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Liang, Qin, Dexheimer, Thomas S, Zhang, Ping, Rosenthal, Andrew S, Villamil, Mark A, You, Changjun, Zhang, Qiuting, Chen, Junjun, Ott, Christine A, Sun, Hongmao, Luci, Diane K, Yuan, Bifeng, Simeonov, Anton, Jadhav, Ajit, Xiao, Hui, Wang, Yinsheng, Maloney, David J, Zhuang, Zhihao
Published in Nature chemical biology (01.04.2014)
Published in Nature chemical biology (01.04.2014)
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High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell–like diffuse large B-cell lymphoma cells
Griner, Lesley A. Mathews, Guha, Rajarshi, Shinn, Paul, Young, Ryan M., Keller, Jonathan M., Liu, Dongbo, Goldlust, Ian S., Yasgar, Adam, McKnight, Crystal, Boxer, Matthew B., Duveau, Damien Y., Jiang, Jian-Kang, Michael, Sam, Mierzwa, Tim, Huang, Wenwei, Walsh, Martin J., Mott, Bryan T., Patel, Paresma, Leister, William, Maloney, David J., Leclair, Christopher A., Rai, Ganesha, Jadhav, Ajit, Peyser, Brian D., Austin, Christopher P., Martin, Scott E., Simeonov, Anton, Ferrer, Marc, Staudt, Louis M., Thomas, Craig J.
Published in Proceedings of the National Academy of Sciences - PNAS (11.02.2014)
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Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy
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Published in Science translational medicine (14.02.2018)
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Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH)
Rai, Ganesha, Brimacombe, Kyle R, Mott, Bryan T, Urban, Daniel J, Hu, Xin, Yang, Shyh-Ming, Lee, Tobie D, Cheff, Dorian M, Kouznetsova, Jennifer, Benavides, Gloria A, Pohida, Katie, Kuenstner, Eric J, Luci, Diane K, Lukacs, Christine M, Davies, Douglas R, Dranow, David M, Zhu, Hu, Sulikowski, Gary, Moore, William J, Stott, Gordon M, Flint, Andrew J, Hall, Matthew D, Darley-Usmar, Victor M, Neckers, Leonard M, Dang, Chi V, Waterson, Alex G, Simeonov, Anton, Jadhav, Ajit, Maloney, David J
Published in Journal of medicinal chemistry (22.11.2017)
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Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds
Horton, John R., Liu, Xu, Gale, Molly, Wu, Lizhen, Shanks, John R., Zhang, Xing, Webber, Philip J., Bell, Joshua S.K., Kales, Stephen C., Mott, Bryan T., Rai, Ganesha, Jansen, Daniel J., Henderson, Mark J., Urban, Daniel J., Hall, Matthew D., Simeonov, Anton, Maloney, David J., Johns, Margaret A., Fu, Haian, Jadhav, Ajit, Vertino, Paula M., Yan, Qin, Cheng, Xiaodong
Published in Cell chemical biology (21.07.2016)
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CN470 is a BET/CBP/p300 multi-bromodomain inhibitor and has an anti-tumor activity against MLL-rearranged acute lymphoblastic leukemia
Imayoshi, Natsuki, Yoshioka, Makoto, Tanaka, Kuniaki, Yang, Shyh-Ming, Akahane, Koshi, Toda, Yuki, Hosogi, Shigekuni, Inukai, Takeshi, Okada, Seiji, Maloney, David J., Nakahata, Tatsutoshi, Takita, Junko, Kato, Itaru, Ashihara, Eishi
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Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors
King, Oliver N F, Li, Xuan Shirley, Sakurai, Masaaki, Kawamura, Akane, Rose, Nathan R, Ng, Stanley S, Quinn, Amy M, Rai, Ganesha, Mott, Bryan T, Beswick, Paul, Klose, Robert J, Oppermann, Udo, Jadhav, Ajit, Heightman, Tom D, Maloney, David J, Schofield, Christopher J, Simeonov, Anton
Published in PloS one (23.11.2010)
Published in PloS one (23.11.2010)
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Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy
Oshima, Nobu, Ishida, Ryo, Kishimoto, Shun, Beebe, Kristin, Brender, Jeffrey R., Yamamoto, Kazutoshi, Urban, Daniel, Rai, Ganesha, Johnson, Michelle S., Benavides, Gloria, Squadrito, Giuseppe L., Crooks, Dan, Jackson, Joseph, Joshi, Abhinav, Mott, Bryan T., Shrimp, Jonathan H., Moses, Michael A., Lee, Min-Jung, Yuno, Akira, Lee, Tobie D., Hu, Xin, Anderson, Tamara, Kusewitt, Donna, Hathaway, Helen H., Jadhav, Ajit, Picard, Didier, Trepel, Jane B., Mitchell, James B., Stott, Gordon M., Moore, William, Simeonov, Anton, Sklar, Larry A., Norenberg, Jeffrey P., Linehan, W. Marston, Maloney, David J., Dang, Chi V., Waterson, Alex G., Hall, Matthew, Darley-Usmar, Victor M., Krishna, Murali C., Neckers, Leonard M.
