The (in)famous GWAS P-value threshold revisited and updated for low-frequency variants
Fadista, João, Manning, Alisa K, Florez, Jose C, Groop, Leif
Published in European journal of human genetics : EJHG (01.08.2016)
Published in European journal of human genetics : EJHG (01.08.2016)
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Journal Article
Variance-quantitative trait loci enable systematic discovery of gene-environment interactions for cardiometabolic serum biomarkers
Westerman, Kenneth E., Majarian, Timothy D., Giulianini, Franco, Jang, Dong-Keun, Miao, Jenkai, Florez, Jose C., Chen, Han, Chasman, Daniel I., Udler, Miriam S., Manning, Alisa K., Cole, Joanne B.
Published in Nature communications (09.07.2022)
Published in Nature communications (09.07.2022)
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Journal Article
Algorithms for the identification of prevalent diabetes in the All of Us Research Program validated using polygenic scores
Szczerbinski, Lukasz, Mandla, Ravi, Schroeder, Philip, Porneala, Bianca C., Li, Josephine H., Florez, Jose C., Mercader, Josep M., Udler, Miriam S., Manning, Alisa K.
Published in Scientific reports (06.11.2024)
Published in Scientific reports (06.11.2024)
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Journal Article
Genotype Score in Addition to Common Risk Factors for Prediction of Type 2 Diabetes
Meigs, James B, Shrader, Peter, Sullivan, Lisa M, McAteer, Jarred B, Fox, Caroline S, Dupuis, Josée, Manning, Alisa K, Florez, Jose C, Wilson, Peter W.F, D'Agostino, Ralph B, Cupples, L. Adrienne
Published in The New England journal of medicine (20.11.2008)
Published in The New England journal of medicine (20.11.2008)
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Journal Article
High-throughput genetic clustering of type 2 diabetes loci reveals heterogeneous mechanistic pathways of metabolic disease
Kim, Hyunkyung, Westerman, Kenneth E., Smith, Kirk, Chiou, Joshua, Cole, Joanne B., Majarian, Timothy, von Grotthuss, Marcin, Kwak, Soo Heon, Kim, Jaegil, Mercader, Josep M., Florez, Jose C., Gaulton, Kyle, Manning, Alisa K., Udler, Miriam S.
Published in Diabetologia (01.03.2023)
Published in Diabetologia (01.03.2023)
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Journal Article
Breast cancer polygenic risk scores are associated with short-term risk of poor prognosis breast cancer
McCarthy, Anne Marie, Manning, Alisa K., Hsu, Sarah, Welch, Michaela, Moy, Beverly, Lehman, Constance D., Armstrong, Katrina
Published in Breast cancer research and treatment (01.11.2022)
Published in Breast cancer research and treatment (01.11.2022)
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Journal Article
STAAR workflow: a cloud-based workflow for scalable and reproducible rare variant analysis
Gaynor, Sheila M, Westerman, Kenneth E, Ackovic, Lea L, Li, Xihao, Li, Zilin, Manning, Alisa K, Philippakis, Anthony, Lin, Xihong
Published in Bioinformatics (26.05.2022)
Published in Bioinformatics (26.05.2022)
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Journal Article
A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study
Kathiresan, Sekar, Manning, Alisa K, Demissie, Serkalem, D'Agostino, Ralph B, Surti, Aarti, Guiducci, Candace, Gianniny, Lauren, Burtt, Nöel P, Melander, Olle, Orho-Melander, Marju, Arnett, Donna K, Peloso, Gina M, Ordovas, Jose M, Cupples, L Adrienne
Published in BMC medical genetics (19.09.2007)
Published in BMC medical genetics (19.09.2007)
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Journal Article
GEM: scalable and flexible gene–environment interaction analysis in millions of samples
Westerman, Kenneth E, Pham, Duy T, Hong, Liang, Chen, Ye, Sevilla-González, Magdalena, Sung, Yun Ju, Sun, Yan V, Morrison, Alanna C, Chen, Han, Manning, Alisa K
Published in Bioinformatics (Oxford, England) (25.10.2021)
Published in Bioinformatics (Oxford, England) (25.10.2021)
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Journal Article
TCF7L2 Genetic Variation Augments Incretin Resistance and Influences Response to a Sulfonylurea and Metformin: The Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans (SUGAR-MGH)
Srinivasan, Shylaja, Kaur, Varinderpal, Chamarthi, Bindu, Littleton, Katherine R, Chen, Ling, Manning, Alisa K, Merino, Jordi, Thomas, Melissa K, Hudson, Margo, Goldfine, Allison, Florez, Jose C
Published in Diabetes care (01.03.2018)
Published in Diabetes care (01.03.2018)
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Journal Article
Genome-Wide Polygenic Risk Score Predicts Incident Type 2 Diabetes in Women With History of Gestational Diabetes
Choi, Jaewon, Lee, Hyunsuk, Kuang, Alan, Huerta-Chagoya, Alicia, Scholtens, Denise M, Choi, Daeho, Han, Minseok, Lowe, William L, Manning, Alisa K, Jang, Hak Chul, Park, Kyong Soo, Kwak, Soo Heon
Published in Diabetes care (01.09.2024)
Published in Diabetes care (01.09.2024)
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Journal Article
Multi-ancestry polygenic mechanisms of type 2 diabetes
Smith, Kirk, Deutsch, Aaron J., McGrail, Carolyn, Kim, Hyunkyung, Hsu, Sarah, Huerta-Chagoya, Alicia, Mandla, Ravi, Schroeder, Philip H., Westerman, Kenneth E., Szczerbinski, Lukasz, Majarian, Timothy D., Kaur, Varinderpal, Williamson, Alice, Zaitlen, Noah, Claussnitzer, Melina, Florez, Jose C., Manning, Alisa K., Mercader, Josep M., Gaulton, Kyle J., Udler, Miriam S.
