Maximizing Diversity from a Kinase Screen: Identification of Novel and Selective pan-Trk Inhibitors for Chronic Pain
Stachel, Shawn J, Sanders, John M, Henze, Darrell A, Rudd, Mike T, Su, Hua-Poo, Li, Yiwei, Nanda, Kausik K, Egbertson, Melissa S, Manley, Peter J, Jones, Kristen L. G, Brnardic, Edward J, Green, Ahren, Grobler, Jay A, Hanney, Barbara, Leitl, Michael, Lai, Ming-Tain, Munshi, Vandna, Murphy, Dennis, Rickert, Keith, Riley, Daniel, Krasowska-Zoladek, Alicja, Daley, Christopher, Zuck, Paul, Kane, Stephanie A, Bilodeau, Mark T
Published in Journal of medicinal chemistry (10.07.2014)
Published in Journal of medicinal chemistry (10.07.2014)
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Discovery of MK-8768, a Potent and Selective mGluR2 Negative Allosteric Modulator
Rudd, Michael T., Manley, Peter J., Hanney, Barbara, Meng, Zhaoyang, Shu, Youheng, de Leon, Pablo, Frie, Jessica L., Han, Yongxin, Wai, Jenny Miu-Chun, Yang, Zhi-Qiang, Perkins, James J., Hurzy, Danielle M., Manikowski, Jesse J., Zhu, Hong, Bungard, Christopher J., Converso, Antonella, Meissner, Robert S., Cosden, Mali L., Hayashi, Ikuo, Ma, Lei, O’Brien, Julie, Uebele, Victor N., Schachter, Joel B., Bhandari, Neetesh, Ward, Gwendolyn J., Fillgrove, Kerry L., Lu, Bing, Liang, Yuexia, Dubost, David C., Puri, Vanita, Eddins, Donnie M., Vardigan, Joshua D., Drolet, Robert E., Kern, Jonathan T., Uslaner, Jason M.
Published in ACS medicinal chemistry letters (10.08.2023)
Published in ACS medicinal chemistry letters (10.08.2023)
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Prediction of Metabolic Clearance for Low-Turnover Compounds Using Plated Hepatocytes with Enzyme Activity Correction
Ma, Bennett, Eisenhandler, Roy, Kuo, Yuhsin, Rearden, Paul, Li, Ying, Manley, Peter J., Smith, Sheri, Menzel, Karsten
Published in European journal of drug metabolism and pharmacokinetics (01.04.2017)
Published in European journal of drug metabolism and pharmacokinetics (01.04.2017)
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Discovery of MK-1832, a Kv1.5 inhibitor with improved selectivity and pharmacokinetics
Wolkenberg, Scott E., Nolt, M. Brad, Bilodeau, Mark T., Trotter, B. Wesley, Manley, Peter J., Kett, Nathan R., Nanda, Kausik K., Wu, Zhicai, Cato, Matthew J., Kane, Stefanie A., Kiss, Laszlo, Spencer, Robert H., Wang, Jixin, Lynch, Joseph J., Regan, Christopher P., Stump, Gary L., Li, Bing, White, Rebecca, Yeh, Suzie, Dinsmore, Christopher J., Lindsley, Craig W., Hartman, George D.
Published in Bioorganic & medicinal chemistry letters (15.02.2017)
Published in Bioorganic & medicinal chemistry letters (15.02.2017)
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Allosteric inhibitors of Akt1 and Akt2: A naphthyridinone with efficacy in an A2780 tumor xenograft model
Bilodeau, Mark T., Balitza, Adrienne E., Hoffman, Jacob M., Manley, Peter J., Barnett, Stanley F., Defeo-Jones, Deborah, Haskell, Kathleen, Jones, Raymond E., Leander, Karen, Robinson, Ronald G., Smith, Anthony M., Huber, Hans E., Hartman, George D.
Published in Bioorganic & medicinal chemistry (01.06.2008)
Published in Bioorganic & medicinal chemistry (01.06.2008)
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Tricyclic imidazole antagonists of the Neuropeptide S Receptor
Trotter, B. Wesley, Nanda, Kausik K., Manley, Peter J., Uebele, Victor N., Condra, Cindra L., Gotter, Anthony L., Menzel, Karsten, Henault, Martin, Stocco, Rino, Renger, John J., Hartman, George D., Bilodeau, Mark T.