Published in Cell reports (Cambridge) (11.02.2020)
Published in Cell reports (Cambridge) (11.02.2020)
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Potent and Selective Inhibitors of Human Reticulocyte 12/15-Lipoxygenase as Anti-Stroke Therapies
Rai, Ganesha, Joshi, Netra, Jung, Joo Eun, Liu, Yu, Schultz, Lena, Yasgar, Adam, Perry, Steve, Diaz, Giovanni, Zhang, Qiangli, Kenyon, Victor, Jadhav, Ajit, Simeonov, Anton, Lo, Eng H, van Leyen, Klaus, Maloney, David J, Holman, Theodore R
Published in Journal of medicinal chemistry (22.05.2014)
Published in Journal of medicinal chemistry (22.05.2014)
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A high-throughput screen to identify novel small molecule inhibitors of the Werner Syndrome Helicase-Nuclease (WRN)
Sommers, Joshua A, Kulikowicz, Tomasz, Croteau, Deborah L, Dexheimer, Thomas, Dorjsuren, Dorjbal, Jadhav, Ajit, Maloney, David J, Simeonov, Anton, Bohr, Vilhelm A, Brosh, Jr, Robert M
Published in PloS one (09.01.2019)
Published in PloS one (09.01.2019)
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Synthesis, Biological Evaluation, and Structure–Activity Relationships of a Novel Class of Apurinic/Apyrimidinic Endonuclease 1 Inhibitors
Rai, Ganesha, Vyjayanti, Vaddadi N, Dorjsuren, Dorjbal, Simeonov, Anton, Jadhav, Ajit, Wilson, David M, Maloney, David J
Published in Journal of medicinal chemistry (12.04.2012)
Published in Journal of medicinal chemistry (12.04.2012)
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Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124
Auld, Douglas S, Lovell, Scott, Thorne, Natasha, Lea, Wendy A, Maloney, David J, Shen, Min, Rai, Ganesha, Battaile, Kevin P, Thomas, Craig J, Simeonov, Anton, Hanzlik, Robert P, Inglese, James
Published in Proceedings of the National Academy of Sciences - PNAS (16.03.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (16.03.2010)
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A High-Content Assay Enables the Automated Screening and Identification of Small Molecules with Specific ALDH1A1-Inhibitory Activity
Yasgar, Adam, Titus, Steven A, Wang, Yuhong, Danchik, Carina, Yang, Shyh-Ming, Vasiliou, Vasilis, Jadhav, Ajit, Maloney, David J, Simeonov, Anton, Martinez, Natalia J
Published in PloS one (27.01.2017)
Published in PloS one (27.01.2017)
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Structure-Based Engineering of Irreversible Inhibitors against Histone Lysine Demethylase KDM5A
Horton, John R, Woodcock, Clayton B, Chen, Qin, Liu, Xu, Zhang, Xing, Shanks, John, Rai, Ganesha, Mott, Bryan T, Jansen, Daniel J, Kales, Stephen C, Henderson, Mark J, Cyr, Matthew, Pohida, Katherine, Hu, Xin, Shah, Pranav, Xu, Xin, Jadhav, Ajit, Maloney, David J, Hall, Matthew D, Simeonov, Anton, Fu, Haian, Vertino, Paula M, Cheng, Xiaodong
Published in Journal of medicinal chemistry (13.12.2018)
Published in Journal of medicinal chemistry (13.12.2018)
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Lead optimization and efficacy evaluation of quinazoline-based BET family inhibitors for potential treatment of cancer and inflammatory diseases
Yang, Shyh-Ming, Yoshioka, Makoto, Strovel, Jeffrey W., Urban, Daniel J., Hu, Xin, Hall, Matthew D., Jadhav, Ajit, Maloney, David J.
