CDH6 and HAGH protein levels in plasma associate with Alzheimer’s disease in APOE ε4 carriers
Ahmad, Shahzad, Milan, Marta del Campo, Hansson, Oskar, Demirkan, Ayse, Agustin, Ruiz, Sáez, Maria E., Giagtzoglou, Nikolaos, Cabrera-Socorro, Alfredo, Bakker, Margot H. M., Ramirez, Alfredo, Hankemeier, Thomas, Stomrud, Erik, Mattsson-Carlgren, Niklas, Scheltens, Philip, van der Flier, Wiesje M., Ikram, M. Arfan, Malarstig, Anders, Teunissen, Charlotte E., Amin, Najaf, van Duijn, Cornelia M.
Published in Scientific reports (19.05.2020)
Published in Scientific reports (19.05.2020)
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Association of lysophosphatidic acids with cerebrospinal fluid biomarkers and progression to Alzheimer’s disease
Ahmad, Shahzad, Orellana, Adelina, Kohler, Isabelle, Frölich, Lutz, de Rojas, Itziar, Gil, Silvia, Boada, Mercè, Hernández, Isabel, Hausner, Lucrezia, Bakker, Margot H. M, Cabrera-Socorro, Alfredo, Amin, Najaf, Ramírez, Alfredo, Ruiz, Agustín, Hankemeier, Thomas, Van Duijn, Cornelia M
Published in Alzheimer's research & therapy (02.10.2020)
Published in Alzheimer's research & therapy (02.10.2020)
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Association of oxidative stress and inflammatory metabolites with Alzheimer's disease cerebrospinal fluid biomarkers in mild cognitive impairment
Ahmad, Shahzad, Yang, Wei, Orellana, Adelina, Frölich, Lutz, de Rojas, Itziar, Cano, Amanda, Boada, Mercè, Hernández, Isabel, Hausner, Lucrezia, Harms, Amy C, Bakker, Margot H M, Cabrera-Socorro, Alfredo, Amin, Najaf, Ramírez, Alfredo, Ruiz, Agustín, Van Duijn, Cornelia M, Hankemeier, Thomas
Published in Alzheimer's research & therapy (30.07.2024)
Published in Alzheimer's research & therapy (30.07.2024)
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Generation of a set of isogenic iPSC lines carrying all APOE genetic variants (Ɛ2/Ɛ3/Ɛ4) and knock-out for the study of APOE biology in health and disease
Schmid, Benjamin, Holst, Bjørn, Clausen, Christian, Bahnassawy, Lamiaa, Reinhardt, Peter, Bakker, Margot H.M., Díaz-Guerra, Eva, Vicario, Carlos, Martino-Adami, Pamela V., Thoenes, Michaela, Ramirez, Alfredo, Fliessbach, Klaus, Grezella, Clara, Brüstle, Oliver, Peitz, Michael, Ebneth, Andreas, Cabrera-Socorro, Alfredo
Published in Stem cell research (01.04.2021)
Published in Stem cell research (01.04.2021)
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Role of Rho kinase pathway in chondroitin sulfate proteoglycan-mediated inhibition of neurite outgrowth in PC12 cells
Gopalakrishnan, Sujatha M., Teusch, Nicole, Imhof, Christiane, Bakker, Margot H. M., Schurdak, Mark, Burns, David J., Warrior, Usha
Published in Journal of neuroscience research (01.08.2008)
Published in Journal of neuroscience research (01.08.2008)
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Identification and characterization of mGlu3 ligands using a high throughput FLIPR assay for detection of agonists, antagonists, and allosteric modulators
Pratt, Steven D, Mezler, Mario, Geneste, Hervé, Bakker, Margot H M, Hajduk, Philip J, Gopalakrishnan, Sujatha M
Published in Combinatorial chemistry & high throughput screening (01.08.2011)
Published in Combinatorial chemistry & high throughput screening (01.08.2011)
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Synthesis and SAR of highly potent dual 5-HT1A and 5-HT1B antagonists as potential antidepressant drugs
KLING, Andreas, LANGE, Udo E. W, UNGER, Liliane, WICKE, Karsten, SCHELLHAAS, Kurt, STEINER, Gerd, MACK, Helmut, BAKKER, Margot H. M, DRESCHER, Karla U, HORNBERGER, Wilfried, HUTCHINS, Charles W, MÖLLER, Achim, MÜLLER, Reinhold, SCHMIDT, Martin
Published in Bioorganic & medicinal chemistry letters (15.12.2005)
Published in Bioorganic & medicinal chemistry letters (15.12.2005)
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Tricyclic isoxazolines : Identification of R226161 as a potential new antidepressant that combines potent serotonin reuptake inhibition and α2-adrenoceptor antagonism
IGNACIO ANDRES, J, ALCAZAR, Jesus, FONT, Luis M, ITURRINO, Laura, LANGLOIS, Xavier, LENAERTS, Ilse, MARTINEZ, Sonia, MEGENS, Anton A, PASTOR, Joaquin, PULLAN, Shirley, STECKLER, Thomas, ALONSO, José M, ALVAREZ, Rosa M, BAKKER, Margot H, BIESMANS, Ilse, CID, José M, DE LUCAS, Ana I, DRINKENBURG, Wilhelmus, FERNANDEZ, Javier
