SAR profiles of spirocyclic nicotinamide derived selective HDAC1/HDAC2 inhibitors (SHI-1:2)
METHOT, Joey L, HAMBLETT, Christopher L, HONGMEI WANG, KRAL, Astrid M, OZEROVA, Nicole, CRUZ, Jonathan C, HAINES, Brian, CHENARD, Melissa, KENIFIC, Candia M, SECRIST, J. Paul, MILLER, Thomas A, MAMPREIAN, Dawn M, JUNG, Joon, HARSCH, Andreas, SZEWCZAK, Alexander A, DAHLBERG, William K, MIDDLETON, Richard E, HUGHES, Bethany, FLEMING, Judith C
Published in Bioorganic & medicinal chemistry (01.12.2008)
Published in Bioorganic & medicinal chemistry (01.12.2008)
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Journal Article
The discovery of 6-amino nicotinamides as potent and selective histone deacetylase inhibitors
Hamblett, Christopher L., Methot, Joey L., Mampreian, Dawn M., Sloman, David L., Stanton, Matthew G., Kral, Astrid M., Fleming, Judith C., Cruz, Jonathan C., Chenard, Melissa, Ozerova, Nicole, Hitz, Anna M., Wang, Hongmei, Deshmukh, Sujal V., Nazef, Naim, Harsch, Andreas, Hughes, Bethany, Dahlberg, William K., Szewczak, Alex A., Middleton, Richard E., Mosley, Ralph T., Secrist, J. Paul, Miller, Thomas A.
Published in Bioorganic & medicinal chemistry letters (01.10.2007)
Published in Bioorganic & medicinal chemistry letters (01.10.2007)
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Journal Article
The Discovery of 3‑((4-Chloro-3-methoxyphenyl)amino)-1-((3R,4S)‑4-cyanotetrahydro‑2H‑pyran-3-yl)‑1H‑pyrazole-4-carboxamide, a Highly Ligand Efficient and Efficacious Janus Kinase 1 Selective Inhibitor with Favorable Pharmacokinetic Properties
Siu, Tony, Brubaker, Jason, Fuller, Peter, Torres, Luis, Zeng, Hongbo, Close, Joshua, Mampreian, Dawn M., Shi, Feng, Liu, Duan, Fradera, Xavier, Johnson, Kevin, Bays, Nathan, Kadic, Elma, He, Fang, Goldenblatt, Peter, Shaffer, Lynsey, Patel, Sangita B., Lesburg, Charles A., Alpert, Carla, Dorosh, Lauren, Deshmukh, Sujal V., Yu, Hongshi, Klappenbach, Joel, Elwood, Fiona, Dinsmore, Christopher J., Fernandez, Rafael, Moy, Lily, Young, Jonathan R.
Published in Journal of medicinal chemistry (14.12.2017)
Published in Journal of medicinal chemistry (14.12.2017)
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Journal Article
Potent benzoazepinone γ-secretase modulators with improved bioavailability
Methot, Joey L., Fischer, Christian, Li, Chaomin, Rivkin, Alexey, Ahearn, Sean P., Brown, William Colby, Kattar, Sam, Kelley, Elizabeth, Mampreian, Dawn M., Schell, Adam, Rosenau, Andrew, Zhou, Hua, Ball, Richard, Deshmukh, Sujal V., Jeliazkova-Mecheva, Valentina V., Diaz, Damaris, Moy, Lily Y., Kenific, Candia M., Moxham, Chris, Shah, Sanjiv, Nuthall, Hugh, Szewczak, Alexander A., Hill, Armetta, Hughes, Bethany, Smotrov, Nadya, Munoz, Benito, Miller, Thomas A., Shearman, Mark S.
