Targeting the multifunctional HBV core protein as a potential cure for chronic hepatitis B
Viswanathan, Usha, Mani, Nagraj, Hu, Zhanying, Ban, Haiqun, Du, Yanming, Hu, Jin, Chang, Jinhong, Guo, Ju-Tao
Published in Antiviral research (01.10.2020)
Published in Antiviral research (01.10.2020)
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Journal Article
Preclinical Profile of AB-423, an Inhibitor of Hepatitis B Virus Pregenomic RNA Encapsidation
Mani, Nagraj, Cole, Andrew G, Phelps, Janet R, Ardzinski, Andrzej, Cobarrubias, Kyle D, Cuconati, Andrea, Dorsey, Bruce D, Evangelista, Ellen, Fan, Kristi, Guo, Fang, Guo, Haitao, Guo, Ju-Tao, Harasym, Troy O, Kadhim, Salam, Kultgen, Steven G, Lee, Amy C H, Li, Alice H L, Long, Quanxin, Majeski, Sara A, Mao, Richeng, McClintock, Kevin D, Reid, Stephen P, Rijnbrand, Rene, Snead, Nicholas M, Micolochick Steuer, Holly M, Stever, Kim, Tang, Sunny, Wang, Xiaohe, Zhao, Qiong, Sofia, Michael J
Published in Antimicrobial agents and chemotherapy (01.06.2018)
Published in Antimicrobial agents and chemotherapy (01.06.2018)
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Journal Article
Novel Dual-Targeting Benzimidazole Urea Inhibitors of DNA Gyrase and Topoisomerase IV Possessing Potent Antibacterial Activity: Intelligent Design and Evolution through the Judicious Use of Structure-Guided Design and Stucture−Activity Relationships
Charifson, Paul S, Grillot, Anne-Laure, Grossman, Trudy H, Parsons, Jonathan D, Badia, Michael, Bellon, Steve, Deininger, David D, Drumm, Joseph E, Gross, Christian H, LeTiran, Arnaud, Liao, Yusheng, Mani, Nagraj, Nicolau, David P, Perola, Emanuele, Ronkin, Steven, Shannon, Dean, Swenson, Lora L, Tang, Qing, Tessier, Pamela R, Tian, Ski-Kai, Trudeau, Martin, Wang, Tiansheng, Wei, Yunyi, Zhang, Hong, Stamos, Dean
Published in Journal of medicinal chemistry (11.09.2008)
Published in Journal of medicinal chemistry (11.09.2008)
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Journal Article
Discovery of pyrazolthiazoles as novel and potent inhibitors of bacterial gyrase
Ronkin, Steven M., Badia, Michael, Bellon, Steve, Grillot, Anne-Laure, Gross, Christian H., Grossman, Trudy H., Mani, Nagraj, Parsons, Jonathan D., Stamos, Dean, Trudeau, Martin, Wei, Yunyi, Charifson, Paul S.
Published in Bioorganic & medicinal chemistry letters (01.05.2010)
Published in Bioorganic & medicinal chemistry letters (01.05.2010)
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Journal Article
In Vitro Phenotypic Characterization of Hepatitis C Virus NS3 Protease Variants Observed in Clinical Studies of Telaprevir
MIN JIANG, MANI, Nagraj, MÜH, Ute, HANZELKA, Brian, TIGGES, Ann, RIJNBRAND, Rene, KIEFFER, Tara L, CHAO LIN, ARDZINSKI, Andrzej, NELSON, Michelle, REAGAN, Dugan, BARTELS, Doug, YI ZHOU, NICOLAS, Olivier, GOVINDA RAO, B
Published in Antimicrobial Agents and Chemotherapy (01.12.2013)
Published in Antimicrobial Agents and Chemotherapy (01.12.2013)
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Journal Article
Safety, pharmacokinetics, and antiviral activity of the capsid inhibitor AB‐506 from Phase 1 studies in healthy subjects and those with hepatitis B
Yuen, Man‐Fung, Berliba, Elina, Sukeepaisarnjaroen, Wattana, Ahn, Sang Hoon, Tanwandee, Tawesak, Lim, Young‐Suk, Kim, Yoon Jun, Poovorawan, Kittiyod, Tangkijvanich, Pisit, Schwabe, Christian, Eley, Timothy, Brown, Joanne, Lee, Amy C. H., Thi, Emily P., Paratala, Bhavna, Mani, Nagraj, Sofia, Michael J., Picchio, Gaston, Sims, Karen D., Gane, Edward J.