Published in Bioorganic & medicinal chemistry (01.06.2007)
Published in Bioorganic & medicinal chemistry (01.06.2007)
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Discovery of a New Series of Centrally Active Tricyclic Isoxazoles Combining Serotonin (5-HT) Reuptake Inhibition with α2-Adrenoceptor Blocking Activity
Andrés, J. Ignacio, Alcázar, Jesús, Alonso, José M, Alvarez, Rosa M, Bakker, Margot H, Biesmans, Ilse, Cid, José M, De Lucas, Ana I, Fernández, Javier, Font, Luis M, Hens, Koen A, Iturrino, Laura, Lenaerts, Ilse, Martínez, Sonia, Megens, Anton A, Pastor, Joaquín, Vermote, Patrick C. M, Steckler, Thomas
Published in Journal of medicinal chemistry (24.03.2005)
Published in Journal of medicinal chemistry (24.03.2005)
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Synthesis of 3a, 4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazoles, displaying combined 5-HT uptake inhibiting and α2-Adrenoceptor antagonistic activities: A novel series of potential antidepressants
IGNACIO ANDRES, J, ALCAZAR, Jesus, BAKKER, Margot H, BIESMANS, Ilse, HEYLEN, Lieve I, MEGENS, Anton A, ALONSO, José M, ALVAREZ, Rosa M, CID, José M, DE LUCAS, Ana I, FERNANDEZ, Javier, MARTINEZ, Sonia, NIETO, Carmen, PASTOR, Joaquin
Published in Bioorganic & medicinal chemistry letters (18.08.2003)
Published in Bioorganic & medicinal chemistry letters (18.08.2003)
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Synthesis of 3a, 4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazoles, displaying combined 5-HT uptake inhibiting and α2-adrenoceptor antagonistic activities. Part 2: Further exploration on the cinnamyl moiety
PASTOR, Joaquin, ALCAZAR, Jesus, LAFUENTE, Celia, MARTINEZ, Sonia, BAKKER, Margot H, BIESMANS, Ilse, HEYLEN, Lieve I, MEGENS, Anton A, ALVAREZ, Rosa M, ANDRES, J. Ignacio, CID, José M, DE LUCAS, Ana I, DIAZ, Adolfo, FERNANDEZ, Javier, FONT, Luis M, ITURRINO, Laura
Published in Bioorganic & medicinal chemistry letters (07.06.2004)
Published in Bioorganic & medicinal chemistry letters (07.06.2004)
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Investigating the Role of APOE Genotype in Human Microglia
Ulm, Brittany, Amin, Najaf, Bahnassawy, Lamiaa, Reinhardt, Peter, Curado, Marco Rocha, Peitz, Michael, Fliessbach, Klaus, Ramirez, Alfredo, Ruiz, Agustin, Ried, Janina S, Bakker, Margot H.M., Van Duijn, Cornelia M
Published in Alzheimer's & dementia (01.12.2023)
Published in Alzheimer's & dementia (01.12.2023)
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Cross‐omics studies of the role of apolipoprotein E in Alzheimer’s disease and dementia: Searching common pathways in patients, populations and cellular models: Alzheimer's disease apolipoprotein pathology for treatment elucidation and development: The adapted project results
van Duijn, Cornelia M., Ahmad, Shahzad, Sáez, María Eugenia, Bennett, Keiryn, Socorro, Alfredo Cabrera, Bakker, Margot H.M., Ramirez, Alfredo, Ruiz, Agustín, Hankemeier, Thomas
Published in Alzheimer's & dementia (01.12.2020)
Published in Alzheimer's & dementia (01.12.2020)
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Cross‐omics studies of the role of apolipoprotein E in Alzheimer’s disease and dementia: Searching common pathways in patients, populations and cellular models
van Duijn, Cornelia M., Ahmad, Shahzad, Sáez, María Eugenia, Bennett, Keiryn, Socorro, Alfredo Cabrera, Bakker, Margot H.M., Ramirez, Alfredo, Ruiz, Agustín, Hankemeier, Thomas
Published in Alzheimer's & dementia (01.12.2020)
Published in Alzheimer's & dementia (01.12.2020)
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Characterization of transcriptional and proteomics changes in brain cells derived from isogenic hiPSCs reveals cell type–and genotype‐specific mechanisms modified by APOE: Alzheimer's disease apolipoprotein pathology for treatment elucidation and development: The adapted project results
Ried, Janina S., Curado, Marco Rocha, Sáez, María Eugenia, Bahnassawy, Lamiaa, Lee, Heyne, Reinhardt, Peter, Mohler, Eric G., Madrid, Laura, Socorro, Alfredo Cabrera, Grezella, Clara, Nicolas, Armel, Rao, Francesco, Ramaswamy, Gayathri, Bakker, Margot H.M.
