전사 활성화 단백질의 이미다조피페라진 억제제
MANDAL PIJUS K, SOTH MICHAEL J, JONES PHILIP, LE KANG, CROSS JASON, CARROLL CHRISTOPHER L, MCAFOOS TIMOTHY J
Year of Publication 12.01.2021
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Year of Publication 12.01.2021
Patent
The consequences of selective inhibition of signal transducer and activator of transcription 3 (STAT3) tyrosine705 phosphorylation by phosphopeptide mimetic prodrugs targeting the Src homology 2 (SH2) domain
McMurray, John S., Mandal, Pijus K., Liao, Warren S., Klostergaard, Jim, Robertson, Fredika M.
Published in JAK-STAT (01.10.2012)
Published in JAK-STAT (01.10.2012)
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Journal Article
Allosteric SHP2 inhibitor IACS-13909 overcomes EGFR-dependent and EGFR-independent resistance mechanisms towards osimertinib
Sun, Yuting, Meyers, Brooke A., Czako, Barbara, Leonard, Paul, Mseeh, Faika, Harris, Angela L., Wu, Qi, Johnson, Sarah, Parker, Connor A., Cross, Jason B., Francesco, Maria Emilia Di, Bivona, Benjamin J., Bristow, Christopher A., Burke, Jason P., Carrillo, Caroline C., Carroll, Christopher L., Chang, Qing, Feng, Ningping, Gao, Guang, Gera, Sonal, Giuliani, Virginia, Huang, Justin K., Jiang, Yongying, Kang, Zhijun, Kovacs, Jeffrey J., Liu, Chiu-Yi, Lopez, Anastasia M., Ma, Xiaoyan, Mandal, Pijus K., McAfoos, Timothy, Miller, Meredith A., Mullinax, Robert A., Peoples, Michael, Ramamoorthy, Vandhana, Seth, Sahil, Spencer, Nakia D., Suzuki, Erika, Williams, Christopher C., Yu, Simon S., Zuniga, Andy M., Draetta, Giulio F., Marszalek, Joseph R., Heffernan, Timothy P., Kohl, Nancy E., Jones, Philip
Published in Cancer research (Chicago, Ill.) (14.09.2020)
Published in Cancer research (Chicago, Ill.) (14.09.2020)
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Journal Article
Abstract B36: The role of the microRNA-200 family in the regulation of tumor cell signaling and metastasis in lung cancer
Roybal, Jonathon D., Peng, David H., Ungewiss, Christin, Mandal, Pijus K., McMurray, John S., Byers, Lauren A., Gibbons, Don L.
Published in Cancer research (Chicago, Ill.) (01.01.2015)
Published in Cancer research (Chicago, Ill.) (01.01.2015)
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Journal Article
Abstract C036: Discovery of IACS-13909, an allosteric SHP2 inhibitor that overcomes multiple mechanisms underlying osimertinib resistance
Sun, Yuting, Meyers, Brooke A, Johnson, Sarah B, Harris, Angela L, Czako, Barbara, Cross, Jason B, Leonard, Paul G, Mseeh, Faika, Francesco, Maria E Di, Parker, Connor A, Wu, Qi, Bristow, Christopher A, Burke, Jason P, Carrillo, Caroline C, Carroll, Christopher L, Chang, Qing, Feng, Ningping, Gera, Sonal, Guang, Gao, Huang, Justin Kwang-Lay, Jiang, Yongying, Kang, Zhijun, Kovacs, Jeffrey J, Ma, Xiaoyan, Mandal, Pijus K, McAfoos, Timothy, Mullinax, Robert A, Peoples, Michael D, Ramamoorthy, Vandhana, Seth, Sahil, Suzuki, Erika, Williams, Christopher Conrad, Yu, Simon S, Zuniga, Andy M, Draetta, Giulio F, Marszalek, Joseph R, Heffernan, Timothy P, Kohl, Nancy E, Jones, Philip
Published in Molecular cancer therapeutics (01.12.2019)
Published in Molecular cancer therapeutics (01.12.2019)
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Journal Article
Abstract A39: Pomhex, a cell-permeable high potency enolase inhibitor with utility for collateral lethality treatment of cancer
Lin, Yu-Hsi, Satani, Nikunj, Hammoudi, Naima, Pisaneschi, Federica, Leonard, Paul, Maxwell, David, Peng, Zhenghong, Link, Todd, Gilbert, Lee IV R., Bosajou, Ananth, Sun, Duoli, Marszalek, Joe, Sun, Yuting, McMurray, John S., Mandal, Pijus K., Francesco, Maria E. Di, Czako, Barbara, Wang, Alan, Bornmann, William, DePinho, Ronald A., Muller, Florian
Published in Molecular cancer therapeutics (01.10.2017)
Published in Molecular cancer therapeutics (01.10.2017)
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Journal Article
Abstract C57: The role of the microRNA-200 family in the regulation of tumor cell signaling and metastasis in lung cancer
Roybal, Jonathon D., Peng, David H., Ungewiss, Christin, Mandal, Pijus K., McMurray, John S., Byers, Lauren A., Gibbons, Don L.
