Discovery of N‑(4-(2,4-Difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro‑1H‑pyrrolo[2,3‑c]pyridin-4-yl)phenyl)ethanesulfonamide (ABBV-075/Mivebresib), a Potent and Orally Available Bromodomain and Extraterminal Domain (BET) Family Bromodomain Inhibitor
McDaniel, Keith F, Wang, Le, Soltwedel, Todd, Fidanze, Steven D, Hasvold, Lisa A, Liu, Dachun, Mantei, Robert A, Pratt, John K, Sheppard, George S, Bui, Mai H, Faivre, Emily J, Huang, Xiaoli, Li, Leiming, Lin, Xiaoyu, Wang, Rongqi, Warder, Scott E, Wilcox, Denise, Albert, Daniel H, Magoc, Terrance J, Rajaraman, Ganesh, Park, Chang H, Hutchins, Charles W, Shen, Jianwei J, Edalji, Rohinton P, Sun, Chaohong C, Martin, Ruth, Gao, Wenqing, Wong, Shekman, Fang, Guowei, Elmore, Steven W, Shen, Yu, Kati, Warren M
Published in Journal of medicinal chemistry (26.10.2017)
Published in Journal of medicinal chemistry (26.10.2017)
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Enabling, Decagram-Scale Synthesis of Macrocyclic MCL‑1 Inhibitor ABBV-467
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Published in Journal of organic chemistry (17.11.2023)
Published in Journal of organic chemistry (17.11.2023)
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Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain Inhibitors
Wang, Le, Pratt, John K, Soltwedel, Todd, Sheppard, George S, Fidanze, Steven D, Liu, Dachun, Hasvold, Lisa A, Mantei, Robert A, Holms, James H, McClellan, William J, Wendt, Michael D, Wada, Carol, Frey, Robin, Hansen, T. Matthew, Hubbard, Robert, Park, Chang H, Li, Leiming, Magoc, Terrance J, Albert, Daniel H, Lin, Xiaoyu, Warder, Scott E, Kovar, Peter, Huang, Xiaoli, Wilcox, Denise, Wang, Rongqi, Rajaraman, Ganesh, Petros, Andrew M, Hutchins, Charles W, Panchal, Sanjay C, Sun, Chaohong, Elmore, Steven W, Shen, Yu, Kati, Warren M, McDaniel, Keith F
Published in Journal of medicinal chemistry (11.05.2017)
Published in Journal of medicinal chemistry (11.05.2017)
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Discovery and optimization of novel constrained pyrrolopyridone BET family inhibitors
Fidanze, Steven D., Liu, Dachun, Mantei, Robert A., Hasvold, Lisa A., Pratt, John K., Sheppard, George S., Wang, Le, Holms, James H., Dai, Yujia, Aguirre, Ana, Bogdan, Andrew, Dietrich, Justin D., Marjanovic, Jasmina, Park, Chang H., Hutchins, Charles W., Lin, Xiaoyu, Bui, Mai H., Huang, Xiaoli, Wilcox, Denise, Li, Leiming, Wang, Rongqi, Kovar, Peter, Magoc, Terrance J., Rajaraman, Ganesh, Albert, Daniel H., Shen, Yu, Kati, Warren M., McDaniel, Keith F.
Published in Bioorganic & medicinal chemistry letters (01.06.2018)
Published in Bioorganic & medicinal chemistry letters (01.06.2018)
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Methylpyrrole inhibitors of BET bromodomains
Hasvold, Lisa A., Sheppard, George S., Wang, Le, Fidanze, Steven D., Liu, Dachun, Pratt, John K., Mantei, Robert A., Wada, Carol K., Hubbard, Robbert, Shen, Yu, Lin, Xiaoyu, Huang, Xiaoli, Warder, Scott E., Wilcox, Denise, Li, Leiming, Buchanan, F. Greg, Smithee, Lauren, Albert, Daniel H., Magoc, Terrance J., Park, Chang H., Petros, Andrew M., Panchal, Sanjay C., Sun, Chaohong, Kovar, Peter, Soni, Nirupama B., Elmore, Steven W., Kati, Warren M., McDaniel, Keith F.