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
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Indole Naphthyridinones as Inhibitors of Bacterial Enoyl-ACP Reductases FabI and FabK
Seefeld, Mark A, Miller, William H, Newlander, Kenneth A, Burgess, Walter J, DeWolf, Walter E, Elkins, Patricia A, Head, Martha S, Jakas, Dalia R, Janson, Cheryl A, Keller, Paul M, Manley, Peter J, Moore, Terrance D, Payne, David J, Pearson, Stewart, Polizzi, Brian J, Qiu, Xiayang, Rittenhouse, Stephen F, Uzinskas, Irene N, Wallis, Nicola G, Huffman, William F
Published in Journal of medicinal chemistry (24.04.2003)
Published in Journal of medicinal chemistry (24.04.2003)
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Decahydroquinoline amides as highly selective CB2 agonists: Role of selectivity on in vivo efficacy in a rodent model of analgesia
Manley, Peter J., Zartman, Amy, Paone, Daniel V., Burgey, Christopher S., Henze, Darrell A., Penna, Kimberly Della, Desai, Reshma, Leitl, Michael D., Lemaire, Wei, White, Rebecca B., Yeh, Suzie, Urban, Mark O., Kane, Stefanie A., Hartman, George D., Bilodeau, Mark T., Trotter, B. Wesley
Published in Bioorganic & medicinal chemistry letters (15.04.2011)
Published in Bioorganic & medicinal chemistry letters (15.04.2011)
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Characterization of Non-Nitrocatechol Pan and Isoform Specific Catechol-O-methyltransferase Inhibitors and Substrates
Robinson, Ronald G, Smith, Sean M, Wolkenberg, Scott E, Kandebo, Monika, Yao, Lihang, Gibson, Christopher R, Harrison, Scott T, Polsky-Fisher, Stacey, Barrow, James C, Manley, Peter J, Mulhearn, James J, Nanda, Kausik K, Schubert, Jeffrey W, Trotter, B. Wesley, Zhao, Zhijian, Sanders, John M, Smith, Robert F, McLoughlin, Debra, Sharma, Sujata, Hall, Dawn L, Walker, Tiffany L, Kershner, Jennifer L, Bhandari, Neetesh, Hutson, Pete H, Sachs, Nancy A
Published in ACS chemical neuroscience (15.02.2012)
Published in ACS chemical neuroscience (15.02.2012)
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Potent N-(1,3-Thiazol-2-yl)pyridin-2-amine Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitors with Excellent Pharmacokinetics and Low Affinity for the hERG Ion Channel
Bilodeau, Mark T, Balitza, Adrienne E, Koester, Timothy J, Manley, Peter J, Rodman, Leonard D, Buser-Doepner, Carolyn, Coll, Kathleen E, Fernandes, Christine, Gibbs, Jackson B, Heimbrook, David C, Huckle, William R, Kohl, Nancy, Lynch, Joseph J, Mao, Xianzhi, McFall, Rosemary C, McLoughlin, Debra, Miller-Stein, Cynthia M, Rickert, Keith W, Sepp-Lorenzino, Laura, Shipman, Jennifer M, Subramanian, Raju, Thomas, Kenneth A, Wong, Bradley K, Yu, Sean, Hartman, George D
Published in Journal of medicinal chemistry (02.12.2004)
Published in Journal of medicinal chemistry (02.12.2004)
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마크로시클릭 우레아 오렉신 수용체 효능제
LIU JIAN, MANLEY PETER J, CHIRIAC MARIA IRINA, RADA VANESSA L, XIAO DONG, KERN JEFFREY C, RUDD MICHAEL T, HURZY DANIELLE M, WU ZHE, ARMACOST KIRA A, STUMP CRAIG A
Year of Publication 07.07.2023
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Year of Publication 07.07.2023
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2,4-Disubstituted pyrimidines: A novel class of KDR kinase inhibitors
Manley, Peter J., Balitza, Adrienne E., Bilodeau, Mark T., Coll, Kathleen E., Hartman, George D., McFall, Rosemary C., Rickert, Keith W., Rodman, Leonard D., Thomas, Kenneth A.
Published in Bioorganic & medicinal chemistry letters (19.05.2003)
Published in Bioorganic & medicinal chemistry letters (19.05.2003)
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Antiarrhythmic agent, MS-551, protects against pinacidil + hypoxia-induced ventricular fibrillation in Langendorff-perfused rabbit isolated heart
Friedrichs, G S, Chi, L, Black, S C, Manley, P J, Lucchesi, B R
Published in Journal of cardiovascular pharmacology (01.01.1994)
Published in Journal of cardiovascular pharmacology (01.01.1994)
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Phenylbutyrates as potent, orally bioavailable vitronectin receptor (integrin αvβ3) antagonists
Miller, William H, Manley, Peter J, Cousins, Russell D, Erhard, Karl F, Heerding, Dirk A, Kwon, Chet, Ross, Stephen T, Samanen, James M, Takata, Dennis T, Uzinskas, Irene N, Yuan, Catherine C.K, Haltiwanger, R.Curtis, Gress, Catherine J, Lark, Michael W, Hwang, Shing-Mei, James, Ian E, Rieman, David J, Willette, Robert N, Yue, Tian-Li, Azzarano, Leonard M, Salyers, Kevin L, Smith, Brian R, Ward, Keith W, Johanson, Kyung O, Huffman, William F
Published in Bioorganic & medicinal chemistry letters (17.04.2003)
Published in Bioorganic & medicinal chemistry letters (17.04.2003)
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Effects of Heparin and N-Acetyl Heparin on Ischemia/Reperfusion-Induced Alterations in Myocardial Function in the Rabbit Isolated Heart
Friedrichs, Gregory S, Kilgore, Kenneth S, Manley, Peter J, Gralinski, Michael R, Lucchesi, Benedict R
Published in Circulation research (01.10.1994)
Published in Circulation research (01.10.1994)
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Substituted [(4-Phenylpiperazinyl)- methyl]benzamides: Selective Dopamine D4 Agonists
Glase, Shelly A, Akunne, Hyacinth C, Georgic, Lynn M, Heffner, Thomas G, MacKenzie, Robert G, Manley, Peter J, Pugsley, Thomas A, Wise, Lawrence D
Published in Journal of medicinal chemistry (06.06.1997)
Published in Journal of medicinal chemistry (06.06.1997)
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QUINOLINE CARBOXAMIDE AND QUINOLINE CARBONITRILE DERIVATIVES AS MGLUR2-NEGATIVE ALLOSTERIC MODULATORS, COMPOSITIONS, AND THEIR USE
BUNGARD CHRISTOPHER JAMES, MENG ZHAOYANG, MANLEY PETER J, DE LEON PABLO, MANIKOWSKI JESSE JOSEF, MEISSNER ROBERT, PERKINS JAMES J, SHU YOUHENG, RUDD MICHAEL T, CONVERSO ANTONELLA, HARTINGH TIMOTHY JOHN, HANNEY BARBARA
Year of Publication 11.07.2014
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Year of Publication 11.07.2014
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