Discovery of 2-(1H-imidazo-2-yl)piperazines as a new class of potent and non-cytotoxic inhibitors of Trypanosoma brucei growth in vitro
Ferrigno, Federica, Biancofiore, Ilaria, Malancona, Savina, Ponzi, Simona, Paonessa, Giacomo, Graziani, Rita, Bresciani, Alberto, Gennari, Nadia, Di Marco, Annalise, Kaiser, Marcel, Summa, Vincenzo, Harper, Steven, Ontoria, Jesus M.
Published in Bioorganic & medicinal chemistry letters (15.12.2018)
Published in Bioorganic & medicinal chemistry letters (15.12.2018)
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Identification of MK-5710 ((8aS)-8a-methyl-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-N-(1-phenyl-1H-pyrazol-5-yl)hexahydroimid azo[1,5-a]pyrazine-7(1H)-carboxamide), a potent smoothened antagonist for use in Hedgehog pathway dependent malignancies, Part 1
Malancona, Savina, Altamura, Sergio, Filocamo, Gessica, Kinzel, Olaf, Hernando, Jose Ignacio Martin, Rowley, Michael, Scarpelli, Rita, Steinkühler, Christian, Jones, Philip
Published in Bioorganic & medicinal chemistry letters (01.08.2011)
Published in Bioorganic & medicinal chemistry letters (01.08.2011)
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Identification of MK-5710 ((8aS)-8a-methyl-1,3-dioxo-2-[(1S,2R)-2-phenylcyclo- propyl]-N-(1-phenyl-1H-pyrazol-5-yl)hexahydro-imidazo[1,5-a]pyrazine-7(1H)-carboxamide), a potent smoothened antagonist for use in Hedgehog pathway dependent malignancies, Part 2
Kinzel, Olaf, Alfieri, Anna, Altamura, Sergio, Brunetti, Mirko, Bufali, Simone, Colaceci, Fabrizio, Ferrigno, Federica, Filocamo, Gessica, Fonsi, Massimiliano, Gallinari, Paola, Malancona, Savina, Hernando, Jose Ignacio Martin, Monteagudo, Edith, Orsale, Maria Vittoria, Palumbi, Maria Cecilia, Pucci, Vincenzo, Rowley, Michael, Sasso, Romina, Scarpelli, Rita, Steinkühler, Christian, Jones, Philip
Published in Bioorganic & medicinal chemistry letters (01.08.2011)
Published in Bioorganic & medicinal chemistry letters (01.08.2011)
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Identification of thieno[3,2- b]pyrroles as allosteric inhibitors of hepatitis C virus NS5B polymerase
Ontoria, Jesus M., Martìn Hernando, Jose I., Malancona, Savina, Attenni, Barbara, Stansfield, Ian, Conte, Immacolata, Ercolani, Caterina, Habermann, Jörg, Ponzi, Simona, Di Filippo, Marcello, Koch, Uwe, Rowley, Michael, Narjes, Frank
Published in Bioorganic & medicinal chemistry letters (01.08.2006)
Published in Bioorganic & medicinal chemistry letters (01.08.2006)
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Improved modular synthesis of thieno[3,2- b]pyrroles and thieno[2,3- b]pyrroles
Malancona, Savina, Hernando, Josè I. Martin, Attenni, Barbara, Ontoria, Jesus M., Narjes, Frank
Published in Tetrahedron letters (08.04.2009)
Published in Tetrahedron letters (08.04.2009)
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Optimization of Thienopyrrole‐Based Finger‐Loop Inhibitors of the Hepatitis C Virus NS5B Polymerase
Martin Hernando, Jose Ignacio, Ontoria, Jesus Maria, Malancona, Savina, Attenni, Barbara, Fiore, Fabrizio, Bonelli, Fabio, Koch, Uwe, Di Marco, Stefania, Colarusso, Stefania, Ponzi, Simona, Gennari, Nadia, Vignetti, Sue Ellen, del Rosario Rico Ferreira, Maria, Habermann, Jörg, Rowley, Michael, Narjes, Frank
