Search Results - "MARIJA PRHAVC" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Discovery of 4′-Chloromethyl-2′-deoxy-3′,5′-di‑O‑isobutyryl-2′-fluorocytidine (ALS-8176), A First-in-Class RSV Polymerase Inhibitor for Treatment of Human Respiratory Syncytial Virus Infection

Discovery of 4′-Chloromethyl-2′-deoxy-3′,5′-di‑O‑isobutyryl-2′-fluorocytidine (ALS-8176), A First-in-Class RSV Polymerase Inhibitor for Treatment of Human Respiratory Syncytial Virus Infection

by Wang, Guangyi, Deval, Jerome, Hong, Jin, Dyatkina, Natalia, Prhavc, Marija, Taylor, Joshua, Fung, Amy, Jin, Zhinan, Stevens, Sarah K, Serebryany, Vladimir, Liu, Jyanwei, Zhang, Qingling, Tam, Yuen, Chanda, Sushmita M, Smith, David B, Symons, Julian A, Blatt, Lawrence M, Beigelman, Leo
Published in Journal of medicinal chemistry (26.02.2015)

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Journal Article

Synthesis and Anti-Hepatitis B Activities of 3'-Fluoro-2'-Substituted Apionucleosides

Synthesis and Anti-Hepatitis B Activities of 3'-Fluoro-2'-Substituted Apionucleosides

by Holan, Martin, Tucker, Kathryn, Dyatkina, Natalia, Liu, Hong, Kinkade, April, Wang, Guangyi, Jin, Zhinan, Prhavc, Marija
Published in Molecules (Basel, Switzerland) (08.04.2022)

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Journal Article

Molecular Basis for the Selective Inhibition of Respiratory Syncytial Virus RNA Polymerase by 2'-Fluoro-4'-Chloromethyl-Cytidine Triphosphate

Molecular Basis for the Selective Inhibition of Respiratory Syncytial Virus RNA Polymerase by 2'-Fluoro-4'-Chloromethyl-Cytidine Triphosphate

by Deval, Jerome, Hong, Jin, Wang, Guangyi, Taylor, Josh, Smith, Lucas K, Fung, Amy, Stevens, Sarah K, Liu, Hong, Jin, Zhinan, Dyatkina, Natalia, Prhavc, Marija, Stoycheva, Antitsa D, Serebryany, Vladimir, Liu, Jyanwei, Smith, David B, Tam, Yuen, Zhang, Qingling, Moore, Martin L, Fearns, Rachel, Chanda, Sushmita M, Blatt, Lawrence M, Symons, Julian A, Beigelman, Leo
Published in PLoS pathogens (01.06.2015)

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Journal Article

Biochemical Effect of Resistance Mutations against Synergistic Inhibitors of RSV RNA Polymerase

Biochemical Effect of Resistance Mutations against Synergistic Inhibitors of RSV RNA Polymerase

by Deval, Jerome, Fung, Amy, Stevens, Sarah K, Jordan, Paul C, Gromova, Tatiana, Taylor, Joshua S, Hong, Jin, Meng, Jia, Wang, Guangyi, Dyatkina, Natalia, Prhavc, Marija, Symons, Julian A, Beigelman, Leo
Published in PloS one (10.05.2016)

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Journal Article

A 7-Deaza-Adenosine Analog Is a Potent and Selective Inhibitor of Hepatitis C Virus Replication with Excellent Pharmacokinetic Properties

A 7-Deaza-Adenosine Analog Is a Potent and Selective Inhibitor of Hepatitis C Virus Replication with Excellent Pharmacokinetic Properties

by OLSEN, David B, ELDRUP, Anne B, GROBLER, Jay A, LAFEMINA, Robert L, MARKEL, Eric J, MIGLIACCIO, Giovanni, PRHAVC, Marija, STAHLHUT, Mark W, TOMASSINI, Joanne E, MACCOSS, Malcolm, HAZUDA, Daria J, CARROLL, Steven S, BARTHOLOMEW, Linda, BHAT, Balkrishen, BOSSERMAN, Michele R, CECCACCI, Alessandra, COLWELL, Lawrence F, FAY, John F, FLORES, Osvaldo A, GETTY, Krista L
Published in Antimicrobial Agents and Chemotherapy (01.10.2004)

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Journal Article

Structure−Activity Relationship of Heterobase-Modified 2‘-C-Methyl Ribonucleosides as Inhibitors of Hepatitis C Virus RNA Replication

