A Small Molecule Inhibitor of Sarcomere Contractility Acutely Relieves Left Ventricular Outflow Tract Obstruction in Feline Hypertrophic Cardiomyopathy
Stern, Joshua A, Markova, Svetlana, Ueda, Yu, Kim, Jae B, Pascoe, Peter J, Evanchik, Marc J, Green, Eric M, Harris, Samantha P
Published in PloS one (14.12.2016)
Published in PloS one (14.12.2016)
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A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice
Green, Eric M., Wakimoto, Hiroko, Anderson, Robert L., Evanchik, Marc J., Gorham, Joshua M., Harrison, Brooke C., Henze, Marcus, Kawas, Raja, Oslob, Johan D., Rodriguez, Hector M., Song, Yonghong, Wan, William, Leinwand, Leslie A., Spudich, James A., McDowell, Robert S., Seidman, J. G., Seidman, Christine E.
Published in Science (American Association for the Advancement of Science) (05.02.2016)
Published in Science (American Association for the Advancement of Science) (05.02.2016)
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Telemetered left-ventricular pressure in Yucatan mini-pigs: Chronic evaluation in a novel genetic model of non-obstructed hypertrophic cardiomyopathy
Geist, Beth, Youngblood, Bradley L., Ueyama, Yukie, LaRose, Amanda, Hamlin, Robert, Evanchik, Marc J., del Rio, Carlos
Published in Journal of pharmacological and toxicological methods (01.09.2019)
Published in Journal of pharmacological and toxicological methods (01.09.2019)
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Simultaneous integration of telemetered left-ventricular pressure and echocardiography in rats: Minimally-invasive serial pressure-volume relationships in the setting of normal and impaired diastolic function
del Rio, Carlos L., Zambataro, Christopher, Bogie, Heather, Yucel, A.J., Ferguson, Brain, Henze, Marcus P., Fernandes, Sarah, Evanchik, Marc J.
Published in Journal of pharmacological and toxicological methods (01.09.2019)
Published in Journal of pharmacological and toxicological methods (01.09.2019)
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Metabolism of (+)-1,4-Dihydro-7-(trans-3-methoxy-4-methylamino-1-pyrrolidinyl)-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic Acid (Voreloxin; Formerly SNS-595), a Novel Replication-Dependent DNA-Damaging Agent
EVANCHIK, Marc J, ALLEN, Darin, YOBURN, Josh C, SILVERMAN, Jeffrey A, HOCH, Ute
Published in Drug metabolism and disposition (01.03.2009)
Published in Drug metabolism and disposition (01.03.2009)
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Discovery and Development of Potent LFA-1/ICAM-1 Antagonist SAR 1118 as an Ophthalmic Solution for Treating Dry Eye
Zhong, Min, Gadek, Thomas R, Bui, Minna, Shen, Wang, Burnier, John, Barr, Kenneth J, Hanan, Emily J, Oslob, Johan D, Yu, Chul H, Zhu, Jiang, Arkin, Michelle R, Evanchik, Marc J, Flanagan, W. Mike, Hoch, Ute, Hyde, Jennifer, Prabhu, Saileta, Silverman, Jeffrey A, Wright, Jasmin
Published in ACS medicinal chemistry letters (08.03.2012)
Published in ACS medicinal chemistry letters (08.03.2012)
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SNS-314, a pan-Aurora kinase inhibitor, shows potent anti-tumor activity and dosing flexibility in vivo
Arbitrario, Jennifer P, Belmont, Brian J, Evanchik, Marc J, Flanagan, W. Michael, Fucini, Raymond V, Hansen, Stig K, Harris, Shannon O, Hashash, Ahmad, Hoch, Ute, Hogan, Jennifer N, Howlett, Anthony R, Jacobs, Jeffrey W, Lam, Joni W, Ritchie, Sean C, Romanowski, Michael J, Silverman, Jeffrey A, Stockett, David E, Teague, Juli N, Zimmerman, Kristin M, Taverna, Pietro