Published in ChemMedChem (05.10.2009)
Published in ChemMedChem (05.10.2009)
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Inhibitors of the hepatitis C virus RNA-dependent RNA polymerase
Attenni, Barbara, Avolio, Salvatore, Colarusso, Stefania, Malancona, Savina, Harper, Steven, Altamura, Sergio, Koch, Uwe, Narjes, Frank
Published in ARKIVOC (19.03.2006)
Published in ARKIVOC (19.03.2006)
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Cyclic Phosphopantothenic Acid Prodrugs for Treatment of Pantothenate Kinase-Associated Neurodegeneration
Auciello, Giulio, Di Marco, Annalise, Gonzalez Paz, Odalys, Malancona, Savina, Harper, Steven, Beconi, Maria, Rossetti, Ilaria, Ciammaichella, Alina, Fezzardi, Paola, Vecchi, Andrea, Bracacel, Elena, Cicero, Daniel, Monteagudo, Edith, Elbaum, Daniel
Published in Journal of medicinal chemistry (24.12.2020)
Published in Journal of medicinal chemistry (24.12.2020)
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Improved Selective Class I HDAC and Novel Selective HDAC3 Inhibitors: Beyond Hydroxamic Acids and Benzamides
Bresciani, Alberto, Ontoria, Jesus M, Biancofiore, Ilaria, Cellucci, Antonella, Ciammaichella, Alina, Di Marco, Annalise, Ferrigno, Federica, Francone, Alessandra, Malancona, Savina, Monteagudo, Edith, Nizi, Emanuela, Pace, Paola, Ponzi, Simona, Rossetti, Ilaria, Veneziano, Maria, Summa, Vincenzo, Harper, Steven
Published in ACS medicinal chemistry letters (11.04.2019)
Published in ACS medicinal chemistry letters (11.04.2019)
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Synthesis and Evaluation of Bifunctional Aminothiazoles as Antiretrovirals Targeting the HIV‑1 Nucleocapsid Protein
Mori, Mattia, Dasso Lang, Maria Chiara, Saladini, Francesco, Palombi, Nastasja, Kovalenko, Lesia, De Forni, Davide, Poddesu, Barbara, Friggeri, Laura, Giannini, Alessia, Malancona, Savina, Summa, Vincenzo, Zazzi, Maurizio, Mely, Yves, Botta, Maurizio
Published in ACS medicinal chemistry letters (11.04.2019)
Published in ACS medicinal chemistry letters (11.04.2019)
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Structure-Based Identification of HIV‑1 Nucleocapsid Protein Inhibitors Active against Wild-Type and Drug-Resistant HIV‑1 Strains
Mori, Mattia, Kovalenko, Lesia, Malancona, Savina, Saladini, Francesco, De Forni, Davide, Pires, Manuel, Humbert, Nicolas, Real, Eleonore, Botzanowski, Thomas, Cianférani, Sarah, Giannini, Alessia, Dasso Lang, Maria Chiara, Cugia, Giulia, Poddesu, Barbara, Lori, Franco, Zazzi, Maurizio, Harper, Steven, Summa, Vincenzo, Mely, Yves, Botta, Maurizio
Published in ACS chemical biology (19.01.2018)
Published in ACS chemical biology (19.01.2018)
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5,6-Dihydroxypyrimidine Scaffold to Target HIV‑1 Nucleocapsid Protein
Malancona, Savina, Mori, Mattia, Fezzardi, Paola, Santoriello, Marisabella, Basta, Andreina, Nibbio, Martina, Kovalenko, Lesia, Speziale, Roberto, Battista, Maria Rosaria, Cellucci, Antonella, Gennari, Nadia, Monteagudo, Edith, Di Marco, Annalise, Giannini, Alessia, Sharma, Rajhans, Pires, Manuel, Real, Eleonore, Zazzi, Maurizio, Dasso Lang, Maria Chiara, De Forni, Davide, Saladini, Francesco, Mely, Yves, Summa, Vincenzo, Harper, Steven, Botta, Maurizio
