Syntheses and structure–activity relationship (SAR) studies of 2,5-diazabicyclo[2.2.1]heptanes as novel α7 neuronal nicotinic receptor (NNR) ligands
Li, Tao, Bunnelle, William H., Ryther, Keith B., Anderson, David J., Malysz, John, Helfrich, Rosalind, Grønlien, Jens H., Håkerud, Monika, Peters, Dan, Schrimpf, Michael R., Gopalakrishnan, Murali, Ji, Jianguo
Published in Bioorganic & medicinal chemistry letters (15.06.2010)
Published in Bioorganic & medicinal chemistry letters (15.06.2010)
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Journal Article
Characterization of human cannabinoid CB2 receptor coupled to chimeric Gαqi5 and Gαqo5 proteins
MALYSZ, John, DAZA, Anthony V, KAGE, Karen, GRAYSON, George K, YAO, Betty B, MEYER, Michael D, GOPALAKRISHNAN, Murali
Published in European journal of pharmacology (28.01.2009)
Published in European journal of pharmacology (28.01.2009)
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Journal Article
Molecular and Cellular Pharmacology: Characterization of human cannabinoid CB2 receptor coupled to chimeric G alpha qi5 and G alpha qo5 proteins
Malysz, John, Daza, Anthony V, Kage, Karen, Grayson, George K, Yao, Betty B, Meyer, Michael D, Gopalakrishnan, Murali
Published in European journal of pharmacology (01.01.2009)
Published in European journal of pharmacology (01.01.2009)
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Journal Article
Characterization of human cannabinoid CB 2 receptor coupled to chimeric Gα qi5 and Gα qo5 proteins
Malysz, John, Daza, Anthony V., Kage, Karen, Grayson, George K., Yao, Betty B., Meyer, Michael D., Gopalakrishnan, Murali
Published in European journal of pharmacology (2009)
Published in European journal of pharmacology (2009)
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Journal Article
Functional characterization and high-throughput screening of positive allosteric modulators of α7 nicotinic acetylcholine receptors in IMR-32 neuroblastoma cells
Gopalakrishnan, Sujatha M, Philip, Betsy M, Gronlien, Jens Halvard, Malysz, John, Anderson, David J, Gopalakrishnan, Murali, Warrior, Usha, Burns, David J
Published in Assay and drug development technologies (01.12.2011)
Published in Assay and drug development technologies (01.12.2011)
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In Vitro Pharmacological Characterization of a Novel Allosteric Modulator of α7 Neuronal Acetylcholine Receptor, 4-(5-(4-Chlorophenyl)-2-methyl-3-propionyl-1 H -pyrrol-1-yl)benzenesulfonamide (A-867744), Exhibiting Unique Pharmacological Profile
Malysz, John, Grønlien, Jens Halvard, Anderson, David J., Håkerud, Monika, Thorin-Hagene, Kirsten, Ween, Hilde, Wetterstrand, Caroline, Briggs, Clark A., Faghih, Ramin, Bunnelle, William H., Gopalakrishnan, Murali
Published in The Journal of pharmacology and experimental therapeutics (01.07.2009)
Published in The Journal of pharmacology and experimental therapeutics (01.07.2009)
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Journal Article
Role of α7 nicotinic acetylcholine receptors in regulating tumor necrosis factor-α (TNF-α) as Revealed by subtype selective agonists
Li, Jinhe, Mathieu, Suzanne L., Harris, Richard, Ji, Jianguo, Anderson, David J., Malysz, John, Bunnelle, William H., Waring, Jeffrey F., Marsh, Kennan C., Murtaza, Anwar, Olson, Lisa M., Gopalakrishnan, Murali
Published in Biochemical pharmacology (01.10.2009)
Published in Biochemical pharmacology (01.10.2009)
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Journal Article
In Vitro Pharmacological Characterization of a Novel Allosteric Modulator of α7 Neuronal Acetylcholine Receptor, 4-(5-(4-Chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744), Exhibiting Unique Pharmacological Profile
John Malysz, Jens Halvard Grønlien, David J. Anderson, Monika Håkerud, Kirsten Thorin-Hagene, Hilde Ween, Caroline Wetterstrand, Clark A. Briggs, Ramin Faghih, William H. Bunnelle, Murali Gopalakrishnan
Published in The Journal of pharmacology and experimental therapeutics (01.07.2009)
Published in The Journal of pharmacology and experimental therapeutics (01.07.2009)
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Journal Article