Published in Cancer chemotherapy and pharmacology (01.03.2010)
Published in Cancer chemotherapy and pharmacology (01.03.2010)
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Imidazopyridine-Based Fatty Acid Synthase Inhibitors That Show Anti-HCV Activity and in Vivo Target Modulation
Oslob, Johan D, Johnson, Russell J, Cai, Haiying, Feng, Shirley Q, Hu, Lily, Kosaka, Yuko, Lai, Julie, Sivaraja, Mohanram, Tep, Samnang, Yang, Hanbiao, Zaharia, Cristiana A, Evanchik, Marc J, McDowell, Robert S
Published in ACS medicinal chemistry letters (10.01.2013)
Published in ACS medicinal chemistry letters (10.01.2013)
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Structure–activity relationship (SAR) of the α-amino acid residue of potent tetrahydroisoquinoline (THIQ)-derived LFA-1/ICAM-1 antagonists
Zhong, Min, Hanan, Emily J., Shen, Wang, Bui, Minna, Arkin, Michelle R., Barr, Kenneth J., Evanchik, Marc J., Hoch, Ute, Hyde, Jennifer, Martell, Jose R., Oslob, Johan D., Paulvannan, Kumar, Prabhu, Saileta, Silverman, Jeffrey A., Wright, Jasmin, Yu, Chul H., Zhu, Jiang, Flanagan, W. Mike
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
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Design and synthesis of 2-amino-pyrazolopyridines as Polo-like kinase 1 inhibitors
Fucini, Raymond V., Hanan, Emily J., Romanowski, Michael J., Elling, Robert A., Lew, Willard, Barr, Kenneth J., Zhu, Jiang, Yoburn, Joshua C., Liu, Yang, Fahr, Bruce T., Fan, Junfa, Lu, Yafan, Pham, Phuongly, Choong, Ingrid C., VanderPorten, Erica C., Bui, Minna, Purkey, Hans E., Evanchik, Marc J., Yang, Wenjin
Published in Bioorganic & medicinal chemistry (15.10.2008)
Published in Bioorganic & medicinal chemistry (15.10.2008)
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Discovery of tetrahydroisoquinoline (THIQ) derivatives as potent and orally bioavailable LFA-1/ICAM-1 antagonists
Zhong, Min, Shen, Wang, Barr, Kenneth J., Arbitrario, Jennifer P., Arkin, Michelle R., Bui, Minna, Chen, Teresa, Cunningham, Brian C., Evanchik, Marc J., Hanan, Emily J., Hoch, Ute, Huen, Karen, Hyde, Jennifer, Kumer, Jeffery L., Lac, Teresa, Lawrence, Chris E., Martell, Jose R., Oslob, Johan D., Paulvannan, Kumar, Prabhu, Saileta, Silverman, Jeffrey A., Wright, Jasmin, Yu, Chul H., Zhu, Jiang, Flanagan, W. Mike
Published in Bioorganic & medicinal chemistry letters (01.09.2010)
Published in Bioorganic & medicinal chemistry letters (01.09.2010)
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Abstract We094: Acute Administration of The Novel Cardiac Sarcomere Modulator EDG-7500, Improves Ventricular Filling While Preserving LVEF In Dogs with Pacing Induced Left-Ventricular Systolic Dysfunction
Evanchik, Marc, Emter, Craig, Del Rio, carlos, Roof, Steve, St Clair, Sydney, Russell, Alan, Henze, Marcus, Semigran, marc
Published in Circulation research (02.08.2024)
Published in Circulation research (02.08.2024)
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CHRONIC TREATMENT WITH THE NOVEL SARCOMERE MODULATOR EDG-7500 IMPROVES LEFT VENTRICULAR DISTENSIBILITY AND CARDIAC OUTPUT RECRUITMENT UNDER STRESS IN A MINIPIG GENETIC MODEL OF NON-OBSTRUCTED HYPERTROPHIC CARDIOMYOPATHY
Evanchik, Marc, Emter, Craig, del Rio, Carlos L., Dinatale, Emily, Henze, Marcus, Roof, Steve, St Clair, Sydney, Lee, Lindsey, Peter, Angela, Russell, Alan, Semigran, Marc J.