Published in Bioorganic & medicinal chemistry letters (15.05.2017)
Published in Bioorganic & medicinal chemistry letters (15.05.2017)
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Substituted 4-amino-1H-pyrazolo[3,4-d]pyrimidines as multi-targeted inhibitors of insulin-like growth factor-1 receptor (IGF1R) and members of ErbB-family receptor kinases
WANG, Gary T, MANTEI, Robert A, BOUSKA, Jennifer, JIEYI WANG, DAVIDSEN, Steven K, BELL, Randy L, SHEPPARD, George S, HUBBARD, Robert D, WILSBACHER, Julie L, QIAN ZHANG, TUCKER, Lora, XIAOMING HU, KOVAR, Peter, JOHNSON, Eric F, OSTERLING, Donald J
Published in Bioorganic & medicinal chemistry letters (15.10.2010)
Published in Bioorganic & medicinal chemistry letters (15.10.2010)
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Discovery and Optimization of Anthranilic Acid Sulfonamides as Inhibitors of Methionine Aminopeptidase-2: A Structural Basis for the Reduction of Albumin Binding
Sheppard, George S, Wang, Jieyi, Kawai, Megumi, Fidanze, Steve D, BaMaung, Nwe Y, Erickson, Scott A, Barnes, David M, Tedrow, Jason S, Kolaczkowski, Lawrence, Vasudevan, Anil, Park, David C, Wang, Gary T, Sanders, William J, Mantei, Robert A, Palazzo, Fabio, Tucker-Garcia, Lora, Lou, Pingping, Zhang, Qian, Park, Chang H, Kim, Ki H, Petros, Andrew, Olejniczak, Edward, Nettesheim, David, Hajduk, Phillip, Henkin, Jack, Lesniewski, Richard, Davidsen, Steven K, Bell, Randy L
Published in Journal of medicinal chemistry (29.06.2006)
Published in Journal of medicinal chemistry (29.06.2006)
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1-(5-Chloro-2-alkoxyphenyl)-3-(5-cyano- pyrazi-2-yl)ureas as Potent and Selective Inhibitors of Chk1 Kinase: Synthesis, Preliminary SAR, and Biological Activities
Wang, Gary T, Li, Gaoquan, Mantei, Robert A, Chen, Zehan, Kovar, Peter, Gu, Wendy, Xiao, Zhan, Zhang, Haiying, Sham, Hing L, Sowin, Thomas, Rosenberg, Saul H, Lin, Nan-Horng
Published in Journal of medicinal chemistry (05.05.2005)
Published in Journal of medicinal chemistry (05.05.2005)
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Lead optimization of methionine aminopeptidase-2 (MetAP2) inhibitors containing sulfonamides of 5,6-disubstituted anthranilic acids
Wang, Gary T., Mantei, Robert A., Kawai, Megumi, Tedrow, Jason S., Barnes, David M., Wang, Jieyi, Zhang, Qian, Lou, Pingping, Garcia, Lora A., Bouska, Jennifer, Yates, Melinda, Park, Chang, Judge, Russell A., Lesniewski, Richard, Sheppard, George S., Bell, Randy L.
Published in Bioorganic & medicinal chemistry letters (15.05.2007)
Published in Bioorganic & medicinal chemistry letters (15.05.2007)
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2,4-Diarylpyrrolidine-3-carboxylic AcidsPotent ETA Selective Endothelin Receptor Antagonists. 1. Discovery of A-127722
Winn, Martin, von Geldern, Thomas W, Opgenorth, Terry J, Jae, Hwan-Soo, Tasker, Andrew S, Boyd, Steven A, Kester, Jeffrey A, Mantei, Robert A, Bal, Radhika, Sorensen, Bryan K, Wu-Wong, Jinshyun R, Chiou, William J, Dixon, Douglas B, Novosad, Eugene I, Hernandez, Lisa, Marsh, Kennan C
Published in Journal of medicinal chemistry (01.03.1996)
Published in Journal of medicinal chemistry (01.03.1996)
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Pyridone-Containing farnesyltransferase inhibitors: synthesis and biological evaluation
Hasvold, Lisa A., Wang, Weibo, Gwaltney, Stephen L., Rockway, Todd W., Nelson, Lissa T.J., Mantei, Robert A., Fakhoury, Stephen A., Sullivan, Gerard M., Li, Qun, Lin, Nan-Horng, Wang, Le, Zhang, Haiying, Cohen, Jerome, Gu, Wen-Zhen, Marsh, Kennan, Bauch, Joy, Rosenberg, Saul, Sham, Hing L.
