Search Results - "MANFREDI, Paolo L" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Esmethadone-HCl (REL-1017): a promising rapid antidepressant

Esmethadone-HCl (REL-1017): a promising rapid antidepressant

by Fava, Maurizio, Stahl, Stephen M., De Martin, Sara, Mattarei, Andrea, Bettini, Ezio, Comai, Stefano, Alimonti, Andrea, Bifari, Francesco, Pani, Luca, Folli, Franco, Guidetti, Clotilde, Furlan, Alberto, Sgrignani, Jacopo, Locatelli, Patrizia, Cavalli, Andrea, O’Gorman, Cedric, Traversa, Sergio, Inturrisi, Charles E., Pappagallo, Marco, Manfredi, Paolo L.
Published in European archives of psychiatry and clinical neuroscience (01.10.2023)

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REL-1017 (esmethadone; d-methadone) does not cause reinforcing effect, physical dependence and withdrawal signs in Sprague Dawley rats

REL-1017 (esmethadone; d-methadone) does not cause reinforcing effect, physical dependence and withdrawal signs in Sprague Dawley rats

by Henningfield, Jack, Gauvin, David, Bifari, Francesco, Fant, Reginald, Shram, Megan, Buchhalter, August, Ashworth, Judy, Lanier, Ryan, Pappagallo, Marco, Inturrisi, Charles, Folli, Franco, Traversa, Sergio, Manfredi, Paolo L
Published in Scientific reports (06.07.2022)

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Esmethadone (REL-1017) and Other Uncompetitive NMDAR Channel Blockers May Improve Mood Disorders via Modulation of Synaptic Kinase-Mediated Signaling

Esmethadone (REL-1017) and Other Uncompetitive NMDAR Channel Blockers May Improve Mood Disorders via Modulation of Synaptic Kinase-Mediated Signaling

by Stahl, Stephen M., De Martin, Sara, Mattarei, Andrea, Bettini, Ezio, Pani, Luca, Guidetti, Clotilde, Folli, Franco, de Somer, Marc, Traversa, Sergio, Inturrisi, Charles E., Pappagallo, Marco, Gentilucci, Marco, Alimonti, Andrea, Fava, Maurizio, Manfredi, Paolo L.
Published in International journal of molecular sciences (13.10.2022)

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REL-1017 (Esmethadone), A Novel NMDAR Blocker for the Treatment of MDD is Not Neurotoxic in Sprague-Dawley Rats

REL-1017 (Esmethadone), A Novel NMDAR Blocker for the Treatment of MDD is Not Neurotoxic in Sprague-Dawley Rats

by Bifari, Francesco, Pappagallo, Marco, Bleavins, Michael, Traversa, Sergio, Folli, Franco, Manfredi, Paolo L
Published in Frontiers in pharmacology (25.04.2022)

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Sex-dependent effects of the uncompetitive N-methyl-D-aspartate receptor antagonist REL-1017 in G93A-SOD1 amyotrophic lateral sclerosis mice

Sex-dependent effects of the uncompetitive N-methyl-D-aspartate receptor antagonist REL-1017 in G93A-SOD1 amyotrophic lateral sclerosis mice

by Colognesi, Martina, Shkodra, Atea, Gabbia, Daniela, Kawamata, Hibiki, Manfredi, Paolo L, Manfredi, Giovanni, De Martin, Sara
Published in Frontiers in neurology (03.05.2024)

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REL-1017 (Esmethadone) Increases Circulating BDNF Levels in Healthy Subjects of a Phase 1 Clinical Study

REL-1017 (Esmethadone) Increases Circulating BDNF Levels in Healthy Subjects of a Phase 1 Clinical Study

by De Martin, Sara, Gabbia, Daniela, Folli, Franco, Bifari, Francesco, Fiorina, Paolo, Ferri, Nicola, Stahl, Stephen, Inturrisi, Charles E, Pappagallo, Marco, Traversa, Sergio, Manfredi, Paolo L
Published in Frontiers in pharmacology (28.04.2021)

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The novel uncompetitive NMDA receptor antagonist esmethadone (REL-1017) has no meaningful abuse potential in recreational drug users