Structure−Activity Relationship of Heterobase-Modified 2‘-C-Methyl Ribonucleosides as Inhibitors of Hepatitis C Virus RNA Replication

by Eldrup, Anne B, Prhavc, Marija, Brooks, Jennifer, Bhat, Balkrishen, Prakash, Thazha P, Song, Quanlai, Bera, Sanjib, Bhat, Neelima, Dande, Prasad, Cook, P. Dan, Bennett, C. Frank, Carroll, Steven S, Ball, Richard G, Bosserman, Michele, Burlein, Christine, Colwell, Lawrence F, Fay, John F, Flores, Osvaldo A, Getty, Krista, LaFemina, Robert L, Leone, Joseph, MacCoss, Malcolm, McMasters, Daniel R, Tomassini, Joanne E, von Langen, Derek, Wolanski, Bohdan, Olsen, David B
Published in Journal of medicinal chemistry (07.10.2004)

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Journal Article

Structure−Activity Relationship of Purine Ribonucleosides for Inhibition of Hepatitis C Virus RNA-Dependent RNA Polymerase

Structure−Activity Relationship of Purine Ribonucleosides for Inhibition of Hepatitis C Virus RNA-Dependent RNA Polymerase

by Eldrup, Anne B, Allerson, Charles R, Bennett, C. Frank, Bera, Sanjib, Bhat, Balkrishen, Bhat, Neelima, Bosserman, Michele R, Brooks, Jennifer, Burlein, Christine, Carroll, Steven S, Cook, P. Dan, Getty, Krista L, MacCoss, Malcolm, McMasters, Daniel R, Olsen, David B, Prakash, Thazha P, Prhavc, Marija, Song, Quanlai, Tomassini, Joanne E, Xia, Jie
Published in Journal of medicinal chemistry (22.04.2004)

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Journal Article

2‘-O-[2-[2-(N,N-Dimethylamino)ethoxy]ethyl] Modified Oligonucleotides: Symbiosis of Charge Interaction Factors and Stereoelectronic Effects

2‘-O-[2-[2-(N,N-Dimethylamino)ethoxy]ethyl] Modified Oligonucleotides: Symbiosis of Charge Interaction Factors and Stereoelectronic Effects

by Prhavc, Marija, Prakash, Thazha P, Minasov, George, Cook, P. Dan, Egli, Martin, Manoharan, Muthiah
Published in Organic letters (12.06.2003)

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Journal Article

2 '-O-Carbamate-containing oligonucleotides: synthesis and properties

2 '-O-Carbamate-containing oligonucleotides: synthesis and properties

by Prhavc, M, Lesnik, EA, Mohan, Manoharan, M
Published in Tetrahedron letters (10.12.2001)

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Journal Article

Synthesis and Anti-Influenza Activity of Pyridine, Pyridazine, and Pyrimidine C‑Nucleosides as Favipiravir (T-705) Analogues

Synthesis and Anti-Influenza Activity of Pyridine, Pyridazine, and Pyrimidine C‑Nucleosides as Favipiravir (T-705) Analogues

by Wang, Guangyi, Wan, Jinqiao, Hu, Yujian, Wu, Xiangyang, Prhavc, Marija, Dyatkina, Natalia, Rajwanshi, Vivek K, Smith, David B, Jekle, Andreas, Kinkade, April, Symons, Julian A, Jin, Zhinan, Deval, Jerome, Zhang, Qingling, Tam, Yuen, Chanda, Sushmita, Blatt, Lawrence, Beigelman, Leonid
Published in Journal of medicinal chemistry (26.05.2016)

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Journal Article

Synthesis and Anti-HCV Activities of 4′-Fluoro-2′-Substituted Uridine Triphosphates and Nucleotide Prodrugs: Discovery of 4′-Fluoro-2′‑C‑methyluridine 5′-Phosphoramidate Prodrug (AL-335) for the Treatment of Hepatitis C Infection

Synthesis and Anti-HCV Activities of 4′-Fluoro-2′-Substituted Uridine Triphosphates and Nucleotide Prodrugs: Discovery of 4′-Fluoro-2′‑C‑methyluridine 5′-Phosphoramidate Prodrug (AL-335) for the Treatment of Hepatitis C Infection

by Wang, Guangyi, Dyatkina, Natalia, Prhavc, Marija, Williams, Caroline, Serebryany, Vladimir, Hu, Yujian, Huang, Yongfei, Wan, Jinqiao, Wu, Xiangyang, Deval, Jerome, Fung, Amy, Jin, Zhinan, Tan, Hua, Shaw, Kenneth, Kang, Hyunsoon, Zhang, Qingling, Tam, Yuen, Stoycheva, Antitsa, Jekle, Andreas, Smith, David B, Beigelman, Leonid
Published in Journal of medicinal chemistry (09.05.2019)

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Journal Article

Synthesis and Anti-HCV Activity of Sugar-Modified Guanosine Analogues: Discovery of AL-611 as an HCV NS5B Polymerase Inhibitor for the Treatment of Chronic Hepatitis C

