Blocking Interleukin (IL)4- and IL13-Mediated Phosphorylation of STAT6 (Tyr641) Decreases M2 Polarization of Macrophages and Protects Against Macrophage-Mediated Radioresistance of Inflammatory Breast Cancer
Rahal, Omar M., Wolfe, Adam R., Mandal, Pijus K., Larson, Richard, Tin, Sanda, Jimenez, Cristina, Zhang, Dadong, Horton, Janet, Reuben, James M., McMurray, John S., Woodward, Wendy A.
Published in International journal of radiation oncology, biology, physics (15.03.2018)
Published in International journal of radiation oncology, biology, physics (15.03.2018)
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Journal Article
Potent and Selective Phosphopeptide Mimetic Prodrugs Targeted to the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 3
Mandal, Pijus K, Gao, Fengqin, Lu, Zhen, Ren, Zhiyong, Ramesh, Rajagopal, Birtwistle, J. Sanderson, Kaluarachchi, Kumaralal K, Chen, Xiaomin, Bast, Robert C, Liao, Warren S, McMurray, John S
Published in Journal of medicinal chemistry (26.05.2011)
Published in Journal of medicinal chemistry (26.05.2011)
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Journal Article
Crystal structure of unphosphorylated STAT3 core fragment
Ren, Zhiyong, Mao, Xiang, Mertens, Claudia, Krishnaraj, Ravi, Qin, Jie, Mandal, Pijus K., Romanowski, Michael J., McMurray, John S., Chen, Xiaomin
Published in Biochemical and biophysical research communications (12.09.2008)
Published in Biochemical and biophysical research communications (12.09.2008)
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Journal Article
Long-Acting Beta Agonists Enhance Allergic Airway Disease
Knight, John M, Mak, Garbo, Shaw, Joanne, Porter, Paul, McDermott, Catherine, Roberts, Luz, You, Ran, Yuan, Xiaoyi, Millien, Valentine O, Qian, Yuping, Song, Li-Zhen, Frazier, Vincent, Kim, Choel, Kim, Jeong Joo, Bond, Richard A, Milner, Joshua D, Zhang, Yuan, Mandal, Pijus K, Luong, Amber, Kheradmand, Farrah, McMurray, John S, Corry, David B
Published in PloS one (25.11.2015)
Published in PloS one (25.11.2015)
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Journal Article
Investigation of the Binding Determinants of Phosphopeptides Targeted to the Src Homology 2 Domain of the Signal Transducer and Activator of Transcription 3. Development of a High-Affinity Peptide Inhibitor
Coleman, Ren, Zhiyong, Mandal, Pijus K, Cameron, Arlin G, Dyer, Garrett A, Muranjan, Seema, Campbell, Martin, Chen, Xiaomin, McMurray, John S
Published in Journal of medicinal chemistry (20.10.2005)
Published in Journal of medicinal chemistry (20.10.2005)
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Journal Article
The bile acid-activated phosphatidylinositol 3-kinase pathway inhibits Fas apoptosis upstream of bid in rodent hepatocytes
Takikawa, Y, Miyoshi, H, Rust, C, Roberts, P, Siegel, R, Mandal, P K, Millikan, R E, Gores, G J
Published in Gastroenterology (New York, N.Y. 1943) (01.06.2001)
Published in Gastroenterology (New York, N.Y. 1943) (01.06.2001)
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Journal Article
Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) Apoenzyme
Hamilton, Matthew M, Mseeh, Faika, McAfoos, Timothy J, Leonard, Paul G, Reyna, Naphtali J, Harris, Angela L, Xu, Alan, Han, Michelle, Soth, Michael J, Czako, Barbara, Theroff, Jay P, Mandal, Pijus K, Burke, Jason P, Virgin-Downey, Brett, Petrocchi, Alessia, Pfaffinger, Dana, Rogers, Norma E, Parker, Connor A, Yu, Simon S, Jiang, Yongying, Krapp, Stephan, Lammens, Alfred, Trevitt, Graham, Tremblay, Martin R, Mikule, Keith, Wilcoxen, Keith, Cross, Jason B, Jones, Philip, Marszalek, Joseph R, Lewis, Richard T
Published in Journal of medicinal chemistry (12.08.2021)
Published in Journal of medicinal chemistry (12.08.2021)
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Journal Article
STAT3 restrains RANK- and TLR4-mediated signalling by suppressing expression of the E2 ubiquitin-conjugating enzyme Ubc13
Zhang, Huiyuan, Hu, Hongbo, Greeley, Nathaniel, Jin, Jin, Matthews, Allison J, Ohashi, Erika, Caetano, Mauricio S., Li, Haiyan S., Wu, Xuefeng, Mandal, Pijus K., McMurray, John S., Moghaddam, Seyed Javad, Sun, Shao-Cong, Watowich, Stephanie S.
