Engineering IL-2 for immunotherapy of autoimmunity and cancer
Hernandez, Rosmely, Põder, Janika, LaPorte, Kathryn M, Malek, Thomas R
Published in Nature reviews. Immunology (01.10.2022)
Published in Nature reviews. Immunology (01.10.2022)
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Journal Article
Regulatory T cells in the treatment of disease
Sharabi, Amir, Tsokos, Maria G, Ding, Ying, Malek, Thomas R, Klatzmann, David, Tsokos, George C
Published in Nature reviews. Drug discovery (01.11.2018)
Published in Nature reviews. Drug discovery (01.11.2018)
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Journal Article
Selective IL-2 responsiveness of regulatory T cells through multiple intrinsic mechanisms supports the use of low-dose IL-2 therapy in type 1 diabetes
Yu, Aixin, Snowhite, Isaac, Vendrame, Francesco, Rosenzwajg, Michelle, Klatzmann, David, Pugliese, Alberto, Malek, Thomas R
Published in Diabetes (New York, N.Y.) (01.06.2015)
Published in Diabetes (New York, N.Y.) (01.06.2015)
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Journal Article
Aptamer-targeted inhibition of mTOR in T cells enhances antitumor immunity
Berezhnoy, Alexey, Castro, Iris, Levay, Agata, Malek, Thomas R, Gilboa, Eli
Published in The Journal of clinical investigation (01.01.2014)
Published in The Journal of clinical investigation (01.01.2014)
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Journal Article
Cytokine Signaling in the Development and Homeostasis of Regulatory T cells
Toomer, Kevin H, Malek, Thomas R
Published in Cold Spring Harbor perspectives in biology (01.03.2018)
Published in Cold Spring Harbor perspectives in biology (01.03.2018)
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Journal Article
Interleukin-2 signaling in the regulation of T cell biology in autoimmunity and cancer
Shouse, Acacia N., LaPorte, Kathryn M., Malek, Thomas R.
Published in Immunity (Cambridge, Mass.) (12.03.2024)
Published in Immunity (Cambridge, Mass.) (12.03.2024)
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Journal Article
IL-2R signaling is essential for functional maturation of regulatory T cells during thymic development
Cheng, Guoyan, Yu, Aixin, Dee, Michael J, Malek, Thomas R
Published in The Journal of immunology (1950) (15.02.2013)
Published in The Journal of immunology (1950) (15.02.2013)
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Journal Article
CD25 and Protein Phosphatase 2A Cooperate to Enhance IL-2R Signaling in Human Regulatory T Cells
Ding, Ying, Yu, Aixin, Tsokos, George C, Malek, Thomas R
Published in The Journal of immunology (1950) (01.07.2019)
Published in The Journal of immunology (1950) (01.07.2019)
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Journal Article
IL-2/CD25: A Long-Acting Fusion Protein That Promotes Immune Tolerance by Selectively Targeting the IL-2 Receptor on Regulatory T Cells
Ward, Natasha C, Yu, Aixin, Moro, Alejandro, Ban, Yuguang, Chen, Xi, Hsiung, Sunnie, Keegan, James, Arbanas, Jaren M, Loubeau, Martine, Thankappan, Anil, Yamniuk, Aaron P, Davis, Jonathan H, Struthers, Mary, Malek, Thomas R
Published in The Journal of immunology (1950) (01.11.2018)
Published in The Journal of immunology (1950) (01.11.2018)
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