Published in ACS medicinal chemistry letters (14.05.2020)
Published in ACS medicinal chemistry letters (14.05.2020)
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Discovery of a Selective Series of Inhibitors of Plasmodium falciparum HDACs
Ontoria, Jesus M, Paonessa, Giacomo, Ponzi, Simona, Ferrigno, Federica, Nizi, Emanuela, Biancofiore, Ilaria, Malancona, Savina, Graziani, Rita, Roberts, David, Willis, Paul, Bresciani, Alberto, Gennari, Nadia, Cecchetti, Ottavia, Monteagudo, Edith, Orsale, Maria V, Veneziano, Maria, Di Marco, Annalise, Cellucci, Antonella, Laufer, Ralph, Altamura, Sergio, Summa, Vincenzo, Harper, Steven
Published in ACS medicinal chemistry letters (12.05.2016)
Published in ACS medicinal chemistry letters (12.05.2016)
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Allosteric inhibitors of hepatitis C virus NS5B polymerase thumb domain site II: Structure-based design and synthesis of new templates
Malancona, Savina, Donghi, Monica, Ferrara, Marco, Martin Hernando, Josè I., Pompei, Marco, Pesci, Silvia, Ontoria, Jesus M., Koch, Uwe, Rowley, Michael, Summa, Vincenzo
Published in Bioorganic & medicinal chemistry (15.04.2010)
Published in Bioorganic & medicinal chemistry (15.04.2010)
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Journal Article
Identification and Biological Evaluation of a Series of 1H-Benzo[de]isoquinoline-1,3(2H)-diones as Hepatitis C Virus NS5B Polymerase Inhibitors
Ontoria, Jesus M, Rydberg, Edwin H, Di Marco, Stefania, Tomei, Licia, Attenni, Barbara, Malancona, Savina, Martin Hernando, José I, Gennari, Nadia, Koch, Uwe, Narjes, Frank, Rowley, Michael, Summa, Vincenzo, Carroll, Steve S, Olsen, David B, De Francesco, Raffaele, Altamura, Sergio, Migliaccio, Giovanni, Carfì, Andrea
Published in Journal of medicinal chemistry (27.08.2009)
Published in Journal of medicinal chemistry (27.08.2009)
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2-(2-Thienyl)-5,6-dihydroxy-4-carboxypyrimidines as Inhibitors of the Hepatitis C Virus NS5B Polymerase: Discovery, SAR, Modeling, and Mutagenesis
Koch, Uwe, Attenni, Barbara, Malancona, Savina, Colarusso, Stefania, Conte, Immacolata, Di Filippo, Marcello, Harper, Steven, Pacini, Barbara, Giomini, Claudia, Thomas, Steven, Incitti, Ilario, Tomei, Licia, De Francesco, Raffaele, Altamura, Sergio, Matassa, Victor G, Narjes, Frank
Published in Journal of medicinal chemistry (09.03.2006)
Published in Journal of medicinal chemistry (09.03.2006)
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Journal Article
Identification of MK-5710 ((8 aS)-8 a-methyl-1,3-dioxo-2-[(1 S,2 R)-2-phenylcyclopropyl]- N-(1-phenyl-1 H-pyrazol-5-yl)hexahydroimid azo[1,5-a]pyrazine-7(1 H)-carboxamide), a potent smoothened antagonist for use in Hedgehog pathway dependent malignancies, Part 1
Malancona, Savina, Altamura, Sergio, Filocamo, Gessica, Kinzel, Olaf, Hernando, Jose Ignacio Martin, Rowley, Michael, Scarpelli, Rita, Steinkühler, Christian, Jones, Philip
Published in Bioorganic & medicinal chemistry letters (2011)
Published in Bioorganic & medicinal chemistry letters (2011)
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