Published in Nature medicine (01.04.2024)
Published in Nature medicine (01.04.2024)
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Journal Article
Bioinformatics pipeline for the systematic mining genomic and proteomic variation linked to rare diseases: The example of monogenic diabetes
Kuznetsova, Ksenia G, Vašíček, Jakub, Skiadopoulou, Dafni, Molnes, Janne, Udler, Miriam, Johansson, Stefan, Njølstad, Pål Rasmus, Manning, Alisa, Vaudel, Marc
Published in PloS one (18.04.2024)
Published in PloS one (18.04.2024)
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Journal Article
Prosaposin is a regulator of progranulin levels and oligomerization
Nicholson, Alexandra M., Finch, NiCole A., Almeida, Marcio, Perkerson, Ralph B., van Blitterswijk, Marka, Wojtas, Aleksandra, Cenik, Basar, Rotondo, Sergio, Inskeep, Venette, Almasy, Laura, Dyer, Thomas, Peralta, Juan, Jun, Goo, Wood, Andrew R., Frayling, Timothy M., Fuchsberger, Christian, Fowler, Sharon, Teslovich, Tanya M., Manning, Alisa K., Kumar, Satish, Curran, Joanne, Lehman, Donna, Abecasis, Goncalo, Duggirala, Ravindranath, Pottier, Cyril, Zahir, Haaris A., Crook, Julia E., Karydas, Anna, Mitic, Laura, Sun, Ying, Dickson, Dennis W., Bu, Guojun, Herz, Joachim, Yu, Gang, Miller, Bruce L., Ferguson, Shawn, Petersen, Ronald C., Graff-Radford, Neill, Blangero, John, Rademakers, Rosa
Published in Nature communications (30.06.2016)
Published in Nature communications (30.06.2016)
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Journal Article
Re-analysis and meta-analysis of summary statistics from gene–environment interaction studies
Pham, Duy T, Westerman, Kenneth E, Pan, Cong, Chen, Ling, Srinivasan, Shylaja, Isganaitis, Elvira, Vajravelu, Mary Ellen, Bacha, Fida, Chernausek, Steve, Gubitosi-Klug, Rose, Divers, Jasmin, Pihoker, Catherine, Marcovina, Santica M, Manning, Alisa K, Chen, Han
Published in Bioinformatics (Oxford, England) (01.12.2023)
Published in Bioinformatics (Oxford, England) (01.12.2023)
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Journal Article
Association and Interaction of Genetics and Area-Level Socioeconomic Factors on the Prevalence of Type 2 Diabetes and Obesity
Cromer, Sara J, Lakhani, Chirag M, Mercader, Josep M, Majarian, Timothy D, Schroeder, Philip, Cole, Joanne B, Florez, Jose C, Patel, Chirag J, Manning, Alisa K, Burnett-Bowie, Sherri-Ann M, Merino, Jordi, Udler, Miriam S
Published in Diabetes care (01.05.2023)
Published in Diabetes care (01.05.2023)
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Journal Article
Genetic Risk Reclassification for Type 2 Diabetes by Age Below or Above 50 Years Using 40 Type 2 Diabetes Risk Single Nucleotide Polymorphisms
de Miguel-Yanes, Jose M, Shrader, Peter, Pencina, Michael J, Fox, Caroline S, Manning, Alisa K, Grant, Richard W, Dupuis, Josèe, Florez, Jose C, D'Agostino, Ralph B. Sr, Cupples, L. Adrienne, Meigs, James B
Published in Diabetes care (01.01.2011)
Published in Diabetes care (01.01.2011)
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