Synthesis and Anti-HCV Activity of Sugar-Modified Guanosine Analogues: Discovery of AL-611 as an HCV NS5B Polymerase Inhibitor for the Treatment of Chronic Hepatitis C

by Wang, Guangyi, Dyatkina, Natalia, Prhavc, Marija, Williams, Caroline, Serebryany, Vladimir, Hu, Yujian, Huang, Yongfei, Wu, Xiangyang, Chen, Tongqian, Huang, Wensheng, Rajwanshi, Vivek K, Deval, Jerome, Fung, Amy, Jin, Zhinan, Stoycheva, Antitsa, Shaw, Kenneth, Gupta, Kusum, Tam, Yuen, Jekle, Andreas, Smith, David B, Beigelman, Leonid
Published in Journal of medicinal chemistry (24.09.2020)

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Journal Article

2;-O-[2-[2-(N,N-Dimethylamino)ethoxy]ethyl] Modified Antisense Oligonucleotides: Symbiosis of Charge Interaction Factors and Stereoelectronic Effects

2;-O-[2-[2-(N,N-Dimethylamino)ethoxy]ethyl] Modified Antisense Oligonucleotides: Symbiosis of Charge Interaction Factors and Stereoelectronic Effects

by Prhavc, Marija, Prakash, Thazha P., Minasov, George, Cook, P. Dan, Egli, Martin, Manoharan, Muthiah
Published in Organic letters (06.04.2016)

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Journal Article

SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF

SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF

by JEROME DEVAL, LEONID BEIGELMAN, DAVID BERNARD SMITH, WANG GUANGYI, MARIJA PRHAVC
Year of Publication 29.11.2018

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Patent

Molecular Basis for the Selective Inhibition of Respiratory Syncytial Virus RNA Polymerase by 2'-Fluoro-4'-Chloromethyl-Cytidine Triphosphate: e1004995

Molecular Basis for the Selective Inhibition of Respiratory Syncytial Virus RNA Polymerase by 2'-Fluoro-4'-Chloromethyl-Cytidine Triphosphate: e1004995

by Deval, Jerome, Hong, Jin, Wang, Guangyi, Taylor, Josh, Smith, Lucas K, Fung, Amy, Stevens, Sarah K, Liu, Hong, Jin, Zhinan, Dyatkina, Natalia, Prhavc, Marija, Stoycheva, Antitsa D, Serebryany, Vladimir, Liu, Jyanwei, Smith, David B, Tam, Yuen, Zhang, Qingling, Moore, Martin L, Fearns, Rachel, Chanda, Sushmita M, Blatt, Lawrence M, Symons, Julian A, Beigelman, Leo
Published in PLoS pathogens (01.06.2015)

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Journal Article

Synthesis of AZT 5‘-Triphosphate Mimics and Their Inhibitory Effects on HIV-1 Reverse Transcriptase

Synthesis of AZT 5‘-Triphosphate Mimics and Their Inhibitory Effects on HIV-1 Reverse Transcriptase

by Wang, Guangyi, Boyle, Nicholas, Chen, Fu, Rajappan, Vasanthakumar, Fagan, Patrick, Brooks, Jennifer L, Hurd, Tiffany, Leeds, Janet M, Rajwanshi, Vivek K, Jin, Yi, Prhavc, Marija, Bruice, Thomas W, Cook, P. Dan
Published in Journal of medicinal chemistry (30.12.2004)

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Journal Article

Structural Rationalization of a Large Difference in RNA Affinity Despite a Small Difference in Chemistry between Two 2‘-O-Modified Nucleic Acid Analogues

Structural Rationalization of a Large Difference in RNA Affinity Despite a Small Difference in Chemistry between Two 2‘-O-Modified Nucleic Acid Analogues

by Pattanayek, Rekha, Sethaphong, Latsavongsakda, Pan, Chongle, Prhavc, Marija, Prakash, Thazha P, Manoharan, Muthiah, Egli, Martin
Published in Journal of the American Chemical Society (24.11.2004)

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Journal Article

Substituted nucleosides, nucleotides and analogs thereof

Substituted nucleosides, nucleotides and analogs thereof

by BEIGELMAN, Leonid, DEVAL, Jerome, PRHAVC, Marija
Year of Publication 05.10.2023

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Patent

Substituted nucleosides, nucleotides and analogs thereof

Substituted nucleosides, nucleotides and analogs thereof

by Prhavc, Marija, Beigelman, Leonid, Deval, Jerome
Year of Publication 03.10.2023

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Patent

LIPID MONOMERS FOR THERAPEUTIC DELIVERY OF RNA

LIPID MONOMERS FOR THERAPEUTIC DELIVERY OF RNA

by JIN, Yi, RAMASESHAN, Mahesh, PRHAVC, Marija
Year of Publication 21.09.2023

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Patent

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