Unique Signaling Profiles of Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 Determine Differences in In Vivo Activity
Rook, Jerri M, Noetzel, Meredith J, Pouliot, Wendy A, Bridges, Thomas M, Vinson, Paige N, Cho, Hyekyung P, Zhou, Ya, Gogliotti, Rocco D, Manka, Jason T, Gregory, Karen J, Stauffer, Shaun R, Dudek, F. Edward, Xiang, Zixiu, Niswender, Colleen M, Daniels, J. Scott, Jones, Carrie K, Lindsley, Craig W, Conn, P. Jeffrey
Published in Biological psychiatry (1969) (15.03.2013)
Published in Biological psychiatry (1969) (15.03.2013)
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Discovery of VU0409106: A negative allosteric modulator of mGlu5 with activity in a mouse model of anxiety
Felts, Andrew S., Rodriguez, Alice L., Morrison, Ryan D., Venable, Daryl F., Manka, Jason T., Bates, Brittney S., Blobaum, Anna L., Byers, Frank W., Daniels, J. Scott, Niswender, Colleen M., Jones, Carrie K., Conn, P. Jeffrey, Lindsley, Craig W., Emmitte, Kyle A.
Published in Bioorganic & medicinal chemistry letters (01.11.2013)
Published in Bioorganic & medicinal chemistry letters (01.11.2013)
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Synthesis and SAR of centrally active mGlu₅ positive allosteric modulators based on an aryl acetylenic bicyclic lactam scaffold
Williams, Richard, Manka, Jason T, Rodriguez, Alice L, Vinson, Paige N, Niswender, Colleen M, Weaver, C. David, Jones, Carrie K, Conn, P. Jeffrey, Lindsley, Craig W, Stauffer, Shaun R
Published in Bioorganic & medicinal chemistry letters (01.03.2011)
Published in Bioorganic & medicinal chemistry letters (01.03.2011)
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Tetrahydronaphthyridine and Dihydronaphthyridinone Ethers As Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 5 (mGlu5)
Turlington, Mark, Malosh, Chrysa, Jacobs, Jon, Manka, Jason T, Noetzel, Meredith J, Vinson, Paige N, Jadhav, Satyawan, Herman, Elizabeth J, Lavreysen, Hilde, Mackie, Claire, Bartolomé-Nebreda, José M, Conde-Ceide, Susana, Martín-Martín, M. Luz, Tong, Han Min, López, Silvia, MacDonald, Gregor J, Steckler, Thomas, Daniels, J. Scott, Weaver, C. David, Niswender, Colleen M, Jones, Carrie K, Conn, P. Jeffrey, Lindsley, Craig W, Stauffer, Shaun R
Published in Journal of medicinal chemistry (10.07.2014)
Published in Journal of medicinal chemistry (10.07.2014)
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The role of aldehyde oxidase and xanthine oxidase in the biotransformation of a novel negative allosteric modulator of metabotropic glutamate receptor subtype 5
Morrison, Ryan D, Blobaum, Anna L, Byers, Frank W, Santomango, Tammy S, Bridges, Thomas M, Stec, Donald, Brewer, Katrina A, Sanchez-Ponce, Raymundo, Corlew, Melany M, Rush, Roger, Felts, Andrew S, Manka, Jason, Bates, Brittney S, Venable, Daryl F, Rodriguez, Alice L, Jones, Carrie K, Niswender, Colleen M, Conn, P Jeffrey, Lindsley, Craig W, Emmitte, Kyle A, Daniels, J Scott
Published in Drug metabolism and disposition (01.09.2012)
Published in Drug metabolism and disposition (01.09.2012)
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Octahydropyrrolo[3,4-c]pyrrole negative allosteric modulators of mGlu1
Manka, Jason T., Rodriguez, Alice L., Morrison, Ryan D., Venable, Daryl F., Cho, Hyekyung P., Blobaum, Anna L., Daniels, J. Scott, Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W., Emmitte, Kyle A.
Published in Bioorganic & medicinal chemistry letters (15.09.2013)
Published in Bioorganic & medicinal chemistry letters (15.09.2013)
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Optimization of an ether series of mGlu5 positive allosteric modulators: Molecular determinants of MPEP-site interaction crossover
Manka, Jason T., Vinson, Paige N., Gregory, Karen J., Zhou, Ya, Williams, Richard, Gogi, Kiran, Days, Emily, Jadhav, Satya, Herman, Elizabeth J., Lavreysen, Hilde, Mackie, Claire, Bartolomé, José M., Macdonald, Gregor J., Steckler, Thomas, Daniels, J. Scott, Weaver, C. David, Niswender, Colleen M., Jones, Carrie K., Conn, P. Jeffrey, Lindsley, Craig W., Stauffer, Shaun R.