Published in Alzheimer's & dementia (01.12.2020)
Published in Alzheimer's & dementia (01.12.2020)
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Multilayer OMICS characterization of APOE‐modulated isogenic hiPSCs elucidates cell‐type–specific mechanisms modified by APOE: A study of the IMI ADAPTED Consortium: Genetics/omics and systems biology
Ried, Janina S., Curado, Marco Rocha, Sáez, María Eugenia, Bahnassawy, Lamiaa, Lee, Heyne, Reinhardt, Peter, Mohler, Eric G., Madrid, Laura, Socorro, Alfredo Cabrera, Grezella, Clara, Nicolas, Armel, Rao, Francesco, Ramaswamy, Gayathri, Bakker, Margot H.M.
Published in Alzheimer's & dementia (01.12.2020)
Published in Alzheimer's & dementia (01.12.2020)
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Proteomic, metabolomic, and transcriptomic examination of APOE transgenic mice: Genetics/omics and systems biology
Mohler, Eric G., Ried, Janina S., Bahnassawy, Lamiaa, Reinhardt, Peter, Curado, Marco Rocha, Bakker, Margot H.M., Nicolas, Armel, Rao, Francesco, Kohler, Isabelle, Hankemeier, Thomas, Ramaswamy, Gayathri, Sáez, María Eugenia
Published in Alzheimer's & dementia (01.12.2020)
Published in Alzheimer's & dementia (01.12.2020)
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Journal Article
Multilayer OMICS characterization of APOE‐modulated isogenic hiPSCs elucidates cell‐type–specific mechanisms modified by APOE: A study of the IMI ADAPTED Consortium
Ried, Janina S., Curado, Marco Rocha, Sáez, María Eugenia, Bahnassawy, Lamiaa, Lee, Heyne, Reinhardt, Peter, Mohler, Eric G., Madrid, Laura, Socorro, Alfredo Cabrera, Grezella, Clara, Nicolas, Armel, Rao, Francesco, Ramaswamy, Gayathri, Bakker, Margot H.M.
Published in Alzheimer's & dementia (01.12.2020)
Published in Alzheimer's & dementia (01.12.2020)
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Modelling AD‐relevant pathophysiology in neurons, astrocytes and microglia from two complete sets of isogenic iPSC lines generated by the ADAPTED project
Socorro, Alfredo Cabrera, Schmid, Benjamin, Clausen, Christian, Holst, Bjørn, Peitz, Michael, Grezella, Clara, Brustle, Oliver, Bahnassawy, Lamiaa, Bennett, Keiryn, Ried, Janina S., Sáez, María Eugenia, Ramaswamy, Gayathri, Ruiz, Agustin, Bakker, Margot H.M., Vicario, Carlos, Lourenco, Teresa Silva, Reinhardt, Peter
Published in Alzheimer's & dementia (01.12.2020)
Published in Alzheimer's & dementia (01.12.2020)
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Proteomic, metabolomic, and transcriptomic examination of APOE transgenic mice
Mohler, Eric G., Ried, Janina S., Bahnassawy, Lamiaa, Reinhardt, Peter, Curado, Marco Rocha, Bakker, Margot H.M., Nicolas, Armel, Rao, Francesco, Kohler, Isabelle, Hankemeier, Thomas, Ramaswamy, Gayathri, Sáez, María Eugenia
Published in Alzheimer's & dementia (01.12.2020)
Published in Alzheimer's & dementia (01.12.2020)
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