Published in Hepatology communications (01.12.2022)
Published in Hepatology communications (01.12.2022)
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Journal Article
Dual Targeting of GyrB and ParE by a Novel Aminobenzimidazole Class of Antibacterial Compounds
GROSSMAN, Trudy H, BARTELS, Douglas J, MANI, Nagraj, MULLIN, Steve, GROSS, Christian H, PARSONS, Jonathan D, YUSHENG LIAO, GRILLOT, Anne-Laure, STAMOS, Dean, OLSON, Eric R, CHARIFSON, Paul S
Published in Antimicrobial Agents and Chemotherapy (01.02.2007)
Published in Antimicrobial Agents and Chemotherapy (01.02.2007)
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Journal Article
In Vitro Characterization of the Antibacterial Spectrum of Novel Bacterial Type II Topoisomerase Inhibitors of the Aminobenzimidazole Class
MANI, Nagraj, GROSS, Christian H, GROSSMAN, Trudy H, PARSONS, Jonathan D, HANZELKA, Brian, MÜH, Ute, MULLIN, Steve, YUSHENG LIAO, GRILLOT, Anne-Laure, STAMOS, Dean, CHARIFSON, Paul S
Published in Antimicrobial Agents and Chemotherapy (01.04.2006)
Published in Antimicrobial Agents and Chemotherapy (01.04.2006)
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Journal Article
Environmental Response and Autoregulation of Clostridium difficile TxeR, a Sigma Factor for Toxin Gene Expression
Mani, Nagraj, Lyras, Dena, Barroso, Lisa, Howarth, Pauline, Wilkins, Tracy, Rood, Julian I, Sonenshein, Abraham L, Dupuy, Bruno
Published in Journal of Bacteriology (01.11.2002)
Published in Journal of Bacteriology (01.11.2002)
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Journal Article
Regulation of toxin and bacteriocin gene expression in Clostridium by interchangeable RNA polymerase sigma factors
Dupuy, Bruno, Raffestin, Stéphanie, Matamouros, Susana, Mani, Nagraj, Popoff, Michel R., Sonenshein, Abraham L.
Published in Molecular microbiology (01.05.2006)
Published in Molecular microbiology (01.05.2006)
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Journal Article
Characterization of V36C, a Novel Amino Acid Substitution Conferring Hepatitis C Virus (HCV) Resistance to Telaprevir, a Potent Peptidomimetic Inhibitor of HCV Protease
Barbotte, Laetitia, Ahmed-Belkacem, Abdelhakim, Chevaliez, Stéphane, Soulier, Alexandre, Hézode, Christophe, Wajcman, Henri, Bartels, Doug J, Zhou, Yi, Ardzinski, Andrzej, Mani, Nagraj, Rao, B Govinda, George, Shelley, Kwong, Ann, Pawlotsky, Jean-Michel
Published in Antimicrobial Agents and Chemotherapy (01.06.2010)
Published in Antimicrobial Agents and Chemotherapy (01.06.2010)
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Journal Article
Hepatitis B virus core protein variant profiles observed in chronic hepatitis B patients treated with capsid inhibitor AB-836
Espiritu, Christine L., Mani, Nagraj, Eley, Timothy, Ardzinski, Andrzej, Stever, Kim, Brown, Joanne, Varughese, Tilly, Sims, Karen, Picchio, Gaston, Lam, Angela M, Sofia, Michael J., Thi, Emily P.
Published in Journal of hepatology (01.06.2023)
Published in Journal of hepatology (01.06.2023)
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Journal Article
SAT-202 - Hepatitis B virus core protein variant profiles observed in chronic hepatitis B patients treated with capsid inhibitor AB-836
Espiritu, Christine L., Mani, Nagraj, Eley, Timothy, Ardzinski, Andrzej, Stever, Kim, Brown, Joanne, Varughese, Tilly, Sims, Karen, Picchio, Gaston, Lam, Angela M, Sofia, Michael J., Thi, Emily P.
Published in Journal of hepatology (01.06.2023)
Published in Journal of hepatology (01.06.2023)
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Journal Article
Inhibition of HBV replication by N-hydroxyisoquinolinedione and N-hydroxypyridinedione ribonuclease H inhibitors
Edwards, Tiffany C., Mani, Nagraj, Dorsey, Bruce, Kakarla, Ramesh, Rijnbrand, Rene, Sofia, Michael J., Tavis, John E.
Published in Antiviral research (01.04.2019)
Published in Antiviral research (01.04.2019)
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