The novel uncompetitive NMDA receptor antagonist esmethadone (REL-1017) has no meaningful abuse potential in recreational drug users

by Shram, Megan J, Henningfield, Jack E, Apseloff, Glen, Gorodetzky, Charles W, De Martin, Sara, Vocci, Frank L, Sapienza, Frank L, Kosten, Thomas R, Huston, Jeff, Buchhalter, August, Ashworth, Judy, Lanier, Ryan, Folli, Franco, Mattarei, Andrea, Guidetti, Clotilde, Comai, Stefano, O'Gorman, Cedric, Traversa, Sergio, Inturrisi, Charles E, Manfredi, Paolo L, Pappagallo, Marco
Published in Translational psychiatry (07.06.2023)

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Drug–Drug Interaction Studies of Esmethadone (REL-1017) Involving CYP3A4- and CYP2D6-Mediated Metabolism

Drug–Drug Interaction Studies of Esmethadone (REL-1017) Involving CYP3A4- and CYP2D6-Mediated Metabolism

by Ferri, Nicola, De Martin, Sara, Stuart, James, Traversa, Sergio, Folli, Franco, Pappagallo, Marco, O’Gorman, Cedric, Guidetti, Clotilde, Mattarei, Andrea, Inturrisi, Charles E., Manfredi, Paolo L.
Published in Drugs in R&D (01.03.2024)

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The N-Methyl-D-Aspartate Receptor Blocker REL-1017 (Esmethadone) Reduces Calcium Influx Induced by Glutamate, Quinolinic Acid, and Gentamicin

The N-Methyl-D-Aspartate Receptor Blocker REL-1017 (Esmethadone) Reduces Calcium Influx Induced by Glutamate, Quinolinic Acid, and Gentamicin

by Bettini, Ezio, De Martin, Sara, Mattarei, Andrea, Pappagallo, Marco, Stahl, Stephen M., Bifari, Francesco, Inturrisi, Charles E., Folli, Franco, Traversa, Sergio, Manfredi, Paolo L.
Published in Pharmaceuticals (Basel, Switzerland) (17.07.2022)

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Pharmacological Comparative Characterization of REL-1017 (Esmethadone-HCl) and Other NMDAR Channel Blockers in Human Heterodimeric N-Methyl-D-Aspartate Receptors

Pharmacological Comparative Characterization of REL-1017 (Esmethadone-HCl) and Other NMDAR Channel Blockers in Human Heterodimeric N-Methyl-D-Aspartate Receptors

by Bettini, Ezio, Stahl, Stephen M., De Martin, Sara, Mattarei, Andrea, Sgrignani, Jacopo, Carignani, Corrado, Nola, Selena, Locatelli, Patrizia, Pappagallo, Marco, Inturrisi, Charles E., Bifari, Francesco, Cavalli, Andrea, Alimonti, Andrea, Pani, Luca, Fava, Maurizio, Traversa, Sergio, Folli, Franco, Manfredi, Paolo L.
Published in Pharmaceuticals (Basel, Switzerland) (01.08.2022)

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Self-reported symptom experience of critically ill cancer patients receiving intensive care

Self-reported symptom experience of critically ill cancer patients receiving intensive care

by Nelson, J E, Meier, D E, Oei, E J, Nierman, D M, Senzel, R S, Manfredi, P L, Davis, S M, Morrison, R S
Published in Critical care medicine (01.02.2001)

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Comment on “Novel Glutamatergic Modulators for the Treatment of Mood Disorders: Current Status

Comment on “Novel Glutamatergic Modulators for the Treatment of Mood Disorders: Current Status

by Pappagallo, Marco, Inturrisi, Charles E., Manfredi, Paolo L.
Published in CNS drugs (01.02.2022)

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REL-1017 (Esmethadone) as Adjunctive Treatment in Patients With Major Depressive Disorder: A Phase 2a Randomized Double-Blind Trial

REL-1017 (Esmethadone) as Adjunctive Treatment in Patients With Major Depressive Disorder: A Phase 2a Randomized Double-Blind Trial

by Fava, Maurizio, Stahl, Stephen, Pani, Luca, De Martin, Sara, Pappagallo, Marco, Guidetti, Clotilde, Alimonti, Andrea, Bettini, Ezio, Mangano, Richard M, Wessel, Thomas, de Somer, Marc, Caron, Judy, Vitolo, Ottavio V, DiGuglielmo, Gina R, Gilbert, Adam, Mehta, Hiren, Kearney, Morgan, Mattarei, Andrea, Gentilucci, Marco, Folli, Franco, Traversa, Sergio, Inturrisi, Charles E, Manfredi, Paolo L
Published in The American journal of psychiatry (01.02.2022)