Published in Nature communications (15.12.2014)
Published in Nature communications (15.12.2014)
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Journal Article
Hydrodehalogenation of Alkyl Iodides with Base-Mediated Hydrogenation and Catalytic Transfer Hydrogenation: Application to the Asymmetric Synthesis of N‑Protected α‑Methylamines
Mandal, Pijus K, Birtwistle, J. Sanderson, McMurray, John S
Published in Journal of organic chemistry (05.09.2014)
Published in Journal of organic chemistry (05.09.2014)
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Journal Article
Targeting the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 6 (STAT6) with Cell-Permeable, Phosphatase-Stable Phosphopeptide Mimics Potently Inhibits Tyr641 Phosphorylation and Transcriptional Activity
Mandal, Pijus K, Morlacchi, Pietro, Knight, J. Morgan, Link, Todd M, Lee, Gilbert R, Nurieva, Roza, Singh, Divyendu, Dhanik, Ankur, Kavraki, Lydia, Corry, David B, Ladbury, John E, McMurray, John S
Published in Journal of medicinal chemistry (25.11.2015)
Published in Journal of medicinal chemistry (25.11.2015)
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Journal Article
Structure−Affinity Relationships of Glutamine Mimics Incorporated into Phosphopeptides Targeted to the SH2 Domain of Signal Transducer and Activator of Transcription 3
Mandal, Pijus K, Ren, Zhiyong, Chen, Xiaomin, Xiong, Chiyi, McMurray, John S
Published in Journal of medicinal chemistry (08.10.2009)
Published in Journal of medicinal chemistry (08.10.2009)
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Journal Article
Conformationally Constrained Peptidomimetic Inhibitors of Signal Transducer and Activator of Transcription 3: Evaluation and Molecular Modeling
Mandal, Pijus K, Limbrick, Donald, Coleman, David R, Dyer, Garrett A, Ren, Zhiyong, Birtwistle, J. Sanderson, Xiong, Chiyi, Chen, Xiaomin, Briggs, James M, McMurray, John S
Published in Journal of medicinal chemistry (23.04.2009)
Published in Journal of medicinal chemistry (23.04.2009)
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Journal Article
Efficient synthesis of apricoxib, CS-706, a selective cyclooxygenase-2 inhibitor, and evaluation of inhibition of prostaglandin E2 production in inflammatory breast cancer cells
Mandal, Pijus K., Freiter, Eric M., Bagsby, Allison L., Robertson, Fredika M., McMurray, John S.
Published in Bioorganic & medicinal chemistry letters (15.10.2011)
Published in Bioorganic & medicinal chemistry letters (15.10.2011)
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Journal Article
Long-Acting Beta Agonists Enhance Allergic Airway Disease
Knight, John M., Ph.D, Mak, Garbo, Shaw, Joanne, McDermott, Catherine, Roberts, Luz, You, Ran, Yuan, Xiaoyi, Millien, Valentine O, Qian, Yuping, Song, Li-Zhen, Frazier, Vincent, Kim, Choel, Kim, Jeong j, Bond, Richard, Luong, Amber U., MD PhD, Kheradmand, Farrah, MD, McMurray, John, Mandal, Pijus K, Morlacchi, Pietro, Milner, Joshua D., MD, Corry, David B., MD
Published in Journal of allergy and clinical immunology (01.02.2015)
Published in Journal of allergy and clinical immunology (01.02.2015)
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Journal Article
A phosphopeptide mimetic prodrug targeting the SH2 domain of Stat3 inhibits tumor growth and angiogenesis
Auzenne, Edmond J, Klostergaard, Jim, Mandal, Pijus K, Liao, Warren S, Lu, Zhen, Gao, Fengqin, Bast, Jr, Robert C, Robertson, Fredika M, McMurray, John S
Published in Journal of experimental therapeutics & oncology (2012)
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Published in Journal of experimental therapeutics & oncology (2012)
Journal Article
Solid-phase synthesis of Stat3 inhibitors incorporating O-carbamoylserine and O-carbamoylthreonine as glutamine mimics
Mandal, Pijus K., Heard, Patricia A., Ren, Zhiyong, Chen, Xiaomin, McMurray, John S.
Published in Bioorganic & medicinal chemistry letters (01.02.2007)
Published in Bioorganic & medicinal chemistry letters (01.02.2007)
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Journal Article
Structure–Activity Studies of Phosphopeptidomimetic Prodrugs Targeting the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 3 (Stat3)
Mandal, Pijus K., Ren, Zhiyong, Chen, Xiaomin, Kaluarachchi, Kumar, Liao, Warren S.-L., McMurray, John S.
Published in International journal of peptide research and therapeutics (01.03.2013)
Published in International journal of peptide research and therapeutics (01.03.2013)
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Journal Article