Published in Journal of the American College of Cardiology (02.04.2024)
Published in Journal of the American College of Cardiology (02.04.2024)
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Abstract 15822: Cardiac Effects of EDG-7500, a Novel Cardiac Sarcomere Regulator: In vitro and in vivo Evidence for Slowing Isovolumic Contraction and Improved Ventricular Compliance
Del Rio, Carlos L, Ma, Weikang, Irving, Thomas, Roof, Steve, Tolley, Jessica, Duvall, Mike, Hawryluk, Natalie, RUSSELL, ALAN, Semigran, marc, Evanchik, Marc
Published in Circulation (New York, N.Y.) (07.11.2023)
Published in Circulation (New York, N.Y.) (07.11.2023)
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Abstract 15612: EDG-7500, a Novel Cardiac Sarcomere Regulator That Preserves Intrinsic Myosin-Motor Function, Improves Cardiac Function and Reserve in a Minipig Model of Hypertrophic Cardiomyopathy
Del Rio, Carlos L, Rupert, Cassady, Tolley, Jessica, Duvall, Mike, Emter, Craig, DiNatale, Emy, Hawryluk, Natalie, RUSSELL, ALAN, Semigran, marc, Evanchik, Marc
Published in Circulation (New York, N.Y.) (07.11.2023)
Published in Circulation (New York, N.Y.) (07.11.2023)
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In vitro and in vivo pharmacokinetic characterization of mavacamten, a first-in-class small molecule allosteric modulator of beta cardiac myosin
Grillo, Mark P., Erve, John C. L., Dick, Ryan, Driscoll, James P., Haste, Nicole, Markova, Svetlana, Brun, Priscilla, Carlson, Timothy J., Evanchik, Marc
Published in Xenobiotica (03.06.2019)
Published in Xenobiotica (03.06.2019)
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Direct and selective myosin-inhibition stabilizes the super-relaxed state of myosin and blunts post-tetanic potentiation in fast-skeletal muscle
Stamper, Breanne, Lehman, Sarah, Madden, Molly, DuVall, Mike, Qian, Ying, Evanchik, Marc, Barthel, Ben, del Rio, Carlos L., Russell, Alan J.
Published in Biophysical journal (11.02.2022)
Published in Biophysical journal (11.02.2022)
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EDG-002, A NOVEL TARGETED SARCOMERE REGULATOR PRESERVES INTRINSIC MYOSIN-MOTOR FUNCTION, BLUNTS HYPERCONTRACTILITY AND ELIMINATES LVOT OBSTRUCTION IN CATS WITH HYPERTROPHIC CARDIOMYOPATHY: IN VITRO AND IN VIVO EVIDENCE
Kaplan, Joanna, Lehman, Sarah, Duvall, Mike, Madden, Molly, Tolley, Jessica, Hawryluk, Natalie, Schlachter, Stephen, Rivas, Victor, Jauregui, Carina, Crofton, Amanda, Harris, Samantha, Stern, Joshua Aaron, del Rio, Carlos L., Russell, Alan, Evanchik, Marc
Published in Journal of the American College of Cardiology (07.03.2023)
Published in Journal of the American College of Cardiology (07.03.2023)
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Isoflurane Anesthesia Masks Elevated Filling Pressures in Hypertensive Rats with Diastolic Dysfunction and Preserved Ejection Fraction: Comparison to Ketamine/Xylaxine Sedation
Zambataro, Christopher A., Ferguson, Brian S., Henze, Marcus P., Evanchik, Marc J., Del Rio, Carlos L.
Published in Journal of molecular and cellular cardiology (01.11.2018)
Published in Journal of molecular and cellular cardiology (01.11.2018)
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Safety and efficacy of vebicorvir administered with entecavir in treatment-naïve patients with chronic hepatitis B virus infection
Sulkowski, Mark S., Agarwal, Kosh, Ma, Xiaoli, Nguyen, Tuan T., Schiff, Eugene R., Hann, Hie-Won L., Dieterich, Douglas T., Nahass, Ronald G., Park, James S., Chan, Sing, Han, Steven-Huy B., Gane, Edward J., Bennett, Michael, Alves, Katia, Evanchik, Marc, Yan, Ran, Huang, Qi, Lopatin, Uri, Colonno, Richard, Ma, Julie, Knox, Steven J., Stamm, Luisa M., Bonacini, Maurizio, Jacobson, Ira M., Ayoub, Walid S., Weilert, Frank, Ravendhran, Natarajan, Ramji, Alnoor, Kwo, Paul Yien, Elkhashab, Magdy, Hassanein, Tarek, Bae, Ho S., Lalezari, Jacob P., Fung, Scott K., Yuen, Man-Fung
Published in Journal of hepatology (01.11.2022)
Published in Journal of hepatology (01.11.2022)
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