Activation of the IRE1 RNase through remodeling of the kinase front pocket by ATP-competitive ligands
Ferri, Elena, Le Thomas, Adrien, Wallweber, Heidi Ackerly, Day, Eric S., Walters, Benjamin T., Kaufman, Susan E., Braun, Marie-Gabrielle, Clark, Kevin R., Beresini, Maureen H., Mortara, Kyle, Chen, Yung-Chia A., Canter, Breanna, Phung, Wilson, Liu, Peter S., Lammens, Alfred, Ashkenazi, Avi, Rudolph, Joachim, Wang, Weiru
Published in Nature communications (14.12.2020)
Published in Nature communications (14.12.2020)
Get full text
Journal Article
Carbofluorination via a palladium-catalyzed cascade reaction
Braun, Marie-Gabrielle, Katcher, Matthew H, Doyle, Abigail G
Published in Chemical science (Cambridge) (01.01.2013)
Published in Chemical science (Cambridge) (01.01.2013)
Get full text
Journal Article
Introduction of Trifluoroethylamine as Amide Isostere by C–H Functionalization of Heteroarenes
Braun, Marie-Gabrielle, Castanedo, Georgette, Qin, Ling, Salvo, Patrick, Zard, Samir Z
Published in Organic letters (04.08.2017)
Published in Organic letters (04.08.2017)
Get full text
Journal Article
Unstable Mechanisms of Resistance to Inhibitors of Escherichia coli Lipoprotein Signal Peptidase
Pantua, Homer, Skippington, Elizabeth, Braun, Marie-Gabrielle, Noland, Cameron L., Diao, Jingyu, Peng, Yutian, Gloor, Susan L., Yan, Donghong, Kang, Jing, Katakam, Anand Kumar, Reeder, Janina, Castanedo, Georgette M., Garland, Keira, Komuves, Laszlo, Sagolla, Meredith, Austin, Cary D., Murray, Jeremy, Xu, Yiming, Modrusan, Zora, Xu, Min, Hanan, Emily J., Kapadia, Sharookh B.
Published in mBio (08.09.2020)
Published in mBio (08.09.2020)
Get full text
Journal Article
Tri- and Tetrasubstituted Functionalized Vinyl Sulfides by Radical Allylation
Debien, Laurent, Braun, Marie-Gabrielle, Quiclet-Sire, Béatrice, Zard, Samir Z
Published in Organic letters (20.12.2013)
Published in Organic letters (20.12.2013)
Get full text
Journal Article
Palladium-Catalyzed Allylic C–H Fluorination
Braun, Marie-Gabrielle, Doyle, Abigail G
Published in Journal of the American Chemical Society (04.09.2013)
Published in Journal of the American Chemical Society (04.09.2013)
Get full text
Journal Article
Discovery of GDC-0077 (Inavolisib), a Highly Selective Inhibitor and Degrader of Mutant PI3Kα
Hanan, Emily J., Braun, Marie-Gabrielle, Heald, Robert A., MacLeod, Calum, Chan, Connie, Clausen, Saundra, Edgar, Kyle A., Eigenbrot, Charles, Elliott, Richard, Endres, Nicholas, Friedman, Lori S., Gogol, Emily, Gu, Xiao-Hui, Thibodeau, Rebecca Hong, Jackson, Philip S., Kiefer, James R., Knight, Jamie D., Nannini, Michelle, Narukulla, Raman, Pace, Amanda, Pang, Jodie, Purkey, Hans E., Salphati, Laurent, Sampath, Deepak, Schmidt, Stephen, Sideris, Steve, Song, Kyung, Sujatha-Bhaskar, Swathi, Ultsch, Mark, Wallweber, Heidi, Xin, Jianfeng, Yeap, SiewKuen, Young, Amy, Zhong, Yu, Staben, Steven T.
Published in Journal of medicinal chemistry (22.12.2022)
Published in Journal of medicinal chemistry (22.12.2022)
Get full text
Journal Article
Disruption of IRE1α through its kinase domain attenuates multiple myeloma
Harnoss, Jonathan M., Le Thomas, Adrien, Shemorry, Anna, Marsters, Scot A., Lawrence, David A., Lu, Min, Chen, Yung-Chia Ariel, Qing, Jing, Totpal, Klara, Kan, David, Segal, Ehud, Merchant, Mark, Reichelt, Mike, Wallweber, Heidi Ackerly, Wang, Weiru, Clark, Kevin, Kaufman, Susan, Beresini, Maureen H., Laing, Steven T., Sandoval, Wendy, Lorenzo, Maria, Wu, Jiansheng, Ly, Justin, De Bruyn, Tom, Heidersbach, Amy, Haley, Benjamin, Gogineni, Alvin, Weimer, Robby M., Lee, Dong, Braun, Marie-Gabrielle, Rudolph, Joachim, VanWyngarden, Michael J., Sherbenou, Daniel W., Gomez-Bougie, Patricia, Amiot, Martine, Acosta-Alvear, Diego, Walter, Peter, Ashkenazi, Avi
Published in Proceedings of the National Academy of Sciences - PNAS (13.08.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (13.08.2019)
Get full text
Journal Article
Discovery of Potent, Selective, and Orally Available IRE1α Inhibitors Demonstrating Comparable PD Modulation to IRE1 Knockdown in a Multiple Myeloma Model
