu, Jothirajah, Bastian, Jolie A., Sall, Daniel J., Smallwood, Jeffrey K., Chirgadze, Nikolay Y., Smith, Gerald F., Foster, Ronald S., Craft, Trelia, Sipes, Philip, Chastain, Marcia, Sheehan, Scott M.
Published in Bioorganic & medicinal chemistry letters (01.11.2007)
Published in Bioorganic & medicinal chemistry letters (01.11.2007)
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A four component coupling strategy for the synthesis of d-phenylglycinamide-derived non-covalent factor Xa inhibitors
Sheehan, Scott M., Masters, John J., Wiley, Michael R., Young, Stephen C., Liebeschuetz, John W., Jones, Stuart D., Murray, Christopher W., Franciskovich, Jeffrey B., Engel, David B., Weber, Wayne W., Marimuthu, Jothirajah, Kyle, Jeffrey A., Smallwood, Jeffrey K., Farmen, Mark W., Smith, Gerald F.
Published in Bioorganic & medicinal chemistry letters (21.07.2003)
Published in Bioorganic & medicinal chemistry letters (21.07.2003)
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Journal Article
cGAS INHIBITORS
AHMED, Adel, GERNERT, Douglas L, CARSON, Cheryl Ann, TROMICZAK, Eric George, LUGAR, Charles W, FORTNER, Kevin Charles, ONOBUN, Emmanuel, CUMMING, Graham Robert, AGEJAS CHICHARRO, Francisco Javier, NAGARAJAN, Shanthi, MARTINEZ BROKAW, Christina, VARIN, Thibault Francois, GREEN, Steven J, CONNER, Scott Eugene, MARIMUTHU, Jothirajah
Year of Publication 25.07.2024
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Year of Publication 25.07.2024
Patent
AZEPINO[4,5-B]INDOLONE CGAS INHIBITORS
AHMED, Adel, GERNERT, Douglas L, CARSON, Cheryl Ann, TROMICZAK, Eric George, LUGAR, Charles W, FORTNER, Kevin Charles, ONOBUN, Emmanuel, CUMMING, Graham Robert, AGEJAS CHICHARRO, Francisco Javier, NAGARAJAN, Shanthi, MARTINEZ BROKAW, Christina, VARIN, Thibault Francois, GREEN, Steven J, CONNER, Scott Eugene, MARIMUTHU, Jothirajah
Year of Publication 27.06.2024
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Year of Publication 27.06.2024
Patent
cGAS INHIBITORS
CONNER, Scott E, AHMED, Adel, GERNERT, Douglas L, NICOLAOU, Christodoulos, CARSON, Cheryl Ann, FRANCISKOVICH, Jeffry B, FORTNER, Kevin Charles, ONOBUN, Emmanuel, STOUT, Stephanie Lange, LUGAR, III, Charles W, NAGARAJAN, Shanthi, VARIN, Thibault, MARTINEZ BROKAW, Christina, GREEN, Steven J, TROMICZAK, Eric G, MARIMUTHU, Jothirajah
Year of Publication 07.12.2023
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Year of Publication 07.12.2023
Patent
CGAS INHIBITORS
CONNER, Scott E, AHMED, Adel, GERNERT, Douglas L, NICOLAOU, Christodoulos, CARSON, Cheryl Ann, LUGAR, Charles W. III, FRANCISKOVICH, Jeffry B, FORTNER, Kevin Charles, ONOBUN, Emmanuel, STOUT, Stephanie Lange, NAGARAJAN, Shanthi, VARIN, Thibault, MARTINEZ BROKAW, Christina, GREEN, Steven J, TROMICZAK, Eric G, MARIMUTHU, Jothirajah
Year of Publication 07.12.2023
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Year of Publication 07.12.2023
Patent
AGGRECANASE INHIBITORS
DURHAM, Timothy, Barrett, WILEY, Michael, Robert, MARIMUTHU, Jothirajah
Year of Publication 28.02.2018
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Year of Publication 28.02.2018
Patent
AGGRECANASE INHIBITORS
WILEY, MICHAEL ROBERT, MARIMUTHU, JOTHIRAJAH, DURHAM, TIMOTHY BARRETT
Year of Publication 31.01.2018
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Year of Publication 31.01.2018
Patent
Aggrecanase-hæmmere
DURHAM, Timothy, Barrett, WILEY, Michael, Robert, MARIMUTHU, Jothirajah
Year of Publication 02.10.2017
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Year of Publication 02.10.2017
Patent
AGGRECANASE INHIBITORS
DURHAM, Timothy, Barrett, WILEY, Michael, Robert, MARIMUTHU, Jothirajah
Year of Publication 16.08.2017
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Year of Publication 16.08.2017
Patent
AGGRECANASE INHIBITORS
DURHAM, TIMOTHY, BARRETT, WILEY, MICHAEL, ROBERT, MARIMUTHU, JOTHIRAJAH
Year of Publication 03.06.2016
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Year of Publication 03.06.2016
Patent