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Characterization of the Safety and Pharmacokinetic Profile of D-Methadone, a Novel N-Methyl-D-Aspartate Receptor Antagonist in Healthy, Opioid-Naive Subjects: Results of Two Phase 1 Studies

by Bernstein, Galina, Davis, Kelly, Mills, Catherine, Wang, Lu, McDonnell, Michael, Oldenhof, John, Inturrisi, Charles, Manfredi, Paolo L, Vitolo, Ottavio V
Published in Journal of clinical psychopharmacology (01.05.2019)

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Case Report: REL-1017 Reduces Abnormal Clinician Administered Dissociative States Scale Scores in Patients with Major Depressive Disorder

Case Report: REL-1017 Reduces Abnormal Clinician Administered Dissociative States Scale Scores in Patients with Major Depressive Disorder

by Guidetti, Clotilde, Pani, Luca, Serra, Giulia, Pappagallo, Marco, Fava, Maurizio, Manfredi, Paolo L.
Published in CNS spectrums (01.04.2022)

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A Phase 2a Double-Blind Randomized Trial of REL-1017 (Esmethadone) in Patients with MDD: Analysis of Subscales from the Symptoms of Depression Questionnaire

A Phase 2a Double-Blind Randomized Trial of REL-1017 (Esmethadone) in Patients with MDD: Analysis of Subscales from the Symptoms of Depression Questionnaire

by Guidetti, Clotilde, Fava, Maurizio, Pani, Luca, Pappagallo, Marco, Serra, Giulia, DeMartin, Sara, Mattarei, Andrea, Manfredi, Paolo L.
Published in CNS spectrums (01.04.2022)

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Letter to the Editor regarding 'Unique pharmacodynamic properties and low abuse liability of the µ-opioid receptor ligand (S)-methadone'

Letter to the Editor regarding 'Unique pharmacodynamic properties and low abuse liability of the µ-opioid receptor ligand (S)-methadone'

by Pappagallo, Marco, Kosten, Thomas R, Gorodetzky, Charles W, Vocci, Frank J, Sapienza, Frank L, De Martin, Sara, Comai, Stefano, Mattarei, Andrea, Inturrisi, Charles E, Manfredi, Paolo L
Published in Molecular psychiatry (28.05.2024)

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Effect of REL-1017 (Esmethadone) on Cholesterol, Triglycerides, PCSK9, and hs-CRP in a Phase 2a Double-Blind Randomized Trial in Patients with MDD

Effect of REL-1017 (Esmethadone) on Cholesterol, Triglycerides, PCSK9, and hs-CRP in a Phase 2a Double-Blind Randomized Trial in Patients with MDD

by Ferri, Nicola, Pappagallo, Marco, Patel, Sheetal, Folli, Franco, De Martin, Sara, Lupo, Maria Giovanna, Traversa, Sergio, Manfredi, Paolo L.
Published in CNS spectrums (01.04.2022)

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Pharmacokinetics, Tolerability, and Safety of Esmethadone in Subjects with Chronic Kidney Disease or Hepatic Impairment

Pharmacokinetics, Tolerability, and Safety of Esmethadone in Subjects with Chronic Kidney Disease or Hepatic Impairment

by Ferri, Nicola, De Martin, Sara, Stuart, James, Traversa, Sergio, Mattarei, Andrea, Comai, Stefano, Folli, Franco, Pappagallo, Marco, Guidetti, Clotilde, Inturrisi, Charles E., Manfredi, Paolo L.
Published in Drugs in R&D (01.06.2024)

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Subanalysis of Subjective Cognitive Measures From a Phase 2, Double-Blind, Randomized Trial of REL-1017 in Patients With Major Depressive Disorder

Subanalysis of Subjective Cognitive Measures From a Phase 2, Double-Blind, Randomized Trial of REL-1017 in Patients With Major Depressive Disorder

by Guidetti, Clotilde, Serra, Giulia, Pani, Luca, Pappagallo, Marco, Maglio, Gino, Martin, Sara De, Mattarei, Andrea, Folli, Franco, Manfredi, Paolo L, Fava, Maurizio
Published in Primary care companion for CNS disorders (14.02.2023)

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