Published in Bioorganic & medicinal chemistry letters (17.11.2003)
Published in Bioorganic & medicinal chemistry letters (17.11.2003)
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Sulfonamide derivatives as Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases
MANTEI ROBERT A, WANG GARY T, PARK CHANG H, HASVOLD LISA, PARK, CHEOL MIN, WANG LE, SONG XIAOHONG, ELMORE STEVEN W, BRUNCKO MILAN, SULLIVAN GERARD M, SOUERS ANDREW J, WANG XILU, MCCLELLAN WILLIAM J, TAO ZHI FU, PETROS ANDREW M, WENDT MICHAEL D, DOHERTY GEORGE A, DING HONG, HEXAMER LAURA, KUNZER AARON R
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Year of Publication 10.11.2015
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Year of Publication 10.11.2015
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Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
MANTEI ROBERT A, WANG GARY T, PARK CHANG H, HASVOLD LISA, PARK, CHEOL MIN, WANG LE, DAI YUJIA, SONG XIAOHONG, ELMORE STEVEN W, BRUNCKO MILAN, SULLIVAN GERARD M, SOUERS ANDREW J, WANG XILU, MCCLELLAN WILLIAM J, TAO ZHI FU, PETROS ANDREW M, WENDT MICHAEL D, DOHERTY GEORGE A, DING HONG, HEXAMER LAURA, KUNZER AARON R
Year of Publication 07.12.2016
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Year of Publication 07.12.2016
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BROMODOMAIN INHIBITORS
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Year of Publication 24.09.2014
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Year of Publication 24.09.2014
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Discovery of a series of pyrrolidine-based endothelin receptor antagonists with enhanced ET A receptor selectivity
Boyd, Steven A, Mantei, Robert A, Tasker, Andrew S, Liu, Gang, Sorensen, Bryan K, Henry Jr, Kenneth J, von Geldern, Thomas W, Winn, Martin, Wu-Wong, Jinshyun R, Chiou, William J, Dixon, Douglas B, Hutchins, Charles W, Marsh, Kennan C, Nguyen, Bach, Opgenorth, Terry J
Published in Bioorganic & medicinal chemistry (01.06.1999)
Published in Bioorganic & medicinal chemistry (01.06.1999)
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APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES
MANTEI ROBERT A, WANG GARY T, PARK CHANG H, HASVOLD LISA, PARK, CHEOL MIN, HANSEN TODD M, WANG LE, DAI YUJIA, SONG XIAOHONG, ELMORE STEVEN W, BRUNCKO MILAN, KUNZER AARON, SULLIVAN GERARD M, SOUERS ANDREW J, WANG XILU, MCCLELLAN WILLIAM J, TAO ZHI FU, PETROS ANDREW M, WENDT MICHAEL D, DOHERTY GEORGE A, DING HONG, HEXAMER LAURA
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Year of Publication 09.04.2013
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SULFONAMIDE DERIVATIVES AS BCL-2-SELECTIVE APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE DISEASES
MANTEI ROBERT A, WANG GARY T, PARK CHANG H, HASVOLD LISA, PARK, CHEOL MIN, HANSEN TODD M, WANG LE, SONG XIAOHONG, ELMORE STEVEN W, BRUNCKO MILAN, KUNZER AARON, SULLIVAN GERARD M, SOUERS ANDREW J, WANG XILU, MCCLELLAN WILLIAM J, TAO ZHI FU, PETROS ANDREW M, WENDT MICHAEL D, DOHERTY GEORGE A, DING HONG, HEXAMER LAURA
Year of Publication 12.12.2012
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Year of Publication 12.12.2012
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Nonpeptide Renin Inhibitors with Good Intraduodenal Bioavailability and Efficacy in Dog
Boyd, Steven A, Fung, Anthony K. L, Baker, William R, Mantei, Robert A, Stein, Herman H, Cohen, Jerome, Barlow, Jennifer L, Klinghofer, Vered, Wessale, Jerry L
Published in Journal of medicinal chemistry (01.09.1994)
Published in Journal of medicinal chemistry (01.09.1994)
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SULFONAMIDE DERIVATIVES AS BCL-2-SELECTIVE APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE DISEASES
MANTEI ROBERT A, WANG GARY T, PARK CHANG H, HASVOLD LISA, PARK, CHEOL MIN, WANG LE, SONG XIAOHONG, ELMORE STEVEN W, BRUNCKO MILAN, SULLIVAN GERARD M, SOUERS ANDREW J, WANG XILU, MCCLELLAN WILLIAM J, TAO ZHI FU, PETROS ANDREW M, WENDT MICHAEL D, DOHERTY GEORGE A, DING HONG, HEXAMER LAURA, KUNZER AARON R
Year of Publication 20.09.2011
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Year of Publication 20.09.2011
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