Published in Bioorganic & medicinal chemistry letters (01.09.2015)
Published in Bioorganic & medicinal chemistry letters (01.09.2015)
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Journal Article
Triazoles as γ-secretase modulators
Fischer, Christian, Zultanski, Susan L, Zhou, Hua, Methot, Joey L, Brown, W. Colby, Mampreian, Dawn M, Schell, Adam J, Shah, Sanjiv, Nuthall, Hugh, Hughes, Bethany L, Smotrov, Nadja, Kenific, Candia M, Cruz, Jonathan C, Walker, Deborah, Bouthillette, Melanie, Nikov, George N, Savage, Dan F, Jeliazkova-Mecheva, Valentina V, Diaz, Damaris, Szewczak, Alexander A, Bays, Nathan, Middleton, Richard E, Munoz, Benito, Shearman, Mark S
Published in Bioorganic & medicinal chemistry letters (01.07.2011)
Published in Bioorganic & medicinal chemistry letters (01.07.2011)
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Journal Article
The Discovery of 3-((4-Chloro-3-methoxyphenyl)amino)-1-((3 R ,4 S )-4-cyanotetrahydro-2 H -pyran-3-yl)-1 H -pyrazole-4-carboxamide, a Highly Ligand Efficient and Efficacious Janus Kinase 1 Selective Inhibitor with Favorable Pharmacokinetic Properties
Siu, Tony, Brubaker, Jason, Fuller, Peter, Torres, Luis, Zeng, Hongbo, Close, Joshua, Mampreian, Dawn M., Shi, Feng, Liu, Duan, Fradera, Xavier, Johnson, Kevin, Bays, Nathan, Kadic, Elma, He, Fang, Goldenblatt, Peter, Shaffer, Lynsey, Patel, Sangita B., Lesburg, Charles A., Alpert, Carla, Dorosh, Lauren, Deshmukh, Sujal V., Yu, Hongshi, Klappenbach, Joel, Elwood, Fiona, Dinsmore, Christopher J., Fernandez, Rafael, Moy, Lily, Young, Jonathan R.
Published in Journal of medicinal chemistry (14.12.2017)
Published in Journal of medicinal chemistry (14.12.2017)
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Journal Article
An unexpected aminocyclopropane reductive rearrangement
Methot, Joey L., Dunstan, Theresa A., Mampreian, Dawn M., Adams, Bruce, Altman, Michael D.
Published in Tetrahedron letters (11.02.2008)
Published in Tetrahedron letters (11.02.2008)
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Journal Article
composto, composição farmacêutica, e, uso do composto
SOLOMON D. KATTAR, DAVID L. SLOMAN, MATTHEW G. STANTON, JOSHUA CLOSE, THOMAS MILLER, CHRISTOPHER HAMBLETT, RICHARD W. HEIDEBRECHT, DAWN M. MAMPREIAN, LAURA T. KLIMAN, JOEY L. METHOT, ANNA A. ZABIEREK, PAUL TEMPEST, SCOTT C. BERK
Year of Publication 13.09.2016
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Year of Publication 13.09.2016
Patent
Spirocyclic compounds
Mampreian, Dawn M, Methot, Joey L, Miller, Thomas, Tempest, Paul, Zabierek, Anna A
Year of Publication 08.01.2013
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Year of Publication 08.01.2013
Patent
Spirocyclic compounds
METHOT JOEY L, TEMPEST PAUL, MAMPREIAN DAWN M, ZABIEREK ANNA A, MILLER THOMAS
Year of Publication 08.01.2013
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Year of Publication 08.01.2013
Patent
ChemInform Abstract: An Unexpected Aminocyclopropane Reductive Rearrangement
Methot, Joey L., Dunstan, Theresa A., Mampreian, Dawn M., Adams, Burce, Altman, Michael D.
Published in ChemInform (10.06.2008)
Published in ChemInform (10.06.2008)
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Journal Article
SPIROCYCLIC COMPOUNDS
METHOT JOEY L, TEMPEST PAUL, MAMPREIAN DAWN M, ZABIEREK ANNA A, MILLER THOMAS
Year of Publication 28.04.2011
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Year of Publication 28.04.2011
Patent
SUBSTITUTED NICOTINAMIDE COMPOUNDS
STANTON, MATTHEW, G, MILLER, THOMAS, SLOMAN, DAVID, L, METHOT, JOEY, L, WILSON, KEVIN, MAMPREIAN, DAWN, M, HAMBLETT, CHRISTOPHER
Year of Publication 19.01.2011
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Year of Publication 19.01.2011
Patent
Benzothiophene derivatives
Mampreian, Dawn M, Miller, Thomas A, Sloman, David L, Stanton, Matthew G, Wilson, Kevin J, Witter, David J
Year of Publication 16.11.2010
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Year of Publication 16.11.2010
Patent
Benzothiophene derivatives
MAMPREIAN DAWN M, MILLER THOMAS A, WITTER DAVID J, STANTON MATTHEW G, WILSON KEVIN J, SLOMAN DAVID L
Year of Publication 16.11.2010
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Year of Publication 16.11.2010
Patent
SPIROCYCLIC COMPOUNDS
SOLOMAN DAVID L, MILLER THOMAS, CLOSE JOSHUA, METHOT JOEY L, TEMPEST PAUL, HAMBLETT CHRISTOPHER, STANTON MATTHEW G, HOFFMAN DAWN M. MAMPREIAN, BERK SCOTT C, KLIMAN LAURA T, HEIDEBRECHT RICHARD W, KATTAR SOLOMON D, ZABIEREK ANNA Z
Year of Publication 23.05.2013
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Year of Publication 23.05.2013
Patent