Braun, Marie-Gabrielle, Ashkenazi, Avi, Beveridge, Ramsay E., Castanedo, Georgette, Wallweber, Heidi Ackerly, Beresini, Maureen H., Clark, Kevin R., De Bruyn, Tom, Fu, Liqiang, Gibbons, Paul, Jiang, Fan, Kaufman, Susan, Kan, David, Kiefer, James R., Leclerc, Jean-Philippe, Lemire, Alexandre, Ly, Cuong, Segal, Ehud, Sims, Jessica, Wang, Weiru, Wei, Wentao, Zhao, Liang, Schwarz, Jacob B., Rudolph, Joachim
Published in Journal of medicinal chemistry (13.06.2024)
Published in Journal of medicinal chemistry (13.06.2024)
Get full text
Journal Article
Discovery and Optimization of Selective Brain-Penetrant EBP Inhibitors that Enhance Oligodendrocyte Formation
Dorel, Ruth, Sun, Dawei, Carruthers, Nicholas, Castanedo, Georgette M., Ung, Peter M.-U., Factor, Daniel C., Li, Tianbo, Baumann, Hannah, Janota, Danielle, Pang, Jodie, Salphati, Laurent, Meklemburg, Robert, Korman, Allison J., Harper, Halie E., Stubblefield, Samantha, Payandeh, Jian, McHugh, Daniel, Lang, Bradley T., Tesar, Paul J., Dere, Edward, Masureel, Matthieu, Adams, Drew J., Volgraf, Matthew, Braun, Marie-Gabrielle
Published in Journal of medicinal chemistry (28.03.2024)
Published in Journal of medicinal chemistry (28.03.2024)
Get full text
Journal Article
Optimization of globomycin analogs as novel gram-negative antibiotics
Garland, Keira, Pantua, Homer, Braun, Marie-Gabrielle, Burdick, Daniel J., Castanedo, Georgette M., Chen, Yi-Chen, Cheng, Yun-Xing, Cheong, Jonathan, Daniels, Blake, Deshmukh, Gauri, Fu, Yuhong, Gibbons, Paul, Gloor, Susan L., Hua, Rongbao, Labadie, Sharada, Liu, Xiongcai, Pastor, Richard, Stivala, Craig, Xu, Min, Xu, Yiming, Zheng, Hao, Kapadia, Sharookh B., Hanan, Emily J.
Published in Bioorganic & medicinal chemistry letters (15.10.2020)
Published in Bioorganic & medicinal chemistry letters (15.10.2020)
Get full text
Journal Article
Green Chemistry Articles of Interest to the Pharmaceutical Industry
Braun, Marie-Gabrielle, Diorazio, Louis, Fraunhoffer, Kenneth, Hayler, John, Hickey, Matthew, Latham, Jonathan, Lovelle, Lucie E, McLaws, Mark, Parsons, Andrew T, Richardson, Paul, Roiban, Gheorghe-Doru, Roosen, Philipp C, Steven, Alan, Terrett, Jack A, White, Timothy, Yin, Jingjun
Published in Organic process research & development (20.03.2020)
Published in Organic process research & development (20.03.2020)
Get full text
Journal Article
Identification of BRaf-Sparing Amino-Thienopyrimidines with Potent IRE1α Inhibitory Activity
Beveridge, Ramsay E, Wallweber, Heidi Ackerly, Ashkenazi, Avi, Beresini, Maureen, Clark, Kevin R, Gibbons, Paul, Ghiro, Elise, Kaufman, Susan, Larivée, Alexandre, Leblanc, Melissa, Leclerc, Jean-Philippe, Lemire, Alexandre, Ly, Cuong, Rudolph, Joachim, Schwarz, Jacob B, Srivastava, Sanjay, Wang, Weiru, Zhao, Liang, Braun, Marie-Gabrielle
Published in ACS medicinal chemistry letters (10.12.2020)
Published in ACS medicinal chemistry letters (10.12.2020)
Get full text
Journal Article
Green Chemistry Articles of Interest to the Pharmaceutical Industry
Braun, Marie-Gabrielle, Díaz-Rodríguez, Alba, Diorazio, Louis, Fei, Zhongbo, Fraunhoffer, Kenneth, Hayler, John, Hickey, Matthew, McLaws, Mark, Richardson, Paul, Roiban, Gheorghe-Doru, Parsons, Andrew T, Steven, Alan, Terrett, Jack, White, Timothy, Yin, Jingjun
Published in Organic process research & development (21.06.2019)
Published in Organic process research & development (21.06.2019)
Get full text
Journal Article
Green Chemistry Articles of Interest to the Pharmaceutical Industry
Braun, Marie-Gabrielle, Díaz-Rodríguez, Alba, Diorazio, Louis, Fei, Zhongbo, Fraunhoffer, Kenneth, Hayler, John, Hickey, Matthew, Hughes, Shaun, McLaws, Mark, Richardson, Paul, Schober, Markus, Smith, Austin G, Steven, Alan, Terrett, Jack, White, Timothy, Yin, Jingjun
Published in Organic process research & development (21.12.2018)
Published in Organic process research & development (21.12.2018)
Get full text
Journal Article
Preclinical development of the PI3K Alpha selective and PIK3CA Mutant selective inhibitor GDC-0077 and prediction of its human pharmacokinetics
Pang, Jodie, Baumgardner, Matthew, Braun, Marie-Gabrielle, Cheong, Jonathan, Edgar, Kyle, Friedman, Lori, Hanan, Emily, Jaochico, Allan, Ma, Shuguang, Plise, Emile, Schmidt, Stephen, Liu, Ning, Song, Kyung, Staben, Steve, Salphati, Laurent
Published in Drug metabolism and pharmacokinetics (01.01.2019)
Published in Drug metabolism and pharmacokinetics (01.01.2019)
Get full text
Journal Article