Published in Bioorganic & medicinal chemistry letters (15.05.2019)
Published in Bioorganic & medicinal chemistry letters (15.05.2019)
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Genomic and protein expression analysis reveals flap endonuclease 1 (FEN1) as a key biomarker in breast and ovarian cancer
Abdel-Fatah, Tarek M.A., Russell, Roslin, Albarakati, Nada, Maloney, David J., Dorjsuren, Dorjbal, Rueda, Oscar M., Moseley, Paul, Mohan, Vivek, Sun, Hongmao, Abbotts, Rachel, Mukherjee, Abhik, Agarwal, Devika, Illuzzi, Jennifer L., Jadhav, Ajit, Simeonov, Anton, Ball, Graham, Chan, Stephen, Caldas, Carlos, Ellis, Ian O., Wilson, David M., Madhusudan, Srinivasan
Published in Molecular oncology (01.10.2014)
Published in Molecular oncology (01.10.2014)
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The function of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) explored using a specific inhibitor that targets the PI5P-binding site
Clarke, Jonathan H, Giudici, Maria-Luisa, Burke, John E, Williams, Roger L, Maloney, David J, Marugan, Juan, Irvine, Robin F
Published in Biochemical journal (01.03.2015)
Published in Biochemical journal (01.03.2015)
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Molecular basis for activation of lecithin:cholesterol acyltransferase by a compound that increases HDL cholesterol
Manthei, Kelly A, Yang, Shyh-Ming, Baljinnyam, Bolormaa, Chang, Louise, Glukhova, Alisa, Yuan, Wenmin, Freeman, Lita A, Maloney, David J, Schwendeman, Anna, Remaley, Alan T, Jadhav, Ajit, Tesmer, John Jg
Published in eLife (27.11.2018)
Published in eLife (27.11.2018)
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Discovery and lead identification of quinazoline-based BRD4 inhibitors
Yang, Shyh-Ming, Urban, Daniel J., Yoshioka, Makoto, Strovel, Jeffrey W., Fletcher, Steven, Wang, Amy Q., Xu, Xin, Shah, Pranav, Hu, Xin, Hall, Matthew D., Jadhav, Ajit, Maloney, David J.
Published in Bioorganic & medicinal chemistry letters (15.11.2018)
Published in Bioorganic & medicinal chemistry letters (15.11.2018)
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Chemoprotective antimalarials identified through quantitative high-throughput screening of Plasmodium blood and liver stage parasites
Dorjsuren, Dorjbal, Eastman, Richard T, Wicht, Kathryn J, Jansen, Daniel, Talley, Daniel C, Sigmon, Benjamin A, Zakharov, Alexey V, Roncal, Norma, Girvin, Andrew T, Antonova-Koch, Yevgeniya, Will, Paul M, Shah, Pranav, Sun, Hongmao, Klumpp-Thomas, Carleen, Mok, Sachel, Yeo, Tomas, Meister, Stephan, Marugan, Juan Jose, Ross, Leila S, Xu, Xin, Maloney, David J, Jadhav, Ajit, Mott, Bryan T, Sciotti, Richard J, Winzeler, Elizabeth A, Waters, Norman C, Campbell, Robert F, Huang, Wenwei, Simeonov, Anton, Fidock, David A
Published in Scientific reports (22.01.2021)
Published in Scientific reports (22.01.2021)
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