Published in Bioorganic & medicinal chemistry letters (15.10.2012)
Published in Bioorganic & medicinal chemistry letters (15.10.2012)
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Discovery of N-Aryl Piperazines as Selective mGluR5 Potentiators with Improved In Vivo Utility
Zhou, Ya, Manka, Jason T, Rodriguez, Alice L, Weaver, C. David, Days, Emily L, Vinson, Paige N, Jadhav, Satyawan, Hermann, Elizabeth J, Jones, Carrie K, Conn, P. Jeffrey, Lindsley, Craig W, Stauffer, Shaun R
Published in ACS medicinal chemistry letters (11.11.2010)
Published in ACS medicinal chemistry letters (11.11.2010)
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Synthesis of Polyfunctionalized Biphenyls as Intermediates for a New Class of Liquid Crystals
Manka, Jason T, Guo, Fengli, Huang, Jianping, Yin, Huiyong, Farrar, John M, Sienkowska, Monika, Benin, Vladimir, Kaszynski, Piotr
Published in Journal of organic chemistry (12.12.2003)
Published in Journal of organic chemistry (12.12.2003)
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Discovery of VU0409106: A negative allosteric modulator of mGlu(5) with activity in a mouse model of anxiety
Felts, Andrew S., Rodriguez, Alice L., Morrison, Ryan D., Venable, Daryl F., Manka, Jason T., Bates, Brittney S., Blobaum, Anna L., Byers, Frank W., Daniels, J. Scott, Niswender, Colleen M., Jones, Carrie K., Conn, P. Jeffrey, Lindsley, Craig W., Emmitte, Kyle A.
Published in Bioorganic & medicinal chemistry letters (01.11.2013)
Published in Bioorganic & medicinal chemistry letters (01.11.2013)
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Journal Article
Octahydropyrrolo[3,4-c]pyrrole negative allosteric modulators of mGlu(1)
Manka, Jason T., Rodriguez, Alice L., Morrison, Ryan D., Venable, Daryl F., Cho, Hyekyung P., Blobaum, Anna L., Daniels, J. Scott, Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W., Emmitte, Kyle A.
Published in Bioorganic & medicinal chemistry letters (15.09.2013)
Published in Bioorganic & medicinal chemistry letters (15.09.2013)
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2,2-Dimethylcyclopropyl-benzamides: Novel positive allosteric modulators of α7 nAChRs
Maag, Hans, Bois, Daisy Joe Du, Loughhead, David G., Manka, Jason, Misner, Dinah, Sahdeo, Sunil, Smith, David B.
Published in Biochemical pharmacology (01.10.2009)
Published in Biochemical pharmacology (01.10.2009)
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Synthesis and SAR of centrally active mGlu sub(5 positive allosteric modulators based on an aryl acetylenic bicyclic lactam scaffold)
Williams, Richard, Manka, Jason T, Rodriguez, Alice L, Vinson, Paige N, Niswender, Colleen M, Weaver, CDavid, Jones, Carrie K, Conn, PJeffrey, Lindsley, Craig W, Stauffer, Shaun R
Published in Bioorganic & medicinal chemistry letters (01.03.2011)
Published in Bioorganic & medicinal chemistry letters (01.03.2011)
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Journal Article
Synthesis and SAR of centrally active mGlu 5 positive allosteric modulators based on an aryl acetylenic bicyclic lactam scaffold
Williams, Richard, Manka, Jason T., Rodriguez, Alice L., Vinson, Paige N., Niswender, Colleen M., Weaver, C. David, Jones, Carrie K., Conn, P. Jeffrey, Lindsley, Craig W., Stauffer, Shaun R.
Published in Bioorganic & medicinal chemistry letters (2011)
Published in Bioorganic & medicinal chemistry letters (2011)
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Novel hexahydropyrrolo[3,4- c]pyrrole CCR5 antagonists
Rotstein, David M., Melville, Chris R., Padilla, Fernando, Cournoyer, Dick, Lee, Eun K., Lemoine, Remy, Petersen, Ann C., Setti, Lina Q., Wanner, Jutta, Chen, Lijing, Filonova, Lubov, Loughhead, David G., Manka, Jason, Lin, Xiao-Fa, Gleason, Shelley, Sankuratri, Surya, Ji, Changhua, deRosier, Andre, Dioszegi, Marianna, Heilek, Gabrielle, Jekle, Andreas, Berry, Pamela, Mau, Cheng-I, Weller, Paul
Published in Bioorganic & medicinal chemistry letters (15.05.2010)
Published in Bioorganic & medicinal chemistry letters (15.05.2010)
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SUBSTITUTED 6-METHYLNICOTINAMIDES AS MGLUR5 POSITIVE ALLOSTERIC MODULATORS
STAUFFER SHAUN R, ZHOU YA, MANKA JASON, LINDSLEY CRAIG W, BARTOLOME NEBREDA JOSE MANUEL, CONN P. JEFFREY, MACDONALD GREGOR JAMES
Year of Publication 07.11.2013
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Year of Publication 07.11.2013
Patent
Discovery of N-Aryl Piperazines as Selective mGlu(5) Potentiators with Efficacy in a Rodent Model Predictive of Anti-Psychotic Activity
Zhou, Ya, Manka, Jason T, Rodriguez, Alice L, Weaver, C David, Days, Emily L, Vinson, Paige N, Jadhav, Satyawan, Hermann, Elizabeth J, Jones, Carrie K, Conn, P Jeffrey, Lindsley, Craig W, Stauffer, Shaun R
Published in ACS medicinal chemistry letters (11.11.2010)
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Published in ACS medicinal chemistry letters (11.11.2010)
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