A Pipeline for the Registration of Calcium Transient Data to Structural Networks of the Interstitial Cells of Cajal
Qian, Anna, Means, Shawn, Malysz, John, Farrugia, Gianrico, Gibbons, Simon J., Du, Peng
Published in 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) (01.07.2019)
Published in 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) (01.07.2019)
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Distinct profiles of alpha7 nAChR positive allosteric modulation revealed by structurally diverse chemotypes
Grønlien, Jens Halvard, Håkerud, Monika, Ween, Hilde, Thorin-Hagene, Kirsten, Briggs, Clark A, Gopalakrishnan, Murali, Malysz, John
Published in Molecular pharmacology (01.09.2007)
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Published in Molecular pharmacology (01.09.2007)
Journal Article
Distinct Profiles of α7 nAChR Positive Allosteric Modulation Revealed by Structurally Diverse Chemotypes
Jens Halvard Grønlien, Monika Håkerud, Hilde Ween, Kirsten Thorin-Hagene, Clark A. Briggs, Murali Gopalakrishnan, John Malysz
Published in Molecular pharmacology (01.09.2007)
Published in Molecular pharmacology (01.09.2007)
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Journal Article
Discovery of 4-(5-(4-Chlorophenyl)-2-methyl-3-propionyl-1 H -pyrrol-1-yl)benzenesulfonamide (A-867744) as a Novel Positive Allosteric Modulator of the α7 Nicotinic Acetylcholine Receptor
Faghih, Ramin, Gopalakrishnan, Sujatha M., Gronlien, Jens Halvard, Malysz, John, Briggs, Clark A., Wetterstrand, Caroline, Ween, Hilde, Curtis, Michael P., Sarris, Kathy A., Gfesser, Gregory A., El-Kouhen, Rachid, Robb, Holly M., Radek, Richard J., Marsh, Kennan C., Bunnelle, William H., Gopalakrishnan, Murali
Published in Journal of medicinal chemistry (28.05.2009)
Published in Journal of medicinal chemistry (28.05.2009)
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Journal Article
An Allosteric Modulator of the α7 Nicotinic Acetylcholine Receptor Possessing Cognition-Enhancing Properties in Vivo
Daniel B. Timmermann, Jens Halvard Grønlien, Kathy L. Kohlhaas, Elsebet Ã. Nielsen, Eva Dam, Tino D. Jørgensen, Philip K. Ahring, Dan Peters, Dorte Holst, Jeppe K. Chrsitensen, John Malysz, Clark A. Briggs, Murali Gopalakrishnan, Gunnar M. Olsen
Published in The Journal of pharmacology and experimental therapeutics (01.10.2007)
Published in The Journal of pharmacology and experimental therapeutics (01.10.2007)
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Journal Article
An allosteric modulator of the alpha7 nicotinic acetylcholine receptor possessing cognition-enhancing properties in vivo
Timmermann, Daniel B, Grønlien, Jens Halvard, Kohlhaas, Kathy L, Nielsen, Elsebet Ø, Dam, Eva, Jørgensen, Tino D, Ahring, Philip K, Peters, Dan, Holst, Dorte, Christensen, Jeppe K, Chrsitensen, Jeppe K, Malysz, John, Briggs, Clark A, Gopalakrishnan, Murali, Olsen, Gunnar M
Published in The Journal of pharmacology and experimental therapeutics (01.10.2007)
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Published in The Journal of pharmacology and experimental therapeutics (01.10.2007)
Journal Article
P2-477: Evidence for broad spectrum symptomatic efficacy across cognitive domains and potential for disease modification in Alzheimer's disease revealed by the novel alpha-7 neuronal nicotinic receptor agonist A-582941
Gopalakrishnan, Murali, Anderson, David, Bunnelle, William, Briggs, Clark, Buccafusco, Jerry, Curzon, Peter, Decker, Michael, Hu, Min, Li, Jinhe, Malysz, John, Markosyan, Stella, Nikkel, Arthur, Radek, Rich, Robb, Holly, Bitner, Robert
Published in Alzheimer's & dementia (01.07.2008)
Published in Alzheimer's & dementia (01.07.2008)
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Journal Article
Alpha3 and alpha 7 nAChR-mediated Ca2+ transient generation in IMR-32 neuroblastoma cells
Ween, Hilde, Thorin-Hagene, Kirsten, Andersen, Elisabeth, Grønlien, Jens Halvard, Lee, Chih-Hung, Gopalakrishnan, Murali, Malysz, John
Published in Neurochemistry international (01.10.2010)
Published in Neurochemistry international (01.10.2010)
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