Published in Cancer research (Chicago, Ill.) (01.02.2013)
Published in Cancer research (Chicago, Ill.) (01.02.2013)
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Journal Article
ChemInform Abstract: Efficient Synthesis of Apricoxib, CS-706, a Selective Cyclooxygenase-2 Inhibitor, and Evaluation of Inhibition of Prostaglandin E2 Production in Inflammatory Breast Cancer Cells
Mandal, Pijus K., Freiter, Eric M., Bagsby, Allison L., Robertson, Fredika M., McMurray, John S.
Published in ChemInform (06.03.2012)
Published in ChemInform (06.03.2012)
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Journal Article
Abstract B8: Selective inhibition of Stat3 Tyr705 phosphorylation inhibits angiogenesis in breast cancer xenografts
McMurray, John S., Klostergaard, Jim, Robertson, Fredika M., Mandal, Pijus K., Auzenne, Edmond J., Liao, Warren S.
Published in Molecular cancer therapeutics (12.11.2011)
Published in Molecular cancer therapeutics (12.11.2011)
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Journal Article
Structureâ[euro]"Activity Studies of Phosphopeptidomimetic Prodrugs Targeting the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 3 (Stat3)
Mandal, Pijus K, Ren, Zhiyong, Chen, Xiaomin, Kaluarachchi, Kumar, Liao, Warren S-l, Mcmurray, John S
Published in International journal of peptide research and therapeutics (01.03.2013)
Published in International journal of peptide research and therapeutics (01.03.2013)
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Journal Article
Abstract 2527: Potent, highly selective peptidomimetic prodrugs targeting the SH2 domain of Stat3 decrease vasculogenic mimicry, invasion, and anchorage independent growth of cancer cells
Mandal, Pijus K., Liao, Warren S., Gao, Fengqin, Robertson, Fredika M., Thudi, Nanda K., Ekmekcioglu, Suhendan, Chattopadhyay, Chandrani, Ren, Zhiyong, Chen, Xiaomin, Lu, Zhen, Bast, Robert C., Ramesh, Rajagopal, McMurray, John S.
Published in Cancer research (Chicago, Ill.) (15.04.2010)
Published in Cancer research (Chicago, Ill.) (15.04.2010)
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Journal Article
Constitutively Serine Phosphorylated STAT3 Provides Chronic Lymphocytic Leukemia (CLL) Cells with Survival Advantage and Promotes Their Proliferation
Hazan-Halevy, Inbal, Ferrajoli, Alessandra, Harris, David, Mandal, Pijus K., McMurray, John S., Keating, Michael, Estrov, Zeev
Published in Blood (16.11.2007)
Published in Blood (16.11.2007)
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Journal Article
STAT3 restrains RANK- and TLR4-mediated signaling by suppressing expression of the E2 ubiquitin ligase Ubc13
Zhang, Huiyuan, Hu, Hongbo, Greeley, Nathaniel, Jin, Jin, Matthews, Allison J., Ohashi, Erika, Caetano, Mauricio S., Li, Haiyan S., Wu, Xuefeng, Mandal, Pijus K., McMurray, John S., Moghaddam, Seyed Javad, Sun, Shao-Cong, Watowich, Stephanie S.
Published in Nature communications (15.12.2014)
Published in Nature communications (15.12.2014)
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Journal Article
52 Constitutive Serine Phosphorylation of STAT3 Induces Proliferation of Chronic Lymphocytic Leukemia Cells
Hazan-Halevy, Inbal, Ferrajoli, Alessandra, Harris, David, Mandal, Pijus K., McMurray, John S., Keating, Michael, Estrov, Zeev
Published in Cytokine (Philadelphia, Pa.) (01.07.2007)
Published in Cytokine (Philadelphia, Pa.) (01.07.2007)
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Journal Article